Search Results - "WHEADON, HELEN"

The application of BH3 mimetics in myeloid leukemias by Parry, Narissa, Wheadon, Helen, Copland, Mhairi

“…Execution of the intrinsic apoptotic pathway is controlled by the BCL-2 proteins at the level of the mitochondrial outer membrane (MOM). This family of…”
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Using topic modeling to detect cellular crosstalk in scRNA-seq by Pancheva, Alexandrina, Wheadon, Helen, Rogers, Simon, Otto, Thomas D

“…Cell-cell interactions are vital for numerous biological processes including development, differentiation, and response to inflammation. Currently, most…”
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CD93 is expressed on chronic myeloid leukemia stem cells and identifies a quiescent population which persists after tyrosine kinase inhibitor therapy by Kinstrie, Ross, Horne, Gillian A., Morrison, Heather, Irvine, David, Munje, Chinmay, Castañeda, Eduardo Gómez, Moka, Hothri A., Dunn, Karen, Cassels, Jennifer E., Parry, Narissa, Clarke, Cassie J., Scott, Mary T., Clark, Richard E., Holyoake, Tessa L., Wheadon, Helen, Copland, Mhairi

“…The introduction of BCR-ABL tyrosine kinase inhibitors has revolutionized the treatment of chronic myeloid leukemia (CML). A major clinical aim remains the…”
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Overcoming BCR::ABL1 dependent and independent survival mechanisms in chronic myeloid leukaemia using a multi-kinase targeting approach by Busch, Caroline, Mulholland, Theresa, Zagnoni, Michele, Dalby, Matthew, Berry, Catherine, Wheadon, Helen

“…Despite improved patient outcome using tyrosine kinase inhibitors (TKIs), chronic myeloid leukaemia (CML) patients require life-long treatment due to leukaemic…”
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PB2475: SECRETED FACTORS FROM BONE MARROW‐DERIVED FIBROBLASTS PROTECT AML CELLS AGAINST APOPTOSIS MEDIATED BY A NOVEL CDK/MCL‐1 INHIBITOR VIA STAT3/MCL‐1 SIGNALLING by Miari, Katerina, Guzman, Monica, Wheadon, Helen, Williams, Mark

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Bioengineered niches that recreate physiological extracellular matrix organisation to support long-term haematopoietic stem cells by Donnelly, Hannah, Ross, Ewan, Xiao, Yinbo, Hermantara, Rio, Taqi, Aqeel F., Doherty-Boyd, W. Sebastian, Cassels, Jennifer, Tsimbouri, Penelope. M., Dunn, Karen M., Hay, Jodie, Cheng, Annie, Meek, R. M. Dominic, Jain, Nikhil, West, Christopher, Wheadon, Helen, Michie, Alison M., Peault, Bruno, West, Adam G., Salmeron-Sanchez, Manuel, Dalby, Matthew J.

“…Long-term reconstituting haematopoietic stem cells (LT-HSCs) are used to treat blood disorders via stem cell transplantation. The very low abundance of LT-HSCs…”
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Macrophages in Acute Myeloid Leukaemia: Significant Players in Therapy Resistance and Patient Outcomes by Miari, Katerina E., Guzman, Monica L., Wheadon, Helen, Williams, Mark T. S.

“…Acute Myeloid Leukaemia (AML) is a commonly occurring severe haematological malignancy, with most patients exhibiting sub-optimal clinical outcomes. Therapy…”
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Leukaemia exposure alters the transcriptional profile and function of BCR::ABL1 negative macrophages in the bone marrow niche by Dawson, Amy, Zarou, Martha M., Prasad, Bodhayan, Bittencourt-Silvestre, Joana, Zerbst, Désirée, Himonas, Ekaterini, Hsieh, Ya-Ching, van Loon, Isabel, Blanco, Giovanny Rodriguez, Ianniciello, Angela, Kerekes, Zsombor, Krishnan, Vaidehi, Agarwal, Puneet, Almasoudi, Hassan, McCluskey, Laura, Hopcroft, Lisa E. M., Scott, Mary T., Baquero, Pablo, Dunn, Karen, Vetrie, David, Copland, Mhairi, Bhatia, Ravi, Coffelt, Seth B., Tiong, Ong Sin, Wheadon, Helen, Zanivan, Sara, Kirschner, Kristina, Helgason, G. Vignir

“…Macrophages are fundamental cells of the innate immune system that support normal haematopoiesis and play roles in both anti-cancer immunity and tumour…”
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Regulation of Embryonic Stem Cell Self-renewal by Phosphoinositide 3-Kinase-dependent Signaling by Paling, Nicholas R D, Wheadon, Helen, Bone, Heather K, Welham, Melanie J

“…The maintenance of murine embryonic stem (ES) cell self-renewal is regulated by leukemia inhibitory factor (LIF)-dependent activation of signal transducer and…”
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Canonical Wnt signaling promotes early hematopoietic progenitor formation and erythroid specification during embryonic stem cell differentiation by Tarafdar, Anuradha, Dobbin, Edwina, Corrigan, Pamela, Freeburn, Robin, Wheadon, Helen

“…The generation of hematopoietic stem cells (HSCs) during development is a complex process linked to morphogenic signals. Understanding this process is…”
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P433: PHARMACOLOGICAL DUAL INHIBITION OF PARP AND TIP60 AS A PROSPECTIVE THERAPEUTIC REGIMEN INDUCES SYNERGISTIC AML CELL DEATH by Ju Park, Tae, Wheadon, Helen, Monaghan, Laura, Huang, Xu, Jorgensen, Heather

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Magnetically levitated mesenchymal stem cell spheroids cultured with a collagen gel maintain phenotype and quiescence by Lewis, Natasha S, Lewis, Emily EL, Mullin, Margaret, Wheadon, Helen, Dalby, Matthew J, Berry, Catherine C

“…Multicellular spheroids are an established system for three-dimensional cell culture. Spheroids are typically generated using hanging drop or non-adherent…”
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BH3 mimetics in combination with nilotinib or ponatinib represent a promising therapeutic strategy in blast phase chronic myeloid leukemia by Parry, Narissa, Busch, Caroline, Aßmann, Victoria, Cassels, Jennifer, Hair, Alan, Helgason, G. Vignir, Wheadon, Helen, Copland, Mhairi

“…Dysregulation of the BCL-2 family is implicated in protecting chronic myeloid leukemia (CML) cells from intracellular damage and BCR::ABL1-inhibition with…”
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P1350: M2‐LIKE MONOCYTE‐DERIVED MACROPHAGES PROTECT AML CELL LINES AND PRIMARY AML CELLS AGAINST THERAPY‐INDUCED APOPTOSIS by Miari, Katerina, Papadopoulou, Athanasia, Martinez, Leandro, Campbell, Victoria, Goodyear, Carl, Wheadon, Helen, Guzman, Monica, Williams, Mark

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Interrogation of novel CDK2/9 inhibitor fadraciclib (CYC065) as a potential therapeutic approach for AML by Chantkran, Wittawat, Hsieh, Ya-Ching, Zheleva, Daniella, Frame, Sheelagh, Wheadon, Helen, Copland, Mhairi

“…Over the last 50 years, there has been a steady improvement in the treatment outcome of acute myeloid leukemia (AML). However, median survival in the elderly…”
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Targeting self-renewal pathways in myeloid malignancies by Sands, William A, Copland, Mhairi, Wheadon, Helen

“…A fundamental property of hematopoietic stem cells (HSCs) is the ability to self-renew. This is a complex process involving multiple signal transduction…”
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Acute Loss of Cited2 Impairs Nanog Expression and Decreases Self‐Renewal of Mouse Embryonic Stem Cells by Kranc, Kamil R., Oliveira, Daniel V., Armesilla-Diaz, Alejandro, Pacheco-Leyva, Ivette, Catarina Matias, Ana, Luisa Escapa, Ana, Subramani, Chithra, Wheadon, Helen, Trindade, Marlene, Nichols, Jennifer, Kaji, Keisuke, Enver, Tariq, Bragança, José

“…Identifying novel players of the pluripotency gene regulatory network centered on Oct4, Sox2, and Nanog as well as delineating the interactions within the…”
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Correction to: Interrogation of novel CDK2/9 inhibitor fadraciclib (CYC065) as a potential therapeutic approach for AML by Chantkran, Wittawat, Hsieh, Ya-Ching, Zheleva, Daniella, Frame, Sheelagh, Wheadon, Helen, Copland, Mhairi

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Patterns of Wnt/Fzd/LRP gene expression during embryonic hematopoiesis by Corrigan, Pamela M, Dobbin, Edwina, Freeburn, Robin W, Wheadon, Helen

“…Wnt signaling plays several roles in hematopoiesis, promoting hemopoietic stem cell (HSC) self-renewal, providing proliferative signals for immature…”
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Micro‐environment alterations through time leading to myeloid malignancies by Nyamondo, Kudzai, Wheadon, Helen

“…The micro‐environment plays a critical role in haematopoietic stem cell (HSC) development, self‐renewal, differentiation and maintenance by providing a…”
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