Search Results - "WILEY, Kathy E"

Telomere length as a risk factor for hereditary prostate cancer by Hurwitz, Lauren M., Heaphy, Christopher M., Joshu, Corinne E., Isaacs, William B., Konishi, Yuko, De Marzo, Angelo M., Isaacs, Sally D., Wiley, Kathy E., Platz, Elizabeth A., Meeker, Alan K.

“…BACKGROUND Telomeres are repetitive nucleotide sequences that stabilize the ends of chromosomes. Critically short telomeres are thought to contribute to cancer…”
Get full text

Associations between hOGG1 sequence variants and prostate cancer susceptibility by JIANFENG XU, ZHENG, Siqun L, ISAACS, William B, TURNER, Aubrey, ISAACS, Sarah D, WILEY, Kathy E, HAWKINS, Gregory A, CHANG, Bao-Li, BLEECKER, Eugene R, WALSH, Patrick C, MEYERS, Deborah A

“…8-Hydroxyguanine is a mutagenic base lesion produced by reactive oxygen species. The hOGG1 gene encodes a DNA glycosylase/AP lyase that can suppress the…”
Get full text

A polymorphism in the CDKN1B gene is associated with increased risk of hereditary prostate cancer by CHANG, Bao-Li, ZHENG, Siqun L, ISAACS, Sarah D, WILEY, Kathy E, TURNER, Aubrey, GE LI, WALSH, Patrick C, MEYERS, Deborah A, ISAACS, William B, JIANFENG XU

“…The loss of cell cycle control is believed to be an important mechanism in the promotion of carcinogenesis. CDKN1B (p27) belongs to the Cip/Kip family and…”
Get full text

Germ-line mutation of NKX3.1 cosegregates with hereditary prostate cancer and alters the homeodomain structure and function by ZHENG, S. Lilly, JU, Jeong-Ho, WALSH, Patrick C, FERRETTI, James, GRUSCHUS, James, ISAACS, William B, GELMANN, Edward P, JIANFENG XU, CHANG, Bao-Li, ORTNER, Elizabeth, JIELIN SUN, ISAACS, Sarah D, JISHANG SUN, WILEY, Kathy E, WENNUAN LIU, ZEMEDKUN, Micheas

“…NKX3.1, a gene mapped to 8p21, is a member of the NK class of homeodomain proteins and is expressed primarily in the prostate. NKX3.1 exerts a…”
Get full text

Polymorphisms in the CYP1A1 gene are associated with prostate cancer risk by Chang, Bao‐li, Zheng, Siqun L., Isaacs, Sarah D., Turner, Aubrey, Hawkins, Gregory A., Wiley, Kathy E., Bleecker, Eugene R., Walsh, Patrick C., Meyers, Deborah A., Isaacs, William B., Xu, Jianfeng

“…CYP1A1 is likely to play an important role in the etiology of CaP through its function in activating environmental procarcinogens and catalyzing the oxidative…”
Get full text

Genome-wide scan for prostate cancer susceptibility genes in the Johns Hopkins hereditary prostate cancer families by Xu, Jianfeng, Gillanders, Elizabeth M., Isaacs, Sarah D., Chang, Bao-li, Wiley, Kathy E., Zheng, S. Lilly, Jones, MaryPat, Gildea, Derek, Riedesel, Erica, Albertus, Julie, Freas-Lutz, Diana, Markey, Carol, Meyers, Deborah A., Walsh, Patrick C., Trent, Jeffrey M., Isaacs, William B.

“…BACKGROUND Although the subject of intensive study, the genetic influences responsible for familial clustering of prostate cancer remain largely unidentified…”
Get full text

Genome-wide screen for prostate cancer susceptibility genes in men with clinically significant disease by Chang, Bao-Li, Isaacs, Sarah D., Wiley, Kathy E., Gillanders, Elizabeth M., Zheng, S. Lilly, Meyers, Deborah A., Walsh, Patrick C., Trent, Jeffrey M., Xu, Jianfeng, Isaacs, William B.

“…BACKGROUND One of the difficulties confronting genetic studies of prostate cancer is the complex and heterogeneous etiology. Given the high population…”
Get full text

Sequence variants of α-methylacyl-CoA racemase are associated with prostate cancer risk by ZHENG, Siqun L, CHANG, Bao-Li, MEYERS, Deborah A, ISAACS, William B, JIANFENG XU, FAITH, Dennis A, JOHNSON, Jill R, ISAACS, Sarah D, HAWKINS, Gregory A, TURNER, Aubrey, WILEY, Kathy E, BLEECKER, Eugene R, WALSH, Patrick C

“…The enzyme alpha-methylacyl-CoA racemase (AMACR) plays an important role in peroxisomal beta-oxidation of branched-chain fatty acid and therefore is relevant…”
Get full text

Polymorphic GGC repeats in the androgen receptor gene are associated with hereditary and sporadic prostate cancer risk by CHANG, Bao-Li, ZHENG, Siqun L, MEYERS, Deborah A, ISAACS, William B, JIANFENG XU, HAWKINS, Gregory A, ISAACS, Sarah D, WILEY, Kathy E, TURNER, Aubrey, CARPTEN, John D, BLEECKER, Eugene R, WALSH, Patrick C, TRENT, Jeffrey M

“…Androgen receptor (AR) has long been hypothesized to play an important role in prostate cancer etiology. Two trinucleotide repeat polymorphisms (CAG and GGC…”
Get full text

Linkage of prostate cancer susceptibility loci to chromosome 1 by JIANFENG XU, ZHENG, Siqun L, BUJNOVSZKY, Piroska, BLEEKER, Eugene R, WALSH, Patrick C, TRENT, Jeffrey M, MEYERS, Deborah A, ISAACS, William B, CHANG, Bao-Li, SMITH, Jeffrey R, CARPTEN, John D, STINE, O. Colin, ISAACS, Sarah D, WILEY, Kathy E, HENNING, Lauren, EWING, Charles

“…Three prostate cancer susceptibility genes have been reported to be linked to different regions on chromosome 1: HPC1 at 1q24-25, PCAP at 1q42-43, and CAPB at…”
Get full text

Linkage and association of CYP17 gene in hereditary and sporadic prostate cancer by Chang, Bao‐li, Zheng, Siqun L., Isaacs, Sarah D., Wiley, Kathy E., Carpten, John D., Hawkins, Gregory A., Bleecker, Eugene R., Walsh, Patrick C., Trent, Jeffrey M., Meyers, Deborah A., Isaacs, William B., Xu, Jianfeng

“…Androgens are essential for prostate development, growth and maintenance and the association between androgen levels and prostate cancer is well established…”
Get full text

Interaction effect of PTEN and CDKN1B chromosomal regions on prostate cancer linkage by JIANFENG XU, LANGEFELD, Carl D, WALSH, Patrick C, TRENT, Jeffrey M, ISAACS, William B, ZHENG, S. Lilly, GILLANDERS, Elizabeth M, CHANG, Bao-Li, ISAACS, Sarah D, WILLIAMS, Adrienne H, WILEY, Kathy E, DIMITROV, Latchezar, MEYERS, Deborah A

“…The tumor suppressor functions of PTEN and CDKN1B have been extensively characterized. Recent data from mouse models suggest that, for some organs, the…”
Get full text

Sequence variants in the human 25-hydroxyvitamin D3 1-α-hydroxylase (CYP27B1) gene are not associated with prostate cancer risk by Hawkins, Gregory A., Cramer, Scott D., Zheng, Siqun L., Isaacs, Sarah D., Wiley, Kathy E., Chang, Bao-Li, Bleecker, Eugene R., Walsh, Patrick C., Meyers, Deborah A., Isaacs, William B., Xu, Jianfeng

“…BACKGROUND 1,25‐dihydroxyvitamin D3 has been shown to have antiproliferative properties on normal and neoplastic prostatic cells. 25‐hydroxyvitamin D3…”
Get full text

Evaluation of DLC1 as a prostate cancer susceptibility gene: mutation screen and association study by ZHENG, Siqun L, MYCHALECKYJ, Josyf C, BLEECKER, Eugene R, WALSH, Patrick C, TRENT, Jeffrey M, MEYERS, Deborah A, ISAACS, William B, JIANFENG XU, HAWKINS, Gregory A, ISAACS, Sarah D, WILEY, Kathy E, TURNER, Aubrey, CHANG, Bao-Li, VON KAP-HERR, Chris, CARPTEN, John D, PETTENATI, Mark

“…A gene or genes on chromosome 8p22-23 have been implicated in prostate carcinogenesis by the observation of frequent deletions of this region in prostate…”
Get full text

Evidence for a general cancer susceptibility locus at 3p24 in families with hereditary prostate cancer by Chang, Bao-Li, Gillanders, Elizabeth M., Isaacs, Sarah D., Wiley, Kathy E., Adams, Tamara, Turner, Aubrey R., Lilly Zheng, S., Meyers, Deborah A., Carpten, John D., Walsh, Patrick C., Trent, Jeffrey M., Xu, Jianfeng, Isaacs, William B.

“…To identify genes that generally increase the risk of cancer, we performed a systematic search throughout the genome in 188 families primarily ascertained for…”
Get full text

Joint effect of HSD3B1 and HSD3B2 genes is associated with hereditary and sporadic prostate cancer susceptibility by CHANG, Bao-Li, ZHENG, Siqun L, MEYERS, Deborah A, ISAACS, William B, JIANFENG XU, HAWKINS, Gregory A, ISAACS, Sarah D, WILEY, Kathy E, TURNER, Aubrey, CARPTEN, John D, BLEECKER, Eugene R, WALSH, Patrick C, TRENT, Jeffrey M

“…3beta-hydroxysteroid dehydrogenases (HSD3Bs), encoded by the HSD3B gene family at 1p13, have long been hypothesized to have a major role in prostate cancer…”
Get full text

Sequence variants in the human 25‐hydroxyvitamin D 3 1‐α‐hydroxylase (CYP27B1) gene are not associated with prostate cancer risk by Hawkins, Gregory A., Cramer, Scott D., Zheng, Siqun L., Isaacs, Sarah D., Wiley, Kathy E., Chang, Bao‐Li, Bleecker, Eugene R., Walsh, Patrick C., Meyers, Deborah A., Isaacs, William B., Xu, Jianfeng

“…Abstract BACKGROUND 1,25‐dihydroxyvitamin D 3 has been shown to have antiproliferative properties on normal and neoplastic prostatic cells. 25‐hydroxyvitamin D…”
Get full text

Sequence variants in the human 25-hydroxyvitamin D3 I-α-hydroxylase (CYP27BI) gene are not associated with prostate cancer risk by HAWKINS, Gregory A, CRAMER, Scott D, JIANFENG XU, ZHENG, Siqun L, ISAACS, Sarah D, WILEY, Kathy E, CHANG, Bao-Li, BLEECKER, Eugene R, WALSH, Patrick C, MEYERS, Deborah A, ISAACS, William B

Get full text