Search Results - "WIELING, J"

LC-MS-MS experiences with internal standards by Wieling, J

“…Over the years of chromatographic evolution, the purpose of using internal standards for quantitative determinations in bioanalysis has shifted from covering…”
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Effect of low-dose ritonavir (100 mg twice daily) on the activity of cytochrome P450 2D6 in healthy volunteers by Aarnoutse, Rob E, Kleinnijenhuis, Johanneke, Koopmans, Peter P, Touw, Daan J, Wieling, Jaap, Hekster, Yechiel A, Burger, David M

“…Objective In the treatment of human immunodeficiency virus infection, the protease inhibitor ritonavir is used in a low dose (100 mg twice daily) to inhibit…”
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CYP2D6 and CYP2C19 activity in a large population of Dutch healthy volunteers : indications for oral contraceptive-related gender differences by TAMMINGA, W. J, WEMER, J, OOSTERHUIS, B, WIELING, J, WILFFERT, B, DE LEIJ, L. F. M. H, DE ZEEUW, R. A, JONKMAN, J. H. G

“…We examined a large database containing results on CYP2D6 and CYP2C19 activity of 4301 Dutch volunteers phenotyped in the context of various clinical…”
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An Empirical Study on the Impact of Bioanalytical Method Variability on Estimation of PK Parameters by Wieling, J., Tump, C.

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‘High throughput’ solid-phase extraction technology and turbo ionspray LC-MS-MS applied to the determination of haloperidol in human plasma by Hempenius, J., Steenvoorden, R.J.J.M., Lagerwerf, F.M., Wieling, J., Jonkman, J.H.G.

“…A quantitative method for the analysis of haloperidol in human plasma is described. Sample clean-up was performed by means of solid-phase extraction using 3M…”
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Rational experimental design for bioanalytical methods validation illustration using an assay method for total captopril in plasma by Wieling, J., Hendriks, G., Tamminga, W.J., Hempenius, J., Mensink, C.K., Oosterhuis, B., Jonkman, J.H.G.

“…Generally, bioanalytical chromatographic methods are validated according to a predefined programme and distinguish a pre-validation phase, a main validation…”
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Direct, On-Site, On-Cartridge Toxicokinetic Sampling Prior to On-Line SPE: A Feasibility Study by Tump, C., Hilhorst, M. J., Ooms, J. A., Wieling, J.

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Pharmacokinetics of [14C]-labelled Losigamone and enantiomers after oral administration to healthy subjects by PEETERS, P. A. M, VAN LIER, J. J, DE MERBEL, N. V, OOSTERHUIS, B, WIELING, J, JONKMAN, J. H. G, KLESSING, K, BIBER, A

“…Losigamone ((+/-)-(R*,S*)-5-(2-chlorophenylhydroxymethyl)-4-methoxy-2 (5H)-furanone; AO-33) is a new potential antiepileptic drug undergoing clinical…”
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Development of a laboratory robotic system for automated bioanalytical methods--I. The determination of theophylline in human plasma: a comparison between the robotized and manual method by Hempenius, J, Wieling, J, Jonkman, J H, de Noord, O E, Coenegracht, P M, Doornbos, D A

“…The quality of bioanalytical methods is often determined by the quality of sample preparation. Using a robot for sample treatment may give better results than…”
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LC-MS-MS experiences with internal standards by WIELING, J

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Development of a laboratory robotic system for automated bioanalytical methods--II. A robot computer program for guarding totally automated bioanalytical methods by Wieling, J, Hempenius, J, Jeuring, H J, Jonkman, J H, Coenegracht, P M, Doornbos, D A

“…The application of fully automated, unattended sample preparation performed by a laboratory robot for the analysis of drugs in biological samples requires the…”
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High-throughput solid-phase extraction for the determination of cimetidine in human plasma by Hempenius, J, Wieling, J, Brakenhoff, J.P.G, Maris, F.A, Jonkman, J.H.G

“…For the implementation and validation of an automated `high-throughput' solid-phase extraction (SPE) system, using microtiter solid-phase technology and a…”
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Monitors for a signal integrity measurement system by Petrescu, V., Pelgrom, M., Veendrick, H., Pavithran, P., Wieling, J.

“…On-chip monitors are an essential part of a signal integrity measurement system. Temperature, voltage and technology monitors need to comply with various…”
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A Signal-Integrity Self-Test Concept for Debugging Nanometer CMOS ICs by Petrescu, V., Pelgrom, M., Veendrick, H., Pavithran, P., Wieling, J.

“…A fully integrated signal-integrity self-test concept is implemented in a 90nm CMOS process. The outputs of different analog monitors are locally converted to…”
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Mephenytoin as a probe for CYP2C19 phenotyping:effect of sample storage, intra‐individual reproducibility and occurrence of adverse events by Tamminga, Wim J., Wemer, Johan, Oosterhuis, Berend, Wieling, Jaap, Touw, Daan J., De Zeeuw, Rokus A., De Leij, Lou F. M. H., Jonkman, Jan H. G.

“…Aims  To further evaluate mephenytoin as a probe for CYP2C19 phenotyping. Methods  Healthy subjects (n = 2638) were phenotyped using the urinary…”
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Evaluation of analytical and clinical performance of a dual-probe phenotyping method for CYP2D6 polymorphism and CYP3A4 activity screening by WIELING, J, TAMMINGA, W. J, SAKIMAN, E. P, OOSTERHUIS, B, WEMER, J, JONKMAN, J. H. G

“…A bioanalytical method for the determination of dextromethorphan (DEX) and its metabolites dextrorphan (DTX), 3-methoxymorphinan (3MM), and 3-hydroxymorphinan…”
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Chemometrics in bioanalytical sample preparation. A fractionated combined mixture and factorial design for the modelling of the recovery of five tricyclic amines from plasma after liquid-liquid extraction prior to high-performance liquid chromatography by Wieling, J, Dijkstra, H, Mensink, C K, Jonkman, J H, Coenegracht, P M, Duineveld, C A, Doornbos, D A

“…A general systematic approach is described for the chemometric modelling of liquid-liquid extraction data of drugs from biological fluids. Extraction solvents…”
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