Search Results - "WESTBROOK, G. L"

Regulation of synaptic timing in the olfactory bulb by an A-type potassium current by Schoppa, N. E, Westbrook, G. L

“…Although rapid synaptic transmission confers signal fidelity, the activity of some neuronal circuits depends on prolonged excitation or inhibition. Here we…”
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Calcium-induced actin depolymerization reduces NMDA channel activity by Rosenmund, C, Westbrook, G L

“…Actin filaments are highly concentrated in postsynaptic densities at central excitatory synapses, but their influence on postsynaptic glutamate receptors is…”
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Regulation of Backpropagating Action Potentials in Mitral Cell Lateral Dendrites by A-Type Potassium Currents by Christie, J. M, Westbrook, G. L

“…Vollum Institute, Oregon Health and Science University, Portland, Oregon 97201 Christie, J. M. and G. L. Westbrook. Regulation of Backpropagating Action…”
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Slow desensitization regulates the availability of synaptic GABA(A) receptors by Overstreet, L S, Jones, M V, Westbrook, G L

“…At central synapses, a large and fast spike of neurotransmitter efficiently activates postsynaptic receptors. However, low concentrations of transmitter can…”
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The impact of receptor desensitization on fast synaptic transmission by Jones, Mathew V., Westbrook, Gary L.

“…The role of desensitization of ligand-gated channels at fast chemical synapses has been difficult to establish. Desensitization has been studied traditionally…”
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Inactivation of NMDA channels in cultured hippocampal neurons by intracellular calcium by Legendre, P, Rosenmund, C, Westbrook, GL

“…Calcium-dependent inactivation of NMDA channels was examined on cultured rat hippocampal neurons using whole-cell voltage-clamp and cell-attached…”
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Tufted Cell Dendrodendritic Inhibition in the Olfactory Bulb Is Dependent on NMDA Receptor Activity by Christie, J. M, Schoppa, N. E, Westbrook, G. L

“…Vollum Institute, Oregon Health Sciences University, Portland, Oregon 97201 Christie, J. M., N. E. Schoppa, and G. L. Westbrook. Tufted Cell Dendrodendritic…”
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Calcium-dependent inactivation of synaptic NMDA receptors in hippocampal neurons by Rosenmund, C, Feltz, A, Westbrook, G L

“…1. We examined whether synaptically activated N-methyl-D-aspartate (NMDA) receptors are regulated by intracellular calcium in cultured hippocampal neurons by…”
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Permeation and block of N-methyl-D-aspartic acid receptor channels by divalent cations in mouse cultured central neurones by Mayer, M L, Westbrook, G L

“…1. Spinal cord and hippocampal neurones in cell culture were voltage clamped using the tight-seal, whole-cell recording technique. The concentration of sodium…”
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Activation kinetics reveal the number of glutamate and glycine binding sites on the N-methyl-D-aspartate receptor by Clements, J D, Westbrook, G L

“…The activation kinetics of N-methyl-D-aspartate (NMDA) channels in outside-out patches from cultured hippocampal neurons were analyzed to determine the number…”
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Rundown of N-methyl-D-aspartate channels during whole-cell recording in rat hippocampal neurons: role of Ca2+ and ATP by Rosenmund, C, Westbrook, G L

“…1. N-methyl-D-aspartate (NMDA) channel activity was studied on cultured rat hippocampal neurons in whole-cell voltage-clamp mode. NMDA responses were evoked by…”
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Cloning and expression of a new member of the L-2-amino-4-phosphonobutyric acid-sensitive class of metabotropic glutamate receptors by Saugstad, J A, Kinzie, J M, Mulvihill, E R, Segerson, T P, Westbrook, G L

“…Despite the cloning of several metabotropic glutamate receptors (mGluR1-6), the activity and localization of the cloned mGluRs do not account for the action of…”
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Nonuniform Probability of Glutamate Release at a Hippocampal Synapse by Rosenmund, Christian, Clements, John D., Westbrook, Gary L.

“…A change in the probability of neurotransmitter release (P$_r$) is an important mechanism underlying synaptic plasticity. Although P$_r$ is often assumed to be…”
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The Time Course of Glutamate in the Synaptic Cleft by Clements, John D., Robin A. J. Lester, Tong, Gang, Jahr, Craig E., Westbrook, Gary L.

“…The peak concentration and rate of clearance of neurotransmitter from the synaptic cleft are important determinants of synaptic function, yet the…”
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L-AP4 inhibits calcium currents and synaptic transmission via a G- protein-coupled glutamate receptor by Trombley, PQ, Westbrook, GL

“…The AP4 (2-amino-4-phosphonobutyrate) receptor is a presynaptic glutamate receptor that inhibits transmitter release via an unknown mechanism. We examined the…”
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Distribution of metabotropic glutamate receptor 7 messenger RNA in the developing and adult rat brain by Kinzie, J.M., Saugstad, J.A., Westbrook, G.L., Segerson, T.P.

“…The large number of metabotropic glutamate receptor subtypes suggests diverse roles in brain function, although specific distribution patterns can give clues…”
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Neurologic impairment following closed head injury predicts post-traumatic neurogenesis by Villasana, L.E., Westbrook, G.L., Schnell, E.

“…In the mammalian hippocampus, neurogenesis persists into adulthood, and increased generation of newborn neurons could be of clinical benefit following…”
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Modulation of calcium currents by a metabotropic glutamate receptor involves fast and slow kinetic components in cultured hippocampal neurons by Sahara, Y, Westbrook, GL

“…The modulation of high-threshold Ca2+ currents by the selective metabotropic glutamate receptor (mGluR) agonist (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic…”
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Modulation of mEPSCs in Olfactory Bulb Mitral Cells by Metabotropic Glutamate Receptors by Schoppa, N. E, Westbrook, G. L

“…N. E. Schoppa and G. L. Westbrook Vollum Institute for Advanced Biomedical Research, Oregon Health Sciences University, Portland, Oregon 97201 Schoppa, N. E…”
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The inhibition of single N-methyl-D-aspartate-activated channels by zinc ions on cultured rat neurones by Legendre, P, Westbrook, G L

“…1. Single channels activated by N-methyl-D-aspartate (NMDA) were studied in outside-out patches of cultured hippocampal neurones in the presence of glycine and…”
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