Search Results - "WIELOCKX, Ben"

Hypoxia Pathway Proteins As Central Mediators of Metabolism in the Tumor Cells and Their Microenvironment by Sormendi, Sundary, Wielockx, Ben

“…Low oxygen tension or hypoxia is a determining factor in the course of many different processes in animals, including when tissue expansion and cellular…”
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Hypoxia Pathway Proteins and Their Impact on the Blood Vasculature by Rodriguez, Diego, Watts, Deepika, Gaete, Diana, Sormendi, Sundary, Wielockx, Ben

“…Every cell in the body requires oxygen for its functioning, in virtually every animal, and a tightly regulated system that balances oxygen supply and demand is…”
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Hypoxia‐inducible factors as key regulators of tumor inflammation by Mamlouk, Soulafa, Wielockx, Ben

“…Low levels of oxygen or hypoxia is often an obstacle in health, particularly in pathological disorders like cancer. The main family of transcription factors…”
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Erythrocytosis: the HIF pathway in control by Franke, Kristin, Gassmann, Max, Wielockx, Ben

“…Organisms living under aerobic conditions need oxygen for the metabolic conversion of nutrition into energy. With the appearance of increasingly complex…”
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Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity by Mitroulis, Ioannis, Ruppova, Klara, Wang, Baomei, Chen, Lan-Sun, Grzybek, Michal, Grinenko, Tatyana, Eugster, Anne, Troullinaki, Maria, Palladini, Alessandra, Kourtzelis, Ioannis, Chatzigeorgiou, Antonios, Schlitzer, Andreas, Beyer, Marc, Joosten, Leo A.B., Isermann, Berend, Lesche, Mathias, Petzold, Andreas, Simons, Kai, Henry, Ian, Dahl, Andreas, Schultze, Joachim L., Wielockx, Ben, Zamboni, Nicola, Mirtschink, Peter, Coskun, Ünal, Hajishengallis, George, Netea, Mihai G., Chavakis, Triantafyllos

“…Trained innate immunity fosters a sustained favorable response of myeloid cells to a secondary challenge, despite their short lifespan in circulation. We thus…”
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Hypoxia Pathway Proteins are Master Regulators of Erythropoiesis by Watts, Deepika, Gaete, Diana, Rodriguez, Diego, Hoogewijs, David, Rauner, Martina, Sormendi, Sundary, Wielockx, Ben

“…Erythropoiesis is a complex process driving the production of red blood cells. During homeostasis, adult erythropoiesis takes place in the bone marrow and is…”
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HIF1α is a direct regulator of steroidogenesis in the adrenal gland by Watts, Deepika, Stein, Johanna, Meneses, Ana, Bechmann, Nicole, Neuwirth, Ales, Kaden, Denise, Krüger, Anja, Sinha, Anupam, Alexaki, Vasileia Ismini, Luis Gustavo Perez-Rivas, Kircher, Stefan, Martinez, Antoine, Theodoropoulou, Marily, Eisenhofer, Graeme, Peitzsch, Mirko, El-Armouche, Ali, Chavakis, Triantafyllos, Wielockx, Ben

“…Endogenous steroid hormones, especially glucocorticoids and mineralocorticoids, derive from the adrenal cortex, and drastic or sustained changes in their…”
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Hematopoietic stem cells can differentiate into restricted myeloid progenitors before cell division in mice by Grinenko, Tatyana, Eugster, Anne, Thielecke, Lars, Ramasz, Beáta, Krüger, Anja, Dietz, Sevina, Glauche, Ingmar, Gerbaulet, Alexander, von Bonin, Malte, Basak, Onur, Clevers, Hans, Chavakis, Triantafyllos, Wielockx, Ben

“…Hematopoietic stem cells (HSCs) continuously replenish all blood cell types through a series of differentiation steps and repeated cell divisions that involve…”
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From Vessels to Neurons-The Role of Hypoxia Pathway Proteins in Embryonic Neurogenesis by Stepien, Barbara K, Wielockx, Ben

“…Embryonic neurogenesis can be defined as a period of prenatal development during which divisions of neural stem and progenitor cells give rise to neurons. In…”
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Hypoxia Pathway Proteins in Normal and Malignant Hematopoiesis by Wielockx, Ben, Grinenko, Tatyana, Mirtschink, Peter, Chavakis, Triantafyllos

“…The regulation of oxygen (O₂) levels is crucial in embryogenesis and adult life, as O₂ controls a multitude of key cellular functions. Low oxygen levels…”
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Exercise-Induced Activated Platelets Increase Adult Hippocampal Precursor Proliferation and Promote Neuronal Differentiation by Leiter, Odette, Seidemann, Suse, Overall, Rupert W., Ramasz, Beáta, Rund, Nicole, Schallenberg, Sonja, Grinenko, Tatyana, Wielockx, Ben, Kempermann, Gerd, Walker, Tara L.

“…Physical activity is a strong positive physiological modulator of adult neurogenesis in the hippocampal dentate gyrus. Although the underlying regulatory…”
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Succinate mediates inflammation-induced adrenocortical dysfunction by Mateska, Ivona, Witt, Anke, Hagag, Eman, Sinha, Anupam, Yilmaz, Canelif, Thanou, Evangelia, Sun, Na, Kolliniati, Ourania, Patschin, Maria, Abdelmegeed, Heba, Henneicke, Holger, Kanczkowski, Waldemar, Wielockx, Ben, Tsatsanis, Christos, Dahl, Andreas, Walch, Axel Karl, Li, Ka Wan, Peitzsch, Mirko, Chavakis, Triantafyllos, Alexaki, Vasileia Ismini

“…The hypothalamus-pituitary-adrenal (HPA) axis is activated in response to inflammation leading to increased production of anti-inflammatory glucocorticoids by…”
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Hypoxia signaling pathway: A central mediator in endocrine tumors by Watts, Deepika, Jaykar, Mangesh T, Bechmann, Nicole, Wielockx, Ben

“…Adequate oxygen levels are essential for the functioning and maintenance of biological processes in virtually every cell, albeit based on specific need. Thus,…”
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HIF2α regulates the synthesis and release of epinephrine in the adrenal medulla by Watts, Deepika, Bechmann, Nicole, Meneses, Ana, Poutakidou, Ioanna K., Kaden, Denise, Conrad, Catleen, Krüger, Anja, Stein, Johanna, El-Armouche, Ali, Chavakis, Triantafyllos, Eisenhofer, Graeme, Peitzsch, Mirko, Wielockx, Ben

“…The adrenal gland and its hormones regulate numerous fundamental biological processes; however, the impact of hypoxia signaling on adrenal function remains…”
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CD38 promotes hematopoietic stem cell dormancy by Ibneeva, Liliia, Singh, Sumeet Pal, Sinha, Anupam, Eski, Sema Elif, Wehner, Rebekka, Rupp, Luise, Kovtun, Iryna, Pérez-Valencia, Juan Alberto, Gerbaulet, Alexander, Reinhardt, Susanne, Wobus, Manja, von Bonin, Malte, Sancho, Jaime, Lund, Frances, Dahl, Andreas, Schmitz, Marc, Bornhäuser, Martin, Chavakis, Triantafyllos, Wielockx, Ben, Grinenko, Tatyana

“…A subpopulation of deeply quiescent, so-called dormant hematopoietic stem cells (dHSCs) resides at the top of the hematopoietic hierarchy and serves as a…”
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Hematopoietic stem cell response to acute thrombocytopenia requires signaling through distinct receptor tyrosine kinases by Ramasz, Beáta, Krüger, Anja, Reinhardt, Julia, Sinha, Anupam, Gerlach, Michael, Gerbaulet, Alexander, Reinhardt, Susanne, Dahl, Andreas, Chavakis, Triantafyllos, Wielockx, Ben, Grinenko, Tatyana

“…Although bone marrow niche cells are essential for hematopoietic stem cell (HSC) maintenance, their interaction in response to stress is not well defined…”
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Hypoxia-Inducible Factors Regulate Osteoclasts in Health and Disease by Meng, Xianyi, Wielockx, Ben, Rauner, Martina, Bozec, Aline

“…Hypoxia-inducible factors (HIFs) have become key transcriptional regulators of metabolism, angiogenesis, erythropoiesis, proliferation, inflammation and…”
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Characterization of Adrenal miRNA-Based Dysregulations in Cushing's Syndrome by Vetrivel, Sharmilee, Zhang, Ru, Engel, Mareen, Oßwald, Andrea, Watts, Deepika, Chen, Alon, Wielockx, Ben, Sbiera, Silviu, Reincke, Martin, Riester, Anna

“…MiRNAs are important epigenetic players with tissue- and disease-specific effects. In this study, our aim was to investigate the putative differential…”
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Epo/EpoR signaling in osteoprogenitor cells is essential for bone homeostasis and Epo-induced bone loss by Rauner Martina, Murray, Marta, Thiele, Sylvia, Watts, Deepika, Neumann Drorit, Gabet Yankel, Hofbauer, Lorenz C, Wielockx Ben

“…High erythropoietin (Epo) levels are detrimental to bone health in adult organisms. Adult mice receiving high doses of Epo lose bone mass due to suppressed…”
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Neuron-Specific Prolyl-4-Hydroxylase Domain 2 Knockout Reduces Brain Injury After Transient Cerebral Ischemia by Kunze, Reiner, Zhou, Wei, Veltkamp, Roland, Wielockx, Ben, Breier, Georg, Marti, Hugo H.

“…Numerous factors involved in the adaptive response to hypoxia, including erythropoietin and vascular endothelial growth factor are transcriptionally regulated…”
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