Search Results - "WICKLEY, Peter J"
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β1-adrenergic receptor autoantibodies mediate dilated cardiomyopathy by agonistically inducing cardiomyocyte apoptosis
Published in Circulation (New York, N.Y.) (24-07-2007)Get full text
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Propofol-induced activation of protein kinase C isoforms in adult rat ventricular myocytes
Published in Anesthesiology (Philadelphia) (01-05-2006)“…Myocardial protection by anesthetics is known to involve activation of protein kinase C (PKC). The authors' objective was to identify the PKC isoforms…”
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Propofol modulates Na+-Ca2+ exchange activity via activation of protein kinase C in diabetic cardiomyocytes
Published in Anesthesiology (Philadelphia) (01-02-2007)“…The authors' objective was to identify the role of the Na+-Ca2+ exchanger (NCX) in mediating the contractile dysfunction observed in diabetic cardiomyocytes…”
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Propofol Activates and Allosterically Modulates Recombinant Protein Kinase Cε
Published in Anesthesiology (Philadelphia) (01-07-2009)“…Myocardial protection by anesthetics is known to involve activation of protein kinase C epsilon (PKC epsilon). A key step in the activation process is…”
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Experimental conditions are important determinants of cardiac inotropic effects of propofol
Published in Anesthesiology (Philadelphia) (01-11-2005)“…The rationale for this study is that the depressant effect of propofol on cardiac function in vitro is highly variable but may be explained by differences in…”
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Propofol restores transient receptor potential vanilloid receptor subtype-1 sensitivity via activation of transient receptor potential ankyrin receptor subtype-1 in sensory neurons
Published in Anesthesiology (Philadelphia) (01-05-2011)“…Cross talk between peripheral nociceptors belonging to the transient receptor potential vanilloid receptor subtype-1 (TRPV1) and ankyrin subtype-1 (TRPA1)…”
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Propofol Modulates Agonist-induced Transient Receptor Potential Vanilloid Subtype-1 Receptor Desensitization via a Protein Kinase Cε-dependent Pathway in Mouse Dorsal Root Ganglion Sensory Neurons
Published in Anesthesiology (Philadelphia) (01-10-2010)“…Background The activity of transient receptor potential vanilloid subtype-1 (TRPV1) receptors, key nociceptive transducers in dorsal root ganglion sensory…”
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Propofol decreases myofilament Ca2+ sensitivity via a protein kinase C-, nitric oxide synthase-dependent pathway in diabetic cardiomyocytes
Published in Anesthesiology (Philadelphia) (01-05-2006)“…The authors' objective was to assess the role of protein kinase C (PKC) and nitric oxide synthase (NOS) in mediating the effects of propofol on diabetic…”
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Journal Article -
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Beta 1-adrenergic receptor autoantibodies mediate dilated cardiomyopathy by agonistically inducing cardiomyocyte apoptosis
Published in Circulation (New York, N.Y.) (24-07-2007)“…Antibodies to the beta1-adrenergic receptor (beta1AR) are detected in a substantial number of patients with idiopathic dilated cardiomyopathy (DCM). The…”
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Journal Article -
10
Propofol modulates agonist-induced transient receptor potential vanilloid subtype-1 receptor desensitization via a protein kinase Cepsilon-dependent pathway in mouse dorsal root ganglion sensory neurons
Published in Anesthesiology (Philadelphia) (01-10-2010)“…The activity of transient receptor potential vanilloid subtype-1 (TRPV1) receptors, key nociceptive transducers in dorsal root ganglion sensory neurons, is…”
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Journal Article -
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{szligbeta} sub(1)-Adrenergic Receptor Autoantibodies Mediate Dilated Cardiomyopathy by Agonistically Inducing Cardiomyocyte Apoptosis
Published in Circulation (New York, N.Y.) (01-07-2007)“…BACKGROUND: Antibodies to the {szligbeta} sub(1)-adrenergic receptor ({szligbeta} sub(1)AR) are detected in a substantial number of patients with idiopathic…”
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Propofol-anesthesia, diabetes and myocardial signal transduction: Role of protein kinase C and nitric oxide
Published 01-01-2008Get full text
Dissertation -
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Propofol-Anesthesia, Diabetes and Myocardial Signal Transduction: Role of Protein Kinase C and Nitric Oxide
Published 01-01-2008“…Induction and maintenance of anesthesia typically causes myocardial depression in healthy patients presenting for cardiac surgery. Moreover, the diabetic…”
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Dissertation -
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