Search Results - "WILHELM, Imola"

In Vitro Models of the Blood–Brain Barrier for the Study of Drug Delivery to the Brain by Wilhelm, Imola, Krizbai, István A

“…The most important obstacle to the drug delivery into the brain is the presence of the blood–brain barrier, which limits the traffic of substances between the…”
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In vitro models of the blood-brain barrier by Wilhelm, Imola, Fazakas, Csilla, Krizbai, Istvan A

“…The blood-brain barrier (BBB) is an active interface between the circulation and the central nervous system (CNS) with a dual function: the barrier function…”
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The Blood-Brain Barrier and Its Intercellular Junctions in Age-Related Brain Disorders by Costea, Laura, Mészáros, Ádám, Bauer, Hannelore, Bauer, Hans-Christian, Traweger, Andreas, Wilhelm, Imola, Farkas, Attila E, Krizbai, István A

“…With age, our cognitive skills and abilities decline. Maybe starting as an annoyance, this decline can become a major impediment to normal daily life. Recent…”
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Pituitary adenylate cyclase activating polypeptide acts against neovascularization in retinal pigment epithelial cells by Fabian, Eszter, Reglodi, Dora, Horvath, Gabriella, Opper, Balazs, Toth, Gabor, Fazakas, Csilla, Vegh, Attila G., Wilhelm, Imola, Krizbai, Istvan A.

“…The purpose of this study was to determine whether pituitary adenylate cyclase activating polypeptide (PACAP) could influence the neovascularization processes…”
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Motoneuronal inflammasome activation triggers excessive neuroinflammation and impedes regeneration after sciatic nerve injury by Molnár, Kinga, Nógrádi, Bernát, Kristóf, Rebeka, Mészáros, Ádám, Pajer, Krisztián, Siklós, László, Nógrádi, Antal, Wilhelm, Imola, Krizbai, István A

“…Peripheral nerve injuries are accompanied by inflammatory reactions, over-activation of which may hinder recovery. Among pro-inflammatory pathways,…”
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Osteosarcoma-Induced Pain Is Mediated by Glial Cell Activation in the Spinal Dorsal Horn, but Not Capsaicin-Sensitive Nociceptive Neurons: A Complex Functional and Morphological Characterization in Mice by Bencze, Noémi, Scheich, Bálint, Szőke, Éva, Wilhelm, Imola, Körmöndi, Sándor, Botz, Bálint, Helyes, Zsuzsanna

“…Bone cancer and its related chronic pain are huge clinical problems since the available drugs are often ineffective or cannot be used long term due to a broad…”
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Paracellular and transcellular migration of metastatic cells through the cerebral endothelium by Herman, Hildegard, Fazakas, Csilla, Haskó, János, Molnár, Kinga, Mészáros, Ádám, Nyúl‐Tóth, Ádám, Szabó, Gábor, Erdélyi, Ferenc, Ardelean, Aurel, Hermenean, Anca, Krizbai, István A., Wilhelm, Imola

“…Breast cancer and melanoma are among the most frequent cancer types leading to brain metastases. Despite the unquestionable clinical significance, important…”
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Role of the blood-brain barrier in the formation of brain metastases by Wilhelm, Imola, Molnár, Judit, Fazakas, Csilla, Haskó, János, Krizbai, István A

“…The majority of brain metastases originate from lung cancer, breast cancer and malignant melanoma. In order to reach the brain, parenchyma metastatic cells…”
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MicroRNAs and Extracellular Vesicles as Distinctive Biomarkers of Precocious and Advanced Stages of Breast Cancer Brain Metastases Development by Figueira, Inês, Godinho-Pereira, Joana, Galego, Sofia, Maia, Joana, Haskó, János, Molnár, Kinga, Malhó, Rui, Costa-Silva, Bruno, Wilhelm, Imola, Krizbai, István A, Brito, Maria Alexandra

“…Triple negative breast cancer presents higher mortality and poorer survival rates than other breast cancer (BC) types, due to the proneness to brain metastases…”
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Senolysis potentiates endothelial progenitor cell adhesion to and integration into the brain vasculature by Lam, Tri Duc, Tóth, István, Hermenean, Anca, Wilhelm, Imola, Kieda, Claudine, Krizbai, István, Farkas, Attila E

“…Background One of the most severe consequences of ageing is cognitive decline, which is associated with dysfunction of the brain microvasculature. Thus,…”
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Endothelial-mesenchymal transition of brain endothelial cells: possible role during metastatic extravasation by Krizbai, István A, Gasparics, Ákos, Nagyőszi, Péter, Fazakas, Csilla, Molnár, Judit, Wilhelm, Imola, Bencs, Rita, Rosivall, László, Sebe, Attila

“…Cancer progression towards metastasis follows a defined sequence of events described as the metastatic cascade. For extravasation and transendothelial…”
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Pericyte‐secreted IGF2 promotes breast cancer brain metastasis formation by Molnár, Kinga, Mészáros, Ádám, Fazakas, Csilla, Kozma, Mihály, Győri, Fanni, Reisz, Zita, Tiszlavicz, László, Farkas, Attila E., Nyúl‐Tóth, Ádám, Haskó, János, Krizbai, István A., Wilhelm, Imola

“…Brain metastases are life‐threatening complications of triple‐negative breast cancer, melanoma, and a few other tumor types. Poor outcome of cerebral secondary…”
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Downregulation of circulating miR 802‐5p and miR 194‐5p and upregulation of brain MEF2C along breast cancer brain metastasization by Sereno, Marta, Haskó, János, Molnár, Kinga, Medina, Sarah J., Reisz, Zita, Malhó, Rui, Videira, Mafalda, Tiszlavicz, László, Booth, Stephanie A., Wilhelm, Imola, Krizbai, István A., Brito, Maria Alexandra

“…Breast cancer brain metastases (BCBMs) have been underinvestigated despite their high incidence and poor outcome. MicroRNAs (miRNAs), and particularly…”
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Expression and regulation of toll-like receptors in cerebral endothelial cells by Nagyőszi, Péter, Wilhelm, Imola, Farkas, Attila E., Fazakas, Csilla, Dung, Ngo Thi Khue, Haskó, János, Krizbai, István A.

“…Cerebral endothelial cells – the principal components of the blood–brain barrier (BBB) – fulfill several important functions in the central nervous system…”
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Foe or friend? Janus-faces of the neurovascular unit in the formation of brain metastases by Wilhelm, Imola, Fazakas, Csilla, Molnár, Kinga, Végh, Attila G, Haskó, János, Krizbai, István A

“…Despite the potential obstacle represented by the blood–brain barrier for extravasating malignant cells, metastases are more frequent than primary tumors in…”
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Editorial: Targeting Neuro-Immuno-Vascular Interactions in the Brain and the Periphery by Wilhelm, Imola, Krizbai, István A, Gherghiceanu, Mihaela, Szőke, Éva, Helyes, Zsuzsanna

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CHANGES IN THE CONTRACTILE PROPERTIES OF BRAIN PERICYTES IN AGING AND CEREBRAL MICROINFARCTS by Győri, Fanni, Meszaros, Adam, Farkas, Attila, Krizbai, Istvan, Wilhelm, Imola

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Neurovascular Inflammaging in Health and Disease by Mészáros, Ádám, Molnár, Kinga, Nógrádi, Bernát, Hernádi, Zsófia, Nyúl-Tóth, Ádám, Wilhelm, Imola, Krizbai, István A

“…Aging is characterized by a chronic low-grade sterile inflammation dubbed as inflammaging, which in part originates from accumulating cellular debris. These,…”
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Cerebral Pericytes and Endothelial Cells Communicate through Inflammasome-Dependent Signals by Kozma, Mihály, Mészáros, Ádám, Nyúl-Tóth, Ádám, Molnár, Kinga, Costea, Laura, Hernádi, Zsófia, Fazakas, Csilla, Farkas, Attila E., Wilhelm, Imola, Krizbai, István A.

“…By upregulation of cell adhesion molecules and secretion of proinflammatory cytokines, cells of the neurovascular unit, including pericytes and endothelial…”
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Nephronectin promotes breast cancer brain metastatic colonization via its integrin-binding domains by Magnussen, Synnøve Norvoll, Toraskar, Jimita, Wilhelm, Imola, Hasko, Janos, Figenschau, Stine Linn, Molnar, Judit, Seppola, Marit, Steigen, Sonja E., Steigedal, Tonje S., Hadler-Olsen, Elin, Krizbai, Istvan A., Svineng, Gunbjørg

“…This study demonstrates a role for the extracellular matrix protein nephronectin (NPNT) in promoting experimental breast cancer brain metastasis, possibly…”
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