Search Results - "WHITE, H"

Validated animal models for antiseizure drug (ASD) discovery: Advantages and potential pitfalls in ASD screening by Barker-Haliski, Melissa, Steve White, H.

“…Since 1993, over 20 new anti-seizure drugs (ASDs) have been identified in well-established animal seizure and epilepsy models and subsequently demonstrated to…”
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Supporting the Health Care Transition From Adolescence to Adulthood in the Medical Home by White, Patience H, Cooley, W Carl

“…Risk and vulnerability encompass many dimensions of the transition from adolescence to adulthood. Transition from pediatric, parent-supervised health care to…”
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Glutamatergic Mechanisms Associated with Seizures and Epilepsy by Barker-Haliski, Melissa, White, H Steve

“…Epilepsy is broadly characterized by aberrant neuronal excitability. Glutamate is the predominant excitatory neurotransmitter in the adult mammalian brain;…”
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Emerging Roles of Vitamin D-Induced Antimicrobial Peptides in Antiviral Innate Immunity by White, John H

“…Vitamin D deficiency, characterized by low circulating levels of calcifediol (25-hydroxyvitamin D, 25D) has been linked to increased risk of infections of…”
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Cenobamate (XCOPRI): Can preclinical and clinical evidence provide insight into its mechanism of action? by Guignet, Michelle, Campbell, Amanda, White, H. Steve

“…Approximately one‐third of people living with epilepsy are unable to obtain seizure control with the currently marketed antiseizure medications (ASMs),…”
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Drug resistance in epilepsy by Perucca, Emilio, Perucca, Piero, White, H Steve, Wirrell, Elaine C

“…Drug resistance is estimated to affect about a third of individuals with epilepsy, but its prevalence differs in relation to the epilepsy syndrome, the cause…”
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New GABA-Targeting Therapies for the Treatment of Seizures and Epilepsy: I. Role of GABA as a Modulator of Seizure Activity and Recently Approved Medications Acting on the GABA System by Perucca, Emilio, Bialer, Meir, White, H. Steve

“…γ-Aminobutyric acid (GABA) is the most prevalent inhibitory neurotransmitter in the mammalian brain and has been found to play an important role in the…”
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Key factors in the discovery and development of new antiepileptic drugs by Bialer, Meir, White, H. Steve

“…Key Points Most available AEDs have been found to exert their anticonvulsant action through a modulatory effect on voltage- and receptor-gated ion channels…”
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Mechanisms of Integral Membrane Protein Insertion and Folding by Cymer, Florian, von Heijne, Gunnar, White, Stephen H.

“…The biogenesis, folding, and structure of α-helical membrane proteins (MPs) are important to understand because they underlie virtually all physiological…”
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Vitamin D and Immunity in Infants and Children by Mailhot, Geneviève, White, John H

“…The last couple of decades have seen an explosion in our interest and understanding of the role of vitamin D in the regulation of immunity. At the molecular…”
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The epidemiology of venous thromboembolism by White, Richard H

“…Venous thromboembolism (VTE) occurs for the first time in approximately 100 persons per 100,000 each year in the United States, and rises exponentially from <5…”
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Biophysical dissection of membrane proteins by White, Stephen H

“…The first atomic-resolution structure of a membrane protein was solved in 1985. Twenty-four years and more than 180 unique structures later, what have we have…”
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New GABA-Targeting Therapies for the Treatment of Seizures and Epilepsy: II. Treatments in Clinical Development by Perucca, Emilio, White, H. Steve, Bialer, Meir

“…The inhibitory neurotransmitter γ-aminobutyric acid (GABA) plays an important role in the modulation of neuronal excitability, and a disruption of GABAergic…”
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Skeletal and Extraskeletal Actions of Vitamin D: Current Evidence and Outstanding Questions by Bouillon, Roger, Marcocci, Claudio, Carmeliet, Geert, Bikle, Daniel, White, John H, Dawson-Hughes, Bess, Lips, Paul, Munns, Craig F, Lazaretti-Castro, Marise, Giustina, Andrea, Bilezikian, John

“…Abstract The etiology of endemic rickets was discovered a century ago. Vitamin D is the precursor of 25-hydroxyvitamin D and other metabolites, including…”
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Anticonvulsive properties of soticlestat, a novel cholesterol 24‐hydroxylase inhibitor by Nishi, Toshiya, Metcalf, Cameron S., Fujimoto, Shinji, Hasegawa, Shigeo, Miyamoto, Maki, Sunahara, Eiji, Watanabe, Sayuri, Kondo, Shinichi, White, H. Steve

“…Objective The formation of 24S‐hydroxycholesterol is a brain‐specific mechanism of cholesterol catabolism catalyzed by cholesterol 24‐hydroxylase (CYP46A1,…”
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Evaluation and Management of Youth-Onset Type 2 Diabetes: A Position Statement by the American Diabetes Association by Arslanian, Silva, Bacha, Fida, Grey, Margaret, Marcus, Marsha D, White, Neil H, Zeitler, Philip

“…Although all types of diabetes result in hyperglycemia, the pathophysiology of each type of diabetes is different. These guidelines summarize available data…”
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Role of nocturnal rostral fluid shift in the pathogenesis of obstructive and central sleep apnoea by White, Laura H., Bradley, T. Douglas

“…Obstructive sleep apnoea (OSA) is common in the general population and increases the risk of motor vehicle accidents due to hypersomnolence from sleep…”
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Vitamin D as an inducer of cathelicidin antimicrobial peptide expression: Past, present and future by White, John H.

“…Vitamin D was discovered as the preventive agent of nutritional rickets, a defect in bone development due to inadequate uptake of dietary calcium. However, a…”
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The ups and downs of alkyl‐carbamates in epilepsy therapy: How does cenobamate differ? by Löscher, Wolfgang, Sills, Graeme J., White, H. Steve

“…Since 1955, several alkyl‐carbamates have been developed for the treatment of anxiety and epilepsy, including meprobamate, flupirtine, felbamate, retigabine,…”
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Progress report on new antiepileptic drugs: A summary of the Eleventh Eilat Conference (EILAT XI) by Bialer, Meir, Johannessen, Svein I, Levy, René H, Perucca, Emilio, Tomson, Torbjörn, White, H. Steve

“…Summary The Eleventh Eilat Conference on New Antiepileptic Drugs (AEDs)-EILAT XI, took place in Eilat, Israel from the 6th to 10th of May 2012. About 100 basic…”
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