Search Results - "WIEBEL, F. J"

Genotoxicity of urban air pollutants in the Czech Republic: Part II. DNA adduct formation in mammalian cells by extractable organic matter by Topinka, J, Schwarz, L.R, Wiebel, F.J, Černá, M, Wolff, T

“…The study was aimed at determining the genotoxic potential of extractable organic matter (EOM) from ambient air particles PM10 (<10 μm) using mammalian cells…”
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DNA adduct formation in mammalian cell cultures by polycyclic aromatic hydrocarbons (PAH) and nitro-PAH in coke oven emission extract by Topinka, J., Schwarz, L.R., Kiefer, F., Wiebel, F.J., Gajdoš, O., Vidová, P., Dobiáš, L., Fried, M., Šrám, R.J., Wolff, T.

“…Mammalian cells in culture were used to study the genotoxic potential of coke oven emissions constituting a complex mixture of chemicals. For this purpose,…”
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Caffeine potentiates the formation of micronuclei caused by environmental chemical carcinogens in V79 Chinese hamster cells by Kiefer, F., Wiebel, F.J.

“…The effect of caffeine on the genotoxicity of several carcinogenic compounds representing various classes of chemicals was investigated in a panel of V79…”
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Bioassay for determining 2,3,7,8-tetrachlorodibenzo- p-dioxin equivalents (TEs) in human hepatoma HepG2 cells by Wiebel, F.J., Wegenke, M., Kiefer, F.

“…2,3,7,8-Tetrachlorodibenzo- p-dioxin (TCDD), 2,3,7,8-tetrachlorodibenzofuran (TCDF), and benz[ a]anthracene (BA) highly induce cytochrome P4501A1, determined…”
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Establishment of a Simple Cleanup Procedure and Bioassay for Determining 2,3,7,8-Tetrachlorodibenzo-p-dioxin Toxicity Equivalents of Environmental Samples by Schwirzer, Siegfried M.G., Hofmaier, Andrea M., Kettrup, Antonius, Nerdinger, Per E., Schramm, Karl-Werner, Thoma, Heinz, Wegenke, Martin, Wiebel, Friedrich J.

“…The study was aimed at establishing a bioassay for the determination of 2,3,7,8-tetrachlorodibenzo-p-dioxin toxicity equivalents (TEQs) in environmental…”
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Impairment of UDP-glucose dehydrogenase and glucuronidation activities in liver and small intestine of rat and guinea pig in vitro by piperine by Reen, R K, Jamwal, D S, Taneja, S C, Koul, J L, Dubey, R K, Wiebel, F J, Singh, J

“…The effects of piperine, a major ingredient of black pepper, on UDP-glucose dehydrogenase (UDP-GDH) and glucuronidation potentials of rat and guinea pig liver…”
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Toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in vitro: H4IIEC3-derived 5L hepatoma cells as a model system by Wiebel, F J, Klose, U, Kiefer, F

“…2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) was investigated for its toxicity in 5L-cells, descendents of the hepatoma line H4IIEC3. TCDD reduced the…”
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Dealkylation of 7-methoxycoumarin as assay for measuring constitutive and phenobarbital-inducible cytochrome P450s by Reen, R K, Ramakanth, S, Wiebel, F J, Jain, M P, Singh, J

“…Six alkyl ethers of 7-hydroxycoumarin, ranging from methoxy- to hexoxycoumarin, were studied for their NADPH-dependent metabolism by liver microsomes of male…”
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Genetically engineered V79 Chinese hamster cells for stable expression of human cytochrome P450IA2 by Wölfel, C, Heinrich-Hirsch, B, Schulz-Schalge, T, Seidel, A, Frank, H, Ramp, U, Wächter, F, Wiebel, F J, Gonzalez, F, Greim, H

“…V79 Chinese hamster cells were genetically engineered for stable expression of human P450IA2. Full length cDNA, encoding human P450IA2, was inserted into an…”
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Inhibition of growth by 2,3,7,8-tetrachlorodibenzo-p-dioxin in 5L rat hepatoma cells is associated with the presence of Ah receptor by Göttlicher, M, Cikryt, P, Wiebel, F J

“…The role of the Ah receptor in mediating the toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) was investigated in 5L rat hepatoma cells containing…”
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Metabolism of fluperlapine by cytochrome P450-dependent and flavin-dependent monooxygenases in continuous cultures of rat and human cells by Fischer, V, Wiebel, F J

“…The metabolism of fluperlapine, a neuroleptic dibenzazepine derivative with a N-methyl-piperazinyl substituent, was investigated in continuous cultures of rat…”
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2,3,7,8-Tetrachlorodibenzo-p-dioxin causes unbalanced growth in 5L rat hepatoma cells by Göttlicher, M, Wiebel, F J

“…5L cells, dedifferentiated descendents of the rat hepatoma line H4IIEC3, constitute one of the rare continuous lines which are sensitive to the toxic effects…”
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Piperine inhibits aflatoxin B1-induced cytotoxicity and genotoxicity in V79 Chinese hamster cells genetically engineered to express rat cytochrome P4502B1 by Reen, R.K, Wiebel, F.J, Singh, J

“…We have investigated the potential of piperine for inhibiting the activity of cytochrome P4502B1 and protecting against aflatoxin B1 (AFB1) in V79MZr2B1 (r2B1)…”
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Differential effects of 12-O-tetradecanoylphorbol 13-acetate on cytochrome P-450-dependent monooxygenase activities in rat hepatoma cells: induction of P-450I and suppression of P-450II by Roesch, S F, Wiebel, F J

“…We have studied the effects of the tumor promoter 12-O-tetradecanoylphorbol 13-acetate (TPA) on cytochrome P-450-dependent monooxygenase activities in several…”
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Toxicity of monocyclic and polycyclic nitroaromatic compounds in a panel of mammalian test cell lines by Perchermeier, M M, Kiefer, F, Wiebel, F J

“…The cytotoxicity of polycyclic and monocyclic nitroarenes was tested in cell lines V79/NH, H4IIEC3/G-, 5L and BWI-J, which are distinguished by their specific…”
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V79 Chinese hamster cells express cytochrome P-450 activity after simultaneous exposure to polycyclic aromatic hydrocarbons and aminophylline by Kiefer, F, Wiebel, F J

“…V79 Chinese hamster lung cells expressed low but significant aryl hydrocarbon hydroxylase activities when treated with an inducer of cytochrome P-450I, such as…”
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Variability in the expression of xenobiotic-metabolizing enzymes during the growth cycle of rat hepatoma cells by Krupski, G, Kiefer, F, Wiebel, F J

“…The activity of various xenobiotic-metabolizing enzymes was examined throughout the growth cycle (16d) of the well-differentiated rat hepatoma cell line…”
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Biological activity of 2,4,8-trichlorodibenzofuran: promotion of rat liver foci and induction of cytochrome P-450-dependent monooxygenases by Deml, E, Wiebel, F J, Oesterle, D

“…The biological activity of 2,4,8-trichlorodibenzofuran (2,4,8-TCDF) was tested using 2 endpoints: (a) the promotion of enzyme-altered, preneoplastic foci…”
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Piperine, a major ingredient of black and long peppers, protects against AFB1-induced cytotoxicity and micronuclei formation in H4IIEC3 rat hepatoma cells by Singh, J, Reen, R K, Wiebel, F J

“…We studied the effect of piperine on the cytotoxicity and genotoxicity of aflatoxin B1 (AFB1) in rat hepatoma cells H4IIEC3/G-(H4IIE) using cellular growth and…”
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Glutathione conjugation protects some, but not all, cell lines against DNA binding of benzo[alpha]pyrene metabolites by Hesse, S, Cumpelik, O, Mezger, M, Kiefer, F, Wiebel, F J

“…Three major types of cell lines were distinguished according to their capacity for glutathione (GSH) conjugation of extracellularly generated…”
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