Search Results - "WIGLEY, W. C"

Natural mutagenesis study of the human steroid 5α-reductase 2 isozyme by WIGLEY, W. C, PRIHODA, J. S, MOWSZOWICZ, I, MENDONCA, B. B, NEW, M. I, WILSON, J. D, RUSSELL, D. W

“…The enzyme steroid 5 alpha-reductase utilizes NADPH to reduce the double bonds of a variety of steroid substrates with generalized 3-oxo, delta 4,5 structures…”
Get full text

Dynamic Association of Proteasomal Machinery with the Centrosome by Wigley, W. Christian, Fabunmi, Rosalind P., Lee, Min Goo, Marino, Christopher R., Muallem, Shmuel, DeMartino, George N., Thomas, Philip J.

“…Although the number of pathologies known to arise from the inappropriate folding of proteins continues to grow, mechanisms underlying the recognition and…”
Get full text

Protein solubility and folding monitored in vivo by structural complementation of a genetic marker protein by Thomas, Philip J, Wigley, W. Christian, Stidham, Rhesa D, Smith, Nathan M, Hunt, John F

“…Protein misfolding is the basis of a number of human diseases and presents an obstacle to the production of soluble recombinant proteins. We present a general…”
Get full text

Activity and Regulation of the Centrosome-associated Proteasome by Fabunmi, R P, Wigley, W C, Thomas, P J, DeMartino, G N

“…Regulated proteolysis is important for maintaining appropriate cellular levels of many proteins. The bulk of intracellular protein degradation is catalyzed by…”
Get full text

Interferon gamma regulates accumulation of the proteasome activator PA28 and immunoproteasomes at nuclear PML bodies by Fabunmi, R P, Wigley, W C, Thomas, P J, DeMartino, G N

“…PA28 is an interferon (gamma) (IFN(gamma)) inducible proteasome activator required for presentation of certain major histocompatibility (MHC) class I antigens…”
Get full text

Regulation of Cl−/ HCO3−Exchange by Cystic Fibrosis Transmembrane Conductance Regulator Expressed in NIH 3T3 and HEK 293 Cells by Lee, Min Goo, Wigley, W. Christian, Zeng, Weizhong, Noel, Laura E., Marino, Christopher R., Thomas, Philip J., Muallem, Shmuel

“…A central function of cystic fibrosis transmembrane conductance regulator (CFTR)-expressing tissues is the secretion of fluid containing 100–140 mmHCO3−. High…”
Get full text

Evidence for multiple genes coding for the isozymes of hexokinase in the highly glycolytic AS-30D rat hepatoma by Wigley, W.Christian, Nakashima, Richard A.

“…We have compared Southern blots of rat hepatoma DNA probed with Types I, II and III hexokinase cDNAs isolated from normal rat tissues. Hybridization patterns…”
Get full text

Detection of a progression-linked DNA restriction fragment in rat hepatoma cells probed with a hexokinase cDNA by Wigley, W C, Corson, G E, Nakashima, R A

“…We have compared genomic DNA isolated from a series of rat hepatomas and from normal rat liver tissue by restriction fragment analysis. Our objective was to…”
Get more information

Transmembrane Domain of Cystic Fibrosis Transmembrane Conductance Regulator:  Design, Characterization, and Secondary Structure of Synthetic Peptides m1−m6 by Wigley, W. Christian, Vijayakumar, S, Jones, Jeffrey D, Slaughter, Clive, Thomas, Philip J

“…Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) give rise to cystic fibrosis (CF), the most common genetic disease in the Caucasian…”
Get full text

Restriction fragment length polymorphism (RFLP) analysis provides evidence for a high degree of homology of mitochondrial DNAs from rat hepatomas versus normal rat livers by NAKASHIMA, R. A, XIN LI, BAYOUTH, J. M, WIGLEY, W. C

“…Where differences have been reported between tumor and normal mitochondrial DNA (mtDNA), they have generally involved limited modifications of the genome…”
Get full text

Detection of a restriction fragment-length polymorphism in human endometrial carcinoma DNA with an alpha-tubulin cDNA probe by Mittanck, D W, Wigley, W C, Li, X, Alecozay, A A, Nakashima, R A

“…We report a significant excess of heterozygotes at an alpha-tubulin locus in individuals with endometrial carcinoma. Although the heterozygous state was not…”
Get more information

The molecular genetics of steroid 5 alpha-reductases by Russell, D W, Berman, D M, Bryant, J T, Cala, K M, Davis, D L, Landrum, C P, Prihoda, J S, Silver, R I, Thigpen, A E, Wigley, W C

Get more information

A Conserved GXXXG Motif in APH-1 Is Critical for Assembly and Activity of the γ-Secretase Complex by Lee, Sheu-Fen, Shah, Sanjiv, Yu, Cong, Wigley, W. Christian, Li, Harry, Lim, Myungsil, Pedersen, Kia, Han, Weiping, Thomas, Philip, Lundkvist, Johan, Hao, Yi-Heng, Yu, Gang

“…The multipass membrane protein APH-1, found in the γ-secretase complex together with presenilin, nicastrin, and PEN-2, is essential for Notch signaling in…”
Get full text

A Conserved GXXXG Motif in APH-1 Is Critical for Assembly and Activity of the [gamma]-Secretase Complex by Lee, S-F, Shah, S, Yu, C, Wigley, W C, Li, H, Lim, M, Pedersen, K, Han, W, Thomas, P, Lundkvist, J, Hao, Y-H, Yu, G

“…The multipass membrane protein APH-1, found in the [gamma]-secretase complex together with presenilin, nicastrin, and PEN-2, is essential for Notch signaling…”
Get full text

A protein sequence that can encode native structure by disfavoring alternate conformations by Thomas, Philip J, Wigley, W. Christian, Corboy, Michael J, Cutler, Todd D, Thibodeau, Patrick H, Oldan, Jorge, Lee, Min Goo, Rizo, Josep, Hunt, John F

“…The linear sequence of amino acids contains all the necessary information for a protein to fold into its unique three-dimensional structure. Native protein…”
Get full text

Regulation of Cl super(-)/ HCO sub(3) super(-) Exchange by Cystic Fibrosis Transmembrane Conductance Regulator Expressed in NIH 3T3 and HEK 293 Cells by Lee, M G, Wigley, W C, Zeng, W, Noel, LE, Marino, C R, Thomas, P J, Muallem, S

“…A central function of cystic fibrosis transmembrane conductance regulator (CFTR)- expressing tissues is the secretion of fluid containing 100-140 mM HCO sub(3)…”
Get full text

A conserved G XXX G motif in APH-1 is critical for assembly and activity of the γ-secretase complex by Lee, SF, Shah, S, Yu, C, Wigley, WC, Li, H, Lim, M, Pedersen, K, Han, WP, Thomas, P, Lundkvist, J

Get full text

Natural mutagenesis study of the human steroid 5 alpha -reductase 1 isozyme by Wigley, W C, Prihoda, J S, Mowszowica, I, Mendonca, B B, New, MI, Wilson, J D, Russell, D W

“…The enzyme steroid 5 alpha -reductase utilizes NADPH to reduce the double bonds of a variety of steroid substrates with generalized 3-oxo, Delta super(4,5)…”
Get full text

Salivary epithelial cells in primary culture: characterization of their growth and functional properties by Wigley, C B, Franks, L M

“…Mouse submandibular salivary gland cells were grown in primary explant culture. After an initial period of degeneration within the explant, surviving…”
Get full text

A comparison of experiment and calculated wave-profiles and wave-resistances for a form having parabolic waterlines by Wigley, W. C. S.

“…It has been found possible to calculate the wave-resistance of simple three dimensional forms, and a number of such results have boon obtained which on the…”
Get full text