Search Results - "WHEELER, CARL"

Effect of “helper lipid” on lipoplex electrostatics by Hirsch-Lerner, Danielle, Zhang, Ming, Eliyahu, Hagit, Ferrari, Marylin E., Wheeler, Carl J., Barenholz, Yechezkel

“…Lipoplexes, which are complexes between cationic liposomes (L +) and nucleic acids, are commonly used as a nucleic acid delivery system in vitro and in vivo…”
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Improved Immunogenicity and Protective Efficacy of a Tuberculosis DNA Vaccine Encoding Ag85 by Protein Boosting by TANGHE, Audrey, D'SOUZA, Sushila, ROSSEELS, Valérie, DENIS, Olivier, OTTENHOFF, Thomas H. M, DALEMANS, Wilfried, WHEELER, Carl, HUYGEN, Kris

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Electroporation-Facilitated Delivery of Plasmid DNA in Skeletal Muscle: Plasmid Dependence of Muscle Damage and Effect of Poloxamer 188 by Hartikka, Jukka, Sukhu, Loretta, Buchner, Carol, Hazard, Diane, Bozoukova, Vesselina, Margalith, Michal, Nishioka, Walter K., Wheeler, Carl J., Manthorp, Marston, Sawdey, Michael

“…Electroporation has been reported to facilitate naked DNA gene transfer in skeletal muscle, but has also been implicated in the pathogenesis of electrical…”
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Vaxfectin enhances the humoral immune response to plasmid DNA-encoded antigens by Hartikka, Jukka, Bozoukova, Vesselina, Ferrari, Marilyn, Sukhu, Loretta, Enas, Joel, Sawdey, Michael, Wloch, Mary K, Tonsky, Katja, Norman, Jon, Manthorpe, Marston, Wheeler, Carl J

“…This report characterizes Vaxfectin, a novel cationic and neutral lipid formulation which enhances antibody responses when complexed with an antigen-encoding…”
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A Novel Cationic Lipid Greatly Enhances Plasmid DNA Delivery and Expression in Mouse Lung by Wheeler, Carl J., Felgner, Philip L., Tsai, Yali J., Marshall, John, Sukhu, Loretta, Doh, Soeun G., Hartikka, Jukka, Nietupski, Jennifer, Manthorpe, Marston, Nichols, Margaret, Plewe, Michael, Liang, Xiaowu, Norman, Jon, Smith, Alan, Cheng, Seng H.

“…Effective gene therapy for lung tissue requires the use of efficient vehicles to deliver the gene of interest into lung cells. When plasmid DNA encoding…”
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Synergy between cationic lipid and co-lipid determines the macroscopic structure and transfection activity of lipoplexes by Ferrari, Marilyn E., Rusalov, Denis, Enas, Joel, Wheeler, Carl J.

“…The large number of cytofectin and co-lipid combinations currently used for lipoplex-mediated gene delivery reflects the fact that the optimal…”
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Trends in lipoplex physical properties dependent on cationic lipid structure, vehicle and complexation procedure do not correlate with biological activity by Ferrari, M E, Rusalov, D, Enas, J, Wheeler, C J

“…Using a group of structurally related cytofectins, the effects of different vehicle constituents and mixing techniques on the physical properties and…”
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Vaxfectin enhances antigen specific antibody titers and maintains Th1 type immune responses to plasmid DNA immunization by Reyes, Luane, Hartikka, Jukka, Bozoukova, Vesselina, Sukhu, Loretta, Nishioka, Walter, Singh, Gita, Ferrari, Marilyn, Enas, Joel, Wheeler, Carl J, Manthorpe, Marston, Wloch, Mary K

“…Antigen specific immune responses were characterized after intramuscular immunization of BALB/c mice with 5 antigen encoding plasmid DNAs (pDNAs) complexed…”
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Improved cationic lipid formulations for in vivo gene therapy by Felgner, P L, Tsai, Y J, Sukhu, L, Wheeler, C J, Manthorpe, M, Marshall, J, Cheng, S H

“…The problem of assessing in vivo activity of gene delivery systems is complex. The reporter gene must be carefully chosen depending on the application…”
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Enhancing effect of vaxfectin on the ability of a Japanese encephalitis DNA vaccine to induce neutralizing antibody in mice by Nukuzuma, Chiyoko, Ajiro, Naoko, Wheeler, Carl J, Konishi, Eiji

“…Vaxfectin, a recently developed adjuvant, was evaluated for its enhancing effect on immunogenicity of a Japanese encephalitis (JE) DNA vaccine plasmid encoding…”
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Cationic liposome-mediated gene transfer to rat salivary epithelial cells in vitro and in vivo by Baccaglini, Lorena, Shamsul Hoque, A. T. M., Wellner, Robert B., Goldsmith, Corinne M., Redman, Robert S., Sankar, Vidya, Kingman, Albert, Barnhart, Kerry M., Wheeler, Carl J., Baum, Bruce J.

“…Background Previously we have shown that gene transfer to salivary gland epithelial cells readily occurs via recombinant adenoviruses, although the response is…”
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A new cationic liposome DNA complex enhances the efficiency of arterial gene transfer in vivo by Stephan, D J, Yang, Z Y, San, H, Simari, R D, Wheeler, C J, Felgner, P L, Gordon, D, Nabel, G J, Nabel, E G

“…An important goal of gene therapy for cardiovascular diseases and cancer is the development of effective vectors for catheter-based gene delivery. Although…”
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Photochemical transfection: a technology for efficient light-directed gene delivery by Høgset, Anders, Prasmickaite, Lina, Hellum, Marit, Engesaeter, Birgit O, Olsen, Vibeke M, Tjelle, Torunn E, Wheeler, Carl J, Berg, Kristian

“…Most synthetic gene delivery vectors are taken up in the cell by endocytosis, and inefficient escape of the transgene from endocytic vesicles often is a major…”
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Phase Behavior, DNA Ordering, and Size Instability of Cationic Lipoplexes by Simberg, Dmitri, Danino, Dganit, Talmon, Yeshayahu, Minsky, Abraham, Ferrari, Marilyn E., Wheeler, Carl J., Barenholz, Yechezkel

“…Mechanisms of cationic lipid-based nucleic acid delivery are receiving increasing attention, but despite this the factors that determine high or low activity…”
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Phase behavior, DNA ordering, and size instability of cationic lipoplexes. Relevance to optimal transfection activity by Simberg, D, Danino, D, Talmon, Y, Minsky, A, Ferrari, M E, Wheeler, C J, Barenholz, Y

“…Mechanisms of cationic lipid-based nucleic acid delivery are receiving increasing attention, but despite this the factors that determine high or low activity…”
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Tissue distribution of the cytofectin component of a plasmid-DNA/cationic lipid complex following intravenous administration in mice by Parker, S E, Ducharme, S, Norman, J, Wheeler, C J

“…Allovectin-7 is a gene therapy agent that consists of plasmid DNA (pDNA) encoding the human HLA-B7 class I and beta2-microglobulin genes (VCL-1005), complexed…”
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Isotopically sensitive branching in the formation of cyclic monoterpenes: proof that (-)-.alpha.-pinene and (-)-.beta.-pinene are synthesized by the same monoterpene cyclase via deprotonation of a common intermediate by Croteau, Rodney B, Wheeler, Carl J, Cane, David E, Ebert, Roxanne, Ha, Hyun Joon

“…To determine whether the bicyclic monoterpene olefins (-)-alpha-pinene and (-)-beta-pinene arise biosynthetically from the same monoterpene cyclase by…”
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Cationic liposome-mediated gene transfer to rat salivary epithelial cellsin vitro andin vivo by Baccaglini, Lorena, Shamsul Hoque, A. T. M., Wellner, Robert B., Goldsmith, Corinne M., Redman, Robert S., Sankar, Vidya, Kingman, Albert, Barnhart, Kerry M., Wheeler, Carl J., Baum, Bruce J.

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Enhanced gene delivery and mechanism studies with a novel series of cationic lipid formulations by FELGNER, J. H, RAJ KUMAR, SRIDHAR, C. N, WHEELER, C. J, TSAI, Y. J, BORDER, R, RAMSEY, P, MARTIN, M, FELGNER, P. L

“…The application of cationic liposome reagents has advanced DNA and mRNA transfection research in vitro, and data are accumulating which show their utility for…”
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Total synthesis of frustulosin and aurocitrin by Ronald, Robert C, Lansinger, Janet M, Lillie, Thomas S, Wheeler, Carl J

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