Search Results - "WIJDENES, John"

Due to interleukin-6 type cytokine redundancy only glycoprotein 130 receptor blockade efficiently inhibits myeloma growth by Burger, Renate, Günther, Andreas, Klausz, Katja, Staudinger, Matthias, Peipp, Matthias, Penas, Eva Maria Murga, Rose-John, Stefan, Wijdenes, John, Gramatzki, Martin

“…Interleukin-6 has an important role in the pathophysiology of multiple myeloma where it supports the growth and survival of the malignant plasma cells in the…”
Get full text

Cytotoxic activity of the maytansinoid immunoconjugate B-B4–DM1 against CD138+ multiple myeloma cells by Tassone, Pierfrancesco, Goldmacher, Victor S., Neri, Paola, Gozzini, Antonella, Shammas, Masood A., Whiteman, Kathleen R., Hylander-Gans, Linda L., Carrasco, Daniel R., Hideshima, Teru, Shringarpure, Reshma, Shi, Jialan, Allam, Charles K., Wijdenes, John, Venuta, Salvatore, Munshi, Nikhil C., Anderson, Kenneth C.

“…We tested the in vitro and in vivo antitumor activity of the maytansinoid DM1 (N2′-deacetyl-N2′-(3-mercapto-1-oxopropyl)-maytansine), a potent antimicrotubule…”
Get full text

Syndecan-1 antigen, a promising new target for triple-negative breast cancer immuno-PET and radioimmunotherapy. A preclinical study on MDA-MB-468 xenograft tumors by Rousseau, Caroline, Ruellan, Anne Lise, Bernardeau, Karine, Kraeber-Bodéré, Françoise, Gouard, Sebastien, Loussouarn, Delphine, Saï-Maurel, Catherine, Faivre-Chauvet, Alain, Wijdenes, John, Barbet, Jacques, Gaschet, Joëlle, Chérel, Michel, Davodeau, François

“…Background Overexpression of syndecan-1 (CD138) in breast carcinoma correlates with a poor prognosis and an aggressive phenotype. The objective of this study…”
Get full text

A plasmocyte selective monoclonal antibody (B-B4) recognizes syndecan-1 by Wijdenes, J, Vooijs, W C, Clément, C, Post, J, Morard, F, Vita, N, Laurent, P, Sun, R X, Klein, B, Dore, J M

“…We developed a new monoclonal antibody. B-B4, which specifically identifies human plasma cells. It strongly reacts with all multiple myeloma cell lines and…”
Get more information

Expression of Interleukin 13 Receptor in Glioma and Renal Cell Carcinoma: IL13Rα2 as a Decoy Receptor for IL13 by Bernard, Jérôme, Treton, Dominique, Vermot-Desroches, Claudine, Boden, Christine, Horellou, Philippe, Angevin, Eric, Galanaud, Pierre, Wijdenes, John, Richard, Yolande

“…Glioma and renal cell carcinoma (RCC) cells express high affinity interleukin 13 (IL13) binding sites, but only RCC cell proliferation was inhibited by IL13…”
Get full text

Soluble IL-6 Receptor Potentiates the Antagonistic Activity of Soluble gp130 on IL-6 Responses by Muller-Newen, Gerhard, Kuster, Andrea, Hemmann, Ulrike, Keul, Radovan, Horsten, Ursula, Martens, Astrid, Graeve, Lutz, Wijdenes, John, Heinrich, Peter C

“…Soluble receptors for several cytokines have been detected in body fluids and are believed to modulate the cytokine response by binding the ligand and thereby…”
Get full text

Alleviation of Systemic Manifestations of Castleman's Disease by Monoclonal Anti-Interleukin-6 Antibody by Beck, Joseph T, Hsu, Su-Ming, Wijdenes, John, Bataille, Regis, Klein, Bernard, Vesole, David, Hayden, Katherine, Jagannath, Sundar, Barlogie, Bart

“…Castleman's disease (angiofollicular lymphoid hyperplasia) is a heterogeneous group of lymphoproliferative disorders of uncertain cause 1 . Two pathologic…”
Get full text

The myeloma cell antigen syndecan‐1 is lost by apoptotic myeloma cells by Jourdan, Michel, Ferlin, Martine, Legouffe, Eric, Horvathova, Mira, Liautard, Janny, Rossi, Jean FranÇois, Wijdenes, John, Brochier, Jean, Klein, Bernard

“…Syndecan‐1 is a cell membrane proteoglycan that binds extracellular matrix components and various growth factors. It is expressed only on malignant plasma…”
Get full text

Characterization of monoclonal antibodies directed against trail or trail receptors by Vermot-Desroches, Claudine, Sergent, Elise, Bonnin, Brigitte, Wijdenes, John

“…A subset of tumour necrosis factor receptor family members is involved in death transducing signals and is, therefore, referred as the “death receptors.”…”
Get full text

Interleukin-6 Family of Cytokines Induced Activation of Different Functional Sites Expressed by gp130 Transducing Protein by Chevalier, S, Fourcin, M, Robledo, O, Wijdenes, J, Pouplard-Barthelaix, A, Gascan, H

“…Gp130 transducing protein was shown to be involved in the formation of the high affinity receptors for interleukin 6 (IL-6), interleukin-11 (IL-11), leukemia…”
Get full text

Studies on the Interleukin-6-type Cytokine Signal Transducer gp130 Reveal a Novel Mechanism of Receptor Activation by Monoclonal Antibodies by Müller-Newen, Gerhard, Küster, Andrea, Wijdenes, John, Schaper, Fred, Heinrich, Peter C.

“…The transmembrane glycoprotein gp130 belongs to the family of hematopoietic cytokine receptors. It represents the common signal transducing receptor component…”
Get full text

The Immunoglobulin-like Module of gp130 Is Required for Signaling by Interleukin-6, but Not by Leukemia Inhibitory Factor by Hammacher, Annet, Richardson, Rachael T., Layton, Judith E., Smith, David K., Angus, Leecia J.L., Hilton, Douglas J., Nicola, Nicos A., Wijdenes, John, Simpson, Richard J.

“…The transmembrane protein gp130 is a shared component of the receptor complexes for the interleukin-6 (IL-6)-type cytokines, which include IL-6, leukemia…”
Get full text

High amounts of circulating interleukin (IL)-6 in the form of monomeric immune complexes during anti-IL-6 therapy. Towards a new methodology for measuring overall cytokine production in human in vivo by Lu, Z Y, Brochier, J, Wijdenes, J, Brailly, H, Bataille, R, Klein, B

“…A patient with plasma cell leukemia was treated with anti-interleukin (IL)-6 monoclonal antibodies (mAb) for 2 months. Using chromatography on protein…”
Get more information

Cyclosporin A inhibition of macrophage colony-stimulating factor (M-CSF) production by activated human T lymphocytes by Frétier, Stéphanie, Besse, Arnaud, Delwail, Adriana, Garcia, Martine, Morel, Franck, Leprivey‐Lorgeot, Valérie, Wijdenes, John, Praloran, Vincent, Lecron, Jean‐Claude

“…M‐CSF is a pleiotropic cytokine involved in the survival, proliferation, and differentiation of cells of the monocyte/macrophagelineage. M‐CSF is produced by…”
Get full text

Human CD4+CD25+ regulatory T cells: proteome analysis identifies galectin-10 as a novel marker essential for their anergy and suppressive function by Kubach, Jan, Lutter, Petra, Bopp, Tobias, Stoll, Sabine, Becker, Christian, Huter, Eva, Richter, Christoph, Weingarten, Petra, Warger, Tobias, Knop, Jürgen, Müllner, Stefan, Wijdenes, John, Schild, Hansjörg, Schmitt, Edgar, Jonuleit, Helmut

“…CD4+CD25+Foxp3+ regulatory T cells (CD25+ Treg cells) direct the maintenance of immunological self-tolerance by active suppression of autoaggressive T-cell…”
Get full text

IL-21-Induced MHC Class II+ NK Cells Promote the Expansion of Human Uncommitted CD4+ Central Memory T Cells in a Macrophage Migration Inhibitory Factor-Dependent Manner by Loyon, Romain, Picard, Emilie, Mauvais, Olivier, Queiroz, Lise, Mougey, Virginie, Pallandre, Jean-René, Galaine, Jeanne, Mercier-Letondal, Patricia, Kellerman, Guillaume, Chaput, Nathalie, Wijdenes, John, Adotévi, Olivier, Ferrand, Christophe, Romero, Pedro, Godet, Yann, Borg, Christophe

“…NK cells are critical for innate immunity-mediated protection. The main roles of NK cells rely on their cytotoxic functions or depend on the tuning of Th1…”
Get full text

Anti-gp130 transducer monoclonal antibodies specifically inhibiting ciliary neurotrophic factor, interleukin-6, interleukin-11, leukemia inhibitory factor or oncostatin M by Gu, Zong-Jiang, Wijdenes, John, Zhang, Xue-Guang, Hallet, Marie-Martine, Clement, Claude, Klein, Bernard

“…Five cytokines activate the gp130 IL-6 transducer: ciliary neurotrophic factor, interleukin-6, interleukin-11, leukemia inhibitory factor and oncostatin M…”
Get full text

Clinical and biologic effects of anti–interleukin‐10 monoclonal antibody administration in systemic lupus erythematosus by Llorente, Luis, Richaud‐Patin, Yvonne, García‐Padilla, Carlos, Claret, Emmanuel, Jakez‐Ocampo, Juan, Cardiel, Mario H., Alcocer‐Varela, Jorge, Grangeot‐Keros, Liliane, Alarcón‐Segovia, Donato, Wijdenes, John, Galanaud, Pierre, Emilie, Dominique

“…Objective To evaluate the safety and clinical efficacy of administering an anti–interleukin‐10 (anti–IL‐10) monoclonal antibody (mAb) to systemic lupus…”
Get full text

Combining somatic mutations present in different in vivo affinity-matured antibodies isolated from immunized Lama glama yields ultra-potent antibody therapeutics by Klarenbeek, Alex, Blanchetot, Christophe, Schragel, Georg, Sadi, Ava S., Ongenae, Nico, Hemrika, Wieger, Wijdenes, John, Spinelli, Silvia, Desmyter, Aline, Cambillau, Christian, Hultberg, Anna, Kretz-Rommel, Anke, Dreier, Torsten, De Haard, Hans J.W., Roovers, Rob C.

“…Abstract Highly potent human antibodies are required to therapeutically neutralize cytokines such as interleukin-6 (IL-6) that is involved in many inflammatory…”
Get full text

A new anti-mesothelin antibody targets selectively the membrane-associated form by Asgarov, Kamal, Balland, Jeremy, Tirole, Charline, Bouard, Adeline, Mougey, Virginie, Ramos, Diana, Barroso, António, Zangiacomi, Vincent, Jary, Marine, Kim, Stefano, Gonzalez-Pajuelo, Maria, Royer, Bernard, de Haard, Hans, Clark, Andy, Wijdenes, John, Borg, Christophe

“…Mesothelin is a glycosylphosphatidylinositol (GPI)-anchored membrane protein that shows promise as a target for antibody-directed cancer therapy. High levels…”
Get full text