Search Results - "WHITE, Lon"

Brain lesions at autopsy in older Japanese-American men as related to cognitive impairment and dementia in the final years of life: a summary report from the Honolulu-Asia aging study by White, Lon

“…This report summarizes findings from 443 autopsies on Japanese-American men followed as active participants in the Honolulu-Asia Aging Study from 1991 through…”
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If Midlife Brain Injury Is a Risk Factor for Alzheimer's Disease and Related Dementias, What Is the Neuropathologic Mechanism? by White, Lon R

“…While we know that brain injuries related to sport and military activities sometimes lead to cognitive impairment or early onset dementia, it is unclear if and…”
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Midlife alcohol consumption and later life cognitive impairment: Light drinking is not protective and APOE genotype does not change this relationship by Chosy, E Julia, Edland, Steven, Launer, Lenore, White, Lon R

“…Much debate exists about the role of light to moderate alcohol intake and subsequent cognitive function. The apolipoprotein E genotype may modify the…”
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Cognitive Impairment in Older Adults and Therapeutic Strategies by Montine, Thomas J, Bukhari, Syed A, White, Lon R

“…Cognitive impairment and its severe form dementia are increasingly prevalent in older adults and loom as a public health disaster unless effective…”
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Microinfarcts, brain atrophy, and cognitive function: The Honolulu Asia Aging Study Autopsy Study by Launer, Lenore J., Hughes, Timothy M., White, Lon R.

“…Objective: This study was untaken to investigate the association of micro brain infarcts (MBIs) with antemortem global cognitive function (CF), and whether…”
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The Honolulu-Asia Aging Study: epidemiologic and neuropathologic research on cognitive impairment by Gelber, Rebecca P, Launer, Lenore J, White, Lon R

“…The Honolulu-Asia Aging Study (HAAS) is a longitudinal epidemiologic investigation of rates, risk factors, and neuropathologic abnormalities associated with…”
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Association of Cognition and Dementia With Neuropathologic Changes of Alzheimer Disease and Other Conditions in the Oldest Old by Montine, Thomas J., Corrada, Maria M., Kawas, Claudia, Bukhari, Syed A., White, Lon R., Tian, Lu, Cholerton, Brenna

“…Age is the largest risk factor for dementia. However, dementia is not universal, even among the oldest-old age groups. Following contemporary neuropathologic…”
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Association of olfactory dysfunction with risk for future Parkinson's disease by Ross, G. Webster, Petrovitch, Helen, Abbott, Robert D., Tanner, Caroline M., Popper, Jordan, Masaki, Kamal, Launer, Lenore, White, Lon R.

“…Objective Although olfactory dysfunction is commonly associated with Parkinson's disease (PD), it is not known whether such dysfunction can predate the onset…”
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Concepts for brain aging: resistance, resilience, reserve, and compensation by Montine, Thomas J, Cholerton, Brenna A, Corrada, Maria M, Edland, Steven D, Flanagan, Margaret E, Hemmy, Laura S, Kawas, Claudia H, White, Lon R

“…A primary goal of research in cognitive impairment and dementia is to understand how some individuals retain sufficient cognitive function for a fulfilling…”
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Neuropathologic comorbidity and cognitive impairment in the Nun and Honolulu-Asia Aging Studies by White, Lon R, Edland, Steven D, Hemmy, Laura S, Montine, Kathleen S, Zarow, Chris, Sonnen, Joshua A, Uyehara-Lock, Jane H, Gelber, Rebecca P, Ross, G Webster, Petrovitch, Helen, Masaki, Kamal H, Lim, Kelvin O, Launer, Lenore J, Montine, Thomas J

“…OBJECTIVE:To examine frequencies and relationships of 5 common neuropathologic abnormalities identified at autopsy with late-life cognitive impairment and…”
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Social vulnerability and survival across levels of frailty in the Honolulu-Asia Aging Study by Armstrong, Joshua J, Andrew, Melissa K, Mitnitski, Arnold, Launer, Lenore J, White, Lon R, Rockwood, Kenneth

“…we evaluated mortality risk in relation to social vulnerability across levels of frailty among a cohort of older Japanese-American men. in secondary analysis…”
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Paradigm Shift: Multiple Potential Pathways to Neurodegenerative Dementia by Perna, Amalia, Montine, Kathleen S., White, Lon R., Montine, Thomas J., Cholerton, Brenna A.

“…Neurodegenerative dementia can result from multiple underlying abnormalities, including neurotransmitter imbalances, protein aggregation, and other neurotoxic…”
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Trends in the incidence and prevalence of Alzheimer’s disease, dementia, and cognitive impairment in the United States by Rocca, Walter A, Petersen, Ronald C, Knopman, David S, Hebert, Liesi E, Evans, Denis A, Hall, Kathleen S, Gao, Sujuan, Unverzagt, Frederick W, Langa, Kenneth M, Larson, Eric B, White, Lon R

“…Abstract Declines in heart disease and stroke mortality rates are conventionally attributed to reductions in cigarette smoking, recognition and treatment of…”
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Racial and Ethnic Differences in the Population-Attributable Fractions of Alzheimer Disease and Related Dementias by Park, Song-Yi, Setiawan, Veronica Wendy, Crimmins, Eileen M, White, Lon R, Wu, Anna H, Cheng, Iona, Darst, Burcu F, Haiman, Christopher A, Wilkens, Lynne R, Le Marchand, Loїc, Lim, Unhee

“…Previous studies estimated that modifiable risk factors explain up to 40% of the dementia cases in the United States and that this population-attributable…”
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Incident prolonged QT interval in midlife and late-life cognitive performance by Suemoto, Claudia K, Gibbons, Laura E, Thacker, Evan L, Jackson, Jonathan D, Satizabal, Claudia L, Bettcher, Brianne M, Launer, Lenore, Phillips, Caroline, White, Lon R, Power, Melinda C

“…Measures of cardiac ventricular electrophysiology have been associated with cognitive performance in cross-sectional studies. We sought to evaluate the…”
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Midlife Blood Pressure, Plasma β-Amyloid, and the Risk for Alzheimer Disease: The Honolulu Asia Aging Study by Shah, Nilay S, Vidal, Jean-Sébastien, Masaki, Kamal, Petrovitch, Helen, Ross, G Webster, Tilley, Cathy, DeMattos, Ronald B, Tracy, Russell P, White, Lon R, Launer, Lenore J

“…β-Amyloid (Aβ), a vasoactive protein, and elevated blood pressure (BP) levels are associated with Alzheimer disease (AD) and possibly vascular dementia. We…”
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Antihypertensive medication use and risk of cognitive impairment: The Honolulu-Asia Aging Study by Gelber, Rebecca P., Ross, G. Webster, Petrovitch, Helen, Masaki, Kamal H., Launer, Lenore J., White, Lon R.

“…OBJECTIVE:To determine the associations between classes of antihypertensive medication use and the risk of cognitive impairment among elderly hypertensive men…”
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Change in Blood Pressure and Incident Dementia: A 32-Year Prospective Study by Stewart, Robert, Xue, Qian-Li, Masaki, Kamal, Petrovitch, Helen, Ross, G Webster, White, Lon R, Launer, Lenore J

“…Studies of the association of high blood pressure (BP) with dementia are not consistent. Understanding long-term trajectories in blood pressure of those who do…”
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Glutathione Peroxidase 4 is associated with Neuromelanin in Substantia Nigra and Dystrophic Axons in Putamen of Parkinson's brain by Bellinger, Frederick P, Bellinger, Miyoko T, Seale, Lucia A, Takemoto, Andrea S, Raman, Arjun V, Miki, Takanori, Manning-Boğ, Amy B, Berry, Marla J, White, Lon R, Ross, G Webster

“…Parkinson's disease is a neurodegenerative disorder characterized pathologically by the loss of nigrostriatal dopamine neurons that project from the substantia…”
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Pre-motor features of Parkinson's disease: the Honolulu-Asia Aging Study experience by Ross, G. Webster, Abbott, Robert D, Petrovitch, Helen, Tanner, Caroline M, White, Lon R

“…Summary The Honolulu-Asia Aging Study is a population based prospective study of neurodegenerative and cerebrovascular diseases in 8006 Japanese-American men,…”
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