Search Results - "WILCOCK, Donna"

Infectious hypothesis of Alzheimer disease by Seaks, Charles E, Wilcock, Donna M

“…Herpes simplex virus 1 (HSV-1) is the most commonly studied pathogen in the context of AD, primarily due to identification years ago of HSV-1 DNA in AD patient…”
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The Important Interface Between Apolipoprotein E and Neuroinflammation in Alzheimer's Disease by Kloske, Courtney M, Wilcock, Donna M

“…Alzheimer's disease (AD) is the most prevalent form of neurodegenerative disease, currently affecting over 5 million Americans with projections expected to…”
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Down's syndrome, neuroinflammation, and Alzheimer neuropathogenesis by Wilcock, Donna M, Griffin, W Sue T

“…Down syndrome (DS) is the result of triplication of chromosome 21 (trisomy 21) and is the prevailing cause of mental retardation. In addition to the mental…”
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The longitudinal early‐onset Alzheimer's disease study (LEADS): Advancing our understanding of Alzheimer's disease in individuals aged 40–64 by Wilcock, Donna M.

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Aging in Down Syndrome and the Development of Alzheimer's Disease Neuropathology by Head, Elizabeth, Lott, Ira T, Wilcock, Donna M, Lemere, Cynthia A

“…Chromosome 21, triplicated in Down Syndrome, contains several genes that are thought to play a critical role in the development of AD neuropathology. The…”
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Assessing activation states in microglia by Colton, Carol A, Wilcock, Donna M

“…Since the original identification of microglia as a principal player in the brain's innate immune response, microglial activation has been widely studied…”
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Soluble Biomarkers of Cerebrovascular Pathologies by Foley, Kate E, Wilcock, Donna M

“…Vascular contributions to cognitive impairment and dementia (VCID) is an all-encompassing term that describes cognitive impairment due to cerebrovascular…”
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Cerebrovascular Smooth Muscle Cells as the Drivers of Intramural Periarterial Drainage of the Brain by Aldea, Roxana, Weller, Roy O, Wilcock, Donna M, Carare, Roxana O, Richardson, Giles

“…The human brain is the organ with the highest metabolic activity but it lacks a traditional lymphatic system responsible for clearing waste products. We have…”
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Hyperhomocysteinemia as a Risk Factor for Vascular Contributions to Cognitive Impairment and Dementia by Price, Brittani R, Wilcock, Donna M, Weekman, Erica M

“…Behind only Alzheimer's disease, vascular contributions to cognitive impairment and dementia (VCID) is the second most common cause of dementia, affecting…”
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Neuroinflammatory phenotype in early Alzheimer's disease by Sudduth, Tiffany L, Schmitt, Frederick A, Nelson, Peter T, Wilcock, Donna M

“…Abstract Alzheimer's disease (AD) involves progressive neurodegeneration in the presence of misfolded proteins and poorly-understood inflammatory changes…”
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Matrix Metalloproteinase in Blood-Brain Barrier Breakdown in Dementia by Weekman, Erica M, Wilcock, Donna M

“…The neurovascular unit, which consists of astrocytic end-feet, neurons, pericytes, and endothelial cells, plays a key role in maintaining brain homeostasis by…”
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Therapeutic Trem2 activation ameliorates amyloid-beta deposition and improves cognition in the 5XFAD model of amyloid deposition by Price, Brittani R, Sudduth, Tiffany L, Weekman, Erica M, Johnson, Sherika, Hawthorne, Danielle, Woolums, Abigail, Wilcock, Donna M

“…Triggering receptor expressed on myeloid cell-2 (TREM2) is a lipid and lipoprotein binding receptor expressed by cells of myeloid origin. Homozygous TREM2…”
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Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models by Lourenco, Mychael V., Frozza, Rudimar L., de Freitas, Guilherme B., Zhang, Hong, Kincheski, Grasielle C., Ribeiro, Felipe C., Gonçalves, Rafaella A., Clarke, Julia R., Beckman, Danielle, Staniszewski, Agnieszka, Berman, Hanna, Guerra, Lorena A., Forny-Germano, Letícia, Meier, Shelby, Wilcock, Donna M., de Souza, Jorge M., Alves-Leon, Soniza, Prado, Vania F., Prado, Marco A. M., Abisambra, Jose F., Tovar-Moll, Fernanda, Mattos, Paulo, Arancio, Ottavio, Ferreira, Sergio T., De Felice, Fernanda G.

“…Defective brain hormonal signaling has been associated with Alzheimer’s disease (AD), a disorder characterized by synapse and memory failure. Irisin is an…”
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Vascular contributions to cognitive impairment and dementia including Alzheimer's disease by Snyder, Heather M, Corriveau, Roderick A, Craft, Suzanne, Faber, James E, Greenberg, Steven M, Knopman, David, Lamb, Bruce T, Montine, Thomas J, Nedergaard, Maiken, Schaffer, Chris B, Schneider, Julie A, Wellington, Cheryl, Wilcock, Donna M, Zipfel, Gregory J, Zlokovic, Berislav, Bain, Lisa J, Bosetti, Francesca, Galis, Zorina S, Koroshetz, Walter, Carrillo, Maria C

“…Abstract Scientific evidence continues to demonstrate the linkage of vascular contributions to cognitive impairment and dementia such as Alzheimer's disease…”
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The importance of continuing development of novel animal models of Alzheimer's disease and Alzheimer's disease and related dementias by Wilcock, Donna M., Lamb, Bruce T.

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Homocysteine, hyperhomocysteinemia and vascular contributions to cognitive impairment and dementia (VCID) by Hainsworth, Atticus H., Yeo, Natalie E., Weekman, Erica M., Wilcock, Donna M.

“…Homocysteine is produced physiologically in all cells, and is present in plasma of healthy individuals (plasma [HCy]: 3–10μM). While rare genetic mutations…”
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Animal Models of Vascular Cognitive Impairment and Dementia (VCID) by Gooch, Jennifer, Wilcock, Donna M.

“…Vascular cognitive impairment and dementia (VCID) is the most common etiology of dementia in the elderly. Both, vascular and Alzheimer’s disease, pathologies…”
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Induction of Hyperhomocysteinemia Models Vascular Dementia by Induction of Cerebral Microhemorrhages and Neuroinflammation by Sudduth, Tiffany L, Powell, David K, Smith, Charles D, Greenstein, Abigail, Wilcock, Donna M

“…Vascular dementia (VaD) is the second leading cause of dementia behind Alzheimer's disease (AD) and is a frequent comorbidity with AD, estimated to occur in as…”
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An emerging role of astrocytes in vascular contributions to cognitive impairment and dementia by Price, Brittani R., Norris, Christopher M., Sompol, Pradoldej, Wilcock, Donna M.

“…Vascular contributions to cognitive impairment and dementia (VCID) is understood to be the second most common cause of dementia after Alzheimer's disease, and…”
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Sex-based differences in effector cells of the adaptive immune system during Alzheimer's disease and related dementias by Lutshumba, Jenny, Wilcock, Donna M., Monson, Nancy L., Stowe, Ann M.

“…Neurological conditions such as Alzheimer's disease (AD) and related dementias (ADRD) present with many challenges due to the heterogeneity of the related…”
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