Search Results - "WICKSTROM, M."

Molecular mechanisms and therapeutic targets in neuroblastoma by Johnsen, John Inge, Dyberg, Cecilia, Fransson, Susanne, Wickström, Malin

“…[Display omitted] Neuroblastoma is the most common extracranical tumor of childhood and the most deadly tumor of infancy. It is characterized by early age…”
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Rho-associated kinase is a therapeutic target in neuroblastoma by Dyberg, Cecilia, Fransson, Susanne, Andonova, Teodora, Sveinbjörnsson, Baldur, Lännerholm-Palm, Jessika, Olsen, Thale K., Forsberg, David, Herlenius, Eric, Martinsson, Tommy, Brodin, Bertha, Kogner, Per, Johnsen, John Inge, Wickström, Malin

“…Neuroblastoma is a peripheral neural system tumor that originates from the neural crest and is the most common and deadly tumor of infancy. Here we show that…”
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Lithium protects hippocampal progenitors, cognitive performance and hypothalamus-pituitary function after irradiation to the juvenile rat brain by Zhou, Kai, Xie, Cuicui, Wickström, Malin, Dolga, Amalia M, Zhang, Yaodong, Li, Tao, Xu, Yiran, Culmsee, Carsten, Kogner, Per, Zhu, Changlian, Blomgren, Klas

“…Cranial radiotherapy in children typically causes delayed and progressive cognitive dysfunction and there is no effective preventive strategy for…”
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Non-surgical relief of cervical radiculopathy through reduction of forward head posture and restoration of cervical lordosis: a case report by Wickstrom, Bret M., Oakley, Paul A., Harrison, Deed E.

“…[Purpose] To present a case demonstrating the relief of cervical radiculopathy following the dramatic reduction of forward head posture and restoration of the…”
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Alternative cytotoxic effects of the postulated IGF-IR inhibitor picropodophyllin in vitro by Wu, Xuping, Sooman, Linda, Wickström, Malin, Fryknäs, Mårten, Dyrager, Christine, Lennartsson, Johan, Gullbo, Joachim

“…The insulin-like growth factor-1 (IGF-I) and its receptors play an important role in transformation and progression of several malignancies. Inhibitors of this…”
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The Process of Systemic Change in Filial Therapy: A Phenomenological Study of Parent Experience by Amy Wickstrom, M. F. T.

“…This phenomenological study represents the first qualitative exploration of parents’ experiences of the process of filial therapy from a systemic lens. Filial…”
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Screening for phenotype selective activity in multidrug resistant cells identifies a novel tubulin active agent insensitive to common forms of cancer drug resistance by Fryknäs, Mårten, Gullbo, Joachim, Wang, Xin, Rickardson, Linda, Jarvius, Malin, Wickström, Malin, Hassan, Saadia, Andersson, Claes, Gustafsson, Mats, Westman, Gunnar, Nygren, Peter, Linder, Stig, Larsson, Rolf

“…Drug resistance is a common cause of treatment failure in cancer patients and encompasses a multitude of different mechanisms. The aim of the present study was…”
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Phenotype-based drug screening in primary ovarian carcinoma cultures identifies intracellular iron depletion as a promising strategy for cancer treatment by Gullbo, Joachim, Fryknäs, Mårten, Rickardson, Linda, Darcy, Padraig, Hägg, Maria, Wickström, Malin, Hassan, Sadia, Westman, Gunnar, Brnjic, Slavica, Nygren, Peter, Linder, Stig, Larsson, Rolf

“…Screening primary cultures of patient tumor cells in response to chemically diverse library of compounds identified VLX 50 as an iron chelator with tumor…”
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Body surface area-based omega-3 fatty acids supplementation strongly correlates to blood concentrations in children by Ljungblad, L., Gleissman, H., Hedberg, G., Wickström, M., Eissler, N., Pickova, J., Johnsen, J.I., Tedroff, K., Strandvik, B., Kogner, P.

“…•Omega-3-dose adjusted to BSA strongly correlated to blood omega-3 concentrations.•Results suggest a supplementation dose of 1500 mg/m2 BSA for further…”
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Pharmacological inhibition of BCL-2 with the FDA-approved drug venetoclax impairs longitudinal bone growth by Velentza, Lilly, Wickström, Malin, Kogner, Per, Ohlsson, Claes, Zaman, Farasat, Sävendahl, Lars

“…Treatment-related skeletal complications are common in childhood cancer patients and survivors. Venetoclax is a BCL-2 inhibitor that has shown efficacy in…”
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The novel melphalan prodrug J1 inhibits neuroblastoma growth in vitro and in vivo by Wickström, Malin, Johnsen, John Inge, Ponthan, Frida, Segerström, Lova, Sveinbjörnsson, Baldur, Lindskog, Magnus, Lövborg, Henrik, Viktorsson, Kristina, Lewensohn, Rolf, Kogner, Per, Larsson, Rolf, Gullbo, Joachim

“…Neuroblastoma is the most common extracranial solid tumor of childhood. The activity of J1 ( l -melphalanyl- p - l -fluorophenylalanine ethyl ester), an…”
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Names of stratigraphic units in Swedish by Bengtson, Peter, Bergman, Stefan, Calner, Mikael, Jansson, Nils F., Johnson, Mark D., Kumpulainen, Risto A., McLoughlin, Stephen, Wasstrom, Annika, Wickstrom, Linda M.

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Omega-3 fatty acids decrease CRYAB, production of oncogenic prostaglandin E2 and suppress tumor growth in medulloblastoma by Ljungblad, Linda, Bergqvist, Filip, Tümmler, Conny, Madawala, Samanthi, Olsen, Thale Kristin, Andonova, Teodora, Jakobsson, Per-Johan, Johnsen, John Inge, Pickova, Jana, Strandvik, Birgitta, Kogner, Per, Gleissman, Helena, Wickström, Malin

“…Medulloblastoma (MB) is one of the most common malignant central nervous system tumors of childhood. Despite intensive treatments that often leads to severe…”
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SOX11 is a novel binding partner and endogenous inhibitor of SAMHD1 ara-CTPase activity in mantle cell lymphoma by Abdelrazak Morsy, Mohammad Hamdy, Lilienthal, Ingrid, Lord, Martin, Merrien, Magali, Wasik, Agata Magdalena, Sureda-Gómez, Marta, Amador, Virginia, Johansson, Henrik J., Lehtiö, Janne, Garcia-Torre, Beatriz, Martin-Subero, Jose Ignacio, Tsesmetzis, Nikolaos, Tao, Sijia, Schinazi, Raymond F., Kim, Baek, Sorteberg, Agnes L., Wickström, Malin, Sheppard, Devon, Rassidakis, Georgios Z., Taylor, Ian A., Christensson, Birger, Campo, Elias, Herold, Nikolas, Sander, Birgitta

“…•SOX11 directly binds, via its HMG domain, to SAMHD1, reducing its tetramerization and inhibiting its ara-CTPase activity in MCL.•The noncompetitive inhibitor…”
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Acute and long-term effects of exposure to sodium monofluoroacetate (1080) in sheep by Wickstrom, M., Arthur, D.G., Cook, C., Eason, C.T., Milne, L., Gooneratne, S.R.

“…Acute and long-term effects of a single, relatively high oral dose (0.25 and 0.30 mg/kg) of sodium monofluoroacetate (1080) on the survival and productivity of…”
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GIT1 protects against breast cancer growth through negative regulation of Notch by Zhang, Songbai, Miyakawa, Ayako, Wickström, Malin, Dyberg, Cecilia, Louhivuori, Lauri, Varas-Godoy, Manuel, Kemppainen, Kati, Kanatani, Shigeaki, Kaczynska, Dagmara, Ellström, Ivar Dehnisch, Elfman, Lotta, Kronqvist, Pauliina, Repo, Heli, Mikoshiba, Katsuhiko, Sahlgren, Cecilia, Johnsen, John Inge, Uhlén, Per

“…Hyperactive Notch signalling is frequently observed in breast cancer and correlates with poor prognosis. However, relatively few mutations in the core Notch…”
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Neuroblastoma-A Neural Crest Derived Embryonal Malignancy by Johnsen, John Inge, Dyberg, Cecilia, Wickström, Malin

“…Neuroblastoma is a neural crest derived malignancy of the peripheral nervous system and is the most common and deadliest tumor of infancy. It is characterized…”
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Alterations in microtubules, intermediate filaments, and microfilaments induced by microcystin-LR in cultured cells by Wickstrom, M L, Khan, S A, Haschek, W M, Wyman, J F, Eriksson, J E, Schaeffer, D J, Beasley, V R

“…Microcystin-LR (MCLR) is a cyanobacterial hepatotoxin that inhibits intracellular serine/threonine protein phosphatases causing disruption of actin…”
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The multiple functions of miR-574-5p in the neuroblastoma tumor microenvironment by Proestler, Eva, Donzelli, Julia, Nevermann, Sheila, Breitwieser, Kai, Koch, Leon F., Best, Tatjana, Fauth, Maria, Wickström, Malin, Harter, Patrick N., Kogner, Per, Lavieu, Grégory, Larsson, Karin, Saul, Meike J.

“…Neuroblastoma is the most common extracranial solid tumor in childhood and arises from neural crest cells of the developing sympathetic nervous system…”
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Tissue Factor/ FVIIa prevents the extrinsic pathway of apoptosis by regulation of the tumor suppressor Death-Associated Protein Kinase 1 (DAPK1) by Åberg, M, Johnell, M, Wickström, M, Siegbahn, A

“…Abstract Introduction This study determines the impact of tissue factor (TF)-signaling on the extrinsic pathway of apoptosis in cancer cells and propose death…”
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