Search Results - "WHITEAKER, Kristi"

Effects of Substitution on 9-(3-Bromo-4-fluorophenyl)-5,9-dihydro-3H,4H-2,6-dioxa-4- azacyclopenta[b]naphthalene-1,8-dione, a Dihydropyridine ATP-Sensitive Potassium Channel Opener by Altenbach, Robert J, Brune, Michael E, Buckner, Steven A, Coghlan, Michael J, Daza, Anthony V, Fabiyi, Adebola, Gopalakrishnan, Murali, Henry, Rodger F, Khilevich, Albert, Kort, Michael E, Milicic, Ivan, Scott, Victoria E, Smith, Jamie C, Whiteaker, Kristi L, Carroll, William A

“…Structure−activity relationships were investigated on the tricyclic dihydropyridine (DHP) KATP openers…”
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Structure-activity studies for a novel series of tricyclic dihydropyrimidines as KATP channel openers (KCOs) by DRIZIN, Irene, HOLLADAY, Mark W, LIN YI, ZHANG, Henry Q, GOPALAKRISHNAN, Sujatha, GOPALAKRISHNAN, Murali, WHITEAKER, Kristi L, BUCKNER, Steven A, SULLIVAN, James P, CARROLL, William A

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Synthesis and Structure−Activity Relationships of a Novel Series of Tricyclic Dihydropyridine-Based KATP Openers That Potently Inhibit Bladder Contractions in Vitro by Carroll, William A, Agrios, Konstantinos A, Altenbach, Robert J, Buckner, Steven A, Chen, Yiyuan, Coghlan, Michael J, Daza, Anthony V, Drizin, Irene, Gopalakrishnan, Murali, Henry, Rodger F, Kort, Michael E, Kym, Philip R, Milicic, Ivan, Smith, Jamie C, Tang, Rui, Turner, Sean C, Whiteaker, Kristi L, Zhang, Henry, Sullivan, James P

“…Structure−activity relationships were investigated on a novel series of tricyclic dihydropyridine-containing KATP openers. This diverse group of analogues,…”
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Validation of FLIPR membrane potential dye for high throughput screening of potassium channel modulators by Whiteaker, K L, Gopalakrishnan, S M, Groebe, D, Shieh, C C, Warrior, U, Burns, D J, Coghlan, M J, Scott, V E, Gopalakrishnan, M

“…A fluorescence-based assay using the FLIPR Membrane Potential Assay Kit (FMP) was evaluated for functional characterization and high throughput screening (HTS)…”
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Structure−Activity Studies of Novel Cyanoguanidine ATP-Sensitive Potassium Channel Openers for the Treatment of Overactive Bladder by Perez-Medrano, Arturo, Brune, Michael E, Buckner, Steven A, Coghlan, Michael J, Fey, Thomas A, Gopalakrishnan, Murali, Gregg, Robert J, Kort, Michael E, Scott, Victoria E, Sullivan, James P, Whiteaker, Kristi L, Carroll, William A

“…A series of novel cyanoguanidine derivatives was designed and synthesized. Condensation of N-(1-benzotriazol-1-yl-2,2-dichloropropyl)-substituted benzamides…”
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Structure-activity studies for a novel series of tricyclic dihydropyridopyrazolones and dihydropyridoisoxazolones as KATP channel openers by DRIZIN, Irene, ALTENBACH, Robert J, CARROLL, William A, BUCKNER, Steven A, WHITEAKER, Kristi L, SCOTT, Victoria E, DARBYSHIRE, John F, JAYANTI, Venkata, HENRY, Rodger F, COGHLAN, Michael J, GOPALAKRISHNAN, Murali

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Characterization of human urinary bladder KATP channels containing SUR2B splice variants expressed in L-cells by SCOTT, Victoria E, DAVIS-TABER, Rachel A, SILVIA, Christopher, HOOGENBOOM, Lisa, WON CHOI, KROEGER, Paul, WHITEAKER, Kristi L, GOPALAKRISHNAN, Murali

“…The molecular properties of the sulfonylurea receptor 2 (SUR2) subunits of K(ATP) channels expressed in urinary bladder were assessed by polymerase chain…”
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(-)-(9S)-9-(3-Bromo-4-fluorophenyl)-2,3,5,6,7,9-hexahydrothieno[3,2-b]quinolin-8(4H)-one 1,1-dioxide (A-278637): a novel ATP-sensitive potassium channel opener efficacious in suppressing urinary bladder contractions. I. In vitro characterization by Gopalakrishnan, Murali, Buckner, Steven A, Whiteaker, Kristi L, Shieh, Char-Chang, Molinari, Eduardo J, Milicic, Ivan, Daza, Anthony V, Davis-Taber, Rachel, Scott, Victoria E, Sellers, Donna, Chess-Williams, Russ, Chapple, Christopher R, Liu, Yi, Liu, Dong, Brioni, Jorge D, Sullivan, James P, Williams, Michael, Carroll, William A, Coghlan, Michael J

“…Alterations in the myogenic activity of the bladder smooth muscle are thought to serve as a basis for the involuntary detrusor contractions associated with the…”
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[125I]A-312110, a novel high-affinity 1,4-dihydropyridine ATP-sensitive K+ channel opener: characterization and pharmacology of binding by Davis-Taber, Rachel, Molinari, Eduardo J, Altenbach, Robert J, Whiteaker, Kristi L, Shieh, Char-Chang, Rotert, Gary, Buckner, Steven A, Malysz, John, Milicic, Ivan, McDermott, Jeffrey S, Gintant, Gary A, Coghlan, Michael J, Carroll, William A, Scott, Victoria E, Gopalakrishnan, Murali

“…Although ATP-sensitive K+ channels continue to be explored for their therapeutic potential, developments in high-affinity radioligands to investigate native…”
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Functional characterization of adenosine receptors and coupling to ATP-sensitive K+ channels in Guinea pig urinary bladder smooth muscle by Gopalakrishnan, Sujatha M, Buckner, Steven A, Milicic, Ivan, Groebe, Duncan R, Whiteaker, Kristi L, Burns, David J, Warrior, Usha, Gopalakrishnan, Murali

“…Although multiple adenosine receptors have been identified, the subtype and underlying mechanisms involved in the relaxation response to adenosine in the…”
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Design and synthesis of novel cyanoguanidine ATP-sensitive potassium channel openers for the treatment of overactive bladder by Perez-Medrano, Arturo, Buckner, Steven A., Coghlan, Michael J., Gregg, Robert J., Gopalakrishnan, Murali, Kort, Michael E., Lynch, John K., Scott, Victoria E., Sullivan, James P., Whiteaker, Kristi L., Carroll, William A.

“…Thiourea derivatives were identified as glyburide-reversible potassium channel openers through high-throughput screening. Based on these findings, a number of…”
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In vitro and in vivo characterization of a novel naphthylamide ATP‐sensitive K+ channel opener, A‐151892 by Gopalakrishnan, Murali, Buckner, Steven A, Shieh, Char‐Chang, Fey, Thomas, Fabiyi, Adebola, Whiteaker, Kristi L, Davis‐Taber, Rachel, Milicic, Ivan, Daza, Anthony V, Scott, Victoria E S, Castle, Neil A, Printzenhoff, David, London, Brecht, Turner, Sean C, Carroll, William A, Sullivan, James P, Coghlan, Michael J, Brune, Michael E

“…Openers of ATP‐sensitive K+ channels are of interest in several therapeutic indications including overactive bladder and other lower urinary tract disorders…”
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Pharmacology of human sulphonylurea receptor SUR1 and inward rectifier K+ channel Kir6.2 combination expressed in HEK‐293 cells by Gopalakrishnan, Murali, Molinari, Eduardo J, Shieh, Char‐Chang, Monteggia, Lisa M, Roch, Jean‐Marc, Whiteaker, Kristi L, Scott, Victoria E S, Sullivan, James P, Brioni, Jorge D

“…The pharmacological properties of KATP channels generated by stable co‐expression of the sulphonylurea receptor SUR1 and the inwardly rectifying K+ channel…”
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Pharmacological characterization of a 1,4‐dihydropyridine analogue, 9‐(3,4‐dichlorophenyl)‐3,3,6,6‐tetramethyl‐3,4,6,7,9,10‐hexahydro‐1,8(2 H ,5 H )‐acridinedione (A‐184209) as a novel K ATP channel inhibitor by Gopalakrishnan, Murali, Miller, Thomas R, Buckner, Steven A, Milicic, Ivan, Molinari, Eduardo J, Whiteaker, Kristi L, Davis‐Taber, Rachel, Scott, Victoria E, Cassidy, Christopher, Sullivan, James P, Carroll, William A

“…This study reports on the identification and characterization of a 1,4‐dihydropyridine analogue,…”
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Characterization of the ATP-sensitive potassium channels (KATP) expressed in guinea pig bladder smooth muscle cells by Gopalakrishnan, M, Whiteaker, K L, Molinari, E J, Davis-Taber, R, Scott, V E, Shieh, C C, Buckner, S A, Milicic, I, Cain, J C, Postl, S, Sullivan, J P, Brioni, J D

“…ATP-sensitive K+ (KATP) channels play an important role in the regulation of smooth muscle membrane potential. To investigate the properties of KATP channels…”
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Synthesis and Structure−Activity Relationships of a Novel Series of 2,3,5,6,7,9-Hexahydrothieno[3,2-b]quinolin-8(4H)-one 1,1-Dioxide KATP Channel Openers:  Discovery of (−)-(9S)-9-(3-Bromo-4-fluorophenyl)-2,3,5,6,7,9- hexahydrothieno[3,2-b]quinolin-8(4H)-one 1,1-Dioxide (A-278637), a Potent KATP Opener That Selectively Inhibits Spontaneous Bladder Contractions by Carroll, William A, Altenbach, Robert J, Bai, Hao, Brioni, Jorge D, Brune, Michael E, Buckner, Steven A, Cassidy, Christopher, Chen, Yiyuan, Coghlan, Michael J, Daza, Anthony V, Drizin, Irene, Fey, Thomas A, Fitzgerald, Michael, Gopalakrishnan, Murali, Gregg, Robert J, Henry, Rodger F, Holladay, Mark W, King, Linda L, Kort, Michael E, Kym, Philip R, Milicic, Ivan, Tang, Rui, Turner, Sean C, Whiteaker, Kristi L, Yi, Lin, Zhang, Henry, Sullivan, James P

“…Structure−activity relationships were investigated on a novel series of sulfonyldihydropyridine-containing KATP openers. Ring sizes, absolute stereochemistry,…”
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Pharmacological and molecular characterization of ATP-sensitive K + channels in the TE671 human medulloblastoma cell line by Miller, Thomas R, Taber, Rachel Davis, Molinari, Eduardo J, Whiteaker, Kristi L, Monteggia, Lisa M, Scott, Victoria E.S, Brioni, Jorge D, Sullivan, James P, Gopalakrishnan, Murali

“…ATP-sensitive K + (K ATP) channels in the human medulloblastoma TE671 cell line were characterized by membrane potential assays utilizing a potentiometric…”
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Fluorescence-based functional assay for sarcolemmal ATP-sensitive potassium channel activation in cultured neonatal rat ventricular myocytes by Whiteaker, Kristi L, Davis-Taber, Rachel, Scott, Victoria E.S, Gopalakrishnan, Murali

“…Introduction: Activation of ATP-sensitive K + channels (K ATP) has been shown to induce ischemic preconditioning that serves as a protective mechanism in the…”
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Species comparison and pharmacological characterization of rat and human CB 2 cannabinoid receptors by Mukherjee, Sutapa, Adams, Monique, Whiteaker, Kristi, Daza, Anthony, Kage, Karen, Cassar, Steven, Meyer, Michael, Yao, Betty Bei

“…Pharmacological effects of cannabinoid ligands are thought to be mediated through cannabinoid CB 1 and CB 2 receptor subtypes. Sequence analysis revealed that…”
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Species comparison and pharmacological characterization of rat and human CB2 cannabinoid receptors by MUKHERJEE, Sutapa, ADAMS, Monique, WHITEAKER, Kristi, DAZA, Anthony, KAGE, Karen, CASSAR, Steven, MEYER, Michael, YAO, Betty Bei

“…Pharmacological effects of cannabinoid ligands are thought to be mediated through cannabinoid CB1 and CB2 receptor subtypes. Sequence analysis revealed that…”
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