Search Results - "WHITEHEAD, S. A"

Dosing Algorithms to Predict Warfarin Maintenance Dose in Caucasians and African Americans by Schelleman, H, Chen, J, Chen, Z, Christie, J, Newcomb, CW, Brensinger, CM, Price, M, Whitehead, AS, Kealey, C, Thorn, CF, Samaha, FF, Kimmel, SE

“…The objective of this study was to determine whether warfarin dosing algorithms developed for Caucasians and African Americans on the basis of clinical,…”
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Warfarin Response and Vitamin K Epoxide Reductase Complex 1 in African Americans and Caucasians by Schelleman, H, Chen, Z, Kealey, C, Whitehead, A S, Christie, J, Price, M, Brensinger, C M, Newcomb, C W, Thorn, C F, Samaha, F F, Kimmel, S E

“…The objective of this study was to determine whether two vitamin K epoxide reductase complex 1 (VKORC1) polymorphisms contribute to the variability in warfarin…”
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Dual effect of metformin on growth inhibition and oestradiol production in breast cancer cells by RICE, S, PELLAT, L, AHMETAGA, A, BANO, G, MASON, HD, WHITEHEAD, SA

“…Evidence has been accumulating for a role for metformin in reducing breast cancer risk in post-menopausal women. It inhibits growth of breast cancer cells via…”
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transcobalamin (TCN2) 776C>G polymorphism affects homocysteine concentrations among subjects with low vitamin B12 status by Stanisawska-Sachadyn, A, Woodside, J.V, Sayers, C.M, Yarnell, J.W, Young, I.S, Evans, A.E, Mitchell, L.E, Whitehead, A.S

“…Background/Objectives: Methionine synthase catalyzes the conversion of 5-methyltetrahydrofolate to tetrahydrofolate and homocysteine (Hcy) to methionine using…”
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Alcohol increases homocysteine and reduces B vitamin concentration in healthy male volunteers—a randomized, crossover intervention study by Gibson, A., Woodside, J.V., Young, I.S., Sharpe, P.C., Mercer, C., Patterson, C.C., Mckinley, M.C., Kluijtmans, L.A.J., Whitehead, A.S., Evans, A.

“…Background: Few studies have examined the effect of alcohol consumption on total homocysteine (tHcy) concentrations. Aim: To assess the effect of an 8-week…”
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Increased prevalence of methylenetetrahydrofolate reductase C677T variant in patients with inflammatory bowel disease, and its clinical implications by Mahmud, N, Molloy, A, McPartlin, J, Corbally, R, Whitehead, A S, Scott, J M, Weir, D G

“…BACKGROUND Inflammatory bowel disease (IBD) is associated with an increased incidence of thromboembolic disease. Hyperhomocysteinaemia (hyper-tHcy), a…”
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Testosterone selectively increases primary follicles in ovarian cortex grafted onto embryonic chick membranes: relevance to polycystic ovaries by Qureshi, A I, Nussey, S S, Bano, G, Musonda, P, Whitehead, S A, Mason, H D

“…Histological studies have demonstrated that polycystic ovaries (PCO) contain increased numbers of preantral follicles with a specific increase in primary…”
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Phytoestrogens inhibit aromatase but not 17β‐hydroxysteroid dehydrogenase (HSD) type 1 in human granulosa‐luteal cells: evidence for FSH induction of 17β‐HSD by Whitehead, S.A., Lacey, M.

“…BACKGROUND: Studies using purified enzyme preparations, placental microsomes or cell lines have shown that certain phytoestrogens can inhibit the enzymes that…”
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The common ‘thermolabile’ variant of methylene tetrahydrofolate reductase is a major determinant of mild hyperhomocysteinaemia by Harmon, D.L., Woodside, J.V., Yarnell, J.W.G., McMaster, D., Young, I.S., McCrum, E.E., Gey, K.F., Whitehead, A.S., Evans, A.E.

“…Mild hyperhomocysteinaemia is a major risk factor for vascular disease and neural tube defects (NTDs), conferring an approximately three-fold relative risk for…”
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Regulation of the Human Acute Phase Serum Amyloid A Genes by Tumour Necrosis Factor‐α, Interleukin‐6 and Glucocorticoids in Hepatic and Epithelial Cell Lines by Thorn, C. F., Lu, Z.‐Y., Whitehead, A. S.

“…The major acute‐phase protein serum amyloid A, A‐SAA, is upregulated by a variety of inflammatory stimuli, including cytokines and glucocorticoids (GCs)…”
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The “Thermolabile” Variant of Methylenetetrahydrofolate Reductase and Neural Tube Defects: An Evaluation of Genetic Risk and the Relative Importance of the Genotypes of the Embryo and the Mother by Shields, Denis C., Kirke, Peadar N., Mills, James L., Ramsbottom, Dorothy, Molloy, Anne M., Burke, Helen, Weir, Donald G., Scott, John M., Whitehead, Alexander S.

“…Recent reports have implicated the “thermolabile” (T) variant of methylenetetrahydrofolate reductase (MTHFR) in the causation of folate-dependent neural tube…”
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Thermolabile variant of 5,10-methylenetetrahydrofolate reductase associated with low red-cell folates: implications for folate intake recommendations by Molloy, A M, Daly, S, Mills, J L, Kirke, P N, Whitehead, A S, Ramsbottom, D, Conley, M R, Weir, D G, Scott, J M

“…The dietary reference values for folate, as for other nutrients, are targeted to the general and supposedly normal population, not people with special needs,…”
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Methylenetetrahydrofolate reductase genotypes and predisposition to atherothrombotic disease. Evidence that all three MTHFR C677T genotypes confer different levels of risk by Kluijtmans, L.A.J, Whitehead, A.S

“…Aims Elevated plasma homocysteine is an independent risk factor for atherothrombotic disease. Individuals homozygous for the methylenetetrahydrofolate…”
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Prospective Evaluation of the Risk Conferred by Factor V Leiden and Thermolabile Methylenetetrahydrofolate Reductase Polymorphisms in Pregnancy by Murphy, Ronan P, Donoghue, Catherine, Nallen, Ruth J, D’Mello, Melwyn, Regan, Carmen, Whitehead, Alexander S, Fitzgerald, Desmond J

“…Factor V (FV) Leiden and thermolabile methylenetetrahydrofolate reductase (MTHFR) are 2 common polymorphisms that have been implicated in vascular thrombosis…”
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Serum amyloid A in the assessment of early inflammatory arthritis by Cunnane, G, Grehan, S, Geoghegan, S, McCormack, C, Shields, D, Whitehead, A S, Bresnihan, B, Fitzgerald, O

“…Acute phase serum amyloid A (A-SAA) has been reported to be more sensitive than C-reactive protein (CRP) as a marker of disease activity. It may function in…”
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Methionine synthase D919G polymorphism is a significant but modest determinant of circulating homocysteine concentrations by Harmon, Dawn L., Shields, Denis C., Woodside, Jayne V., McMaster, Dorothy, Yarnell, John W.G., Young, Ian S., Peng, Kun, Shane, Barry, Evans, Alun E., Whitehead, Alexander S.

“…Elevation in plasma homocysteine concentration has been associated with vascular disease and neural tube defects. Methionine synthase is a vitamin…”
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Total homocysteine is not a determinant of arterial pulse wave velocity in young healthy adults by Woodside, J.V., McMahon, R., Gallagher, A.M., Cran, G.W., Boreham, C.A., Murray, L.J., Strain, J.J., McNulty, H., Robson, P.J., Brown, K.S., Whitehead, A.S., Savage, M., Young, I.S.

“…Aims: Hyperhomocysteinaemia has been associated with reduced pulse wave velocity (PWV) in patients with end-stage renal disease and in those with hypertension…”
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Homocysteine and risk of premature coronary heart disease : Evidence for a common gene mutation by GALLAGHER, P. M, MELEADY, R, SHIELDS, D. C, KOK SOON TAN, MCMASTER, D, ROZEN, R, EVANS, A, GRAHAM, I. M, WHITEHEAD, A. S

“…Plasma homocysteine levels are modulated by nutritional and genetic factors, among which is the enzyme methylenetetrahydrofolate reductase (MTHFR). A common…”
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A genetic defect in 5,10 methylenetetrahydrofolate reductase in neural tube defects by Whitehead, A S, Gallagher, P, Mills, J L, Kirke, P N, Burke, H, Molloy, A M, Weir, D G, Shields, D C, Scott, J M

“…It is now well-established that folic acid, taken peri-conceptionally, can reduce the risk of neural tube defects (NTDs). Recent work has demonstrated that an…”
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Phase I trial of UFT/leucovorin and irinotecan in patients with advanced cancer by Veronese, M.L., Stevenson, J.P., Sun, W., Redlinger, M., Algazy, K., Giantonio, B., Hahn, S., Vaughn, D., Thorn, C., Whitehead, A.S., Haller, D.G., O'Dwyer, P.J.

“…UFT (BMS-200604, Uftoral®) is an oral fluoropyrimidine that combines uracil and the 5-fluorouracil (5-FU) prodrug, ftorafur, in a 4:1 molar ratio with…”
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