Search Results - "WHITEHOUSE, D. B"

Anti‐neutrophil cytoplasmic antibodies (ANCA) against bactericidal/permeability‐increasing protein (BPI) and cystic fibrosis lung disease by MAHADEVA, R, DUNN, A. C, LOCKWOOD, C. M, WESTERBEEK, R. C, SHARPLES, L, WHITEHOUSE, D. B, CARROLL, N. R, ROSS-RUSSELL, R. I, WEBB, A. K, BILTON, D, LOMAS, D. A

“…Persistent infection with Pseudomonas aeruginosa and inflammatory mechanisms play an important role in cystic fibrosis (CF) lung disease. ANCA against BPI, a…”
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C-antineutrophil cytoplasmic antibody positivity in vasculitis patients is associated with the Z allele of alpha-1-antitrypsin, and P-antineutrophil cytoplasmic antibody positivity with the S allele by GRIFFITH, M. E, LOVEGROVE, J. U, GASKIN, G, WHITEHOUSE, D. B, PUSEY, C. D

“…Antineutrophil cytoplasmic antibodies (ANCA) in vasculitis have either cANCA or pANCA patterns as defined by immunofluorescence. The target autoantigen of…”
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Mapping Recombination Hotspots in Human Phosphoglucomutase (PGM1) by Ping Yip, Shea, Lovegrove, Jenny U., Rana, Naheed A., Hopkinson, David A., Whitehouse, David B.

“…Human phosphoglucomutase (PGM1) is a highly polymorphic protein. Three mutations and four intragenic recombination events between the three mutation sites…”
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A phylogenetic approach to the identification of phosphoglucomutase genes by Whitehouse, D B, Tomkins, J, Lovegrove, J U, Hopkinson, D A, McMillan, W O

“…The expanding molecular database provides unparalleled opportunities for characterizing genes and for studying groups of related genes. We use sequences drawn…”
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Improvement of SSCP analysis by use of denaturants by Yip, S P, Hopkinson, D A, Whitehouse, D B

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Identification and characterisation of polymorphisms in human phosphoglucomutase (PGM1) by YIP, S. P., PUTT, W., HOPKINSON, D. A., WHITEHOUSE, D. B.

“…This study is part of our effort to map recombination hotspots in two regions (site A, 18 kb; site B, 40 kb) of the human phosphoglucomutase PGM1 gene…”
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Phosphoglucomutase 1 : a gene with two promoters and a duplicated first exon by PUTT, W, IVES, J. H, HOLLYOAKE, M, HOPKINSON, D. A, WHITEHOUSE, D. B, EDWARDS, Y. H

“…In view of its central role in glycolysis and gluconeogenesis and its polymorphic genetic variability, the phosphoglucomutase 1 (PGM1) gene in man has been the…”
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The Classical Human Phosphoglucomutase (PGM1) Isozyme Polymorphism is Generated by Intragenic Recombination by March, R. E., Putt, W., Hollyoake, M., Ives, J. H., Lovegrove, J. U., Hopkinson, D. A., Edwards, Y. H., Whitehouse, D. B.

“…The molecular basis of the classical human phosphoglucomutase 1 (PGM1) isozyme polymorphism has been established. In 1964, when this genetic polymorphism was…”
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A new alpha 1-antitrypsin mutation, Thr–Met 85, (PI Zbristol) associated with novel electrophoretic properties by LOVEGROVE, J. U., JEREMIAH, S., GILLETT, G. T., TEMPLE, I. K., POVEY, S., WHITEHOUSE, D. B.

“…A new AAT allele (PI Zbristol) has been discovered in a woman with an obstetric history of three perinatal deaths from fulminant liver disease and no living…”
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Characterisation of an epitope recognised by a monoclonal antibody against horse alcohol dehydrogenase using peptides synthesised on solid support by Leone, N.A., Whitehouse, D.B., Swallow, D.M., Wallace, G.R., Adinolfi, A.

“…Immunological analysis, using the Pepscan technique, of the tetradecapeptide, Pro 344-Glu 357 (PLITHVLPFEKINE), from horse liver alcohol dehydrogenase has…”
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Molecular and cytological investigations of phosphoglucomutase (PGM1) in the K562 cell line by TOMKINS, J., FOX, M., LOVEGROVE, J. U., PARRINGTON, J., HOPKINSON, D. A., WHITEHOUSE, D. B.

“…Phosphoglucomutase 1 (PGM1) deficiency is a stable characteristic of the erythroleukaemic cell line, K562, whereas the activity of the isozymes of the other…”
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New monoclonal antibodies to non-glycosylated domains of the secreted mucins MUC5B and MUC7 by Rousseau, K, Wickstrom, C, Whitehouse, D B, Carlstedt, I, Swallow, D M

“…The separation and characterization of salivary mucins is not straightforward because of their large size, heterogeneity, and molecular interactions. The MUC5B…”
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Identification of alpha(1)-antitrypsin variants in plasma with the use of proteomic technology by Mills, K, Mills, P B, Clayton, P T, Johnson, A W, Whitehouse, D B, Winchester, B G

“…Proteomic technology permits the investigation of genetic metabolic diseases at the level of protein expression. Changes in the expression, polypeptide…”
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α1-Antitrypsin deficiency alleles and the Taq-I G→A allele in cystic fibrosis lung disease by MAHADEVA, R, WESTERBEEK, R. C, PERRY, D. J, LOVEGROVE, J. U, WHITEHOUSE, D. B, CARROLL, N. R, ROSS-RUSSELL, R. I, WEBB, A. K, BRILTON, D, LOMAS, D. A

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Prenatal diagnosis of alpha-1-antitrypsin deficiency by PCR of linked polymorphisms: a study of 17 cases by Abbott, C M, Lovegrove, J U, Whitehouse, D B, Hopkinson, D A, Povey, S

“…We describe our experiences of prenatal diagnosis of alpha-1-antitrypsin deficiency using closely linked polymorphisms detected by Southern blotting and the…”
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Antigenic analysis of the major human phosphoglucomutase isozymes: PGM1, PGM2, PGM3 and PGM4 by Drago, G A, Hopkinson, D A, Westwood, S A, Whitehouse, D B

“…The cross-reactivity of human phosphoglucomutase isozymes (PGM1, PGM2, PGM3 and PGM4) has been investigated using anti-rabbit muscle PGM polyclonal antibodies…”
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Genetic studies on a new deficiency gene (PIZtun) at the PI locus by Whitehouse, D B, Abbott, C M, Lovegrove, J U, McIntosh, I, McMahon, C J, Mieli-Vergani, G, Mowat, A P, Hopkinson, D A

“…During a study of the alpha 1 antitrypsin (AAT) protein and its locus (PI) by high resolution isoelectric focusing and direct molecular analysis of 106 PIZ…”
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Genetic polymorphism and linkage of the sixth and seventh complement components (C6 and C7) in the Common marmoset by WHITEHOUSE, D. B

“…Using polyacrylamide gel isoelectric focusing and standard specific hemolytic detection methods, genetic polymorphisms have been found in the sixth and seventh…”
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Genetic polymorphisms of animal complement components by Whitehouse, D B

“…This review summarizes current knowledge of complement polymorphisms in non-human vertebrate species. The information presented is intended to be…”
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Phosphoglucomutase 1: Complete Human and Rabbit mRNA Sequences and Direct Mapping of this Highly Polymorphic Marker on Human Chromosome 1 by Whitehouse, D. B., Putt, W., Lovegrove, J. U., Morrison, K., Hollyoake, M., Fox, M. F., Hopkinson, D. A., Edwards, Y. H.

“…A cDNA clone encoding the mRNA for the highly polymorphic human enzyme phosphoglucomutase 1 (PGM1; EC 5.4.2.2) has been isolated and characterized. This was…”
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