Search Results - "WEST, A"

Mitochondrial dysfunction as a trigger of innate immune responses and inflammation by West, A. Phillip

“…A growing literature indicates that mitochondria are key participants in innate immune pathways, functioning as both signaling platforms and contributing to…”
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Mitochondrial DNA in innate immune responses and inflammatory pathology by West, A. Phillip, Shadel, Gerald S.

“…Key Points Mitochondrial DNA (mtDNA), which is well known for its role in oxidative phosphorylation and cellular energetics, is increasingly being recognized…”
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Impaired lysosomal acidification triggers iron deficiency and inflammation in vivo by Yambire, King Faisal, Rostosky, Christine, Watanabe, Takashi, Pacheu-Grau, David, Torres-Odio, Sylvia, Sanchez-Guerrero, Angela, Senderovich, Ola, Meyron-Holtz, Esther G, Milosevic, Ira, Frahm, Jens, West, A Phillip, Raimundo, Nuno

“…Lysosomal acidification is a key feature of healthy cells. Inability to maintain lysosomal acidic pH is associated with aging and neurodegenerative diseases…”
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Overstated carbon emission reductions from voluntary REDD+ projects in the Brazilian Amazon by West, Thales A. P., Börner, Jan, Sills, Erin O., Kontoleon, Andreas

“…Reducing emissions from deforestation and forest degradation (REDD+) has gained international attention over the past decade, as manifested in both United…”
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A conserved PLPLRT/SD motif of STING mediates the recruitment and activation of TBK1 by Zhao, Baoyu, Du, Fenglei, Xu, Pengbiao, Shu, Chang, Sankaran, Banumathi, Bell, Samantha L., Liu, Mengmeng, Lei, Yuanjiu, Gao, Xinsheng, Fu, Xiaofeng, Zhu, Fanxiu, Liu, Yang, Laganowsky, Arthur, Zheng, Xueyun, Ji, Jun-Yuan, West, A. Phillip, Watson, Robert O., Li, Pingwei

“…Nucleic acids from bacteria or viruses induce potent immune responses in infected cells 1 – 4 . The detection of pathogen-derived nucleic acids is a central…”
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Mitochondria in innate immune responses by Ghosh, Sankar, West, A. Phillip, Shadel, Gerald S

“…Key Points The innate immune system has a key role in the mammalian immune response. Recent research has demonstrated that mitochondria participate in a broad…”
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cGAS drives noncanonical-inflammasome activation in age-related macular degeneration by Kerur, Nagaraj, Fukuda, Shinichi, Banerjee, Daipayan, Kim, Younghee, Fu, Dongxu, Apicella, Ivana, Varshney, Akhil, Yasuma, Reo, Fowler, Benjamin J, Baghdasaryan, Elmira, Marion, Kenneth M, Huang, Xiwen, Yasuma, Tetsuhiro, Hirano, Yoshio, Serbulea, Vlad, Ambati, Meenakshi, Ambati, Vidya L, Kajiwara, Yuji, Ambati, Kameshwari, Hirahara, Shuichiro, Bastos-Carvalho, Ana, Ogura, Yuichiro, Terasaki, Hiroko, Oshika, Tetsuro, Kim, Kyung Bo, Hinton, David R, Leitinger, Norbert, Cambier, John C, Buxbaum, Joseph D, Kenney, M Cristina, Jazwinski, S Michal, Nagai, Hiroshi, Hara, Isao, West, A Phillip, Fitzgerald, Katherine A, Sadda, SriniVas R, Gelfand, Bradley D, Ambati, Jayakrishna

“…Degeneration of the retinal pigment epithelium is a hallmark of geographic atrophy, a type of age-related macular degeneration. Kerur et al . show that this…”
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The Long Noncoding RNAs NEAT1 and MALAT1 Bind Active Chromatin Sites by West, Jason A., Davis, Christopher P., Sunwoo, Hongjae, Simon, Matthew D., Sadreyev, Ruslan I., Wang, Peggy I., Tolstorukov, Michael Y., Kingston, Robert E.

“…Mechanistic roles for many lncRNAs are poorly understood, in part because their direct interactions with genomic loci and proteins are difficult to assess…”
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Sulphide oxidation and carbonate dissolution as a source of CO2 over geological timescales by Torres, Mark A., West, A. Joshua, Li, Gaojun

“…Sulphide oxidation coupled to carbonate dissolution can provide a transient source of carbon dioxide to Earth’s atmosphere and so balance the Cenozoic increase…”
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Adaptation and Inclusive Fitness by West, Stuart A., Gardner, Andy

“…Inclusive fitness theory captures how individuals can influence the transmission of their genes to future generations by influencing either their own…”
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Apoptotic Caspases Prevent the Induction of Type I Interferons by Mitochondrial DNA by Rongvaux, Anthony, Jackson, Ruaidhrí, Harman, Christian C.D., Li, Tuo, West, A. Phillip, de Zoete, Marcel R., Wu, Youtong, Yordy, Brian, Lakhani, Saquib A., Kuan, Chia-Yi, Taniguchi, Tadatsugu, Shadel, Gerald S., Chen, Zhijian J., Iwasaki, Akiko, Flavell, Richard A.

“…The mechanism by which cells undergo death determines whether dying cells trigger inflammatory responses or remain immunologically silent. Mitochondria play a…”
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The molecular basis of tight nuclear tethering and inactivation of cGAS by Zhao, Baoyu, Xu, Pengbiao, Rowlett, Chesley M., Jing, Tao, Shinde, Omkar, Lei, Yuanjiu, West, A. Phillip, Liu, Wenshe Ray, Li, Pingwei

“…Nucleic acids derived from pathogens induce potent innate immune responses 1 – 6 . Cyclic GMP–AMP synthase (cGAS) is a double-stranded DNA sensor that…”
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A review of odd-chain fatty acid metabolism and the role of pentadecanoic Acid (c15:0) and heptadecanoic Acid (c17:0) in health and disease by Jenkins, Benjamin, West, James A, Koulman, Albert

“…The role of C17:0 and C15:0 in human health has recently been reinforced following a number of important biological and nutritional observations. Historically,…”
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Earthquake‐Induced Chains of Geologic Hazards: Patterns, Mechanisms, and Impacts by Fan, Xuanmei, Scaringi, Gianvito, Korup, Oliver, West, A. Joshua, Westen, Cees J., Tanyas, Hakan, Hovius, Niels, Hales, Tristram C., Jibson, Randall W., Allstadt, Kate E., Zhang, Limin, Evans, Stephen G., Xu, Chong, Li, Gen, Pei, Xiangjun, Xu, Qiang, Huang, Runqiu

“…Large earthquakes initiate chains of surface processes that last much longer than the brief moments of strong shaking. Most moderate‐ and large‐magnitude…”
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TLR signalling augments macrophage bactericidal activity through mitochondrial ROS by West, A. Phillip, Brodsky, Igor E., Rahner, Christoph, Woo, Dong Kyun, Erdjument-Bromage, Hediye, Tempst, Paul, Walsh, Matthew C., Choi, Yongwon, Shadel, Gerald S., Ghosh, Sankar

“…Mitochondrial role in innate immunity The stimulation of a subset of surface Toll-like receptors (TLRs), transmembrane proteins of the innate immune system…”
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Tectonic and climatic controls on silicate weathering by West, A. Joshua, Galy, Albert, Bickle, Mike

“…Understanding the controls on chemical weathering, especially of silicate minerals, remains a major challenge, despite its importance in controlling the…”
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Role of path information in visual perception of joint stiffness by West, Jr, A Michael, Huber, Meghan E, Hogan, Neville

“…Humans have an astonishing ability to extract hidden information from the movement of others. In previous work, subjects observed the motion of a simulated…”
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genetical theory of kin selection by GARDNER, A, WEST, S.A, WILD, G

“…Natural selection operates both directly, via the impact of a trait upon the individual's own fitness, and indirectly, via the impact of the trait upon the…”
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Invited Commentary: Long term Impact of Day Only Skin Abscess Protocol in a Tertiary Institution by West, Michaela A.

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Initiation and Runout of Post‐Seismic Debris Flows: Insights From the 2015 Gorkha Earthquake by Dahlquist, Maxwell P., West, A. Joshua

“…Post‐seismic debris flows are an important hazard following large earthquakes, propagating destruction downstream from hillslopes where coseismic landslides…”
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