Search Results - "WHITHAM, R. H"

Impact of interferon beta-1a on neurologic disability in relapsing multiple sclerosis by RUDICK, R. A, GOODKIN, D. E, ALAM, J. J, SIMONIAN, N. A, CAMPION, M. K, BARTOSZAK, D. M, BOURDETTE, D. N, BRAIMAN, J, BROWNSCHEIDLE, C. M, COATS, M. E, COHAN, S. L, DOUGHERTY, D. S, JACOBS, L. D, KINKEL, R. P, MASS, M. K, MUNSCHAUER, F. E, PRIORE, R. L, PULLICINO, P. M, SCHEROKMAN, B. J, WEISTOCK-GUTTMAN, B, WHITHAM, R. H, COOKFAIR, D. L, HERNDON, R. M, RICHERT, J. R, SALAZAR, A. M, FISCHER, J. S, GRANGER, C. V, SIMON, J. H

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Lymphocytes from SJL/J mice immunized with spinal cord respond selectively to a peptide of proteolipid protein and transfer relapsing demyelinating experimental autoimmune encephalomyelitis by WHITHAM, R. H, BOURDETTE, D. N, HASHIM, G. A, HERNDON, R. M, ILG, R. C, VANDENBARK, A. A, OFFNER, H

“…Relapsing experimental autoimmune encephalomyelitis (R-EAE) can be induced in SJL/J mice by immunization with spinal cord homogenate and adjuvant. The specific…”
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Blocking OX-40/OX-40 Ligand Interaction In Vitro and In Vivo Leads to Decreased T Cell Function and Amelioration of Experimental Allergic Encephalomyelitis by Weinberg, Andrew D, Wegmann3, Keith W, Funatake, Castle, Whitham, Ruth H

“…The OX-40R is a member of the TNF receptor family and is expressed primarily on activated CD4+ T cells. When the OX-40R is engaged by the OX-40 ligand…”
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Impact of interferon beta-1a on neurologic disability in relapsing multiple sclerosis: Multiple sclerosis by RUDICK, R. A, GOODKIN, D. E, ALAM, J. J, SIMONIAN, N. A, CAMPION, M. K, BARTOSZAK, D. M, BOURDETTE, D. N, BRAIMAN, J, BROWNSCHEIDLE, C. M, COATS, M. E, COHAN, S. L, DOUGHERTY, D. S, JACOBS, L. D, KINKEL, R. P, MASS, M. K, MUNSCHAUER, F. E, PRIORE, R. L, PULLICINO, P. M, SCHEROKMAN, B. J, WEISTOCK-GUTTMAN, B, WHITHAM, R. H, COOKFAIR, D. L, HERNDON, R. M, RICHERT, J. R, SALAZAR, A. M, FISCHER, J. S, GRANGER, C. V, SIMON, J. H

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Location of a new encephalitogenic epitope (residues 43 to 64) in proteolipid protein that induces relapsing experimental autoimmune encephalomyelitis in PL/J and (SJL x PL)F1 mice by Whitham, RH, Jones, RE, Hashim, GA, Hoy, CM, Wang, RY, Vandenbark, AA, Offner, H

“…Synthetic peptides of proteolipid protein (PLP) were screened for their ability to induce experimental autoimmune encephalomyelitis (EAE) in SJL/J, PL/J, and…”
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Treatment of relapsing experimental autoimmune encephalomyelitis with T cell receptor peptides by Whitham, R H, Kotzin, B L, Buenafe, A C, Weinberg, A D, Jones, R E, Hashim, G A, Hoy, C M, Vandenbark, A A, Offner, H

“…Restricted T cell receptor (TCR) VB gene usage by T cells for recognition of antigens involved in the production of experimental autoimmune encephalomyelitis…”
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Induction of experimental autoimmune encephalomyelitis in severe combined immunodeficient mice reconstituted with allogeneic or xenogeneic hematopoietic cells by Jones, RE, Bourdette, DN, Whitham, RH, Offner, H, Vandenbark, AA

“…Severe combined immunodeficient (SCID) C.B-17-scid/scid (H-2d) strain mice are deficient for T and B lymphocytes and lack all of the immune functions…”
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T cell lines selected with synthetic peptides are highly encephalitogenic in SJL/J mice by Bourdette, D N, Vandenbark, A A, Hashim, G, Whitham, R H, Offner, H

“…T cell lines were selected from basic protein (BP)-immunized SJL/J mice using synthetic peptides encompassing the major SJL/J encephalitogenic determinant…”
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Serum anti-myelin antibodies in chronic relapsing experimental allergic encephalomyelitis by Whitham, R H, Nilaver, G, Bourdette, D N, Seil, F J

“…To investigate the role of anti-myelin antibodies in chronic relapsing experimental allergic encephalomyelitis (CR-EAE), sera from SJL/J mice with CR-EAE…”
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Immunity to T Cell Receptor Peptides in Multiple Sclerosis. III. Preferential Immunogenicity of Complementarity-Determining Region 2 Peptides from Disease-Associated T Cell Receptor BV Genes by Bourdette, Dennis N, Chou, Yuan K, Whitham, Ruth H, Buckner, Jane, Kwon, Hi Jong, Nepom, Gerald T, Buenafe, Abigail, Cooper, Shelley A, Allegretta, Mark, Hashim, George A, Offner, Halina, Vandenbark, Arthur A

“…Vaccination with synthetic TCR peptides from the BV5S2 complementarity-determining region 2 (CDR2) can boost significantly the frequency of circulating CD4+…”
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IL-7 enhances Ag-specific human T cell response by increasing expression of IL-2R α and γ chains by Chou, Yuan K., Bourdette, Dennis N., Barnes, David, Finn, Thomas P., Murray, Susan, Unsicker, Laura, Robey, Ian, Whitham, Ruth H., Buenafe, Abigail C., Allegretta, Mark, Offner, Halina, Vandenbark, Arthur A.

“…Interleukin-7 has demonstrated potent enhancing effects on the growth and differentiation of several immature cell types, including thymocytes, and on survival…”
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Treatment of relapsing autoimmune encephalomyelitis with T cell receptor Vβ-specific antibodies when proteolipid protein is the autoantigen by Whitham, R.H., Wingett, D., Wineman, J., Mass, M., Wegmann, K., Vandenbark, A., Offner, H.

“…Monoclonal antibodies (mAbs) directed against the Vβ chain of the T cell receptor (TCR) of pathogenic T cells have been used to treat acute murine experimental…”
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Encephalitogenic T lymphocytes develop from SJL/J hematopoietic cells transplanted into severe combined immunodeficient (SCID) mice by Jones, R E, Whitham, R H, Sullivan, T, Mass, M, Bourdette, D N

“…Previously, we constructed chimeras by injecting hematopoietic cells from experimental autoimmune encephalomyelitis (EAE)-susceptible SJL (H-2s) strain mice…”
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Immunity to TCR peptides in multiple sclerosis. I. Successful immunization of patients with synthetic V beta 5.2 and V beta 6.1 CDR2 peptides [published erratum appears in J Immunol 1994 Jul 15;153(2):910] by Bourdette, DN, Whitham, RH, Chou, YK, Morrison, WJ, Atherton, J, Kenny, C, Liefeld, D, Hashim, GA, Offner, H, Vandenbark, AA

“…Immunization with disease-associated TCR V region peptides is an effective treatment for experimental autoimmune encephalomyelitis. Myelin basic…”
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The procurement of physicians for the armed forces by WHITHAM, R H

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Functional assay for human CD4+CD25+ Treg cells reveals an age-dependent loss of suppressive activity by Tsaknaridis, Laura, Spencer, Leslie, Culbertson, Nicole, Hicks, Kevin, LaTocha, Dorian, Chou, Yuan K., Whitham, Ruth H., Bakke, Antony, Jones, Richard E., Offner, Halina, Bourdette, Dennis N., Vandenbark, Arthur A.

“…CD4+CD25+ regulatory T cells (Treg cells) prevent T cell‐mediated autoimmune diseases in rodents. To develop a functional Treg assay for human blood cells, we…”
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Neuromyelitis optica: two new cases and review of the literature by WHITHAM, R. H, BREY, R. L

“…The clinical features of two recent cases of neuromyelitis optica are reviewed, along with 43 cases from the literature. Severe bilateral visual impairment,…”
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Immunity of TCR peptides in multiple sclerosis. I: Successful immunization of patients with synthetic Vβ5.2 and Vβ6.1 CDR2 peptides by BOURDETTE, D. N, WHITHAM, R. H, CHOU, Y. K, MORRISON, W. J, ATHERTON, J, KENNY, C, LIEFELD, D, HASHIM, G. A, OFFNER, H, VANDENBARK, A. A

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Functional assay for human CD4 super(+)CD25 super(+) Treg cells reveals an age-dependent loss of suppressive activity by Tsaknaridis, L, Spencer, L, Culbertson, N, Hicks, K, LaTocha, D, Chou, Y K, Whitham, R H, Bakke, A, Jones, R E, Offner, H, Bourdette, D N, Vandenbark, A A

“…CD4 super(+)CD25 super(+) regulatory T cells (Treg cells) prevent T cell-mediated autoimmune diseases in rodents. To develop a functional Treg assay for human…”
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The role of autoimmune T lymphocytes in the pathogenesis of multiple sclerosis by HOHFELD, R, MEINL, E, WEKERLE, H, WEBER, F, ZIPP, F, SCHMIDT, S, SOTGIU, S, GOEBELS, N, VOLTZ, R, SPULER, S, IGLESIAS, A

“…Autoimmune T cells play a key role as regulators and effectors of autoimmune disease. In multiple sclerosis (MS), activated T cells specific for myelin…”
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