Search Results - "WHITE, Andrea J"

Diversity in medullary thymic epithelial cells controls the activity and availability of iNKT cells by Lucas, Beth, White, Andrea J., Cosway, Emilie J., Parnell, Sonia M., James, Kieran D., Jones, Nick D., Ohigashi, Izumi, Takahama, Yousuke, Jenkinson, William E., Anderson, Graham

“…The thymus supports multiple αβ T cell lineages that are functionally distinct, but mechanisms that control this multifaceted development are poorly…”
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Combined multidimensional single-cell protein and RNA profiling dissects the cellular and functional heterogeneity of thymic epithelial cells by Klein, Fabian, Veiga-Villauriz, Clara, Börsch, Anastasiya, Maio, Stefano, Palmer, Sam, Dhalla, Fatima, Handel, Adam E., Zuklys, Saulius, Calvo-Asensio, Irene, Musette, Lucas, Deadman, Mary E., White, Andrea J., Lucas, Beth, Anderson, Graham, Holländer, Georg A.

“…The network of thymic stromal cells provides essential niches with unique molecular cues controlling T cell development and selection. Recent single-cell RNA…”
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Context-Dependent Development of Lymphoid Stroma from Adult CD34+ Adventitial Progenitors by Sitnik, Katarzyna M., Wendland, Kerstin, Weishaupt, Holger, Uronen-Hansson, Heli, White, Andrea J., Anderson, Graham, Kotarsky, Knut, Agace, William W.

“…Despite the key role of primary and secondary lymphoid organ stroma in immunity, our understanding of the heterogeneity and ontogeny of these cells remains…”
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Redefining thymus medulla specialization for central tolerance by Cosway, Emilie J, Lucas, Beth, James, Kieran D, Parnell, Sonia M, Carvalho-Gaspar, Manuela, White, Andrea J, Tumanov, Alexei V, Jenkinson, William E, Anderson, Graham

“…During αβT cell development, the thymus medulla represents an essential microenvironment for T cell tolerance. This functional specialization is attributed to…”
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Failures in thymus medulla regeneration during immune recovery cause tolerance loss and prime recipients for auto-GVHD by Alawam, Abdullah S, Cosway, Emilie J, James, Kieran D, Lucas, Beth, Bacon, Andrea, Parnell, Sonia M, White, Andrea J, Jenkinson, William E, Anderson, Graham

“…Bone marrow transplantation (BMT) is a widely used therapy for blood cancers and primary immunodeficiency. Following transplant, the thymus plays a key role in…”
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Dynamic changes in intrathymic ILC populations during murine neonatal development by Jones, Rhys, Cosway, Emilie J., Willis, Claire, White, Andrea J., Jenkinson, William E., Fehling, Hans J., Anderson, Graham, Withers, David R.

“…Members of the innate lymphoid cell (ILC) family have been implicated in the development of thymic microenvironments and the recovery of this architecture…”
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An essential role for medullary thymic epithelial cells during the intrathymic development of invariant NKT cells by White, Andrea J, Jenkinson, William E, Cowan, Jennifer E, Parnell, Sonia M, Bacon, Andrea, Jones, Nick D, Jenkinson, Eric J, Anderson, Graham

“…In the thymus, interactions with both cortical and medullary microenvironments regulate the development of self-tolerant conventional CD4(+) and CD8(+) αβT…”
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The alarmin IL33 orchestrates type 2 immune-mediated control of thymus regeneration by Cosway, Emilie J., James, Kieran D., White, Andrea J., Parnell, Sonia M., Bacon, Andrea, McKenzie, Andrew N. J., Jenkinson, W. E., Anderson, Graham

“…As the primary site of T-cell development, the thymus dictates immune competency of the host. The rates of thymus function are not constant, and thymus…”
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A type 2 cytokine axis for thymus emigration by White, Andrea J, Baik, Song, Parnell, Sonia M, Holland, Amanda M, Brombacher, Frank, Jenkinson, William E, Anderson, Graham

“…In the thymus, stromal microenvironments support a developmental program that generates mature T cells ready for thymic exit. The cellular and molecular…”
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Embryonic keratin19+ progenitors generate multiple functionally distinct progeny to maintain epithelial diversity in the adult thymus medulla by Lucas, Beth, White, Andrea J., Klein, Fabian, Veiga-Villauriz, Clara, Handel, Adam, Bacon, Andrea, Cosway, Emilie J., James, Kieran D., Parnell, Sonia M., Ohigashi, Izumi, Takahama, Yousuke, Jenkinson, William E., Hollander, Georg A., Lu, Wei-Yu, Anderson, Graham

“…The thymus medulla is a key site for immunoregulation and tolerance, and its functional specialisation is achieved through the complexity of medullary thymic…”
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Developmental conversion of thymocyte-attracting cells into self-antigen-displaying cells in embryonic thymus medulla epithelium by Ohigashi, Izumi, White, Andrea J, Yang, Mei-Ting, Fujimori, Sayumi, Tanaka, Yu, Jacques, Alison, Kiyonari, Hiroshi, Matsushita, Yosuke, Turan, Sevilay, Kelly, Michael C, Anderson, Graham, Takahama, Yousuke

“…Thymus medulla epithelium establishes immune self-tolerance and comprises diverse cellular subsets. Functionally relevant medullary thymic epithelial cells…”
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Rank Signaling Links the Development of Invariant γδ T Cell Progenitors and Aire+ Medullary Epithelium by Roberts, Natalie A., White, Andrea J., Jenkinson, William E., Turchinovich, Gleb, Nakamura, Kyoko, Withers, David R., McConnell, Fiona M., Desanti, Guillaume E., Benezech, Cecile, Parnell, Sonia M., Cunningham, Adam F., Paolino, Magdalena, Penninger, Josef M., Simon, Anna Katharina, Nitta, Takeshi, Ohigashi, Izumi, Takahama, Yousuke, Caamano, Jorge H., Hayday, Adrian C., Lane, Peter J.L., Jenkinson, Eric J., Anderson, Graham

“…The thymic medulla provides a specialized microenvironment for the negative selection of T cells, with the presence of autoimmune regulator (Aire)-expressing…”
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Lymphotoxin signals from positively selected thymocytes regulate the terminal differentiation of medullary thymic epithelial cells by White, Andrea J, Nakamura, Kyoko, Jenkinson, William E, Saini, Manoj, Sinclair, Charles, Seddon, Benedict, Narendran, Parth, Pfeffer, Klaus, Nitta, Takeshi, Takahama, Yousuke, Caamano, Jorge H, Lane, Peter J L, Jenkinson, Eric J, Anderson, Graham

“…The thymic medulla represents a key site for the induction of T cell tolerance. In particular, autoimmune regulator (Aire)-expressing medullary thymic…”
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Retinoic Acid Signaling in Thymic Epithelial Cells Regulates Thymopoiesis by Wendland, Kerstin, Niss, Kristoffer, Kotarsky, Knut, Wu, Nikita Y H, White, Andrea J, Jendholm, Johan, Rivollier, Aymeric, Izarzugaza, Jose M G, Brunak, Søren, Holländer, Georg A, Anderson, Graham, Sitnik, Katarzyna M, Agace, William W

“…Despite the essential role of thymic epithelial cells (TEC) in T cell development, the signals regulating TEC differentiation and homeostasis remain…”
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Developmentally regulated availability of RANKL and CD40 ligand reveals distinct mechanisms of fetal and adult cross-talk in the thymus medulla by Desanti, Guillaume E, Cowan, Jennifer E, Baik, Song, Parnell, Sonia M, White, Andrea J, Penninger, Josef M, Lane, Peter J L, Jenkinson, Eric J, Jenkinson, William E, Anderson, Graham

“…T cell tolerance in the thymus is a key step in shaping the developing T cell repertoire. Thymic medullary epithelial cells play multiple roles in this…”
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Progressive Changes in CXCR4 Expression That Define Thymocyte Positive Selection Are Dispensable For Both Innate and Conventional αβT-cell Development by Lucas, Beth, White, Andrea J., Parnell, Sonia M., Henley, Peter M., Jenkinson, William E., Anderson, Graham

“…The ordered migration of immature thymocytes through thymic microenvironments generates both adaptive MHC restricted αβT-cells and innate CD1d-restricted…”
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Mesenchymal cells regulate retinoic acid receptor-dependent cortical thymic epithelial cell homeostasis by Sitnik, Katarzyna M, Kotarsky, Knut, White, Andrea J, Jenkinson, William E, Anderson, Graham, Agace, William W

“…The vitamin A metabolite and transcriptional modulator retinoic acid (RA) is recognized as an important regulator of epithelial cell homeostasis in several…”
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An Epithelial Progenitor Pool Regulates Thymus Growth by Jenkinson, William E, Bacon, Andrea, White, Andrea J, Anderson, Graham, Jenkinson, Eric J

“…Thymic epithelium provides an essential cellular substrate for T cell development and selection. Gradual age-associated thymic atrophy leads to a reduction in…”
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Sequential phases in the development of Aire-expressing medullary thymic epithelial cells involve distinct cellular input by White, Andrea J, Withers, David R, Parnell, Sonia M, Scott, Hamish S, Finke, Daniela, Lane, Peter J.L, Jenkinson, Eric J, Anderson, Graham

“…Intrathymic deletion of immature thymocytes that express self-reactive TCR specificities is essential in the generation of self tolerance. Medullary thymic…”
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Natural Th17 cells are critically regulated by functional medullary thymic microenvironments by Jenkinson, William E, McCarthy, Nicholas I, Dutton, Emma E, Cowan, Jennifer E, Parnell, Sonia M, White, Andrea J, Anderson, Graham

“…Abstract The thymic medulla is critical for the enforcement of central tolerance. In addition to deletion of auto-reactive T-cells, the thymic medulla supports…”
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