Search Results - "WIESENER, Michael S"

Inhibition of Prolyl Hydroxylases Increases Erythropoietin Production in ESRD by BERNHARDT, Wanja M, WIESENER, Michael S, SCIGALLA, Paul, CHOU, James, SCHMIEDER, Roland E, GUNZLER, Volkmar, ECKARDT, Kai-Uwe

“…The reasons for inadequate production of erythropoietin (EPO) in patients with ESRD are poorly understood. A better understanding of EPO regulation, namely…”
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cfNOMe - A single assay for comprehensive epigenetic analyses of cell-free DNA by Erger, Florian, Nörling, Deborah, Borchert, Domenica, Leenen, Esther, Habbig, Sandra, Wiesener, Michael S, Bartram, Malte P, Wenzel, Andrea, Becker, Christian, Toliat, Mohammad R, Nürnberg, Peter, Beck, Bodo B, Altmüller, Janine

“…Cell-free DNA (cfDNA) analysis has become essential in cancer diagnostics and prenatal testing. We present cfNOMe, a two-in-one method of measuring cfDNA…”
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Biallelic Expression of Mucin-1 in Autosomal Dominant Tubulointerstitial Kidney Disease: Implications for Nongenetic Disease Recognition by Knaup, Karl X, Hackenbeck, Thomas, Popp, Bernt, Stoeckert, Johanna, Wenzel, Andrea, Büttner-Herold, Maike, Pfister, Frederick, Schueler, Markus, Seven, Didem, May, Annette M, Halbritter, Jan, Gröne, Hermann-Josef, Reis, André, Beck, Bodo B, Amann, Kerstin, Ekici, Arif B, Wiesener, Michael S

“…Providing the correct diagnosis for patients with tubulointerstitial kidney disease and secondary degenerative disorders, such as hypertension, remains a…”
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Hypoxia-inducible protein 2 is a novel lipid droplet protein and a specific target gene of hypoxia-inducible factor-1 by Gimm, Tina, Wiese, Melanie, Teschemacher, Barbara, Deggerich, Anke, Schödel, Johannes, Knaup, Karl X, Hackenbeck, Thomas, Hellerbrand, Claus, Amann, Kerstin, Wiesener, Michael S, Höning, Stefan, Eckardt, Kai-Uwe, Warneck, Christina

“…Hypoxia-inducible protein 2 (HIG2) has been implicated in canonical Wnt signaling, both as target and activator. The potential link between hypoxia and an…”
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Renal fibrosis is the common feature of autosomal dominant tubulointerstitial kidney diseases caused by mutations in mucin 1 or uromodulin by Ekici, Arif B, Hackenbeck, Thomas, Morinière, Vincent, Pannes, Andrea, Buettner, Maike, Uebe, Steffen, Janka, Rolf, Wiesener, Antje, Hermann, Ingo, Grupp, Sina, Hornberger, Martin, Huber, Tobias B, Isbel, Nikky, Mangos, George, McGinn, Stella, Soreth-Rieke, Daniela, Beck, Bodo B, Uder, Michael, Amann, Kerstin, Antignac, Corinne, Reis, André, Eckardt, Kai-Uwe, Wiesener, Michael S

“…For decades, ill-defined autosomal dominant renal diseases have been reported, which originate from tubular cells and lead to tubular atrophy and interstitial…”
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Hypoxia-inducible Transcription Factors Stabilization in the Thick Ascending Limb Protects against Ischemic Acute Kidney Injury by SCHLEY, Gunnar, KLANKE, Bernd, MAXWELL, Patrick H, WILLAM, Carsten, SCHÖDEL, Johannes, FORSTREUTER, Frauke, SHUKLA, Deepa, KURTZ, Armin, AMANN, Kerstin, WIESENER, Michael S, ROSEN, Seymour, ECKARDT, Kai-Uwe

“…Hypoxia-inducible transcription factors (HIF) protect cells against oxygen deprivation, and HIF stabilization before ischemia mitigates tissue injury. Because…”
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Depression, Anxiety, Resilience and Coping Pre and Post Kidney Transplantation - Initial Findings from the Psychiatric Impairments in Kidney Transplantation (PI-KT)-Study by Müller, Helge H, Englbrecht, Matthias, Wiesener, Michael S, Titze, Stephanie, Heller, Katharina, Groemer, Teja W, Schett, Georg, Eckardt, Kai-Uwe, Kornhuber, Johannes, Maler, Juan Manuel

“…Depression/anxiety, impaired Health-Related Quality of Life (HRQoL) and coping and resilience structures, are associated with increased mortality/poor outcome…”
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Mutations in mitochondrial DNA causing tubulointerstitial kidney disease by Connor, Thomas M, Hoer, Simon, Mallett, Andrew, Gale, Daniel P, Gomez-Duran, Aurora, Posse, Viktor, Antrobus, Robin, Moreno, Pablo, Sciacovelli, Marco, Frezza, Christian, Duff, Jennifer, Sheerin, Neil S, Sayer, John A, Ashcroft, Margaret, Wiesener, Michael S, Hudson, Gavin, Gustafsson, Claes M, Chinnery, Patrick F, Maxwell, Patrick H

“…Tubulointerstitial kidney disease is an important cause of progressive renal failure whose aetiology is incompletely understood. We analysed a large pedigree…”
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HIF Activation Protects From Acute Kidney Injury by WEIDEMANN, Alexander, BERNHARDT, Wanja M, WILLAM, Carsten, KLANKE, Bernd, DANIEL, Christoph, BUCHHOLZ, Björn, CAMPEAN, Valentina, AMANN, Kerstin, WARNECKE, Christina, WIESENER, Michael S, ECKARDT, Kai-Uwe

“…The contribution of hypoxia to cisplatin-induced renal tubular injury is controversial. Because the hypoxia-inducible factor (HIF) pathway is a master…”
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Preconditional activation of hypoxia-inducible factors ameliorates ischemic acute renal failure by BERNHARDT, Wanja M, CAMPEAN, Valentina, WILLAM, Carsten, WIESENER, Michael S, ECKARDT, Kai-Uwe, KANY, Sarah, JÜRGENSEN, Jan-Steffen, WEIDEMANN, Alexander, WARNECKE, Christina, AREND, Michael, KLAUS, Stephen, GÜNZLER, Volkmar, AMANN, Kerstin

“…Activation of hypoxia-inducible transcription factor (HIF) has been identified as an important mechanism of cellular adaptation to low oxygen. Normoxic…”
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Renal tubular HIF-2α expression requires VHL inactivation and causes fibrosis and cysts by Schietke, Ruth E, Hackenbeck, Thomas, Tran, Maxine, Günther, Regina, Klanke, Bernd, Warnecke, Christina L, Knaup, Karl X, Shukla, Deepa, Rosenberger, Christian, Koesters, Robert, Bachmann, Sebastian, Betz, Peter, Schley, Gunnar, Schödel, Johannes, Willam, Carsten, Winkler, Thomas, Amann, Kerstin, Eckardt, Kai-Uwe, Maxwell, Patrick, Wiesener, Michael S

“…The Hypoxia-inducible transcription Factor (HIF) represents an important adaptive mechanism under hypoxia, whereas sustained activation may also have…”
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Discordant Clinical Course of Vitamin-D-Hydroxylase (CYP24A1) Associated Hypercalcemia in Two Adult Brothers With Nephrocalcinosis by Jobst-Schwan, Tilman, Pannes, Andrea, Schlingmann, Karl Peter, Eckardt, Kai-Uwe, Beck, Bodo B., Wiesener, Michael S.

“…Background/Aims: Hypercalcemia can result in nephrocalcinosis/nephrolithiasis and may lead to renal failure. Idiopathic infantile hypercalcemia is caused by…”
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Mutual Regulation of Hypoxia-Inducible Factor and Mammalian Target of Rapamycin as a Function of Oxygen Availability by Knaup, Karl X, Jozefowski, Katrin, Schmidt, Regina, Bernhardt, Wanja M, Weidemann, Alexander, Juergensen, Jan Steffen, Warnecke, Christina, Eckardt, Kai-Uwe, Wiesener, Michael S

“…The mammalian target of rapamycin (mTOR) regulates cellular growth and proliferation, mainly by controlling cellular translation. Most tumors show constitutive…”
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Tumor suppressor activity and epigenetic inactivation of hepatocyte growth factor activator inhibitor type 2/SPINT2 in papillary and clear cell renal cell carcinoma by MORRIS, Mark R, GENTLE, Dean, LATIF, Farida, MAHER, Eamonn R, ABDULRAHMAN, Mahera, MAINA, Esther N, GUPTA, Kunal, BANKS, Rosamonde E, WIESENER, Michael S, KISHIDA, Takeshi, YAO, Masahiro, TEH, Bin

“…Following treatment with a demethylating agent, 5 of 11 renal cell carcinoma (RCC) cell lines showed increased expression of hepatocyte growth factor (HGF)…”
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Mutation Analysis of Hypoxia-inducible Factors HIF1A and HIF2A in Renal Cell Carcinoma by Morris, Mark R, Hughes, David J, Tian, Ya-Min, Ricketts, Christopher J, Lau, Kah Weng, Gentle, Dean, Shuib, Salwati, Serrano-Fernandez, Pablo, Lubinski, Jan, Wiesener, Michael S, Pugh, Christopher W, Latif, Farida, Ratcliffe, Peter J, Maher, Eamonn R

“…Background: Inactivation of the Von Hippel-Lindau (VHL) tumour suppressor gene leading to overexpression of hypoxia-inducible transcription factors (HIF)-1α…”
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Lysyl Oxidases LOX and LOXL2 Are Necessary and Sufficient to Repress E-cadherin in Hypoxia: INSIGHTS INTO CELLULAR TRANSFORMATION PROCESSES MEDIATED BY HIF-1 by Schietke, Ruth, Warnecke, Christina, Wacker, Ingrid, Schödel, Johannes, Mole, David R, Campean, Valentina, Amann, Kerstin, Goppelt-Struebe, Margarete, Behrens, Jürgen, Eckardt, Kai-Uwe, Wiesener, Michael S

“…Hypoxia has been shown to promote tumor metastasis and lead to therapy resistance. Recent work has demonstrated that hypoxia represses E-cadherin expression, a…”
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Biallelic ANKS6 mutations cause late-onset ciliopathy with chronic kidney disease through YAP dysregulation by Schwarz, Hannah, Popp, Bernt, Airik, Rannar, Torabi, Nasrin, Knaup, Karl X, Stoeckert, Johanna, Wiech, Thorsten, Amann, Kerstin, Reis, André, Schiffer, Mario, Wiesener, Michael S, Schueler, Markus

“…Abstract Nephronophthisis-related ciliopathies (NPHP-RC) comprises a group of inherited kidney diseases, caused by mutations in genes encoding proteins…”
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PI(3,4)P2-mediated cytokinetic abscission prevents early senescence and cataract formation by Gulluni, Federico, Prever, Lorenzo, Li, Huayi, Krafcikova, Petra, Corrado, Ilaria, Lo, Wen-Ting, Margaria, Jean Piero, Chen, Anlu, De Santis, Maria Chiara, Cnudde, Sophie J, Fogerty, Joseph, Yuan, Alex, Massarotti, Alberto, Sarijalo, Nasrin Torabi, Vadas, Oscar, Williams, Roger L, Thelen, Marcus, Powell, David R, Schueler, Markus, Wiesener, Michael S, Balla, Tamas, Baris, Hagit N, Tiosano, Dov, McDermott, Jr, Brian M, Perkins, Brian D, Ghigo, Alessandra, Martini, Miriam, Haucke, Volker, Boura, Evzen, Merlo, Giorgio Roberto, Buchner, David A, Hirsch, Emilio

“…Cytokinetic membrane abscission is a spatially and temporally regulated process that requires ESCRT (endosomal sorting complexes required for…”
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Suspected colonic cancer turns out to be disseminated tuberculosis in a kidney transplant recipient: A case report by Schmidt-Lauber, Christian, Jacobi, Johannes, Polifka, Iris, Hilgers, Karl F., Wiesener, Michael S.

“…Active tuberculosis constitutes a relevant risk for kidney transplant recipients. In contrast to immunocompetent hosts, kidney transplant recipients often show…”
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Hypoxia and hypoxia-inducible factor-1 alpha modulate lipopolysaccharide-induced dendritic cell activation and function by Jantsch, Jonathan, Chakravortty, Dipshikha, Turza, Nadine, Prechtel, Alexander T, Buchholz, Björn, Gerlach, Roman G, Volke, Melanie, Gläsner, Joachim, Warnecke, Christina, Wiesener, Michael S, Eckardt, Kai-Uwe, Steinkasserer, Alexander, Hensel, Michael, Willam, Carsten

“…Dendritic cells (DC) play a key role in linking innate and adaptive immunity. In inflamed tissues, where DC become activated, oxygen tensions are usually low…”
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