Search Results - "WIELAND, Heike A"

Osteoarthritis - an untreatable disease? by Wieland, Heike A, Michaelis, Martin, Kirschbaum, Bernhard J, Rudolphi, Karl A

“…Osteoarthritis is a painful and disabling disease that affects millions of patients. Its aetiology is largely unknown, but is most likely multi-factorial…”
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Effects of the neuropeptide Y Y2 receptor antagonist BIIE0246 on presynaptic inhibition by neuropeptide Y in rat hippocampal slices by WEISER, Thomas, WIELAND, Heike A, DOODS, Henri N

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BIIE0246: A selective and high affinity neuropeptide Y Y2 receptor antagonist by Doods, Henri, Gaida, Wolfram, Wieland, Heike A, Dollinger, Horst, Schnorrenberg, Gerd, Esser, Franz, Engel, Wolfhard, Eberlein, Wolfgang, Rudolf, Klaus

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Characterisation of Neuropeptide Y Receptor Subtypes by Synthetic NPY Analogues and by Anti-receptor Antibodies by Eckard, Christophe P., Cabrele, Chiara, Wieland, Heike A., Beck-Sickinger, Annette G.

“…Neuropeptide Y (NPY), a 36-mer neuromodulator, binds to the receptors Y1, Y2, Y4 and Y5 with nanomolar affinity. They all belong to the rhodopsin-like…”
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The SK‐N‐MC cell line expresses an orexin binding site different from recombinant orexin 1‐type receptor by Wieland, Heike A., Söll, Richard M., Doods, Henri N., Stenkamp, Dirk, Hurnaus, Rudolf, Lämmle, Bärbel, Beck‐Sickinger, Annette G.

“…Orexin A and B (also known as hypocretins), two recently discovered neuropeptides, play an important role in food intake, sleep/wake cycle and neuroendocrine…”
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The first highly potent and selective non-peptide neuropeptide Y Y1 receptor antagonist: BIBP3226 by Rudolf, K, Eberlein, W, Engel, W, Wieland, H A, Willim, K D, Entzeroth, M, Wienen, W, Beck-Sickinger, A G, Doods, H N

“…The design and subsequent in vitro and in vivo biological characterisation of the first potent and selective non-peptide neuropeptide Y Y1 receptor antagonist,…”
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Four amino acid exchanges convert a diazepam-insensitive, inverse agonist-preferring GABAA receptor into a diazepam-preferring GABAA receptor by Wieland, Heike A, Lueddens, Hartmut

“…Benzodiazepines (BZ) exert their effects through GABAA receptors, which belong to the superfamily of ligand-gated ion channels. Coexpression of recombinant…”
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BIBP 3226, the first selective neuropeptide Y1 receptor antagonist: A review of its pharmacological properties by Doods, Henri N., Wieland, Heike A., Engel, Wolfhard, Eberlein, Wolfgang, Willim, Klaus-Dieter, Entzeroth, Michael, Wienen, Wolfgang, Rudolf, Klaus

“…Based on the assumption that the pharmacophoric groups interacting with the Y1 receptor are located in the C-terminal part of neuropeptide Y, low molecular…”
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Ala31-Aib32:  Identification of the Key Motif for High Affinity and Selectivity of Neuropeptide Y at the Y5-Receptor by Cabrele, Chiara, Wieland, Heike A, Koglin, Norman, Stidsen, Carsten, Beck-Sickinger, Annette G

“…The turn-inducing sequence Ala-Aib introduced into positions 31 and 32 of neuropeptide Y (NPY) and its analogues has been identified as the key structure for…”
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Validation of a diffusion chamber as in vitro system for the analysis of compound diffusibility through cartilage tissue by Kreiselmeier, Alexander, Ulmer, Wolfgang, Stöve, Johannes, Wieland, Heike A., Gerwin, Nicole, Bartnik, Eckart, Schudok, Manfred, Heute, Steffen, Breitenfelder, Michael, Scharf, Hanns-Peter, Schwarz, Markus L.R.

“…The validation of a diffusion chamber comprising a donor and a receptor side separated by a cartilage membrane was undertaken according to the basic principles…”
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Characterization of the NPGP receptor and identification of a novel short mRNA isoform in human hypothalamus by Laemmle, Baerbel, Schindler, Marcus, Beilmann, Mario, Hamilton, Bradford S, Doods, Henri N, Wieland, Heike A

“…Recently, an orphan G protein coupled receptor (GPCR) termed NPGPR was described. A shorter variant of this receptor lacking exon 1 was shown to have…”
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Modified, cyclic dodecapeptide analog of neuropeptide Y is the smallest full agonist at the human Y2 receptor by Rist, Beate, Zerbe, Oliver, Ingenhoven, Nikolaus, Scapozza, Leonardo, Peers, Chris, Vaughan, Peter F.T, McDonald, Ruth L, Wieland, Heike A, Beck-Sickinger, Annette G

“…In order to stabilize the C‐terminal dodecapeptide of neuropeptide Y (NPY) we replaced Leu28 and Thr32 by Lys and Glu, respectively, and subsequently linked…”
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The First Selective Agonist for the Neuropeptide YY5Receptor Increases Food Intake in Rats by Cabrele, Chiara, Langer, Michael, Bader, Reto, Wieland, Heike A., Doods, Henri N., Zerbe, Oliver, Beck-Sickinger, Annette G.

“…The first Y5 receptor-selective analog of neuropeptide Y (NPY), [Ala31,Aib32]NPY, has been developed and biologically characterized. Using competition binding…”
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Divalent cations influencing neuropeptide Y receptor subtype binding in rat hippocampus and cortex membranes as well as in recombinant cells by Wieland, Heike A, Willim, K, Doods, Henri N

“…At least six types of neuropeptide Y (NPY) receptors (Y1–Y6) have been pharmacologically distinguished of which only the Y1, Y2, Y4 and Y5 subtypes have been…”
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A rational approach for the development of reduced-size analogues of neuropeptide Y with high affinity to the Y1 receptor by Rist, B, Wieland, H A, Willim, K D, Beck-Sickinger, A G

“…Four sets of centrally truncated analogues of neuropeptide Y have been synthesized. In each series the N-terminal part was constant, while the C-terminal…”
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A single histidine in GABAA receptors is essential for benzodiazepine agonist binding by Wieland, H A, Lüddens, H, Seeburg, P H

“…Benzodiazepines (BZ) modulate neurotransmitter-evoked chloride currents at the gamma-aminobutyric acid type A (GABAA) receptor, the major inhibitory ion…”
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Correction: Osteoarthritis — an untreatable disease by Wieland, Heike A., Michaelis, Martin, Kirschbaum, Bernhard J., Rudolphi, Karl. A.

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Y-receptor affinity modulation by the design of pancreatic polypeptide/neuropeptide Y chimera led to Y5-receptor ligands with picomolar affinity by Cabrele, Chiara, Wieland, Heike A., Langer, Michael, Stidsen, Carsten E., Beck-Sickinger, Annette G.

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Ala 31 -Aib 32 :  Identification of the Key Motif for High Affinity and Selectivity of Neuropeptide Y at the Y 5 -Receptor by Cabrele, Chiara, Wieland, Heike A., Koglin, Norman, Stidsen, Carsten, Beck-Sickinger, Annette G.

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Y-receptor affinity modulation by the design of pancreatic polypeptide/neuropeptide Y chimera led to Y 5-receptor ligands with picomolar affinity by Cabrele, Chiara, Wieland, Heike A., Langer, Michael, Stidsen, Carsten E., Beck-Sickinger, Annette G.

“…Neuropeptide Y (NPY) and pancreatic polypeptide (PP) bind to the Y-receptors with very different affinities: NPY has high affinity for the receptors Y 1, Y 2…”
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