Search Results - "WETZEL, Marie"

SAR650984, A Novel Humanized CD38-Targeting Antibody, Demonstrates Potent Antitumor Activity in Models of Multiple Myeloma and Other CD38+ Hematologic Malignancies by DECKERT, Jutta, WETZEL, Marie-Cécile, DUMONTET, Charles, PLESA, Adriana, CHIRON, Marielle, LEJEUNE, Pascale, CHITTENDEN, Thomas, PARK, Peter U, BLANC, Véronique, BARTLE, Laura M, SKALETSKAYA, Anna, GOLDMACHER, Victor S, VALLEE, François, QING, Zhou-Liu, FERRARI, Paul, POUZIEUX, Stéphanie, LAHOUTE, Charlotte

“…The CD38 cell surface antigen is expressed in diverse hematologic malignancies including multiple myeloma, B-cell non-Hodgkin lymphoma (NHL), B-cell chronic…”
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SAR650984: A Potent Anti-CD38 Therapeutic Antibody with Three Mechanisms of Action (Apoptosis, ADCC, CDC) for Hematological Malignancies by Park, Peter U., Blanc, Véronique, Deckert, Jutta, Lejeune, Pascale, Bartle, Laura M., Skaletskaya, Anna, Mayo, Michele F., Zhang, Chonghui, Wetzel, Marie-Cécile, Tavares, Daniel J., Lutz, Robert J., Chittenden, Thomas, Bissery, Marie-Christine, Lambert, John M., Goldmacher, Victor S.

“…CD38 is a promising target for antibody therapeutics for the treatment of various hematological malignancies, including multiple myeloma as well as…”
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Coniosetin, a novel tetramic acid antibiotic from Coniochaeta ellipsoidea DSM 13856 by Segeth, Marian Paul, Bonnefoy, Alain, Brönstrup, Mark, Knauf, Martin, Schummer, Dietmar, Toti, Luigi, Vértesy, László, Wetzel-Raynal, Marie-Cécile, Wink, Joachim, Seibert, Gerhard

“…The coprophilic ascomycete Coniochaeta ellipsoidea DSM 13856 forms the new antibiotic coniosetin (1) in surface cultures grown on a medium containing malt…”
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Investigating the Plasma Pharmacokinetics of Oral Capecitabine Chemotherapy in Carcinoma-Bearing Dogs by Wetzel, Sarah Marie

“…Canine malignant cancers are a devastating reality to many pet owners. Oral chemotherapy has become increasingly popular as a treatment option due to many…”
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17β-Hydroxysteroid dehydrogenases (17β-HSDs) as therapeutic targets: Protein structures, functions, and recent progress in inhibitor development by Marchais-Oberwinkler, Sandrine, Henn, Claudia, Möller, Gabriele, Klein, Tobias, Negri, Matthias, Oster, Alexander, Spadaro, Alessandro, Werth, Ruth, Wetzel, Marie, Xu, Kuiying, Frotscher, Martin, Hartmann, Rolf W., Adamski, Jerzy

“…17β-Hydroxysteroid dehydrogenases (17β-HSDs) are oxidoreductases, which play a key role in estrogen and androgen steroid metabolism by catalyzing final steps…”
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Epiphyseal lymphoid infiltrates of the knee in adolescents by Urbanschitz, Lukas, Agten, Christoph Amadeus, Bühler, Marco Matteo, Wetzel, Marie Sarah, Müller, Daniel Andreas

“…We present three adolescents with focal lesions of the distal femur that were shown to be benign aggregates of small lymphocytes and plasma cells of unknown…”
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17 beta -HSD2 inhibitors for the treatment of osteoporosis: Identification of a promising scaffold by Wetzel, Marie, Marchais-Oberwinkler, Sandrine, Hartmann, Rolf W

“…17 beta -Hydroxysteroid dehydrogenase type 2 (17 beta -HSD2) catalyses the conversion of active 17 beta -hydroxysteroids into the less active 17-ketosteroids…”
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New Drug-Like Hydroxyphenylnaphthol Steroidomimetics As Potent and Selective 17β-Hydroxysteroid Dehydrogenase Type 1 Inhibitors for the Treatment of Estrogen-Dependent Diseases by Marchais-Oberwinkler, Sandrine, Wetzel, Marie, Ziegler, Erika, Kruchten, Patricia, Werth, Ruth, Henn, Claudia, Hartmann, Rolf W, Frotscher, Martin

“…Inhibition of 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1) is a novel and attractive approach to reduce the local levels of the active estrogen…”
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Introduction of an Electron Withdrawing Group on the Hydroxyphenylnaphthol Scaffold Improves the Potency of 17β-Hydroxysteroid Dehydrogenase Type 2 (17β-HSD2) Inhibitors by Wetzel, Marie, Marchais-Oberwinkler, Sandrine, Perspicace, Enrico, Möller, Gabriele, Adamski, Jerzy, Hartmann, Rolf W

“…Estrogen deficiency in postmenopausal women or elderly men is often associated with the skeletal disease osteoporosis. The supplementation of estradiol (E2) in…”
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17β-HSD2 inhibitors for the treatment of osteoporosis: Identification of a promising scaffold by Wetzel, Marie, Marchais-Oberwinkler, Sandrine, Hartmann, Rolf W.

“…17β-Hydroxysteroid dehydrogenase type 2 (17β-HSD2) catalyses the conversion of active 17β-hydroxysteroids into the less active 17-ketosteroids thereby…”
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Discovery of a new class of bicyclic substituted hydroxyphenylmethanones as 17β-hydroxysteroid dehydrogenase type 2 (17β-HSD2) inhibitors for the treatment of osteoporosis by Wetzel, Marie, Gargano, Emanuele M., Hinsberger, Stefan, Marchais-Oberwinkler, Sandrine, Hartmann, Rolf W.

“…E2 deficiency in elderly people has directly an effect on the skeleton and can lead to osteoporosis. As 17β-hydroxysteroid dehydrogenase type 2 (17β-HSD2)…”
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Structural Optimization of 2,5-Thiophene Amides as Highly Potent and Selective 17β-Hydroxysteroid Dehydrogenase Type 2 Inhibitors for the Treatment of Osteoporosis by Marchais-Oberwinkler, Sandrine, Xu, Kuiying, Wetzel, Marie, Perspicace, Enrico, Negri, Matthias, Meyer, Arne, Odermatt, Alex, Möller, Gabriele, Adamski, Jerzy, Hartmann, Rolf W

“…Inhibition of 17β-HSD2 is an attractive mechanism for the treatment of osteoporosis. We report here the optimization of human 17β-HSD2 inhibitors in the…”
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Triazole ring-opening leads to the discovery of potent nonsteroidal 17β-hydroxysteroid dehydrogenase type 2 inhibitors by Xu, Kuiying, Al-Soud, Yaseen A., Wetzel, Marie, Hartmann, Rolf W., Marchais-Oberwinkler, Sandrine

“…17β-Hydroxysteroid dehydrogenase type 2 (17β-HSD2) catalyzes the oxidation of the highly potent steroids: the estrogen estradiol (E2) and the androgen…”
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Structural characterization of a potent humanized anti-CD38 antibody in phase I by Vallée, Francois, Pouzieux, Stephanie, Rak, Alexey, Michoux, François, Wetzel, Marie-Cécile, Deckert, Jutta, Kannt, Aimo, Blanc, Veronique, Mikol, Vincent

“…Abstract only CD38 is a type II transmembrane glycoprotein with both ADP-rybosyl cyclase and glycohydrolase activities. CD38 is highly expressed at the surface…”
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Abstract 4735: SAR650984: Characterization of a potent phase I humanized anti-CD38 antibody for the treatment of multiple myeloma and other hematologic malignancies by Wetzel, Marie-Cécile, Nicolazzi, Céline, Vallée, François, Deckert, Jutta, Dumontet, Charles, Plesa, Adriana, Kannt, Aimo, Mikol, Vincent, Chiron, Marielle, Vincent, Loïc, Blanc, Veronique

“…Abstract SAR650984, a humanized antibody targeting the type II transmembrane glycoprotein CD38 is currently in phase I dose escalation in patients with…”
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Structural and functional analysis of spontaneous anti-nitrophenyl antibodies in three cyprinid fish species: carp (Cyrinus carpio), goldfish (Carassius auratus) and tench (Tinca tinca) by Vilain, C, Wetzel, M C, Du Pasquier, L, Charlemagne, J

“…High spontaneous anti-trinitrophenyl (TNP) activities were found in three Cyprinid fish species: Carp (Cyprinus carpio), Goldfish (Carassius auratus) and Tench…”
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Antibody diversity in fish. Isoelectrofocalisation study of individually-purified specific antibodies in three teleost fish species: tench, carp and goldfish by Wetzel, M C, Charlemagne, J

“…Natural anti-DNP antibodies were isolated by affinity chromatography from individual sera of three Cyprinid fish species (carp, goldfish and tench) and their…”
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Challenging Biological Justifications for the Orgasm Gap: Implications for Immutability Beliefs and Orgasm Pursuit by Wetzel, Grace Marie

“…The orgasm gap between cisgender men and women remains a pressing gender equality issue. Researchers in the sexuality field have established that differences…”
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17β-Hydroxysteroid dehydrogenases (17β-HSDs) as therapeutic targets: Protein structures, functions, and recent progress in inhibitor development: Targeted Inhibitors for Steroid Transforming Enzymes by MARCHAIS-OBERWINKLER, Sandrine, HENN, Claudia, FROTSCHER, Martin, HARTMANN, Rolf W, ADAMSKI, Jerzy, MÖLLER, Gabriele, KLEIN, Tobias, NEGRI, Matthias, OSTER, Alexander, SPADARO, Alessandro, WERTH, Ruth, WETZEL, Marie, KUIYING XU

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The psychologist's role in relationship to the elderly at the end of life and his family by Wetzel, Marie-Françoise

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