Search Results - "WHITFIELD, Jonathan"

The long journey to bring a Myc inhibitor to the clinic by Whitfield, Jonathan R, Soucek, Laura

“…The oncogene Myc is deregulated in the majority of human tumors and drives numerous hallmarks of cancer. Despite its indisputable role in cancer development…”
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Strategies to Inhibit Myc and Their Clinical Applicability by Whitfield, Jonathan R, Beaulieu, Marie-Eve, Soucek, Laura

“…Myc is an oncogene deregulated in most-perhaps all-human cancers. Each Myc family member, c-, L-, and N-Myc, has been connected to tumor progression and…”
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Between immunomodulation and immunotolerance: The role of IFNγ in SARS-CoV-2 disease by Todorović-Raković, Nataša, Whitfield, Jonathan R.

“…•IFNγ stands out as a promising endogenous biomarker in various diseases.•IFNγ exemplifies a biomarker with a complex role in virus-host interactions.•It has…”
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Therapeutic implications of the interplay between interferons and ER in breast cancer by Todorović-Raković, Nataša, Whitfield, Jonathan R.

“…The involvement of interferons (IFNs) in various diseases, including breast cancer, has sparked controversy due to their diverse roles in immunity and…”
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Editorial: MYC as a disease target beyond cancer by Whitfield, Jonathan R

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Inhibition of Myc family proteins eradicates KRas-driven lung cancer in mice by Soucek, Laura, Whitfield, Jonathan R, Sodir, Nicole M, Massó-Vallés, Daniel, Serrano, Erika, Karnezis, Anthony N, Swigart, Lamorna Brown, Evan, Gerard I

“…The principal reason for failure of targeted cancer therapies is the emergence of resistant clones that regenerate the tumor. Therapeutic efficacy therefore…”
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Tumor microenvironment: becoming sick of Myc by Whitfield, Jonathan R., Soucek, Laura

“…Several years ago, we described Myc as “the oncogene from hell”, since evidence had just emerged that Myc, aside from being responsible for cell-cycle…”
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Intrinsic cell-penetrating activity propels Omomyc from proof of concept to viable anti-MYC therapy by Beaulieu, Marie-Eve, Jauset, Toni, Massó-Vallés, Daniel, Martínez-Martín, Sandra, Rahl, Peter, Maltais, Loïka, Zacarias-Fluck, Mariano F, Casacuberta-Serra, Sílvia, Serrano Del Pozo, Erika, Fiore, Christopher, Foradada, Laia, Cano, Virginia Castillo, Sánchez-Hervás, Meritxell, Guenther, Matthew, Romero Sanz, Eduardo, Oteo, Marta, Tremblay, Cynthia, Martín, Génesis, Letourneau, Danny, Montagne, Martin, Morcillo Alonso, Miguel Ángel, Whitfield, Jonathan R, Lavigne, Pierre, Soucek, Laura

“…Inhibiting MYC has long been considered unfeasible, although its key role in human cancers makes it a desirable target for therapeutic intervention. One reason…”
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Ibrutinib exerts potent antifibrotic and antitumor activities in mouse models of pancreatic adenocarcinoma by Massó-Vallés, Daniel, Jauset, Toni, Serrano, Erika, Sodir, Nicole M, Pedersen, Kim, Affara, Nesrine I, Whitfield, Jonathan R, Beaulieu, Marie-Eve, Evan, Gerard I, Elias, Laurence, Arribas, Joaquín, Soucek, Laura

“…Pancreatic ductal adenocarcinoma (PDAC) is characterized by a dense stromal fibroinflammatory reaction that is a major obstacle to effective therapy. The…”
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The appropriateness of abdominal X-ray requests in the acute medical initial admissions unit by Ananthan, Kiruthika, Whitfield, Jonathan P

“…Background/Aims Abdominal X-rays are frequently requested by clinicians in the Aberdeen Royal Infirmary acute medical initial assessment unit. Method The…”
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Myc inhibition is effective against glioma and reveals a role for Myc in proficient mitosis by Annibali, Daniela, Whitfield, Jonathan R., Favuzzi, Emilia, Jauset, Toni, Serrano, Erika, Cuartas, Isabel, Redondo-Campos, Sara, Folch, Gerard, Gonzàlez-Juncà, Alba, Sodir, Nicole M., Massó-Vallés, Daniel, Beaulieu, Marie-Eve, Swigart, Lamorna B., Mc Gee, Margaret M., Somma, Maria Patrizia, Nasi, Sergio, Seoane, Joan, Evan, Gerard I., Soucek, Laura

“…Gliomas are the most common primary tumours affecting the adult central nervous system and respond poorly to standard therapy. Myc is causally implicated in…”
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MYC targeting by OMO-103 in solid tumors: a phase 1 trial by Garralda, Elena, Beaulieu, Marie-Eve, Moreno, Víctor, Casacuberta-Serra, Sílvia, Martínez-Martín, Sandra, Foradada, Laia, Alonso, Guzman, Massó-Vallés, Daniel, López-Estévez, Sergio, Jauset, Toni, Corral de la Fuente, Elena, Doger, Bernard, Hernández, Tatiana, Perez-Lopez, Raquel, Arqués, Oriol, Castillo Cano, Virginia, Morales, Josefa, Whitfield, Jonathan R., Niewel, Manuela, Soucek, Laura, Calvo, Emiliano

“…Among the ‘most wanted’ targets in cancer therapy is the oncogene MYC, which coordinates key transcriptional programs in tumor development and maintenance. It…”
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Efficacy of Servo-Controlled Splanchnic Venous Compression in the Treatment of Orthostatic Hypotension: A Randomized Comparison With Midodrine by Okamoto, Luis E, Diedrich, André, Baudenbacher, Franz J, Harder, René, Whitfield, Jonathan S, Iqbal, Fahad, Gamboa, Alfredo, Shibao, Cyndya A, Black, Bonnie K, Raj, Satish R, Robertson, David, Biaggioni, Italo

“…Splanchnic venous pooling is a major hemodynamic determinant of orthostatic hypotension, but is not specifically targeted by pressor agents, the mainstay of…”
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The effect of environmental chemicals on the tumor microenvironment by Casey, Stephanie C, Vaccari, Monica, Al-Mulla, Fahd, Al-Temaimi, Rabeah, Amedei, Amedeo, Barcellos-Hoff, Mary Helen, Brown, Dustin G, Chapellier, Marion, Christopher, Joseph, Curran, Colleen S, Forte, Stefano, Hamid, Roslida A, Heneberg, Petr, Koch, Daniel C, Krishnakumar, P K, Laconi, Ezio, Maguer-Satta, Veronique, Marongiu, Fabio, Memeo, Lorenzo, Mondello, Chiara, Raju, Jayadev, Roman, Jesse, Roy, Rabindra, Ryan, Elizabeth P, Ryeom, Sandra, Salem, Hosni K, Scovassi, A Ivana, Singh, Neetu, Soucek, Laura, Vermeulen, Louis, Whitfield, Jonathan R, Woodrick, Jordan, Colacci, Annamaria, Bisson, William H, Felsher, Dean W

“…Potentially carcinogenic compounds may cause cancer through direct DNA damage or through indirect cellular or physiological effects. To study possible…”
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Reducing MYC's transcriptional footprint unveils a good prognostic gene signature in melanoma by Zacarías-Fluck, Mariano F, Massó-Vallés, Daniel, Giuntini, Fabio, González-Larreategui, Íñigo, Kaur, Jastrinjan, Casacuberta-Serra, Sílvia, Jauset, Toni, Martínez-Martín, Sandra, Martín-Fernández, Génesis, Serrano Del Pozo, Erika, Foradada, Laia, Grueso, Judit, Nonell, Lara, Beaulieu, Marie-Eve, Whitfield, Jonathan R, Soucek, Laura

“…MYC's key role in oncogenesis and tumor progression has long been established for most human cancers. In melanoma, its deregulated activity by amplification of…”
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Smart Multi-Frequency Bioelectrical Impedance Spectrometer for BIA and BIVA Applications by Harder, Rene, Diedrich, Andre, Whitfield, Jonathan S., Buchowski, Macie S., Pietsch, John B., Baudenbacher, Franz J.

“…Bioelectrical impedance analysis (BIA) is a noninvasive and commonly used method for the assessment of body composition including body water. We designed a…”
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MYC: there is more to it than cancer by Zacarías-Fluck, Mariano F, Soucek, Laura, Whitfield, Jonathan R

“…MYC is a pleiotropic transcription factor involved in multiple cellular processes. While its mechanism of action and targets are not completely elucidated, it…”
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Noninvasive Venous Waveform Analysis Correlates With Pulmonary Capillary Wedge Pressure and Predicts 30-Day Admission in Patients With Heart Failure Undergoing Right Heart Catheterization by ALVIS, BRET, HUSTON, JESSICA, SCHMECKPEPER, JEFFERY, POLCZ, MONICA, CASE, MARISA, HARDER, RENE, WHITFIELD, JONATHAN S., SPEARS, KENDALL G., BREED, MEGHAN, VAUGHN, LEXIE, BROPHY, COLLEEN, HOCKING, KYLE M., LINDENFELD, JOANN

“…•Noninvasive venous waveform analysis in heart failure (NIVAHF) is a noninvasive, wristband, remote monitoring technology that is designed to provide a…”
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Tamoxifen administration to mice by Whitfield, Jonathan, Littlewood, Trevor, Soucek, Laura

“…The strategy of fusing a protein of interest to a hormone-binding domain (HBD) of a steroid hormone receptor allows fine control of the activity of the fused…”
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Dominant-Negative c-Jun Promotes Neuronal Survival by Reducing BIM Expression and Inhibiting Mitochondrial Cytochrome c Release by Whitfield, Jonathan, Neame, Stephen J, Paquet, Luc, Bernard, Ora, Ham, Jonathan

“…Sympathetic neurons require nerve growth factor for survival and die by apoptosis in its absence. Key steps in the death pathway include c-Jun activation,…”
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