Search Results - "WHITMARSH, A. J"

Role of mitogen-activated protein kinase kinase 4 in cancer by Whitmarsh, A J, Davis, R J

“…Mitogen-activated protein (MAP) kinase kinase 4 (MKK4) is a component of stress activated MAP kinase signaling modules. It directly phosphorylates and…”
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Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways by WHITMARSH, A. J, DAVIS, R. J

“…Mitogen-activated protein (MAP) kinases are proline-directed serine/threonine kinases that are activated by dual phosphorylation on threonine and tyrosine…”
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Regulation of transcription factor function by phosphorylation by Whitmarsh, A J, Davis, R J

“…Changes in protein phosphorylation represent a mechanism that is frequently employed by cells to regulate transcription factor activity. In response to…”
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Selective interaction of JNK protein kinase isoforms with transcription factors by Gupta, S., Barrett, T., Whitmarsh, A. J., Cavanagh, J., Sluss, H. K., Dérijard, B., Davis, R. J.

“…The JNK protein kinase is a member of the MAP kinase group that is activated in response to dual phosphorylation on threonine and tyrosine. Ten JNK isoforms…”
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A Mammalian Scaffold Complex That Selectively Mediates MAP Kinase Activation by Whitmarsh, Alan J., Cavanagh, Julie, Tournier, Cathy, Yasuda, Jun, Davis, Roger J.

“…The c-Jun NH$_2$-terminal kinase (JNK) group of mitogen-activated protein (MAP) kinases is activated by the exposure of cells to multiple forms of stress. A…”
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Defective T Cell Differentiation in the Absence of Jnk1 by Dong, Chen, Yang, Derek D., Wysk, Mark, Whitmarsh, Alan J., Davis, Roger J., Flavell, Richard A.

“…The c-Jun NH$_2$-terminal kinase (JNK) signaling pathway has been implicated in the immune response that is mediated by the activation and differentiation of…”
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MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway by Raingeaud, Joël, Whitmarsh, Alan J., Barrett, Tamera, Dérijard, Benoit, Davis, Roger J.

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Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene by Yang, Derek D, Kuan, Chia-Yi, Whitmarsh, Alan J, Rinócn, Mercedes, Zheng, Timothy S, Davis, Roger J, Rakic, Pasko, Flavell, Richard A

“…Excitatory amino acids induce both acute membrane depolarization and latent cellular toxicity, which often leads to apoptosis in many neurological disorders,…”
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The JIP family of MAPK scaffold proteins by Whitmarsh, A J

“…The components of MAPK (mitogen-activated protein kinase) signalling pathways can assemble into complexes that are co-ordinated by regulatory proteins…”
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JNK is required for effector T-cell function but not for T-cell activation by Flavell, Richard A, Dong, Chen, Yang, Derek D, Tournier, Cathy, Whitmarsh, Alan J, Xu, Jie, Davis, Roger J

“…The hallmark of T-cell activation is the production of interleukin 2 (IL-2). c-Jun amino-terminal kinase (JNK), a MAP kinase that phosphorylates c-Jun and…”
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Integration of MAP Kinase Signal Transduction Pathways at the Serum Response Element by Whitmarsh, Alan J., Shore, Paul, Sharrocks, Andrew D., Davis, Roger J.

“…The ternary complex factor (TCF) subfamily of ETS-domain transcription factors bind with serum response factor (SRF) to the serum response element (SRE) and…”
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JIP1 binding to RBP-Jk mediates cross-talk between the Notch1 and JIP1-JNK signaling pathway by Kim, M-Y, Ann, E-J, Mo, J-S, Dajas-Bailador, F, Seo, M-S, Hong, J-A, Jung, J, Choi, Y-H, Yoon, J-H, Kim, S-M, Choi, E-J, Hoe, H-S, Whitmarsh, A J, Park, H-S

“…Notch1 signaling has a critical function in maintaining a balance among cell proliferation, differentiation, and apoptosis. Our earlier work showed that the…”
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Requirement of the JIP1 scaffold protein for stress-induced JNK activation by Whitmarsh, A J, Kuan, C Y, Kennedy, N J, Kelkar, N, Haydar, T F, Mordes, J P, Appel, M, Rossini, A A, Jones, S N, Flavell, R A, Rakic, P, Davis, R J

“…The c-Jun N-terminal kinase (JNK) signal transduction pathway is activated in response to the exposure of cells to environmental stress. Components of the JNK…”
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Role of p38 and JNK mitogen-activated protein kinases in the activation of ternary complex factors by Whitmarsh, Alan J., Yang, Shen-Hsi, Su, Michael S.-S., Sharrocks, Andrew D., Davis, Roger J.

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Transcriptional regulation by the MAP kinase signaling cascades by Yang, Shen-Hsi, Sharrocks, Andrew D., Whitmarsh, Alan J.

“…A major function of the mitogen-activated protein kinase (MAPK) pathways is to control eukaryotic gene expression programmes in response to extracellular…”
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Structural organization of MAP-kinase signaling modules by scaffold proteins in yeast and mammals by Whitmarsh, Alan J., Davis, Roger J.

“…MAP-kinase signaling pathways are activated by multiple extracellular stimuli. The specificity of activation and function of MAP-kinase signaling modules is…”
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A Critical Role of Neural-Specific JNK3 for Ischemic Apoptosis by Kuan, Chia-Yi, Whitmarsh, Alan J., Yang, Derek D., Liao, Guanghong, Schloemer, Aryn J., Dong, Chen, Bao, Jue, Banasiak, Kenneth J., Haddad, Gabriel G., Flavell, Richard A., Davis, Roger J., Rakic, Pasko

“…c-Jun N-terminal kinase (JNK) signaling is an important contributor to stress-induced apoptosis, but it is unclear whether JNK and its isoforms (JNK1, JNK2,…”
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Determinants of DNA-binding specificity of ETS-domain transcription factors by Shore, Paul, Whitmarsh, Alan J., Bhaskaran, R., Davis, Roger J., Waltho, Jonathon P., Sharrocks, Andrew D.

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The JIP Group of Mitogen-Activated Protein Kinase Scaffold Proteins by Yasuda, Jun, Whitmarsh, Alan J., Cavanagh, Julie, Sharma, Manoj, Davis, Roger J.

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Analyzing JNK and p38 mitogen-activated protein kinase activity by Whitmarsh, A J, Davis, R J

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