Search Results - "WHITE, Peter W"

Preclinical Characterization of BI 201335, a C-Terminal Carboxylic Acid Inhibitor of the Hepatitis C Virus NS3-NS4A Protease by WHITE, Peter W, LLINAS-BRUNET, Montse, KUKOLJ, George, AMAD, Ma'an, BETHELL, Richard C, BOLGER, Gordon, CORDINGLEY, Michael G, JIANMIN DUAN, GARNEAU, Michel, LAGACE, Lisette, THIBEAULT, Diane

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Evaluation of Phosphatidylinositol-4-Kinase IIIα as a Hepatitis C Virus Drug Target by VAILLANCOURT, Frederic H, BRAULT, Martine, CHIU, Tim T, MAHROUCHE, Louiza, FAUCHER, Anne-Marie, CARTIER, Mireille, CORDINGLEY, Michael G, BETHELL, Richard C, HUIPING JIANG, WHITE, Peter W, KUKOLJ, George, PILOTE, Louise, UYTTERSPROT, Nathalie, GAILLARD, Elias T, STOTTZ, James H, KNIGHT, Brian L, PANTAGES, Lynn, MCFARIAND, Mary, BREITFELDER, Steffen

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

In Vitro Resistance Profile of the Hepatitis C Virus NS3 Protease Inhibitor BI 201335 by LAGACE, Lisette, WHITE, Peter W, THIBEAULT, Diane, TRIKI, Ibtissem, SONGPING ZHAO, KUKOLJ, George, BOUSQUET, Christiane, DANSEREAU, Nathalie, DO, Florence, LLINAS-BRUNET, Montse, MARQUIS, Martin, MASSARIOL, Marie-Josée, MAURICE, Roger, SPICKLER, Catherine

“…OA  Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

The Liver Partition Coefficient-Corrected Inhibitory Quotient and the Pharmacokinetic-Pharmacodynamic Relationship of Directly Acting Anti-Hepatitis C Virus Agents in Humans by JIANMIN DUAN, BOLGER, Gordon, KUKOLJ, George, WHITE, Peter W, BETHELL, Richard C, CORDINGLEY, Michael G, GARNEAU, Michel, AMAD, Ma'an, BATONGA, Joëlle, MONTPETIT, Hélène, OTIS, François, JUTRAS, Martin, LAPEYRE, Nicole, RHEAUME, Manon

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Discovery of Small-Molecule Inhibitors of the ATPase Activity of Human Papillomavirus E1 Helicase by Faucher, Anne-Marie, White, Peter W, Brochu, Christian, Grand-Maître, Chantal, Rancourt, Jean, Fazal, Gulrez

“…The Boehringer Ingelheim compound collection was screened for inhibitors of the ATPase activity of human papillomavirus E1 helicase to develop antiviral agents…”
Get full text

Sensitivity of NS3 Serine Proteases from Hepatitis C Virus Genotypes 2 and 3 to the Inhibitor BILN 2061 by THIBEAULT, Diane, BOUSQUET, Christiane, GINGRAS, Rock, LAGACE, Lisette, MAURICE, Roger, WHITE, Peter W, LAMARRE, Daniel

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Use of the Fused NS4A Peptide−NS3 Protease Domain To Study the Importance of the Helicase Domain for Protease Inhibitor Binding to Hepatitis C Virus NS3-NS4A by Thibeault, Diane, Massariol, Marie-Josée, Zhao, Songping, Welchner, Ewald, Goudreau, Nathalie, Gingras, Rock, Llinàs-Brunet, Montse, White, Peter W

“…The NS3 protein of hepatitis C virus is unusual because it encodes two unrelated enzymatic activities in linked protease and helicase domains. It has also been…”
Get full text

Crystal Structure of the E2 Transactivation Domain of Human Papillomavirus Type 11 Bound to a Protein Interaction Inhibitor by Wang, Yong, Coulombe, René, Cameron, Dale R., Thauvette, Louise, Massariol, Marie-Josée, Amon, Lynn M., Fink, Dominique, Titolo, Steve, Welchner, Ewald, Yoakim, Christiane, Archambault, Jacques, White, Peter W.

“…Interaction between the E2 protein and E1 helicase of human papillomaviruses (HPVs) is essential for the initiation of viral DNA replication. We recently…”
Get full text

Selective inhibition of CDK7 reveals high-confidence targets and new models for TFIIH function in transcription by Rimel, Jenna K, Poss, Zachary C, Erickson, Benjamin, Maas, Zachary L, Ebmeier, Christopher C, Johnson, Jared L, Decker, Tim-Michael, Yaron, Tomer M, Bradley, Michael J, Hamman, Kristin B, Hu, Shanhu, Malojcic, Goran, Marineau, Jason J, White, Peter W, Brault, Martine, Tao, Limei, DeRoy, Patrick, Clavette, Christian, Nayak, Shraddha, Damon, Leah J, Kaltheuner, Ines H, Bunch, Heeyoun, Cantley, Lewis C, Geyer, Matthias, Iwasa, Janet, Dowell, Robin D, Bentley, David L, Old, William M, Taatjes, Dylan J

“…CDK7 associates with the 10-subunit TFIIH complex and regulates transcription by phosphorylating the C-terminal domain (CTD) of RNA polymerase II (RNAPII). Few…”
Get full text

Biphenylsulfonacetic Acid Inhibitors of the Human Papillomavirus Type 6 E1 Helicase Inhibit ATP Hydrolysis by an Allosteric Mechanism Involving Tyrosine 486 by WHITE, Peter W, FAUCHER, Anne-Marie, MASSARIOL, Marie-Josée, WELCHNER, Ewald, RANCOURT, Jean, CARTIER, Mireille, ARCHAMBAULT, Jacques

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Inhibition of Human Papillomavirus DNA Replication by Small Molecule Antagonists of the E1-E2 Protein Interaction by White, Peter W., Titolo, Steve, Brault, Karine, Thauvette, Louise, Pelletier, Alex, Welchner, Ewald, Bourgon, Lise, Doyon, Louise, Ogilvie, William W., Yoakim, Christiane, Cordingley, Michael G., Archambault, Jacques

“…Human papillomavirus (HPV) DNA replication is initiated by recruitment of the E1 helicase by the E2 protein to the viral origin. Screening of our corporate…”
Get full text

Structure-thermodynamics-relationships of hepatitis C viral NS3 protease inhibitors by Wypych, Rachel M., LaPlante, Steven R., White, Peter W., Martin, Stephen F.

“…Thermodynamic parameters were determined for structurally-related inhibitors of HCV NS3 protease to assess how binding entropies and enthalpies vary with…”
Get full text

Potency, safety, and pharmacokinetics of the NS3/4A protease inhibitor BI201335 in patients with chronic HCV genotype-1 infection by Manns, Michael P, Bourlière, Marc, Benhamou, Yves, Pol, Stanislas, Bonacini, Maurizio, Trepo, Christian, Wright, David, Berg, Thomas, Calleja, José L, White, Peter W, Stern, Jerry O, Steinmann, Gerhard, Yong, Chan-Loi, Kukolj, George, Scherer, Joe, Boecher, Wulf O

“…Background & Aims BI201335 is a highly specific and potent HCV protease inhibitor. This multiple rising dose trial evaluated antiviral activity and safety in…”
Get full text

Combined X-ray, NMR, and Kinetic Analyses Reveal Uncommon Binding Characteristics of the Hepatitis C Virus NS3-NS4A Protease Inhibitor BI 201335 by Lemke, Christopher T., Goudreau, Nathalie, Zhao, Songping, Hucke, Oliver, Thibeault, Diane, Llinàs-Brunet, Montse, White, Peter W.

“…Hepatitis C virus infection, a major cause of liver disease worldwide, is curable, but currently approved therapies have suboptimal efficacy. Supplementing…”
Get full text

Discovery of Hepatitis C Virus NS3-4A Protease Inhibitors with Improved Barrier to Resistance and Favorable Liver Distribution by Moreau, Benoît, O’Meara, Jeff A., Bordeleau, Josée, Garneau, Michel, Godbout, Cedrickx, Gorys, Vida, Leblanc, Mélissa, Villemure, Elisia, White, Peter W., Llinàs-Brunet, Montse

“…Given the emergence of resistance observed for the current clinical-stage hepatitis C virus (HCV) NS3 protease inhibitors, there is a need for new inhibitors…”
Get full text

Discovery of a Potent and Selective Noncovalent Linear Inhibitor of the Hepatitis C Virus NS3 Protease (BI 201335) by Llinàs-Brunet, Montse, Bailey, Murray D, Goudreau, Nathalie, Bhardwaj, Punit K, Bordeleau, Josée, Bös, Michael, Bousquet, Yves, Cordingley, Michael G, Duan, Jiamin, Forgione, Pat, Garneau, Michel, Ghiro, Elise, Gorys, Vida, Goulet, Sylvie, Halmos, Ted, Kawai, Stephen H, Naud, Julie, Poupart, Marc-André, White, Peter W

“…C-Terminal carboxylic acid containing inhibitors of the NS3 protease are reported. A novel series of linear tripeptide inhibitors that are very potent and…”
Get full text

Characterization of the Binding Site for Inhibitors of the HPV11 E1−E2 Protein Interaction on the E2 Transactivation Domain by Photoaffinity Labeling and Mass Spectrometry by Davidson, Walter, McGibbon, Graham A, White, Peter W, Yoakim, Christiane, Hopkins, Jerry L, Guse, Ingrid, Hambly, David M, Frego, Lee, Ogilvie, William W, Lavallée, Pierre, Archambault, Jacques

“…An indandione-containing class of inhibitors abrogates DNA replication of human papillomavirus (HPV) types 6 and 11 by binding reversibly to the…”
Get full text

Small molecule inhibitors of the human papillomavirus E1-E2 interaction by White, Peter W, Faucher, Anne-Marie, Goudreau, Nathalie

“…Human papillomaviruses are responsible for multiple human diseases, including cervical cancer caused by multiple high-risk types and genital warts caused by…”
Get more information

Molecular Mechanism by Which a Potent Hepatitis C Virus NS3-NS4A Protease Inhibitor Overcomes Emergence of Resistance by O'Meara, Jeff A., Lemke, Christopher T., Godbout, Cédrickx, Kukolj, George, Lagacé, Lisette, Moreau, Benoît, Thibeault, Diane, White, Peter W., Llinàs-Brunet, Montse

“…Although optimizing the resistance profile of an inhibitor can be challenging, it is potentially important for improving the long term effectiveness of…”
Get full text

Human rhinovirus VPg uridylylation AlphaScreen for high-throughput screening by Gingras, Rock, Mekhssian, Kevork, Fenwick, Craig, White, Peter W, Thibeault, Diane

“…As an obligate step for picornaviruses to replicate their genome, the small viral peptide VPg must first be specifically conjugated with uridine nucleotides at…”
Get more information