Search Results - "WESTERHOFF, H. V"

Emergence and Its Place in Nature: A Case Study of Biochemical Networks by Boogerd, F. C., Bruggeman, F. J., Richardson, R. C., Stephan, A., Westerhoff, H. V.

“…We will show that there is a strong form of emergence in cell biology. Beginning with C.D. Broad's classic discussion of emergence, we distinguish two…”
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A metabolic control analysis of kinetic controls in ATP free energy metabolism in contracting skeletal muscle by Jeneson, J A, Westerhoff, H V, Kushmerick, M J

“…A system analysis of ATP free energy metabolism in skeletal muscle was made using the principles of metabolic control theory. We developed a network model of…”
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Cytosolic triglycerides and oxidative stress in central obesity: the missing link between excessive atherosclerosis, endothelial dysfunction, and β-cell failure? by Bakker, Stephan J.L, IJzerman, Richard G, Teerlink, Tom, Westerhoff, Hans V, Gans, Reinold O.B, Heine, Robert J

“…Central obesity is increasingly recognized as a risk factor for atherosclerosis and type 2 diabetes mellitus. Here we present a hypothesis that may explain the…”
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Approaches to Biosimulation of Cellular Processes by Bruggeman, F. J, Westerhoff, H. V

“…Modelling and simulation are at the heart of the rapidly developing field of systems biology. This paper reviews various types of models, simulation methods,…”
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Magainins and the Disruption of Membrane-Linked Free-Energy Transduction by Westerhoff, Hans V., Juretić, Davor, Hendler, Richard W., Zasloff, Michael

“…Magainins, a family of positively charged peptides, are partly if not wholly responsible for antimicrobial activity in skin extracts of Xenopus laevis. We…”
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The evolution of molecular biology into systems biology by Westerhoff, Hans V, Palsson, Bernhard O

“…Systems analysis has historically been performed in many areas of biology, including ecology, developmental biology and immunology. More recently, the genomics…”
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Autoamplification of a Two-Component Regulatory System Results in “Learning” Behavior by Hoffer, S M, Westerhoff, H V, Hellingwerf, K J, Postma, P W, Tommassen, J

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Intracellular glucose concentration in derepressed yeast cells consuming glucose is high enough to reduce the glucose transport rate by 50 by Teusink, B, Diderich, J.A, Westerhoff, H.V, Dam, K. van, Walsh, M.C

“…In Saccharomyces cerevisiae cells exhibiting high-affinity glucose transport, the glucose consumption rate at extracellular concentrations above 10 mM was only…”
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Electric potentiation, cooperativity, and synergism of magainin peptides in protein-free liposomes by Vaz Gomes, A, de Waal, A, Berden, J. A, Westerhoff, H. V

“…Magainins, positively charged peptides present in the skin of Xenopus laevis, are known to permeabilize free-energy transducing membranes. Structural studies…”
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Quasi-linear relationship between Gibbs free energy of ATP hydrolysis and power output in human forearm muscle by Jeneson, J A, Westerhoff, H V, Brown, T R, Van Echteld, C J, Berger, R

“…The postulated strictly linear descriptions of the rate dependence of oxidative phosphorylation in skeletal muscle on the free energy of ATP hydrolysis (delta…”
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Structure and partitioning of bacterial DNA: determined by a balance of compaction and expansion forces? by Woldringh, C L, Jensen, P R, Westerhoff, H V

“…The mechanisms that determine chromosome structure and chromosome partitioning in bacteria are largely unknown. Here we discuss two hypotheses: (i) the…”
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Control of MAPK signalling: from complexity to what really matters by HORNBERG, Jorrit J, BINDER, Bernd, BRUGGEMAN, Frank J, SCHOEBERL, Birgit, HEINRICH, Reinhart, WESTERHOFF, Hans V

“…Oncogenesis results from changes in kinetics or in abundance of proteins in signal transduction networks. Recently, it was shown that control of signalling…”
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Control Analysis of the Dependence of Escherichia coli Physiology on the H+-ATPase by Jensen, Peter Ruhdal, Michelsen, Ole, Westerhoff, Hans V.

“…The H+-ATPase plays a central role in Escherichia coli free-energy transduction and hence in E. coli physiology. We here investigate the extent to which this…”
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Transcriptome meets metabolome: hierarchical and metabolic regulation of the glycolytic pathway by ter Kuile, Benno H, Westerhoff, Hans V

“…The fact that information flows from DNA to RNA to protein to function suggests that regulation is ‘hierarchical’, i.e. dominated by regulation of gene…”
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The Glycolytic Flux in Escherichia coli Is Controlled by the Demand for ATP by Koebmann, Brian J, Westerhoff, Hans V, Snoep, Jacky L, Nilsson, Dan, Jensen, Peter R

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Glucose and the ATP paradox in yeast by Somsen, O J, Hoeben, M A, Esgalhado, E, Snoep, J L, Visser, D, van der Heijden, R T, Heijnen, J J, Westerhoff, H V

“…A sustained decrease in the intracellular ATP concentration has been observed when extra glucose was added to yeast cells growing aerobically under glucose…”
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A functional genomics strategy that uses metabolome data to reveal the phenotype of silent mutations by Oliver, Stephen G, Raamsdonk, Léonie M, Teusink, Bas, Broadhurst, David, Zhang, Nianshu, Hayes, Andrew, Walsh, Michael C, Berden, Jan A, Brindle, Kevin M, Kell, Douglas B, Rowland, Jem J, Westerhoff, Hans V, van Dam, Karel

“…A large proportion of the 6,000 genes present in the genome of Saccharomyces cerevisiae, and of those sequenced in other organisms, encode proteins of unknown…”
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Metabolic channelling and control of the flux by Kholodenko, Boris N., Westerhoff, Hans V.

“…Metabolic control theory is extended to include channelled metabolism in general. A simple relationship between the flux control by the enzymes and the degree…”
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Control theory of regulatory cascades by Kahn, D, Westerhoff, H V

“…We have extended Metabolic Control Theory to include cascades consisting of several modules controlling each other solely via regulatory effects. We derive…”
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Quantification of the contribution of various steps to the control of mitochondrial respiration by Groen, A K, Wanders, R J, Westerhoff, H V, van der Meer, R, Tager, J M

“…Using principles developed by Kacser and Burns ((1973) in Rate Control of Biological Processes (Davies, D. D., ed) pp. 65-104, Cambridge University Press,…”
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