Search Results - "WETSEL, R. A"

Activation of C3a receptor is required in cigarette smoke-mediated emphysema by Yuan, X, Shan, M, You, R, Frazier, M V, Hong, M J, Wetsel, R A, Drouin, S, Seryshev, A, Song, L-Z, Cornwell, L, Rossen, R D, Corry, D B, Kheradmand, F

“…Exposure to cigarette smoke can initiate sterile inflammatory responses in the lung and activate myeloid dendritic cells (mDCs) that induce differentiation of…”
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Cutting Edge: Targeted Disruption of the C3a Receptor Gene Demonstrates a Novel Protective Anti-Inflammatory Role for C3a in Endotoxin-Shock by Kildsgaard, Jens, Hollmann, Travis J, Matthews, Kirstin W, Bian, Ka, Murad, Ferid, Wetsel, Rick A

“…The complement anaphylatoxin C3a, on binding the C3aR, mediates numerous proinflammatory activities. In addition, recent in vitro studies with C3a have…”
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Expression of the Complement Anaphylatoxin C3a and C5a Receptors on Bronchial Epithelial and Smooth Muscle Cells in Models of Sepsis and Asthma by Drouin, Scott M, Kildsgaard, Jens, Haviland, Joie, Zabner, Joseph, Jia, Hong Pen, McCray, Paul B., Jr, Tack, Brian F, Wetsel, Rick A

“…The presence of the complement-derived anaphylatoxin peptides, C3a and C5a, in the lung can induce respiratory distress characterized by contraction of the…”
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Cutting Edge: The Absence of C3 Demonstrates a Role for Complement in Th2 Effector Functions in a Murine Model of Pulmonary Allergy by Drouin, Scott M, Corry, David B, Kildsgaard, Jens, Wetsel, Rick A

“…Asthma is a chronic disease of the lung resulting from airway obstruction. Although the initiating causes are not entirely clear, the airway inflammation in…”
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The C5a receptor is expressed by human renal proximal tubular epithelial cells by Zahedi, R., Braun, M., Wetsel, R. A., Ault, B. H., Khan, A., Welch, T. R., Frenzke, M., Davis, A. E.

“…The C5a receptor is expressed by a variety of cell types. These studies demonstrate by immunohistochemistry that the receptor is present on the surface of…”
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Attenuation of Experimental Autoimmune Demyelination in Complement-Deficient Mice by Nataf, Serge, Carroll, Steven L, Wetsel, Rick A, Szalai, Alexander J, Barnum, Scott R

“…The exact mechanisms leading to CNS inflammation and myelin destruction in multiple sclerosis and in its animal model, experimental allergic encephalomyelitis…”
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Hypersusceptibility of A/J Mice to Tuberculosis is in Part Due to a Deficiency of the Fifth Complement Component (C5) by Jagannath, C., Hoffmann, H., Sepulveda, E., Actor, J. K., Wetsel, R. A., Hunter, R. L.

“…Mycobacterium tuberculosis (MTB) causes tuberculosis in man, which occurs as an acute, chronic or dormant disease reactivating over several years. The…”
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Cellular expression of the C5a anaphylatoxin receptor (C5aR): demonstration of C5aR on nonmyeloid cells of the liver and lung by Haviland, DL, McCoy, RL, Whitehead, WT, Akama, H, Molmenti, EP, Brown, A, Haviland, JC, Parks, WC, Perlmutter, DH, Wetsel, RA

“…The small-complement C5 activation fragment, C5a, is a potent phlogistic molecule that, on binding to the C5a Receptor (C5aR), mediates contraction of smooth…”
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Requisite Role for Complement C5 and the C5a Receptor in Granulomatous Response to Mycobacterial Glycolipid Trehalose 6,6′‐Dimycolate by Borders, C. W., Courtney, A., Ronen, K., Pilar Laborde‐Lahoz, M., Guidry, T. V., Hwang, S.‐A., Olsen, M., Hunter, R. L., Hollmann, T. J., Wetsel, R. A., Actor, J. K.

“…The development of pulmonary granulomatous lesions during mycobacterial infection is a complex phenomenon, in part caused by responses elicited towards the…”
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TNF-alpha-mediated expression of the receptor for anaphylatoxin C5a on neurons in experimental Listeria meningoencephalitis by Stahel, PF, Frei, K, Eugster, HP, Fontana, A, Hummel, KM, Wetsel, RA, Ames, RS, Barnum, SR

“…The anaphylatoxin C5a has been implicated in the pathogenesis of bacterial meningitis as a potent mediator of inflammation in the subarachnoid space. We…”
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Deletion of carboxypeptidase N delays onset of experimental cerebral malaria by DARLEY, M. M., RAMOS, T. N., WETSEL, R. A., BARNUM, S. R.

“…Summary Complement contributes to inflammation during pathogen infections; however, less is known regarding its role during malaria and in the severest form of…”
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Enhanced expression of chemotactic receptors in multiple sclerosis lesions by MÜLLER-LADNER, U, JONES, J. L, WETSEL, R. A, GAY, S, RAINE, C. S, BARNUM, S. R

“…We have previously shown that astrocytes and microglia express the receptors for C5a, interleukin-8 (IL-8) and N-formyl-Met-Leu-Phe (FMLP) in vitro. The…”
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Genetic disruption of the murine complement C3 promoter region generates deficient mice with extrahepatic expression of C3 mRNA by Circolo, Antonella, Garnier, Gérard, Fukuda, Wataru, Wang, Xeufeng, Hidvegi, Tünde, Szalai, Alexander J, Briles, David E, Volanakis, John E, Wetsel, Rick A, Colten, Harvey R

“…Genetic deficiencies of the complement protein C3 occur naturally in humans and animal models and have been induced in mice by targeted deletion of the C3…”
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A Role for Complement C5 in Organism Containment and Granulomatous Response during Murine Tuberculosis by Actor, J. K., Breij, E., Wetsel, R. A., Hoffmann, H., Hunter Jr, R. L., Jagannath, C.

“…The molecular mechanisms underlying protective granuloma formation and control of bacterial growth during infection with Mycobacterium tuberculosis (MTB) are…”
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Type I human complement C2 deficiency. A 28-base pair gene deletion causes skipping of exon 6 during RNA splicing by C A Johnson, P Densen, R K Hurford, Jr, H R Colten, R A Wetsel

“…Two variants of a genetic deficiency of complement protein C2 (C2D) have been previously identified. No C2 protein translation is detected in type I…”
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Carboxypeptidase N: a pleiotropic regulator of inflammation by Matthews, Kirstin W, Mueller-Ortiz, Stacey L, Wetsel, Rick A

“…Carboxypeptidase N (CPN) is a plasma zinc metalloprotease, which consists of two enzymatically active small subunits (CPN1) and two large subunits (CPN2) that…”
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Murine complement C2 and factor B genomic and cDNA cloning reveals different mechanisms for multiple transcripts of C2 and B by Ishikawa, N, Nonaka, M, Wetsel, R.A., Colten, H.R.

“…Murine genomic and cDNA clones were isolated to ascertain the mechanisms accounting for previously recognized multiple forms of complement C2 and factor B mRNA…”
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Absence of the Complement Anaphylatoxin C3a Receptor Suppresses Th2 Effector Functions in a Murine Model of Pulmonary Allergy by Drouin, Scott M, Corry, David B, Hollman, Travis J, Kildsgaard, Jens, Wetsel, Rick A

“…Asthma is a chronic inflammatory disease of the lung resulting in airway obstruction. The airway inflammation of asthma is strongly linked to Th2 lymphocytes…”
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Cis- and trans-acting elements required for constitutive and cytokine-regulated expression of the mouse complement C3 gene by KAWAMURA, N, SINGER, L, WETSEL, R. A, COLTEN, H. R

“…The third component of complement (C3) is an important mediator of inflammation. Murine and human genomic cosmid clones were isolated, characterized and…”
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Inhibition of Complement Activation by a Secreted Staphylococcus aureus Protein by Lee, Lawrence Y. L., Höök, Magnus, Haviland, David, Wetsel, Rick A., Yonter, Edward O., Syribeys, Peter, Vernachio, John, Brown, Eric L.

“…Staphylococcus aureus can cause a variety of acute and chronic diseases. The ability of S. aureus to cause persistent infections has been linked to its ability…”
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