Search Results - "WICHE, Gerhard"

Plectin-Mediated Intermediate Filament Functions: Why Isoforms Matter by Wiche, Gerhard

“…This essay focuses on the role of plectin and its various isoforms in mediating intermediate filament (IF) network functions. It is based on previous studies…”
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Plectin in Health and Disease by Wiche, Gerhard

“…In light of recent progress in defining a unifying mechanism for the versatile functions and disease involvement of the cytolinker protein plectin, a series of…”
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The many faces of plectin and plectinopathies: pathology and mechanisms by Winter, Lilli, Wiche, Gerhard

“…Plectin, a giant multifunctional cytolinker protein, plays a crucial role in stabilizing and orchestrating intermediate filament networks in cells. Mutations…”
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Networking and anchoring through plectin: a key to IF functionality and mechanotransduction by Wiche, Gerhard, Osmanagic-Myers, Selma, Castañón, Maria J

“…Intermediate filaments (IFs) are involved in multiple cellular processes that are essential for the maintenance of cell and tissue integrity as well as…”
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Keeping the vimentin network under control: cell-matrix adhesion-associated plectin 1f affects cell shape and polarity of fibroblasts by Burgstaller, Gerald, Gregor, Martin, Winter, Lilli, Wiche, Gerhard

“…Focal adhesions (FAs) located at the ends of actin/myosin-containing contractile stress fibers form tight connections between fibroblasts and their underlying…”
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Plectin isoform 1-dependent nuclear docking of desmin networks affects myonuclear architecture and expression of mechanotransducers by Staszewska, Ilona, Fischer, Irmgard, Wiche, Gerhard

“…Plectin is a highly versatile cytoskeletal protein that acts as a mechanical linker between intermediate filament (IF) networks and various cellular…”
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Plectin-mediated cytoskeletal crosstalk controls cell tension and cohesion in epithelial sheets by Prechova, Magdalena, Adamova, Zuzana, Schweizer, Anna-Lena, Maninova, Miloslava, Bauer, Andreas, Kah, Delf, Meier-Menches, Samuel M, Wiche, Gerhard, Fabry, Ben, Gregor, Martin

“…The coordinated interplay of cytoskeletal networks critically determines tissue biomechanics and structural integrity. Here, we show that plectin, a major…”
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Plectin–intermediate filament partnership in skin, skeletal muscle, and peripheral nerve by Castañón, Maria J., Walko, Gernot, Winter, Lilli, Wiche, Gerhard

“…Plectin is a large, 500-kDa, intermediate filament (IF)-associated protein. It acts as a cytoskeletal crosslinker and signaling scaffold, affecting mechanical…”
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An Organoruthenium Anticancer Agent Shows Unexpected Target Selectivity For Plectin by Meier, Samuel M., Kreutz, Dominique, Winter, Lilli, Klose, Matthias H. M., Cseh, Klaudia, Weiss, Tamara, Bileck, Andrea, Alte, Beatrix, Mader, Johanna C., Jana, Samir, Chatterjee, Annesha, Bhattacharyya, Arindam, Hejl, Michaela, Jakupec, Michael A., Heffeter, Petra, Berger, Walter, Hartinger, Christian G., Keppler, Bernhard K., Wiche, Gerhard, Gerner, Christopher

“…Organometallic metal(arene) anticancer agents require ligand exchange for their anticancer activity and this is generally believed to confer low selectivity…”
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Mechanosensing through focal adhesion‐anchored intermediate filaments by Gregor, Martin, Osmanagic‐Myers, Selma, Burgstaller, Gerald, Wolfram, Michael, Fischer, Irmgard, Walko, Gernot, Resch, Guenter P., Jörgl, Almut, Herrmann, Harald, Wiche, Gerhard

“…Integrin‐based mechanotransduction involves a complex focal adhesion (FA)‐associated machinery that is able to detect and respond to forces exerted either…”
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Plectin Isoform 1b Mediates Mitochondrion-Intermediate Filament Network Linkage and Controls Organelle Shape by Winter, Lilli, Abrahamsberg, Christina, Wiche, Gerhard

“…Plectin is a versatile intermediate filament (IF)--bound cytolinker protein with a variety of differentially spliced isoforms accounting for its multiple…”
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The Diversity of Intermediate Filaments in Astrocytes by Potokar, Maja, Morita, Mitsuhiro, Wiche, Gerhard, Jorgačevski, Jernej

“…Despite the remarkable complexity of the individual neuron and of neuronal circuits, it has been clear for quite a while that, in order to understand the…”
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Role of plectin in cytoskeleton organization and dynamics by Wiche, G

“…Plectin and its isoforms are versatile cytoskeletal linker proteins of very large size (>500 kDa) that are abundantly expressed in a wide variety of mammalian…”
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Chemical chaperone ameliorates pathological protein aggregation in plectin-deficient muscle by Winter, Lilli, Staszewska, Ilona, Mihailovska, Eva, Fischer, Irmgard, Goldmann, Wolfgang H, Schröder, Rolf, Wiche, Gerhard

“…The ubiquitously expressed multifunctional cytolinker protein plectin is essential for muscle fiber integrity and myofiber cytoarchitecture. Patients suffering…”
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Plectin ensures intestinal epithelial integrity and protects colon against colitis by Krausova, Alzbeta, Buresova, Petra, Sarnova, Lenka, Oyman-Eyrilmez, Gizem, Skarda, Jozef, Wohl, Pavel, Bajer, Lukas, Sticova, Eva, Bartonova, Lenka, Pacha, Jiri, Koubkova, Gizela, Prochazka, Jan, Spörrer, Marina, Dürrbeck, Christopher, Stehlikova, Zuzana, Vit, Martin, Ziolkowska, Natalia, Sedlacek, Radislav, Jirak, Daniel, Kverka, Miloslav, Wiche, Gerhard, Fabry, Ben, Korinek, Vladimir, Gregor, Martin

“…Plectin, a highly versatile cytolinker protein, provides tissues with mechanical stability through the integration of intermediate filaments (IFs) with cell…”
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Identifying Plectin Isoform Functions through Animal Models by Castañón, Maria J., Wiche, Gerhard

“…Plectin, a high-molecular-weight cytoskeletal linker protein, binds with high affinity to intermediate filaments of all types and connects them to junctional…”
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Plectin isoform P1b and P1d deficiencies differentially affect mitochondrial morphology and function in skeletal muscle by Winter, Lilli, Kuznetsov, Andrey V, Grimm, Michael, Zeöld, Anikó, Fischer, Irmgard, Wiche, Gerhard

“…Plectin, a versatile 500-kDa cytolinker protein, is essential for muscle fiber integrity and function. The most common disease caused by mutations in the human…”
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Unexpected gain of function for the scaffolding protein plectin due to mislocalization in pancreatic cancer by Shin, Soo J., Smith, Jeffrey A., Rezniczek, Günther A., Pan, Sheng, Ru Chen, Brentnall, Teresa A., Wiche, Gerhard, Kelly, Kimberly A.

“…We recently demonstrated that plectin is a robust biomarker for pancreatic ductal adenocarcinoma (PDAC), one of the most aggressive malignancies. In normal…”
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Reconstitution of cytolinker-mediated crosstalk between actin and vimentin by Petitjean, Irene Istúriz, Tran, Quang D., Goutou, Angeliki, Kabir, Zima, Wiche, Gerhard, Leduc, Cécile, Koenderink, Gijsje H.

“…Cell shape and motility are determined by the cytoskeleton, an interpenetrating network of actin filaments, microtubules, and intermediate filaments. The…”
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Trichoplein/mitostatin regulates endoplasmic reticulum-mitochondria juxtaposition by Cerqua, Cristina, Anesti, Vassiliki, Pyakurel, Aswin, Liu, Dan, Naon, Deborah, Wiche, Gerhard, Baffa, Raffaele, Dimmer, Kai S, Scorrano, Luca

“…Trichoplein/mitostatin (TpMs) is a keratin‐binding protein that partly colocalizes with mitochondria and is often downregulated in epithelial cancers, but its…”
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