Search Results - "WHITFIELD, G. K"

The Nuclear Vitamin D Receptor: Biological and Molecular Regulatory Properties Revealed by Haussler, Mark R., Whitfield, G. Kerr, Haussler, Carol A., Hsieh, Jui‐Cheng, Thompson, Paul D., Selznick, Sanford H., Dominguez, Carlos Encinas, Jurutka, Peter W.

“…The scope of this review will be limited to highlighting the actions of 1 alpha ,25-dihydroxyvitamin D sub(3) (1,25(OH) sub(2)D sub(3)) mediated by nuclear…”
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The vitamin D hormone and its nuclear receptor: molecular actions and disease states by Haussler, M R, Haussler, C A, Jurutka, P W, Thompson, P D, Hsieh, J-C, Remus, L S, Selznick, S H, Whitfield, G K

“…Vitamin D plays a major role in bone mineral homeostasis by promoting the transport of calcium and phosphate to ensure that the blood levels of these ions are…”
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Distinct retinoid X receptor activation function-2 residues mediate transactivation in homodimeric and vitamin D receptor heterodimeric contexts by Thompson, PD, Remus, LS, Hsieh, JC, Jurutka, PW, Whitfield, GK, Galligan, MA, Encinas Dominguez, C, Haussler, CA, Haussler, MR

“…The vitamin D receptor (VDR) stimulates transcription as a 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3))-activated heterodimer with retinoid X receptor (RXR)…”
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Phosphorylation of the human vitamin D receptor by protein kinase C. Biochemical and functional evaluation of the serine 51 recognition site by JUI-CHENG HSIEH, JURUTKA, P. W, NAKAJIMA, S, GALLIGAN, M. A, HAUSSLER, C. A, SHIMIZU, Y, SHIMIZU, N, WHITFIELD, G. K, HAUSSLER, M. R

“…We have reported previously that the human vitamin D receptor (hVDR) is selectively phosphorylated by protein kinase C-beta (PKC-beta), in vitro, on a serine…”
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Human vitamin D receptor phosphorylation by casein kinase II at Ser-208 potentiates transcriptional activation by Jurutka, P.W. (University of Arizona, Tucson, AZ.), Hsieh, J.C, Nakajima, S, Haussler, C.A, Whitfield, G.K, Haussler, M.R

“…The potential functional significance of human 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] receptor (hVDR) phosphorylation at Ser-208 was evaluated by…”
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New understanding of the molecular mechanism of receptor-mediated genomic actions of the vitamin D hormone by Haussler, M R, Jurutka, P W, Hsieh, J C, Thompson, P D, Selznick, S H, Haussler, C A, Whitfield, G K

“…The nuclear vitamin D receptor (VDR) binds the 1,25-dihydroxyvitamin D3 [1,25(OH)2D3]hormone with high affinity and elicits its actions to regulate gene…”
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Phosphorylation of serine 208 in the human vitamin D receptor. The predominant amino acid phosphorylated by casein kinase II, in vitro, and identification as a significant phosphorylation site in intact cells by JURUTKA, P. W, JUI-CHENG HSIEH, MACDONALD, P. N, TERPENING, C. M, HAUSSLER, C. A, HAUSSLER, M. R, WHITFIELD, G. K

“…The human 1,25-dihydroxyvitamin D3 receptor (hVDR), like other members of the steroid/thyroid receptor superfamily, has been observed to undergo rapid…”
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A highly conserved region in the hormone-binding domain of the human vitamin D receptor contains residues vital for heterodimerization with retinoid X receptor and for transcriptional activation by Whitfield, G K, Hsieh, J C, Nakajima, S, MacDonald, P N, Thompson, P D, Jurutka, P W, Haussler, C A, Haussler, M R

“…Residues located between amino acids 244 and 263 in the human vitamin D receptor (hVDR) show extensive homology with other members of the…”
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The polymorphic N terminus in human vitamin D receptor isoforms influences transcriptional activity by modulating interaction with transcription factor IIB by Jurutka, P W, Remus, L S, Whitfield, G K, Thompson, P D, Hsieh, J C, Zitzer, H, Tavakkoli, P, Galligan, M A, Dang, H T, Haussler, C A, Haussler, M R

“…The human vitamin D receptor (hVDR) is a ligand-regulated transcription factor that mediates the actions of the 1,25-dihydroxyvitamin D3 hormone to effect bone…”
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The C-terminal region of the vitamin D receptor is essential to form a complex with a receptor auxiliary factor required for high affinity binding to the vitamin D-responsive element by Nakajima, S, Hsieh, J C, MacDonald, P N, Galligan, M A, Haussler, C A, Whitfield, G K, Haussler, M R

“…The human vitamin D receptor (hVDR) requires another nuclear protein(s), designated receptor auxiliary factor (RAF), for optimal binding to the vitamin…”
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Functionally relevant polymorphisms in the human nuclear vitamin D receptor gene by Kerr Whitfield, G, Remus, Lenore S, Jurutka, Peter W, Zitzer, Heike, Oza, Anish K, Dang, Hope T.L, Haussler, Carol A, Galligan, Michael A, Thatcher, Michelle L, Dominguez, Carlos Encinas, Haussler, Mark R

“…The functional significance of two unlinked human vitamin D receptor (hVDR) gene polymorphisms was evaluated in twenty human fibroblast cell lines. Genotypes…”
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Baculovirus-mediated expression of the human vitamin D receptor. Functional characterization, vitamin D response element interactions, and evidence for a receptor auxiliary factor by MacDonald, P N, Haussler, C A, Terpening, C M, Galligan, M A, Reeder, M C, Whitfield, G K, Haussler, M R

“…A baculovirus expression vector system (BEVS) was used to overproduce the full-length human vitamin D receptor (hVDR) in Spodoptera frugiperda ovarian cells…”
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Suppression of ANP Gene Transcription by Liganded Vitamin D Receptor: Involvement of Specific Receptor Domains by Chen, Songcang, Wu, Jianming, Hsieh, Jui-Cheng, Whitfield, G. Kerr, Jurutka, Peter W, Haussler, Mark R, Gardner, David G

“…We showed previously that liganded vitamin D receptor (VDR) effects a suppression of human atrial natriuretic peptide (hANP) gene-promoter activity in cultured…”
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Liganded VDR induces CYP3A4 in small intestinal and colon cancer cells via DR3 and ER6 vitamin D responsive elements by Thompson, Paul D, Jurutka, Peter W, Kerr Whitfield, G, Myskowski, Sandy M, Eichhorst, Kristina R, Encinas Dominguez, Carlos, Haussler, Carol A, Haussler, Mark R

“…The nuclear vitamin D receptor (VDR) mediates the effects of 1,25-dihydroxyvitamin D 3 (1,25D 3) to alter intestinal gene transcription and promote calcium…”
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Cloning of a Functional Vitamin D Receptor from the Lamprey (Petromyzon marinus), an Ancient Vertebrate Lacking a Calcified Skeleton and Teeth by Whitfield, G. Kerr, Dang, Hope T. L, Schluter, Samuel F, Bernstein, Ralph M, Bunag, Tara, Manzon, Lori A, Hsieh, Grace, Encinas Dominguez, Carlos, Youson, John H, Haussler, Mark R, Marchalonis, John J

“…The nuclear vitamin D receptor (VDR) mediates the actions of its 1,25-dihydroxyvitamin D3 ligand to control gene expression in terrestrial vertebrates…”
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The glycoprotein alpha-subunit is critical for secretion and stability of the human thyrotropin beta-subunit by Matzuk, M M, Kornmeier, C M, Whitfield, G K, Kourides, I A, Boime, I

“…TSH is a member of a family of heterodimeric glycoprotein hormones which have a common alpha-subunit but differ in their hormone-specific beta-subunit. To…”
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Vitamin D receptors from patients with resistance to 1,25-dihydroxyvitamin D3: point mutations confer reduced transactivation in response to ligand and impaired interaction with the retinoid X receptor heterodimeric partner by Whitfield, G K, Selznick, S H, Haussler, C A, Hsieh, J C, Galligan, M A, Jurutka, P W, Thompson, P D, Lee, S M, Zerwekh, J E, Haussler, M R

“…Hereditary hypocalcemic vitamin D-resistant rickets is attributable to defects in the nuclear receptor for 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3]. Two novel…”
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The T-Box near the Zinc Fingers of the Human Vitamin D Receptor Is Required for Heterodimeric DNA Binding and Transactivation by Hsieh, J.C., Jurutka, P.W., Selznick, S.H., Reeder, M.C., Haussler, C.A., Whitfield, G.K., Haussler, M.R.

“…The T-box mediates binding of retinoid X receptor (RXR) homodimers to DNA while the P- and D-box in the zinc fingers of steroid hormone receptors play roles in…”
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Steroid hormone receptors: Evolution, ligands, and molecular basis of biologic function by Whitfield, G. Kerr, Jurutka, Peter W., Haussler, Carol A., Haussler, Mark R.

“…The characterization of the superfamily of nuclear receptors, in particular the steroid/retinoid/thyroid hormone receptors, has resulted in a more complete…”
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26 REGULATION OF FGF23 BY 1,25-DIHYDROXYVITAMIN D3: A SECONDARY MECHANISM INVOLVING HISTONE H4 ACETYLATION by Hopper, H. A., Whitfield, G. K., Haussler, M. R.

“…FGF23 is a newly recognized regulator of serum phosphate, acting reciprocally to 1,25-dihydroxyvitamin D3 (1,25D), the hormonally active form of vitamin D. The…”
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