Search Results - "WILD, Peter J"

Automated Gleason grading of prostate cancer tissue microarrays via deep learning by Arvaniti, Eirini, Fricker, Kim S., Moret, Michael, Rupp, Niels, Hermanns, Thomas, Fankhauser, Christian, Wey, Norbert, Wild, Peter J., Rüschoff, Jan H., Claassen, Manfred

“…The Gleason grading system remains the most powerful prognostic predictor for patients with prostate cancer since the 1960s. Its application requires…”
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Combined mutation in Vhl, Trp53 and Rb1 causes clear cell renal cell carcinoma in mice by Harlander, Sabine, Schönenberger, Désirée, Toussaint, Nora C, Prummer, Michael, Catalano, Antonella, Brandt, Laura, Moch, Holger, Wild, Peter J, Frew, Ian J

“…Through combined deletion of Vhl , Trp53 and Rb1 in renal epithelial cells, the authors develop a new mouse model of renal cell carcinoma that recapitulates…”
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Prostate cancer–associated SPOP mutations confer resistance to BET inhibitors through stabilization of BRD4 by Dai, Xiangpeng, Gan, Wenjian, Li, Xiaoning, Wang, Shangqian, Zhang, Wei, Huang, Ling, Liu, Shengwu, Zhong, Qing, Guo, Jianping, Zhang, Jinfang, Chen, Ting, Shimizu, Kouhei, Beca, Francisco, Blattner, Mirjam, Vasudevan, Divya, Buckley, Dennis L, Qi, Jun, Buser, Lorenz, Liu, Pengda, Inuzuka, Hiroyuki, Beck, Andrew H, Wang, Liewei, Wild, Peter J, Garraway, Levi A, Rubin, Mark A, Barbieri, Christopher E, Wong, Kwok-Kin, Muthuswamy, Senthil K, Huang, Jiaoti, Chen, Yu, Bradner, James E, Wei, Wenyi

“…Recurrent mutations in SPOP -encoding a Cullin 3-based E3 ubiquitin ligase- in prostate cancer disrupt the recognition and degradation of ubiquitination…”
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TRIM24 Is an Oncogenic Transcriptional Activator in Prostate Cancer by Groner, Anna C., Cato, Laura, de Tribolet-Hardy, Jonas, Bernasocchi, Tiziano, Janouskova, Hana, Melchers, Diana, Houtman, René, Cato, Andrew C.B., Tschopp, Patrick, Gu, Lei, Corsinotti, Andrea, Zhong, Qing, Fankhauser, Christian, Fritz, Christine, Poyet, Cédric, Wagner, Ulrich, Guo, Tiannan, Aebersold, Ruedi, Garraway, Levi A., Wild, Peter J., Theurillat, Jean-Philippe, Brown, Myles

“…Androgen receptor (AR) signaling is a key driver of prostate cancer (PC). While androgen-deprivation therapy is transiently effective in advanced disease,…”
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Prognostic significance of POLE proofreading mutations in endometrial cancer by Church, David N, Stelloo, Ellen, Nout, Remi A, Valtcheva, Nadejda, Depreeuw, Jeroen, ter Haar, Natalja, Noske, Aurelia, Amant, Frederic, Tomlinson, Ian P M, Wild, Peter J, Lambrechts, Diether, Jürgenliemk-Schulz, Ina M, Jobsen, Jan J, Smit, Vincent T H B M, Creutzberg, Carien L, Bosse, Tjalling

“…Current risk stratification in endometrial cancer (EC) results in frequent over- and underuse of adjuvant therapy, and may be improved by novel biomarkers. We…”
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Ubiquitylome analysis identifies dysregulation of effector substrates in SPOP-mutant prostate cancer by Theurillat, Jean-Philippe P., Udeshi, Namrata D., Errington, Wesley J., Svinkina, Tanya, Baca, Sylvan C., Pop, Marius, Wild, Peter J., Blattner, Mirjam, Groner, Anna C., Rubin, Mark A., Moch, Holger, Privé, Gilbert G., Carr, Steven A., Garraway, Levi A.

“…Cancer genome characterization has revealed driver mutations in genes that govern ubiquitylation; however, the mechanisms by which these alterations promote…”
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DNA hypermethylation within TERT promoter upregulates TERT expression in cancer by Lee, Donghyun D, Leão, Ricardo, Komosa, Martin, Gallo, Marco, Zhang, Cindy H, Lipman, Tatiana, Remke, Marc, Heidari, Abolfazl, Nunes, Nuno Miguel, Apolónio, Joana D, Price, Aryeh J, De Mello, Ramon Andrade, Dias, João S, Huntsman, David, Hermanns, Thomas, Wild, Peter J, Vanner, Robert, Zadeh, Gelareh, Karamchandani, Jason, Das, Sunit, Taylor, Michael D, Hawkins, Cynthia E, Wasserman, Jonathan D, Figueiredo, Arnaldo, Hamilton, Robert J, Minden, Mark D, Wani, Khalida, Diplas, Bill, Yan, Hai, Aldape, Kenneth, Akbari, Mohammad R, Danesh, Arnavaz, Pugh, Trevor J, Dirks, Peter B, Castelo-Branco, Pedro, Tabori, Uri

“…Replicative immortality is a hallmark of cancer cells governed by telomere maintenance. Approximately 90% of human cancers maintain their telomeres by…”
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Strategies to enable large-scale proteomics for reproducible research by Poulos, Rebecca C., Hains, Peter G., Shah, Rohan, Lucas, Natasha, Xavier, Dylan, Manda, Srikanth S., Anees, Asim, Koh, Jennifer M. S., Mahboob, Sadia, Wittman, Max, Williams, Steven G., Sykes, Erin K., Hecker, Michael, Dausmann, Michael, Wouters, Merridee A., Ashman, Keith, Yang, Jean, Wild, Peter J., deFazio, Anna, Balleine, Rosemary L., Tully, Brett, Aebersold, Ruedi, Speed, Terence P., Liu, Yansheng, Reddel, Roger R., Robinson, Phillip J., Zhong, Qing

“…Reproducible research is the bedrock of experimental science. To enable the deployment of large-scale proteomics, we assess the reproducibility of mass…”
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Increased HRD score in cisplatin resistant penile cancer cells by Winkelmann, Ria, Bankov, Katrin, Döring, Claudia, Cinatl, Jaroslav, Grothe, Sebastian, Rothweiler, Florian, Michaelis, Martin, Schmitt, Christina, Wild, Peter J, Demes, Melanie, Cinatl, Jr, Jindrich, Vallo, Stefan

“…Penile cancer is a rare disease in demand for new therapeutic options. Frequently used combination chemotherapy with 5 fluorouracil (5-FU) and cisplatin (CDDP)…”
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Impact of rescanning and repositioning on radiomic features employing a multi-object phantom in magnetic resonance imaging by Bernatz, Simon, Zhdanovich, Yauheniya, Ackermann, Jörg, Koch, Ina, Wild, Peter J., dos Santos, Daniel Pinto, Vogl, Thomas J., Kaltenbach, Benjamin, Rosbach, Nicolas

“…Our purpose was to analyze the robustness and reproducibility of magnetic resonance imaging (MRI) radiomic features. We constructed a multi-object fruit…”
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High‐throughput proteomic analysis of FFPE tissue samples facilitates tumor stratification by Zhu, Yi, Weiss, Tobias, Zhang, Qiushi, Sun, Rui, Wang, Bo, Yi, Xiao, Wu, Zhicheng, Gao, Huanhuan, Cai, Xue, Ruan, Guan, Zhu, Tiansheng, Xu, Chao, Lou, Sai, Yu, Xiaoyan, Gillet, Ludovic, Blattmann, Peter, Saba, Karim, Fankhauser, Christian D., Schmid, Michael B., Rutishauser, Dorothea, Ljubicic, Jelena, Christiansen, Ailsa, Fritz, Christine, Rupp, Niels J., Poyet, Cedric, Rushing, Elisabeth, Weller, Michael, Roth, Patrick, Haralambieva, Eugenia, Hofer, Silvia, Chen, Chen, Jochum, Wolfram, Gao, Xiaofei, Teng, Xiaodong, Chen, Lirong, Zhong, Qing, Wild, Peter J., Aebersold, Ruedi, Guo, Tiannan

“…Formalin‐fixed, paraffin‐embedded (FFPE), biobanked tissue samples offer an invaluable resource for clinical and biomarker research. Here, we developed a…”
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Tumor-associated macrophages and Tregs influence and represent immune cell infiltration of muscle-invasive bladder cancer and predict prognosis by Koll, Florestan J, Banek, Severine, Kluth, Luis, Köllermann, Jens, Bankov, Katrin, Chun, Felix K-H, Wild, Peter J, Weigert, Andreas, Reis, Henning

“…Muscle-invasive urothelial bladder cancer (MIBC) is associated with limited response rates to systemic therapy, risk of recurrence and death. Tumor…”
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Evaluation of automatic discrimination between benign and malignant prostate tissue in the era of high precision digital pathology by Zhdanovich, Yauheniya, Ackermann, Jörg, Wild, Peter J, Köllermann, Jens, Bankov, Katrin, Döring, Claudia, Flinner, Nadine, Reis, Henning, Wenzel, Mike, Höh, Benedikt, Mandel, Philipp, Vogl, Thomas J, Harter, Patrick, Filipski, Katharina, Koch, Ina, Bernatz, Simon

“…Prostate cancer is a major health concern in aging men. Paralleling an aging society, prostate cancer prevalence increases emphasizing the need for efficient…”
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KRAS Mutations in Squamous Cell Carcinomas of the Lung by Acker, Fabian, Stratmann, Jan, Aspacher, Lukas, Nguyen, Ngoc Thien Thu, Wagner, Sebastian, Serve, Hubert, Wild, Peter J, Sebastian, Martin

“…is one of the most commonly mutated oncogenes in cancer, enabling tumor proliferation and maintenance. After various approaches to target have failed over the…”
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Comparative analysis of mRNA and protein degradation in prostate tissues indicates high stability of proteins by Shao, Wenguang, Guo, Tiannan, Toussaint, Nora C., Xue, Peng, Wagner, Ulrich, Li, Li, Charmpi, Konstantina, Zhu, Yi, Wu, Jianmin, Buljan, Marija, Sun, Rui, Rutishauser, Dorothea, Hermanns, Thomas, Fankhauser, Christian Daniel, Poyet, Cedric, Ljubicic, Jelena, Rupp, Niels, Rüschoff, Jan H., Zhong, Qing, Beyer, Andreas, Ji, Jiafu, Collins, Ben C., Liu, Yansheng, Rätsch, Gunnar, Wild, Peter J., Aebersold, Ruedi

“…Deterioration of biomolecules in clinical tissues is an inevitable pre-analytical process, which affects molecular measurements and thus potentially confounds…”
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Optimizing identification of consensus molecular subtypes in muscle-invasive bladder cancer: a comparison of two sequencing methods and gene sets using FFPE specimens by Koll, Florestan J, Döring, Claudia, Olah, Csilla, Szarvas, Tibor, Köllermann, Jens, Hoeh, Benedikt, Chun, Felix K-H, Reis, Henning, Wild, Peter J

“…Molecular subtypes predict prognosis in muscle-invasive bladder cancer (MIBC) and are explored as predictive markers. To provide a common base for molecular…”
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Impact of IDH1 mutation on clinical course of patients with intrahepatic cholangiocarcinoma: a retrospective analysis from a German tertiary center by Kinzler, Maximilian N., Jeroch, Jan, Klasen, Christina, Himmelsbach, Vera, Koch, Christine, Finkelmeier, Fabian, Trojan, Jörg, Zeuzem, Stefan, Pession, Ursula, Reis, Henning, Demes, Melanie C., Wild, Peter J., Walter, Dirk

“…Purpose IDH1 mutation is a known biomarker for targeted therapy of intrahepatic cholangiocarcinoma (iCCA), while its prognostic relevance for current…”
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SPOP Mutations in Prostate Cancer across Demographically Diverse Patient Cohorts by Blattner, Mirjam, Lee, Daniel J, O'Reilly, Catherine, Park, Kyung, MacDonald, Theresa Y, Khani, Francesca, Turner, Kevin R, Chiu, Ya-Lin, Wild, Peter J, Dolgalev, Igor, Heguy, Adriana, Sboner, Andrea, Ramazangolu, Sinan, Hieronymus, Haley, Sawyers, Charles, Tewari, Ashutosh K, Moch, Holger, Yoon, Ghil Suk, Known, Yong Chul, Andrén, Ove, Fall, Katja, Demichelis, Francecsa, Mosquera, Juan Miguel, Robinson, Brian D, Barbieri, Christopher E, Rubin, Mark A

“…Abstract BACKGROUND: Recurrent mutations in the Speckle-Type POZ Protein ( SPOP ) gene occur in up to 15% of prostate cancers. However, the frequency and…”
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CT-radiomics and clinical risk scores for response and overall survival prognostication in TACE HCC patients by Bernatz, Simon, Elenberger, Oleg, Ackermann, Jörg, Lenga, Lukas, Martin, Simon S., Scholtz, Jan-Erik, Koch, Vitali, Grünewald, Leon D., Herrmann, Yannis, Kinzler, Maximilian N., Stehle, Angelika, Koch, Ina, Zeuzem, Stefan, Bankov, Katrin, Doering, Claudia, Reis, Henning, Flinner, Nadine, Schulze, Falko, Wild, Peter J., Hammerstingl, Renate, Eichler, Katrin, Gruber-Rouh, Tatjana, Vogl, Thomas J., dos Santos, Daniel Pinto, Mahmoudi, Scherwin

“…We aimed to identify hepatocellular carcinoma (HCC) patients who will respond to repetitive transarterial chemoembolization (TACE) to improve the treatment…”
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Convergent network effects along the axis of gene expression during prostate cancer progression by Charmpi, Konstantina, Guo, Tiannan, Zhong, Qing, Wagner, Ulrich, Sun, Rui, Toussaint, Nora C, Fritz, Christine E, Yuan, Chunhui, Chen, Hao, Rupp, Niels J, Christiansen, Ailsa, Rutishauser, Dorothea, Rüschoff, Jan H, Fankhauser, Christian, Saba, Karim, Poyet, Cedric, Hermanns, Thomas, Oehl, Kathrin, Moore, Ariane L, Beisel, Christian, Calzone, Laurence, Martignetti, Loredana, Zhang, Qiushi, Zhu, Yi, Martínez, María Rodríguez, Manica, Matteo, Haffner, Michael C, Aebersold, Ruedi, Wild, Peter J, Beyer, Andreas

“…Tumor-specific genomic aberrations are routinely determined by high-throughput genomic measurements. It remains unclear how complex genome alterations affect…”
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