Search Results - "WIECKOWSKA, Anna"

Structure-based search for new inhibitors of cholinesterases by Bajda, Marek, Więckowska, Anna, Hebda, Michalina, Guzior, Natalia, Sotriffer, Christoph A, Malawska, Barbara

“…Cholinesterases are important biological targets responsible for regulation of cholinergic transmission, and their inhibitors are used for the treatment of…”
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Recent development of multifunctional agents as potential drug candidates for the treatment of Alzheimer's disease by Guzior, Natalia, Wieckowska, Anna, Panek, Dawid, Malawska, Barbara

“…Alzheimer's disease (AD) is a complex and progressive neurodegenerative disorder. The available therapy is limited to the symptomatic treatment and its…”
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Dual Inhibitors of Amyloid‑β and Tau Aggregation with Amyloid‑β Disaggregating Properties: Extended In Cellulo, In Silico, and Kinetic Studies of Multifunctional Anti-Alzheimer’s Agents by Pasieka, Anna, Panek, Dawid, Szałaj, Natalia, Espargaró, Alba, Więckowska, Anna, Malawska, Barbara, Sabaté, Raimon, Bajda, Marek

“…In Alzheimer’s disease, neurons slowly degenerate due to the accumulation of misfolded amyloid β and tau proteins. In our research, we performed extended…”
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Development of an in-vivo active reversible butyrylcholinesterase inhibitor by Košak, Urban, Brus, Boris, Knez, Damijan, Šink, Roman, Žakelj, Simon, Trontelj, Jurij, Pišlar, Anja, Šlenc, Jasna, Gobec, Martina, Živin, Marko, Tratnjek, Larisa, Perše, Martina, Sałat, Kinga, Podkowa, Adrian, Filipek, Barbara, Nachon, Florian, Brazzolotto, Xavier, Więckowska, Anna, Malawska, Barbara, Stojan, Jure, Raščan, Irena Mlinarič, Kos, Janko, Coquelle, Nicolas, Colletier, Jacques-Philippe, Gobec, Stanislav

“…Alzheimer’s disease (AD) is characterized by severe basal forebrain cholinergic deficit, which results in progressive and chronic deterioration of memory and…”
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Microwave-Assisted Synthesis of Weinreb and MAP Aryl Amides via Pd-Catalyzed Heck Aminocarbonylation Using Mo(CO)6 or W(CO)6 by Wiȩckowska, Anna, Fransson, Rebecca, Odell, Luke R, Larhed, Mats

“…A simple and expedient process for the Heck aminocarbonylative synthesis of Weinreb and MAP amide acylating agents, from aryl halides, is reported. This…”
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Diagnosis of nonalcoholic fatty liver disease: invasive versus noninvasive by Wieckowska, Anna, Feldstein, Ariel E

“…Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in the United States and many other parts of the world. Its prevalence…”
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Design, Synthesis, and Biological Evaluation of 1‑Benzylamino-2-hydroxyalkyl Derivatives as New Potential Disease-Modifying Multifunctional Anti-Alzheimer’s Agents by Panek, Dawid, Więckowska, Anna, Jończyk, Jakub, Godyń, Justyna, Bajda, Marek, Wichur, Tomasz, Pasieka, Anna, Knez, Damijan, Pišlar, Anja, Korabecny, Jan, Soukup, Ondrej, Sepsova, Vendula, Sabaté, Raimon, Kos, Janko, Gobec, Stanislav, Malawska, Barbara

“…The multitarget approach is a promising paradigm in drug discovery, potentially leading to new treatment options for complex disorders, such as Alzheimer’s…”
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Design, Synthesis, and Biological Evaluation of 2-(Benzylamino-2-Hydroxyalkyl)Isoindoline-1,3-Diones Derivatives as Potential Disease-Modifying Multifunctional Anti-Alzheimer Agents by Panek, Dawid, Więckowska, Anna, Pasieka, Anna, Godyń, Justyna, Jończyk, Jakub, Bajda, Marek, Knez, Damijan, Gobec, Stanislav, Malawska, Barbara

“…The complex nature of Alzheimer's disease calls for multidirectional treatment. Consequently, the search for multi-target-directed ligands may lead to…”
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Discovery of Novel pERK1/2- or β‑Arrestin-Preferring 5‑HT1A Receptor-Biased Agonists: Diversified Therapeutic-like versus Side Effect Profile by Sniecikowska, Joanna, Gluch-Lutwin, Monika, Bucki, Adam, Więckowska, Anna, Siwek, Agata, Jastrzebska-Wiesek, Magdalena, Partyka, Anna, Wilczyńska, Daria, Pytka, Karolina, Latacz, Gniewomir, Przejczowska-Pomierny, Katarzyna, Wyska, Elżbieta, Wesołowska, Anna, Pawłowski, Maciej, Newman-Tancredi, Adrian, Kolaczkowski, Marcin

“…Novel 1-(1-benzoylpiperidin-4-yl)­methanamine derivatives with high affinity and selectivity for serotonin 5-HT1A receptors were obtained and tested in four…”
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Connecting GSK-3β Inhibitory Activity with IKK-β or ROCK-1 Inhibition to Target Tau Aggregation and Neuroinflammation in Alzheimer's Disease-Discovery, In Vitro and In Cellulo Activity of Thiazole-Based Inhibitors by Góral, Izabella, Wichur, Tomasz, Sługocka, Emilia, Godyń, Justyna, Szałaj, Natalia, Zaręba, Paula, Głuch-Lutwin, Monika, Mordyl, Barbara, Panek, Dawid, Więckowska, Anna

“…GSK-3β, IKK-β, and ROCK-1 kinases are implicated in the pathomechanism of Alzheimer's disease due to their involvement in the misfolding and accumulation of…”
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Novel Multitarget-Directed Ligands Aiming at Symptoms and Causes of Alzheimer’s Disease by Więckowska, Anna, Wichur, Tomasz, Godyń, Justyna, Bucki, Adam, Marcinkowska, Monika, Siwek, Agata, Więckowski, Krzysztof, Zaręba, Paula, Knez, Damijan, Głuch-Lutwin, Monika, Kazek, Grzegorz, Latacz, Gniewomir, Mika, Kamil, Kołaczkowski, Marcin, Korabecny, Jan, Soukup, Ondrej, Benkova, Marketa, Kieć-Kononowicz, Katarzyna, Gobec, Stanislav, Malawska, Barbara

“…Alzheimer’s disease (AD) is a major public health problem, which is due to its increasing prevalence and lack of effective therapy or diagnostics. The…”
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Design, synthesis and biological evaluation of new phthalimide and saccharin derivatives with alicyclic amines targeting cholinesterases, beta-secretase and amyloid beta aggregation by Panek, Dawid, Więckowska, Anna, Wichur, Tomasz, Bajda, Marek, Godyń, Justyna, Jończyk, Jakub, Mika, Kamil, Janockova, Jana, Soukup, Ondrej, Knez, Damijan, Korabecny, Jan, Gobec, Stanislav, Malawska, Barbara

“…The complexity of Alzheimer's disease (AD) calls for search of multifunctional compounds as potential candidates for effective therapy. A series of phthalimide…”
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Novel Aryloxyethyl Derivatives of 1‑(1-Benzoylpiperidin-4-yl)methanamine as the Extracellular Regulated Kinases 1/2 (ERK1/2) Phosphorylation-Preferring Serotonin 5‑HT1A Receptor-Biased Agonists with Robust Antidepressant-like Activity by Sniecikowska, Joanna, Gluch-Lutwin, Monika, Bucki, Adam, Więckowska, Anna, Siwek, Agata, Jastrzebska-Wiesek, Magdalena, Partyka, Anna, Wilczyńska, Daria, Pytka, Karolina, Pociecha, Krzysztof, Cios, Agnieszka, Wyska, Elżbieta, Wesołowska, Anna, Pawłowski, Maciej, Varney, Mark A, Newman-Tancredi, Adrian, Kolaczkowski, Marcin

“…Novel 1-(1-benzoylpiperidin-4-yl)­methanamine derivatives were designed as “biased agonists” of serotonin 5-HT1A receptors. The compounds were tested in signal…”
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1-Benzylpyrrolidine-3-amine-based BuChE inhibitors with anti-aggregating, antioxidant and metal-chelating properties as multifunctional agents against Alzheimer’s disease by Wichur, Tomasz, Więckowska, Anna, Więckowski, Krzysztof, Godyń, Justyna, Jończyk, Jakub, Valdivieso, Álvaro del Río, Panek, Dawid, Pasieka, Anna, Sabaté, Raimon, Knez, Damijan, Gobec, Stanislav, Malawska, Barbara

“…Complex pathomechanism of Alzheimer’s disease (AD) prompts researchers to develop multifunctional molecules in order to find effective therapy against AD. We…”
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Bacterial type I signal peptidase inhibitors - Optimized hits from nature by Szałaj, Natalia, Benediktsdottir, Andrea, Rusin, Dominika, Karlén, Anders, Mowbray, Sherry L., Więckowska, Anna

“…The ever-increasing number of bacteria resistant to the currently available antibacterial agents is a great medical problem today, and new antibiotics with…”
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Noninvasive diagnosis and monitoring of nonalcoholic steatohepatitis: Present and future by Wieckowska, Anna, McCullough, Arthur J., Feldstein, Ariel E.

“…Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in the United States, and its prevalence is increasing worldwide. It…”
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Multitargeting Histamine H3 Receptor Ligands among Acetyl- and Propionyl-Phenoxyalkyl Derivatives by Łażewska, Dorota, Kaleta, Maria, Zaręba, Paula, Godyń, Justyna, Dubiel, Mariam, Honkisz-Orzechowska, Ewelina, Doroz-Płonka, Agata, Więckowska, Anna, Stark, Holger, Kieć-Kononowicz, Katarzyna

“…Alzheimer’s disease (AD) is a neurodegenerative disorder, for which there is no effective cure. Current drugs only slow down the course of the disease, and,…”
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Novel drug-like fluorenyl derivatives as selective butyrylcholinesterase and β-amyloid inhibitors for the treatment of Alzheimer’s disease by Pasieka, Anna, Panek, Dawid, Zaręba, Paula, Sługocka, Emilia, Gucwa, Natalia, Espargaró, Alba, Latacz, Gniewomir, Khan, Nadia, Bucki, Adam, Sabaté, Raimon, Więckowska, Anna, Malawska, Barbara

“…[Display omitted] •Novel series of multifunctional ligands targeting symptoms and causes of Alzheimer’s disease was designed and synthesized.•The inhibitory…”
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Ophthalmological symptoms in children with intracranial cysts by Gotz Wieckowska, Anna, Glowka, Lidia, Brazert, Agata, Pawlak, Marta

“…The purpose of this study was to perform an ophthalmological assessment in children with intracranial cysts and to assess the correlation between the…”
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Non‐syndromic anophthalmia/microphthalmia can be caused by a PORCN variant inherited in X‐linked recessive manner by Wawrocka, Anna, Walczak‐Sztulpa, Joanna, Pawlak, Marta, Gotz‐Wieckowska, Anna, Krawczynski, Maciej R.

“…Anophthalmia and microphthalmia (A/M) represent severe developmental ocular malformations, corresponding, respectively, to absent eyeball or reduced size of…”
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