Search Results - "WHITAKER, Hayley C"

The evolutionary history of lethal metastatic prostate cancer by Gundem, Gunes, Van Loo, Peter, Kremeyer, Barbara, Alexandrov, Ludmil B., Tubio, Jose M. C., Papaemmanuil, Elli, Brewer, Daniel S., Kallio, Heini M. L., Högnäs, Gunilla, Annala, Matti, Kivinummi, Kati, Goody, Victoria, Latimer, Calli, O'Meara, Sarah, Dawson, Kevin J., Isaacs, William, Emmert-Buck, Michael R., Nykter, Matti, Foster, Christopher, Kote-Jarai, Zsofia, Easton, Douglas, Whitaker, Hayley C., Neal, David E., Cooper, Colin S., Eeles, Rosalind A., Visakorpi, Tapio, Campbell, Peter J., McDermott, Ultan, Wedge, David C., Bova, G. Steven

“…The subclonal composition of human prostate tumours and their metastases has been mapped by whole-genome sequencing, thus establishing the evolutionary trees…”
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Joint estimation of relaxation and diffusion tissue parameters for prostate cancer with relaxation-VERDICT MRI by Palombo, Marco, Valindria, Vanya, Singh, Saurabh, Chiou, Eleni, Giganti, Francesco, Pye, Hayley, Whitaker, Hayley C., Atkinson, David, Punwani, Shonit, Alexander, Daniel C., Panagiotaki, Eleftheria

“…This work presents a biophysical model of diffusion and relaxation MRI for prostate called relaxation vascular, extracellular and restricted diffusion for…”
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Structural basis for the nuclear import of the human androgen receptor by Cutress, Mark L, Whitaker, Hayley C, Mills, Ian G, Stewart, Murray, Neal, David E

“…Ligand-dependent nuclear import is crucial for the function of the androgen receptor (AR) in both health and disease. The unliganded AR is retained in the…”
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Prognostic and Therapeutic Impact of Argininosuccinate Synthetase 1 Control in Bladder Cancer as Monitored Longitudinally by PET Imaging by ALLEN, Michael D, PHUONG LUONG, LATTANZIO, Laura, CHMIELEWSKA-KASSASSIR, Malgorzata, TOMLINSON, Ian, ROYLANCE, Rebecca, WHITAKER, Hayley C, WARREN, Anne Y, NEAL, David, FREZZA, Christian, BELTRAN, Luis, JONES, Louise J, HUDSON, Chantelle, CHELALA, Claude, WU, Bor-Wen, BOMALASKI, John S, JACKSON, Robert C, LU, Yong-Jie, CROOK, Tim, LEMOINE, Nicholas R, MATHER, Stephen, FOSTER, Julie, SOSABOWSKI, Jane, LEYTON, Julius, AVRIL, Norbert, LI, Chien-Feng, SZLOSAREK, Peter W, DELAGE, Barbara, GHAZALY, Essam, CUTTS, Rosalind, MING YUAN, SYED, Nelofer, LO NIGRO, Cristiana

“…Targeted therapies have yet to have significant impact on the survival of patients with bladder cancer. In this study, we focused on the urea cycle enzyme…”
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Use of artificial intelligence in the detection of primary prostate cancer in multiparametric MRI with its clinical outcomes: a protocol for a systematic review and meta-analysis by Thomas, Maya, Murali, Sanjana, Simpson, Benjamin Scott S, Freeman, Alex, Kirkham, Alex, Kelly, Daniel, Whitaker, Hayley C, Zhao, Yi, Emberton, Mark, Norris, Joseph M

“…Introduction Multiparametric MRI (mpMRI) has transformed the prostate cancer diagnostic pathway, allowing for improved risk stratification and more targeted…”
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Engrailed-2 (EN2): A Tumor Specific Urinary Biomarker for the Early Diagnosis of Prostate Cancer by MORGAN, Richard, BOXALL, Angela, ANNELS, Nicola, MICHAEL, Agnieszka, PANDHA, Hardev, BHATT, Aagna, BAILEY, Michael, HINDLEY, Richard, LANGLEY, Stephen, WHITAKER, Hayley C, NEAL, David E, ISMAIL, Mohammed, WHITAKER, Hamish

“…Prostate cancer (PC) is the second most common cause of cancer related death in men. A number of key limitations with prostate specific antigen (PSA),…”
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The architecture of clonal expansions in morphologically normal tissue from cancerous and non-cancerous prostates by Buhigas, Claudia, Warren, Anne Y, Leung, Wing-Kit, Whitaker, Hayley C, Luxton, Hayley J, Hawkins, Steve, Kay, Jonathan, Butler, Adam, Xu, Yaobo, Woodcock, Dan J, Merson, Sue, Frame, Fiona M, Sahli, Atef, Abascal, Federico, Martincorena, Iñigo, Bova, G Steven, Foster, Christopher S, Campbell, Peter, Maitland, Norman J, Neal, David E, Massie, Charlie E, Lynch, Andy G, Eeles, Rosalind A, Cooper, Colin S, Wedge, David C, Brewer, Daniel S

“…Up to 80% of cases of prostate cancer present with multifocal independent tumour lesions leading to the concept of a field effect present in the normal…”
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The oncological relevance of fragile sites in cancer by Simpson, Benjamin S., Pye, Hayley, Whitaker, Hayley C.

“…Recent developments in sequencing the cancer genome have provided the first in-depth mapping of structural variants (SV) across 38 tumour types. Sixteen…”
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Co-targeting PIM and PI3K/mTOR using multikinase inhibitor AUM302 and a combination of AZD-1208 and BEZ235 in prostate cancer by Luszczak, Sabina, Simpson, Benjamin S., Stopka-Farooqui, Urszula, Sathyadevan, Vignesh Krishna, Echeverria, Lina M. Carmona, Kumar, Christopher, Costa, Helena, Haider, Aiman, Freeman, Alex, Jameson, Charles, Ratynska, Marzena, Ben-Salha, Imen, Sridhar, Ashwin, Shaw, Greg, Kelly, John D., Pye, Hayley, Gately, Kathy A., Whitaker, Hayley C., Heavey, Susan

“…PIM and PI3K/mTOR pathways are often dysregulated in prostate cancer, and may lead to decreased survival, increased metastasis and invasion. The pathways are…”
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Conditions associated with circulating tumor-associated folate receptor 1 protein in healthy men and women by Kelemen, Linda E, Brenton, James D, Parkinson, Christine, C Whitaker, Hayley, Piskorz, Anna M, Csizmadi, Ilona, Robson, Paula J

“…Serum concentrations of the tumor-associated folate receptor 1 (FOLR1) protein may be a marker for early cancer detection, yet concentrations have also been…”
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Clinical outcomes associated with prostate cancer conspicuity on biparametric and multiparametric MRI: a protocol for a systematic review and meta-analysis of biochemical recurrence following radical prostatectomy by Morka, Naomi, Simpson, Benjamin S, Ball, Rhys, Freeman, Alex, Kirkham, Alex, Kelly, Daniel, Whitaker, Hayley C, Emberton, Mark, Norris, Joseph M

“…IntroductionThere is an increasing body of evidence to suggest that visibility of prostate cancer on magnetic resonance (MRI) may be related to likelihood of…”
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Genetic Landscape of Prostate Cancer Conspicuity on Multiparametric Magnetic Resonance Imaging: A Systematic Review and Bioinformatic Analysis by Norris, Joseph M., Simpson, Benjamin S., Parry, Marina A., Allen, Clare, Ball, Rhys, Freeman, Alex, Kelly, Daniel, Kim, Hyung L., Kirkham, Alex, You, Sungyong, Kasivisvanathan, Veeru, Whitaker, Hayley C., Emberton, Mark

“…Multiparametric magnetic resonance imaging (mpMRI) detects most, but not all, clinically significant prostate cancer. The genetic basis of prostate cancer…”
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LYRIC/AEG-1 Is Targeted to Different Subcellular Compartments by Ubiquitinylation and Intrinsic Nuclear Localization Signals by THIRKETTLE, HayleyJ, GIRLING, Joanne, WARREN, Anne Y, MILLS, Ian G, SAHADEVAN, Kanagasabai, LEUNG, Hing, HAMDY, Freddie, WHITAKER, Hayley C, NEAL, David E

“…Purpose: LYRIC/AEG-1 has been reported to influence breast cancer survival and metastases, and its altered expression has been found in a number of cancers…”
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The rs10993994 risk allele for prostate cancer results in clinically relevant changes in microseminoprotein-beta expression in tissue and urine by Whitaker, Hayley C, Kote-Jarai, Zsofia, Ross-Adams, Helen, Warren, Anne Y, Burge, Johanna, George, Anne, Bancroft, Elizabeth, Jhavar, Sameer, Leongamornlert, Daniel, Tymrakiewicz, Malgorzata, Saunders, Edward, Page, Elizabeth, Mitra, Anita, Mitchell, Gillian, Lindeman, Geoffrey J, Evans, D Gareth, Blanco, Ignacio, Mercer, Catherine, Rubinstein, Wendy S, Clowes, Virginia, Douglas, Fiona, Hodgson, Shirley, Walker, Lisa, Donaldson, Alan, Izatt, Louise, Dorkins, Huw, Male, Alison, Tucker, Kathy, Stapleton, Alan, Lam, Jimmy, Kirk, Judy, Lilja, Hans, Easton, Douglas, Cooper, Colin, Eeles, Rosalind, Neal, David E

“…Microseminoprotein-beta (MSMB) regulates apoptosis and using genome-wide association studies the rs10993994 single nucleotide polymorphism in the MSMB promoter…”
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Which Prostate Cancers are Undetected by Multiparametric Magnetic Resonance Imaging in Men with Previous Prostate Biopsy? An Analysis from the PICTURE Study by Norris, Joseph M., Simmons, Lucy A.M., Kanthabalan, Abi, Freeman, Alex, McCartan, Neil, Moore, Caroline M., Punwani, Shonit, Whitaker, Hayley C., Emberton, Mark, Ahmed, Hashim U.

“…Multiparametric magnetic resonance imaging (mpMRI) has improved risk stratification for suspected prostate cancer in patients following prior biopsy. However,…”
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Exploring Patient Views and Acceptance of Multiparametric Magnetic Resonance Imaging for the Investigation of Suspected Prostate Cancer (the PACT Study): A Mixed-Methods Study Protocol by Norris, Joseph M, Kasivisvanathan, Veeru, Allen, Clare, Ball, Rhys, Freeman, Alex, Ghei, Maneesh, Kirkham, Alex, Whitaker, Hayley C, Kelly, Daniel, Emberton, Mark

“…The introduction of multiparametric magnetic resonance imaging (mpMRI) has improved the diagnosis of suspected prostate cancer, accurately risk-stratifying men…”
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A Modified Newcastle-Ottawa Scale for Assessment of Study Quality in Genetic Urological Research by Norris, Joseph M., Simpson, Benjamin S., Ball, Rhys, Freeman, Alex, Kirkham, Alex, Parry, Marina A., Moore, Caroline M., Whitaker, Hayley C., Emberton, Mark

“…Our modification of the traditional Newcastle-Ottawa scale enables urological researchers to effectively appraise and communicate the quality of genetic-based…”
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Analysis of the genetic phylogeny of multifocal prostate cancer identifies multiple independent clonal expansions in neoplastic and morphologically normal prostate tissue by Cooper, Colin S, Eeles, Rosalind, Wedge, David C, Van Loo, Peter, Gundem, Gunes, Alexandrov, Ludmil B, Kremeyer, Barbara, Butler, Adam, Lynch, Andrew G, Camacho, Niedzica, Massie, Charlie E, Kay, Jonathan, Luxton, Hayley J, Edwards, Sandra, Kote-Jarai, Zsofia, Dennis, Nening, Merson, Sue, Leongamornlert, Daniel, Zamora, Jorge, Corbishley, Cathy, Thomas, Sarah, Nik-Zainal, Serena, Ramakrishna, Manasa, O'Meara, Sarah, Matthews, Lucy, Clark, Jeremy, Hurst, Rachel, Mithen, Richard, Bristow, Robert G, Boutros, Paul C, Fraser, Michael, Cooke, Susanna, Raine, Keiran, Jones, David, Menzies, Andrew, Stebbings, Lucy, Hinton, Jon, Teague, Jon, McLaren, Stuart, Mudie, Laura, Hardy, Claire, Anderson, Elizabeth, Joseph, Olivia, Goody, Victoria, Robinson, Ben, Maddison, Mark, Gamble, Stephen, Greenman, Christopher, Berney, Dan, Hazell, Steven, Livni, Naomi, Fisher, Cyril, Ogden, Christopher, Kumar, Pardeep, Thompson, Alan, Woodhouse, Christopher, Nicol, David, Mayer, Erik, Dudderidge, Tim, Shah, Nimish C, Gnanapragasam, Vincent, Voet, Thierry, Campbell, Peter, Futreal, Andrew, Easton, Douglas, Warren, Anne Y, Foster, Christopher S, Stratton, Michael R, Whitaker, Hayley C, McDermott, Ultan, Brewer, Daniel S, Neal, David E

“…Colin Cooper and colleagues report genome-wide sequences of multiple samples of multifocal cancer and morphologically normal tissue from the prostates of three…”
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ssVERDICT: Self-supervised VERDICT-MRI for enhanced prostate tumor characterization by Sen, Snigdha, Singh, Saurabh, Pye, Hayley, Moore, Caroline M, Whitaker, Hayley C, Punwani, Shonit, Atkinson, David, Panagiotaki, Eleftheria, Slator, Paddy J

“…Demonstrating and assessing self-supervised machine-learning fitting of the VERDICT (vascular, extracellular and restricted diffusion for cytometry in tumors)…”
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Mutational signatures of ionizing radiation in second malignancies by Behjati, Sam, Gundem, Gunes, Wedge, David C., Roberts, Nicola D., Tarpey, Patrick S., Cooke, Susanna L., Van Loo, Peter, Alexandrov, Ludmil B., Ramakrishna, Manasa, Davies, Helen, Nik-Zainal, Serena, Hardy, Claire, Latimer, Calli, Raine, Keiran M., Stebbings, Lucy, Menzies, Andy, Jones, David, Shepherd, Rebecca, Butler, Adam P., Teague, Jon W., Jorgensen, Mette, Khatri, Bhavisha, Pillay, Nischalan, Shlien, Adam, Futreal, P. Andrew, Badie, Christophe, McDermott, Ultan, Bova, G. Steven, Richardson, Andrea L., Flanagan, Adrienne M., Stratton, Michael R., Campbell, Peter J.

“…Ionizing radiation is a potent carcinogen, inducing cancer through DNA damage. The signatures of mutations arising in human tissues following in vivo exposure…”
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