Search Results - "WEST, David B"

Transcriptome Analysis of Targeted Mouse Mutations Reveals the Topography of Local Changes in Gene Expression by West, David B, Engelhard, Eric K, Adkisson, Michael, Nava, A J, Kirov, Julia V, Cipollone, Andreanna, Willis, Brandon, Rapp, Jared, de Jong, Pieter J, Lloyd, Kent C

“…The unintended consequences of gene targeting in mouse models have not been thoroughly studied and a more systematic analysis is needed to understand the…”
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A lacZ reporter gene expression atlas for 313 adult KOMP mutant mouse lines by West, David B, Pasumarthi, Ravi K, Baridon, Brian, Djan, Esi, Trainor, Amanda, Griffey, Stephen M, Engelhard, Eric K, Rapp, Jared, Li, Bowen, de Jong, Pieter J, Lloyd, K C Kent

“…Expression of the bacterial beta-galactosidase reporter gene (lacZ) in the vector used for the Knockout Mouse Project (KOMP) is driven by the endogenous…”
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Sphingosine-1-phosphate lyase expression in embryonic and adult murine tissues by Borowsky, Alexander D., Bandhuvula, Padmavathi, Kumar, Ashok, Yoshinaga, Yuko, Nefedov, Mikhail, Fong, Loren G., Zhang, Meng, Baridon, Brian, Dillard, Lisa, de Jong, Pieter, Young, Stephen G., West, David B., Saba, Julie D.

“…Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid involved in immunity, inflammation, angiogenesis, and cancer. S1P lyase (SPL) is the essential enzyme…”
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Reporter Gene Silencing in Targeted Mouse Mutants Is Associated with Promoter CpG Island Methylation by Kirov, Julia V, Adkisson, Michael, Nava, A J, Cipollone, Andreana, Willis, Brandon, Engelhard, Eric K, Lloyd, K C Kent, de Jong, Pieter, West, David B

“…Targeted mutations in mouse disrupt local chromatin structure and may lead to unanticipated local effects. We evaluated targeted gene promoter silencing in a…”
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Effects of conjugated linoleic acid on body fat and energy metabolism in the mouse by West, D B, Delany, J P, Camet, P M, Blohm, F, Truett, A A, Scimeca, J

“…Conjugated linoleic acid (CLA) is a naturally occurring group of dienoic derivatives of linoleic acid found in the fat of beef and other ruminants. CLA is…”
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Tracking angiogenesis induced by skin wounding and contact hypersensitivity using a Vegfr2-luciferase transgenic mouse by Zhang, Ning, Fang, Zuxu, Contag, Pamela R., Purchio, Anthony F., West, David B.

“…The vascular endothelial growth factor-2 (VEGFR2) gene is transcriptionally regulated during angiogenesis. The ability to monitor and quantify VEGFR2…”
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Serum Amyloid A-Luciferase Transgenic Mice: Response to Sepsis, Acute Arthritis, and Contact Hypersensitivity and the Effects of Proteasome Inhibition by Zhang, Ning, Ahsan, Muhammad H, Purchio, Anthony F, West, David B

“…Acute phase serum amyloid A proteins (A-SAAs) are multifunctional apolipoproteins produced in large amounts during the acute phase of an inflammation and also…”
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Conjugated linoleic acid rapidly reduces body fat content in mice without affecting energy intake by DeLany, J.P. (Louisiana State University, Baton Rouge, LA.), Blohm, F, Truett, A.A, Scimeca, J.A, West, D.B

“…Recent reports have demonstrated that conjugated linoleic acid (CLA) has effects on body fat accumulation. In our previous work, CLA reduced body fat…”
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Positional cloning of the combined hyperlipidemia gene Hyplip1 by Lusis, Aldons J, Bodnar, Jackie S, Chatterjee, Aurobindo, Castellani, Lawrence W, Ross, David A, Ohmen, Jeffrey, Cavalcoli, James, Wu, Chenyan, Dains, Katherine M, Catanese, Joe, Chu, Michael, Sheth, Sonal S, Charugundla, Kanti, Demant, Peter, West, David B, de Jong, Pieter

“…Familial combined hyperlipidemia (FCHL, MIM-144250) is a common, multifactorial and heterogeneous dyslipidemia predisposing to premature coronary artery…”
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High-throughput discovery of novel developmental phenotypes by Dickinson, Mary E., Flenniken, Ann M., Ji, Xiao, Teboul, Lydia, Wong, Michael D., White, Jacqueline K., Meehan, Terrence F., Weninger, Wolfgang J., Westerberg, Henrik, Adissu, Hibret, Baker, Candice N., Bower, Lynette, Brown, James M., Caddle, L. Brianna, Chiani, Francesco, Clary, Dave, Cleak, James, Daly, Mark J., Denegre, James M., Doe, Brendan, Dolan, Mary E., Edie, Sarah M., Fuchs, Helmut, Gailus-Durner, Valerie, Galli, Antonella, Gambadoro, Alessia, Gallegos, Juan, Guo, Shiying, Horner, Neil R., Hsu, Chih-Wei, Johnson, Sara J., Kalaga, Sowmya, Keith, Lance C., Lanoue, Louise, Lawson, Thomas N., Lek, Monkol, Mark, Manuel, Marschall, Susan, Mason, Jeremy, McElwee, Melissa L., Newbigging, Susan, Nutter, Lauryl M. J., Peterson, Kevin A., Ramirez-Solis, Ramiro, Rowland, Douglas J., Ryder, Edward, Samocha, Kaitlin E., Seavitt, John R., Selloum, Mohammed, Szoke-Kovacs, Zsombor, Tamura, Masaru, Trainor, Amanda G., Tudose, Ilinca, Wakana, Shigeharu, Warren, Jonathan, Wendling, Olivia, West, David B., Wong, Leeyean, Yoshiki, Atsushi, Wurst, Wolfgang, MacArthur, Daniel G., Tocchini-Valentini, Glauco P., Gao, Xiang, Flicek, Paul, Bradley, Allan, Skarnes, William C., Justice, Monica J., Parkinson, Helen E., Moore, Mark, Wells, Sara, Braun, Robert E., Svenson, Karen L., de Angelis, Martin Hrabe, Herault, Yann, Mohun, Tim, Mallon, Ann-Marie, Henkelman, R. Mark, Brown, Steve D. M., Adams, David J., Lloyd, K. C. Kent, McKerlie, Colin, Beaudet, Arthur L., Bućan, Maja, Murray, Stephen A.

“…Approximately one-third of all mammalian genes are essential for life. Phenotypes resulting from knockouts of these genes in mice have provided tremendous…”
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Diet-induced obesity and hepatic gene expression alterations in C57BL/6J and ICAM-1-deficient mice by Gregoire, Francine M, Zhang, Qin, Smith, Steven J, Tong, Carmen, Ross, David, Lopez, Henry, West, David B

“…The effects of high-fat feeding on the development of obesity were evaluated in intercellular adhesion molecule-1 (ICAM-1) knockout and C57BL/6J (B6) male mice…”
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A large scale hearing loss screen reveals an extensive unexplored genetic landscape for auditory dysfunction by Bowl, Michael R., Simon, Michelle M., Ingham, Neil J., Greenaway, Simon, Santos, Luis, Cater, Heather, Taylor, Sarah, Mason, Jeremy, Kurbatova, Natalja, Pearson, Selina, Bower, Lynette R., Clary, Dave A., Meziane, Hamid, Reilly, Patrick, Minowa, Osamu, Kelsey, Lois, Tocchini-Valentini, Glauco P., Gao, Xiang, Bradley, Allan, Skarnes, William C., Moore, Mark, Beaudet, Arthur L., Justice, Monica J., Seavitt, John, Dickinson, Mary E., Wurst, Wolfgang, de Angelis, Martin Hrabe, Herault, Yann, Wakana, Shigeharu, Nutter, Lauryl M. J., Flenniken, Ann M., McKerlie, Colin, Murray, Stephen A., Svenson, Karen L., Braun, Robert E., West, David B., Lloyd, K. C. Kent, Adams, David J., White, Jacqui, Karp, Natasha, Flicek, Paul, Smedley, Damian, Meehan, Terrence F., Parkinson, Helen E., Teboul, Lydia M., Wells, Sara, Steel, Karen P., Mallon, Ann-Marie, Brown, Steve D. M.

“…The developmental and physiological complexity of the auditory system is likely reflected in the underlying set of genes involved in auditory function. In…”
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An Inducible Nitric Oxide Synthase-Luciferase Reporter System for In Vivo Testing of Anti-inflammatory Compounds in Transgenic Mice by Zhang, Ning, Weber, Aneil, Li, Bonnie, Lyons, Richard, Contag, Pamela R, Purchio, Anthony F, West, David B

“…The inducible NO synthase gene (iNOS) plays a role in a number of chronic and acute conditions, including septic shock and contact hypersensitivity autoimmune…”
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Macronutrient diet selection in thirteen mouse strains by Smith, B K, Andrews, P K, West, D B

“…The strain distribution for macronutrient diet selection was described in 13 mouse strains (AKR/J, NZB/B1NJ, C57BL/6J, C57BL/6ByJ, DBA/2J, SPRET/Ei, CD-1,…”
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A TRANSGENIC MOUSE MODEL WITH A LUCIFERASE REPORTER FOR STUDYING IN VIVO TRANSCRIPTIONAL REGULATION OF THE HUMAN CYP3A4 GENE by WEISHENG ZHANG, PURCHIO, Anthony F, CHEN, Kevin, JIANMING WU, LI LU, COFFEE, Richard, CONTAG, Pamela R, WEST, David B

“…Cytochrome P450 3A4 (CYP3A4) plays an important role in drug metabolism, and the enzymatic activity of CYP3A4 contributes to many adverse drug-drug…”
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In Vivo Monitoring of Pancreatic β-Cells in a Transgenic Mouse Model by Smith, Steven J., Zhang, Hongbing, Clermont, Anne O., Powers, Alvin C., Kaufman, Dixon B., Purchio, Anthony F., West, David B.

“…We generated a transgenic mouse model (RIP-luc) for the in vivo monitoring of pancreatic islet mass and function in response to metabolic disease. Using the…”
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Efficient gene targeting in mouse zygotes mediated by CRISPR/Cas9-protein by Jung, Chris J., Zhang, Junli, Trenchard, Elizabeth, Lloyd, Kent C., West, David B., Rosen, Barry, de Jong, Pieter J.

“…The CRISPR/Cas9 system has rapidly advanced targeted genome editing technologies. However, its efficiency in targeting with constructs in mouse zygotes via…”
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DIFFERENTIAL REGULATION OF THE HUMAN CYP3A4 PROMOTER IN TRANSGENIC MICE AND RATS by WEISHENG ZHANG, PURCHIO, Anthony F, COFFEE, Richard, WEST, David B

“…Previously we described a transgenic mouse model [FVB/NTg( CYP3A4-luc )Xen] using a reporter construct consisting of 13 kilobases of the human CYP3A4 promoter…”
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Increased flavor preference and lick activity for sucrose and corn oil in SWR/J vs. AKR/J mice by Smith, B K, Volaufova, J, West, D B

“…Nutrient preferences and orosensory responses were characterized in two mouse inbred strains. In two-bottle solution tests (tastant vs. vehicle; ascending…”
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Regulation of IκBα expression involves both NF-κB and the MAP kinase signaling pathways by Zhang, Ning, Ahsan, Muhammad H, Zhu, Lingyun, Sambucetti, Lidia C, Purchio, Anthony F, West, David B

“…Abstract IκBα is an inhibitor of the nuclear transcription factor NF-κB. Binding of IκBα to NF-κB inactivates the transcriptional activity of NF-κB. Expression…”
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