Search Results - "WIKEL, J. H"

Three- and Four-Dimensional-Quantitative Structure Activity Relationship (3D/4D-QSAR) Analyses of CYP2C9 Inhibitors by EKINS, S, BRAVI, G, BINKLEY, S, GILLESPIE, J. S, RING, B. J, WIKEL, J. H, WRIGHTON, S. A

“…The interaction of competitive type inhibitors with the active site of cytochrome P450 (CYP) 2C9 has been predicted using three- and four-dimensional…”
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Three-dimensional-quantitative structure activity relationship analysis of cytochrome P-450 3A4 substrates by Ekins, S, Bravi, G, Wikel, J H, Wrighton, S A

“…To gain a better understanding of the active site of cytochrome P-450 (CYP) 3A4, a three-dimensional-quantitative structure activity relationship model was…”
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3-Phenyl-4-hydroxyquinolin-2(1H)-ones: potent and selective antagonists at the strychnine-insensitive glycine site on the N-methyl-D-aspartate receptor complex by McQuaid, Loretta A, Smith, Edward C. R, Lodge, David, Pralong, Etienne, Wikel, James H, Calligaro, David O, O'Malley, Patrick J

“…The N-methyl-D-aspartic acid (NMDA) ion channel complex has been implicated in a number of excitotoxic events leading to neuronal degeneration. The…”
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Three-dimensional quantitative structure-activity relationship for inhibition of human ether-a-go-go-related gene potassium channel by Ekins, Sean, Crumb, William J, Sarazan, R Dustan, Wikel, James H, Wrighton, Steven A

“…The protein product of the human ether-a-go-go gene (hERG) is a potassium channel that when inhibited by some drugs may lead to cardiac arrhythmia. Previously,…”
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Use of Conformationally Restricted Benzamidines as Arginine Surrogates in the Design of Platelet GPIIb-IIIa Receptor Antagonists by Sall, Daniel J, Arfsten, Ann E, Bastian, Jolie A, Denney, Michael L, Harms, Cathy S, McCowan, Jefferson R, Morin, John M, Rose, Jack W, Scarborough, Robert M, Smyth, Mark S, Um, Suzane L, Utterback, Barbara G, Vasileff, Robert T, Wikel, James H, Wyss, Virginia L, Jakubowski, Joseph A

“…The use of 5,6-bicyclic amidines as arginine surrogates in the design of a novel class of potent platelet glycoprotein IIb-IIIa receptor (GPIIb-IIIa)…”
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Progress in predicting human ADME parameters in silico by Ekins, Sean, Waller, Chris L, Swaan, Peter W, Cruciani, Gabriele, Wrighton, Steven A, Wikel, James H

“…Understanding the development of a scientific approach is a valuable exercise in gauging the potential directions the process could take in the future. The…”
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Development of Dual-Acting Agents for Thromboxane Receptor Antagonism and Thromboxane Synthase Inhibition. 3. Synthesis and Biological Activities of Oxazolecarboxamide-Substituted ω-Phenyl-ω-(3-pyridyl)alkenoic Acid Derivatives and Related Compounds by Takeuchi, Kumiko, Kohn, Todd J, True, Timothy A, Mais, Dale E, Wikel, James H, Utterback, Barbara G, Wyss, Virginia L, Jakubowski, Joseph A

“…A novel series of oxazolecarboxamide-substituted ω-phenyl-ω-(3-pyridyl)alkenoic acid derivatives was discovered as potent dual-acting agents to block the TXA2…”
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Three- and four-dimensional quantitative structure activity relationship analyses of cytochrome P-450 3A4 inhibitors by Ekins, S, Bravi, G, Binkley, S, Gillespie, J S, Ring, B J, Wikel, J H, Wrighton, S A

“…The program Catalyst was used to build three-dimensional quantitative structure activity relationship (3D-QSAR) pharmacophore models of the structural features…”
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Dibasic benzo[ b]thiophene derivatives as a novel class of active site directed thrombin inhibitors. 2. Exploring interactions at the proximal (S 2) binding site by Sall, Daniel J., Briggs, Stephen L., Chirgadze, Nickolay Y., Clawson, David K., Gifford-Moore, Donetta S., Klimkowski, Valentine J., McCowan, Jefferson R., Smith, Gerald F., Wikel, James H.

“…In an effort to increase the thrombin inhibitory activity of a novel series of inhibitors (i.e., 1a), substituents were incorporated at the C-3″ position of…”
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Diamino benzo[b]thiophene derivatives as a novel class of active site directed thrombin inhibitors : 3. enhancing activity by imposing conformational restriction in the C-4 side chain by BASTIAN, J. A, CHIRGADZE, N, DENNEY, M. L, GIFFORD-MOORE, D. S, SALL, D. J, SMITH, G. F, WIKEL, J. H

“…The preparation and biological evaluation of a series of benzo[b]thiophene diamine thrombin inhibitors possessing conformationally restricted C-4" linkers are…”
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Three-dimensional quantitative structure activity relationship analyses of substrates for CYP2B6 by Ekins, S, Bravi, G, Ring, B J, Gillespie, T A, Gillespie, J S, Vandenbranden, M, Wrighton, S A, Wikel, J H

“…To begin to build an understanding of the interactions of CYP2B6 with substrates, two different 3-dimensional quantitative structure activity relationship…”
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Synthesis of syn and anti isomers of 6-[[(hydroxyimino)phenyl]methyl]-1-[(1-methylethyl)sulfonyl]-1H-benzimidazol-2-amine. Inhibitors of rhinovirus multiplication by Wikel, J. H, Paget, C. J, DeLong, D. C, Nelson, J. D, Wu, C. Y. E, Paschal, J. W, Dinner, A, Templeton, R. J, Chaney, M. O

“…The synthesis and antirhinovirus activity of syn and anti isomers of 6-[[(hydroxyimino)phenyl]methyl]-1-[(1-methylethyl)sulfonyl]-1H-benzimidazol-2-amine (4…”
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Three and four dimensional-quantitative structure activity relationship (3D/4D-QSAR) analyses of CYP2D6 inhibitors by Ekins, S, Bravi, G, Binkley, S, Gillespie, J S, Ring, B J, Wikel, J H, Wrighton, S A

“…Three- and four-dimensional quantitative structure activity relationship (3D/4D-QSAR) pharmacophore models of competitive inhibitors of CYP2D6 were constructed…”
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Comparative QSAR studies of two series of 1,4-dihydropyridines as slow calcium channel blockers by Wikel, J H, Bemis, K G, Kurz, K, Denney, M L, Main, B W, Moore, R A, Smith, T, Shingleton, L, Holland, D R

“…Quantitative structure activity analysis was applied to two series of dihydropyridine (DHP) calcium channel blocking agents. One series of compounds was…”
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Depletion of cardiac norepinephrine in rats and mice by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) by Fuller, R W, Hahn, R A, Snoddy, H D, Wikel, J H

“…1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is a commercially available chemical reagent. Although little has been known about its biological effects,…”
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1,2-Dibenzamidobenzene Inhibitors of Human Factor Xa by Herron, David K, Goodson, Theodore, Wiley, Michael R, Weir, Leonard C, Kyle, Jeffrey A, Yee, Ying K, Tebbe, Ann Louise, Tinsley, Jennifer M, Mendel, David, Masters, John J, Franciskovich, Jeffry B, Sawyer, J. Scott, Beight, Douglas W, Ratz, Andrew M, Milot, Guy, Hall, Steven E, Klimkowski, Valentine J, Wikel, James H, Eastwood, Brian J, Towner, Richard D, Gifford-Moore, Donetta S, Craft, Trelia J, Smith, Gerald F

“…High-throughput screening of a combinatorial library of diamidophenols yielded lead compounds with the ability to inhibit human factor Xa (fXa) at micromolar…”
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LY249933: a cardioselective 1,4-dihydropyridine with positive inotropic activity by Holland, D R, Wikel, J H, Kauffman, R F, Smallwood, J K, Zimmerman, K M, Utterback, B G, Turk, J A, Steinberg, M I

“…Compound LY249933 and its component diastereomers, (RR) and (SR), were studied for their vascular and cardiac effects in vitro and in vivo. In guinea pig…”
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Three-Dimensional Quantitative Structure-Permeability Relationship Analysis for a Series of Inhibitors of Rhinovirus Replication by Ekins, Sean, Durst, Gregory L, Stratford, Robert E, Thorner, David A, Lewis, Richard, Loncharich, Richard J, Wikel, James H

“…Multiple three-dimensional quantitative structure−activity relationship (3D-QSAR) approaches were applied to predicting passive Caco-2 permeability for a…”
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Experimental Designs for Selecting Molecules from Large Chemical Databases by Higgs, Richard E, Bemis, Kerry G, Watson, Ian A, Wikel, James H

“…Recent developments in high-throughput screening and combinatorial chemistry have generated interest in experimental design methods to select subsets of…”
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Benzylamine antioxidants: relationship between structure, peroxyl radical scavenging, lipid peroxidation inhibition and cytoprotection by Yu, Melvin J, McCowan, Jefferson R, Phebus, Lee A, Towner, Richard D, Ho, Peter P. K, Keith, Priscilla T, Luttman, Charlotte A, Saunders, Royal D, Ruterbories, Kenneth J

“…Three homologous series of 3,5-dialkoxy-4-hydroxybenzylamines were prepared and tested (1) as peroxyl radical scavengers in homogeneous aqueous solution, (2)…”
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