Search Results - "WHITE, Morris"

Insulin action at a molecular level – 100 years of progress by White, Morris F., Kahn, C. Ronald

“…The discovery of insulin 100 years ago and its application to the treatment of human disease in the years since have marked a major turning point in the…”
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The role of hepatokines in NAFLD by Stefan, Norbert, Schick, Fritz, Birkenfeld, Andreas L., Häring, Hans-Ulrich, White, Morris F.

“…Non-alcoholic fatty liver disease (NAFLD) is not only a consequence of insulin resistance, but it is also an important cause of insulin resistance and major…”
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Targeting Forkhead box O1 from the concept to metabolic diseases: lessons from mouse models by Cheng, Zhiyong, White, Morris F

“…Forkhead box O (FOXO) transcription factors have been implicated in regulating the metabolism, cellular proliferation, stress resistance, apoptosis, and…”
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Insulin-like signaling, nutrient homeostasis, and life span by Taguchi, Akiko, White, Morris F

“…Insulin-like signaling is critical for nutrient homeostasis, growth and survival. However, work with lower metazoans-Caenorhabditis elegans and…”
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IRS proteins and diabetic complications by Lavin, Deborah P., White, Morris F., Brazil, Derek P.

“…IRS proteins are cellular adaptor molecules that mediate many of the key metabolic actions of insulin. When tyrosine is phosphorylated by the activated insulin…”
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Brain IRS2 Signaling Coordinates Life Span and Nutrient Homeostasis by Taguchi, Akiko, Wartschow, Lynn M, White, Morris F

“…Reduced insulin-like signaling extends the life span of Caenorhabditis elegans and DROSOPHILA: Here, we show that, in mice, less insulin receptor substrate-2…”
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1632-P: Effects of MTOR Signaling in Muscle-Specific Irs1/2 Knockout Mice by STOEHR, OLIVER, COPPS, KYLE D., TAO, RONGYA, WHITE, MORRIS F.

“…Disruption of Irs1 and Irs2 expression in skeletal and cardiac muscle (MDKO mice) caused death from dilated cardiomyopathy within the first 30 days of life…”
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Insulin Signaling in Health and Disease by White, Morris F.

“…The signaling pathways used by insulin have been identified [M. White, Insulin Signaling Pathway, Sci. STKE (Connections Map, as seen November 2003),…”
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G protein-coupled receptors (GPCRs) That Signal via Protein Kinase A (PKA) Cross-talk at Insulin Receptor Substrate 1 (IRS1) to Activate the phosphatidylinositol 3-kinase (PI3K)/AKT Pathway by Law, Nathan C., White, Morris F., Hunzicker-Dunn, Mary E.

“…G protein-coupled receptors (GPCRs) activate PI3K/v-AKT thymoma viral oncoprotein (AKT) to regulate many cellular functions that promote cell survival,…”
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Inactivating hepatic follistatin alleviates hyperglycemia by Tao, Rongya, Wang, Caixia, Stöhr, Oliver, Qiu, Wei, Hu, Yue, Miao, Ji, Dong, X. Charlie, Leng, Sining, Stefater, Margaret, Stylopoulos, Nicholas, Lin, Lin, Copps, Kyle D., White, Morris F.

“…Unsuppressed hepatic glucose production (HGP) contributes substantially to glucose intolerance and diabetes, which can be modeled by the genetic inactivation…”
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Insulin Receptor Substrates Irs1 and Irs2 Coordinate Skeletal Muscle Growth and Metabolism via the Akt and AMPK Pathways by Long, Yun Chau, Cheng, Zhiyong, Copps, Kyle D., White, Morris F.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Hyperglycemia induces vascular smooth muscle cell dedifferentiation by suppressing insulin receptor substrate-1–mediated p53/KLF4 complex stabilization by Xi, Gang, Shen, Xinchun, Wai, Christine, White, Morris F., Clemmons, David R.

“…Hyperglycemia and insulin resistance accelerate atherosclerosis by an unclear mechanism. The two factors down-regulate insulin receptor substrate-1 (IRS-1), an…”
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Regulation of glucose homeostasis through a XBP-1-FoxO1 interaction by Ozcan, Umut, Zhou, Yingjiang, Lee, Justin, Reno, Candace M, Sun, Cheng, Park, Sang Won, Chung, Jason, Lee, Jaemin, Fisher, Simon J, White, Morris F, Biddinger, Sudha B

“…Insulin dials down endogenous hepatic glucose production after a meal by deactivating the transcription factor FoxO1. In a mouse model of insulin resistance,…”
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IRS proteins and the common path to diabetes by White, Morris F

“…Although a full understanding of insulin/insulin-like growth factor (IGF) action is evolving, the discovery of insulin receptor substrate (IRS) proteins and…”
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Genetic inactivation of pyruvate dehydrogenase kinases improves hepatic insulin resistance induced diabetes by Tao, Rongya, Xiong, Xiwen, Harris, Robert A, White, Morris F, Dong, Xiaocheng C

“…Pyruvate dehydrogenase kinases (PDK1-4) play a critical role in the inhibition of the mitochondrial pyruvate dehydrogenase complex especially when blood…”
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Endotoxemia-mediated activation of acetyltransferase P300 impairs insulin signaling in obesity by Cao, Jia, Peng, Jinghua, An, Hongying, He, Qiyi, Boronina, Tatiana, Guo, Shaodong, White, Morris F., Cole, Philip A., He, Ling

“…Diabetes and obesity are characterized by insulin resistance and chronic low-grade inflammation. An elevated plasma concentration of lipopolysaccharide (LPS)…”
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Irs2 deficiency alters hippocampus-associated behaviors during young adulthood by Tanokashira, Daisuke, Wang, Wei, Maruyama, Megumi, Kuroiwa, Chiemi, White, Morris F., Taguchi, Akiko

“…Type 2 diabetes mellitus (T2DM), characterized by hyperglycemia and insulin resistance, has been recognized as a risk factor for cognitive impairment and…”
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Inactivation of Hepatic Foxo1 by Insulin Signaling Is Required for Adaptive Nutrient Homeostasis and Endocrine Growth Regulation by Dong, Xiaocheng C., Copps, Kyle D., Guo, Shaodong, Li, Yedan, Kollipara, Ramya, DePinho, Ronald A., White, Morris F.

“…The forkhead transcription factor Foxo1 regulates expression of genes involved in stress resistance and metabolism. To assess the contribution of Foxo1 to…”
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Regulating insulin signaling and beta-cell function through IRS proteins by White, Morris F

“…Diabetes mellitus is a complex disorder that arises from various causes, including dysregulated glucose sensing and impaired insulin secretion (maturity onset…”
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FoxO1 suppresses Fgf21 during hepatic insulin resistance to impair peripheral glucose utilization and acute cold tolerance by Stöhr, Oliver, Tao, Rongya, Miao, Ji, Copps, Kyle D., White, Morris F.

“…Fgf21 (fibroblast growth factor 21) is a regulatory hepatokine that, in pharmacologic form, powerfully promotes weight loss and glucose homeostasis. Although…”
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