Search Results - "WIDMER, S"

Telehealth mitigates COPD disease progression compared to standard of care: a randomized controlled crossover trial by Rassouli, F., Germann, A., Baty, F., Kohler, M., Stolz, D., Thurnheer, R., Brack, T., Kähler, C., Widmer, S., Tschirren, U., Sievi, N. A., Tamm, M., Brutsche, M. H.

“…Background We showed excellent adherence and satisfaction with our telehealth care (TC) approach for COPD. Here, the results of a consecutive randomized…”
Get full text

Systematic classification of melanoma cells by phenotype-specific gene expression mapping by Widmer, Daniel S., Cheng, Phil F., Eichhoff, Ossia M., Belloni, Benedetta C., Zipser, Marie C., Schlegel, Natalie C., Javelaud, Delphine, Mauviel, Alain, Dummer, Reinhard, Hoek, Keith S.

“…Summary There is growing evidence that the metastatic spread of melanoma is driven not by a linear increase in tumorigenic aggressiveness, but rather by…”
Get full text

Novel MITF targets identified using a two-step DNA microarray strategy by Hoek, Keith S., Schlegel, Natalie C., Eichhoff, Ossia M., Widmer, Daniel S., Praetorius, Christian, Einarsson, Steingrimur O., Valgeirsdottir, Sigridur, Bergsteinsdottir, Kristin, Schepsky, Alexander, Dummer, Reinhard, Steingrimsson, Eirikur

“…Summary Malignant melanoma is a chemotherapy‐resistant cancer with high mortality. Recent advances in our understanding of the disease at the molecular level…”
Get full text

Uncertainty quantification in chemical systems by Najm, H. N., Debusschere, B. J., Marzouk, Y. M., Widmer, S., Le Maître, O. P.

“…We demonstrate the use of multiwavelet spectral polynomial chaos techniques for uncertainty quantification in non‐isothermal ignition of a methane–air system…”
Get full text

Decoupled Space and Time Sampling of Motion and Defocus Blur for Unified Rendering of Transparent and Opaque Objects by Widmer, S., Wodniok, D., Thul, D., Guthe, S., Goesele, M.

“…We propose a unified rendering approach that jointly handles motion and defocus blur for transparent and opaque objects at interactive frame rates. Our key…”
Get full text

Manufacture of porous biodegradable polymer conduits by an extrusion process for guided tissue regeneration by Widmer, Markus S., Gupta, Puneet K., Lu, Lichun, Meszlenyi, Rudolf K., Evans, Gregory R.D., Brandt, Keith, Savel, Tom, Gurlek, Ali, Patrick, Charles W., Mikos, Antonios G.

“…We have fabricated porous, biodegradable tubular conduits for guided tissue regeneration using a combined solvent casting and extrusion technique. The…”
Get full text

A proliferative melanoma cell phenotype is responsive to RAF/MEK inhibition independent of BRAF mutation status by Zipser, Marie C., Eichhoff, Ossia M., Widmer, Daniel S., Schlegel, Natalie C., Schoenewolf, Nicola L., Stuart, Darrin, Liu, Weihua, Gardner, Humphrey, Smith, Paul D., Nuciforo, Paolo, Dummer, Reinhard, Hoek, Keith S.

“…Summary Oncogenic mutations within the MAPK pathway are frequent in melanoma, and targeting of MAPK signaling has yielded spectacular responses in a…”
Get full text

Longitudinal change of COPD assessment test (CAT) in a telehealthcare cohort is associated with exacerbation risk by Rassouli, Frank, Baty, Florent, Stolz, Daiana, Albrich, Werner Christian, Tamm, Michael, Widmer, Sandra, Brutsche, Martin Hugo

“…There are only scarce data regarding the evolution of the chronic obstructive pulmonary disease (COPD) assessment test (CAT) over time. Our aim was to…”
Get full text

In vivo evaluation of poly( l-lactic acid) porous conduits for peripheral nerve regeneration by Evans, G.R.D., Brandt, K., Widmer, M.S., Lu, L., Meszlenyi, R.K., Gupta, P.K., Mikos, A.G., Hodges, J., Williams, J., Gürlek, A., Nabawi, A., Lohman, R., Patrick, C.W.

“…The present study provides in vivo trials of poly( l-lactic acid) (PLLA) as a porous biodegradable nerve conduit using a 10 mm sciatic nerve defect model in…”
Get full text

The ambivalence of challenge stressors: Time pressure associated with both negative and positive well-being by Widmer, Pascale S., Semmer, Norbert K., Kälin, Wolfgang, Jacobshagen, Nicola, Meier, Laurenz L.

“…According to the challenge–hindrance model, challenge stressors contain both stressful and challenging aspects, hindrance stressors only stressful aspects…”
Get full text

Romidepsin and Azacitidine Synergize in their Epigenetic Modulatory Effects to Induce Apoptosis in CTCL by Rozati, Sima, Cheng, Phil F, Widmer, Daniel S, Fujii, Kazuyasu, Levesque, Mitchell P, Dummer, Reinhard

“…Cutaneous T-cell lymphomas (CTCL) are a heterogeneous group of malignancies that despite available therapies commonly relapse. The emergence of combination…”
Get full text

Hypoxia Contributes to Melanoma Heterogeneity by Triggering HIF1α-Dependent Phenotype Switching by Widmer, Daniel S., Hoek, Keith S., Cheng, Phil F., Eichhoff, Ossia M., Biedermann, Thomas, Raaijmakers, Marieke I.G., Hemmi, Silvio, Dummer, Reinhard, Levesque, Mitchell P.

“…We have previously reported a model for melanoma progression in which oscillation between melanoma cell phenotypes characterized by invasion or proliferation…”
Get full text

Evolution of late-stage metastatic melanoma is dominated by aneuploidy and whole genome doubling by Vergara, Ismael A., Mintoff, Christopher P., Sandhu, Shahneen, McIntosh, Lachlan, Young, Richard J., Wong, Stephen Q., Colebatch, Andrew, Cameron, Daniel L., Kwon, Julia Lai, Wolfe, Rory, Peng, Angela, Ellul, Jason, Dou, Xuelin, Fedele, Clare, Boyle, Samantha, Arnau, Gisela Mir, Raleigh, Jeanette, Hatzimihalis, Athena, Szeto, Pacman, Mooi, Jennifer, Widmer, Daniel S., Cheng, Phil F., Amann, Valerie, Dummer, Reinhard, Hayward, Nicholas, Wilmott, James, Scolyer, Richard A., Cho, Raymond J., Bowtell, David, Thorne, Heather, Alsop, Kathryn, Cordner, Stephen, Woodford, Noel, Leditschke, Jodie, O’Brien, Patricia, Dawson, Sarah-Jane, McArthur, Grant A., Mann, Graham J., Levesque, Mitchell P., Papenfuss, Anthony T., Shackleton, Mark

“…Although melanoma is initiated by acquisition of point mutations and limited focal copy number alterations in melanocytes-of-origin, the nature of genetic…”
Get full text

PI3K signalling is required for a TGFβ-induced epithelial-mesenchymal-like transition (EMT-like) in human melanoma cells by Schlegel, Natalie C., von Planta, Anina, Widmer, Daniel S., Dummer, Reinhard, Christofori, Gerhard

“…Epithelial to mesenchymal transition (EMT) is a programme defined in epithelial cells and recognized as playing a critical role in cancer progression. Although…”
Get full text

The effects of chronic developmental hypoxia on swimming performance in zebrafish by Widmer, S., Moore, F. B.-G., Bagatto, B.

“…Relative to normoxia‐reared fish, hypoxia‐reared zebrafish Danio rerio achieved 24·9 and 21·4% slower maximal swim velocities in both normoxic and hypoxic…”
Get full text

Methylation-dependent SOX9 expression mediates invasion in human melanoma cells and is a negative prognostic factor in advanced melanoma by Cheng, Phil F, Shakhova, Olga, Widmer, Daniel S, Eichhoff, Ossia M, Zingg, Daniel, Frommel, Sandra C, Belloni, Benedetta, Raaijmakers, Marieke Ig, Goldinger, Simone M, Santoro, Raffaella, Hemmi, Silvio, Sommer, Lukas, Dummer, Reinhard, Levesque, Mitchell P

“…Melanoma is the most fatal skin cancer displaying a high degree of molecular heterogeneity. Phenotype switching is a mechanism that contributes to melanoma…”
Get full text

Osteoblastic phenotype of rat marrow stromal cells cultured in the presence of dexamethasone, β-glycerolphosphate, and L-ascorbic acid by Peter, Susan J., Liang, Catalina R., Kim, Daniel J., Widmer, Markus S., Mikos, Antonios G.

“…We investigated the effects of the time course of addition of osteogenic supplements dexamethasone, beta-glycerolphosphate, and L-ascorbic acid to rat marrow…”
Get full text

The development and beta-test of a computer-therapy program for anxiety and depression: hurdles and lessons by Proudfoot, J, Swain, S, Widmer, S, Watkins, E, Goldberg, D, Marks, I, Mann, A, Gray, J.A

“…This paper describes the development and beta-test of an eight-session computer therapy program for anxiety and depression, ‘ Beating the Blues’. Developed by…”
Get full text

Co-existence of BRAF and NRAS driver mutations in the same melanoma cells results in heterogeneity of targeted therapy resistance by Raaijmakers, Marieke I G, Widmer, Daniel S, Narechania, Apurva, Eichhoff, Ossia, Freiberger, Sandra N, Wenzina, Judith, Cheng, Phil F, Mihic-Probst, Daniela, Desalle, Rob, Dummer, Reinhard, Levesque, Mitchell P

“…Acquired chemotherapeutic resistance of cancer cells can result from a Darwinistic evolution process in which heterogeneity plays an important role. In order…”
Get full text

3PC-014 Evaluation of the microbiological quality of non-sterile drugs prepared in a hospital pharmacy by Widmer, S, Deuster, S

“…Background and importancePharmaceutical compounding is an integral part of the services provided by pharmacies for the specific needs of patients. For these…”
Get full text