Search Results - "WHIRLEDGE, Shannon"

Glucocorticoids and Reproduction: Traffic Control on the Road to Reproduction by Whirledge, Shannon, Cidlowski, John A

“…Glucocorticoids are steroid hormones that regulate diverse cellular functions and are essential to facilitate normal physiology. However, stress-induced levels…”
Get full text

Glucocorticoid Signaling in Health and Disease: Insights From Tissue-Specific GR Knockout Mice by Whirledge, Shannon, DeFranco, Donald B

“…Abstract Glucocorticoids are adrenally produced hormones critically involved in development, general physiology, and control of inflammation. Since their…”
Get full text

Stress and the HPA Axis: Balancing Homeostasis and Fertility by Joseph, Dana N, Whirledge, Shannon

“…An organism's reproductive fitness is sensitive to the environment, integrating cues of resource availability, ecological factors, and hazards within its…”
Get full text

A Role for Glucocorticoids in Stress-Impaired Reproduction: Beyond the Hypothalamus and Pituitary by Whirledge, Shannon, Cidlowski, John A

“…In addition to the well-characterized role of the sex steroid receptors in regulating fertility and reproduction, reproductive events are also mediated by the…”
Get full text

Decidualization dampens toll-like receptor mediated inflammatory responses in human endometrial stromal cells by upregulating IκBα by Tong, Mancy, Scott, Jacy N., Whirledge, Shannon D., Abrahams, Vikki M.

“…Endometrial stromal cells (EnSCs) are the major cell type of the human endometrium and they undergo dramatic differentiation, termed decidualization, every…”
Get full text

Uterine glucocorticoid receptors are critical for fertility in mice through control of embryo implantation and decidualization by Whirledge, Shannon D., Oakley, Robert H., Myers, Page H., Lydon, John P., DeMayo, Francesco, Cidlowski, John A.

“…In addition to thewell-characterized role of the sex steroid receptors in fertility and reproduction, organs of the female reproductive tract are also…”
Get full text

Gene X environment: the cellular environment governs the transcriptional response to environmental chemicals by Burman, Andreanna, Garcia-Milian, Rolando, Whirledge, Shannon

“…An individual's response to environmental exposures varies depending on their genotype, which has been termed the gene-environment interaction. The phenotype…”
Get full text

Determining the endocrine disruption potential of industrial chemicals using an integrative approach: Public databases, in vitro exposure, and modeling receptor interactions by Alofe, Olubusayo, Kisanga, Edwina, Inayat-Hussain, Salmaan H., Fukumura, Masao, Garcia-Milian, Rolando, Perera, Lalith, Vasiliou, Vasilis, Whirledge, Shannon

“…Environmental and occupational exposure to industrial chemicals has been linked to toxic and carcinogenic effects in animal models and human studies. However,…”
Get full text

TNF-α Regulated Endometrial Stroma Secretome Promotes Trophoblast Invasion by You, Yuan, Stelzl, Patrick, Joseph, Dana N, Aldo, Paulomi B, Maxwell, Anthony J, Dekel, Nava, Liao, Aihua, Whirledge, Shannon, Mor, Gil

“…Successful implantation requires the coordinated migration and invasion of trophoblast cells from out of the blastocyst and into the endometrium. This process…”
Get full text

Neonatal Genistein Exposure and Glucocorticoid Signaling in the Adult Mouse Uterus by Whirledge, Shannon D, Kisanga, Edwina P, Oakley, Robert H, Cidlowski, John A

“…Female reproductive tract development is sensitive to the endocrine-disrupting potential of environmental estrogens. Early-life exposure to the dietary…”
Get full text

Ghrelin partially protects against cisplatin-induced male murine gonadal toxicity in a GHSR-1a-dependent manner by Whirledge, Shannon D, Garcia, Jose M, Smith, Roy G, Lamb, Dolores J

“…The chemotherapeutic drug cisplatin causes a number of dose-dependent side effects, including cachexia and testicular damage. Patients receiving a high…”
Get full text

Combinatorial actions of glucocorticoid and mineralocorticoid stress hormone receptors are required for preventing neurodegeneration of the mouse hippocampus by Oakley, Robert H., Whirledge, Shannon D., Petrillo, Maria G., Riddick, Natallia V., Xu, Xiaojiang, Moy, Sheryl S., Cidlowski, John A.

“…Chronic stress contributes to numerous human pathologies including cognition impairments and psychiatric disorders. Glucocorticoids are primary stress hormones…”
Get full text

Generating diversity in human glucocorticoid signaling through a racially diverse polymorphism in the beta isoform of the glucocorticoid receptor by Whirledge, Shannon D, Jewell, Christine M, Barber, Lisa M, Xu, Xiaojiang, Katen, Kevin S, Garantziotis, Stavros, Cidlowski, John A

“…Alternative splicing of the human glucocorticoid receptor gene generates two isoforms, hGRα and hGRβ . hGR β functions as a dominant-negative regulator of hGR…”
Get full text

Deletion of hippocampal Glucocorticoid receptors unveils sex-biased microRNA expression and neuronal morphology alterations in mice by Tejos-Bravo, Macarena, Oakley, Robert H., Whirledge, Shannon D., Corrales, Wladimir A., Silva, Juan P., García-Rojo, Gonzalo, Toledo, Jorge, Sanchez, Wendy, Román-Albasini, Luciano, Aliaga, Esteban, Aguayo, Felipe, Olave, Felipe, Maracaja-Coutinho, Vinicius, Cidlowski, John A., Fiedler, Jenny L.

“…Sex differences in the brain have prompted many researchers to investigate the underlying molecular actors, such as the glucocorticoid receptor (GR). This…”
Get full text

Ghrelin Partially Protects Against Cisplatin-Induced Male Murine Gonadal Toxicity in a GHSR-1a-Dependent Manner1 by Whirledge, Shannon D, Garcia, Jose M, Smith, Roy G, Lamb, Dolores J

“…The chemotherapeutic drug cisplatin causes a number of dose-dependent side effects, including cachexia and testicular damage. Patients receiving a high…”
Get full text

In Silico Exploration of the Potential Role of Acetaminophen and Pesticides in the Etiology of Autism Spectrum Disorder by Furnary, Tristan, Garcia-Milian, Rolando, Liew, Zeyan, Whirledge, Shannon, Vasiliou, Vasilis

“…Recent epidemiological studies suggest that prenatal exposure to acetaminophen (APAP) is associated with increased risk of Autism Spectrum Disorder (ASD), a…”
Get full text

Updates on molecular and environmental determinants of luteal progesterone production by DeWitt, Natalie A., Whirledge, Shannon, Kallen, Amanda N.

“…Progesterone, a critical hormone in reproduction, is a key sex steroid in the establishment and maintenance of early pregnancy and serves as an intermediary…”
Get full text

LOCAL ACTIVATION OF GLUCOCORTICOID SIGNALING IN UTERINE FIBROID CELLS DRIVES GROWTH by Glenn, Tanya L., Silva, Erin, Suarez, Pablo, Flannery, Clare, Whirledge, Shannon

Get full text

Estradiol Antagonism of Glucocorticoid-Induced GILZ Expression in Human Uterine Epithelial Cells and Murine Uterus by Whirledge, Shannon, Cidlowski, John A

“…Sex hormone signaling regulates a variety of functions in the uterine endometrium essential for embryo implantation and immunity. Epithelial cells of the…”
Get full text

Antiphospholipid antibodies increase endometrial stromal cell decidualization, senescence and inflammation via TLR4, ROS and p38 MAP kinase signaling by Tong, Mancy, Kayani, Teimur, Jones, Deidre M, Salmon, Jane E, Whirledge, Shannon, Chamley, Lawrence W, Abrahams, Vikki M

Get full text