Search Results - "WERMELING, D"

Pharmacokinetics and Pharmacodynamics of Intrathecal Ziconotide in Chronic Pain Patients by Wermeling, Daniel, Drass, Michael, Ellis, David, Mayo, Martha, McGuire, Dawn, O'Connell, Damian, Hale, Victoria, Chao, Stella

“…The pharmacokinetics and pharmacodynamics of ziconotide were assessed over a 48‐hour period following intrathecal (IT) administration (1, 5, 7.5, or 10 μg) to…”
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Differential Effects of Prenatal Stress in Two Inbred Strains of Rats by Stöhr, T, Wermeling, D.Schulte, Szuran, T, Pliska, V, Domeney, A, Welzl, H, Weiner, I, Feldon, J

“…STÖHR, T., D. SCHULTE WERMELING, T. SZURAN, V. PLISKA, A. DOMENEY, H. WELZL, I. WEINERAND J. FELDON. Differential effects of prenatal stress in two inbred…”
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Rat Strain Differences in Open-Field Behavior and the Locomotor Stimulating and Rewarding Effects of Amphetamine by Stöhr, Thomas, Wermeling, Doris Schulte, Weiner, Ina, Feldon, Joram

“…STÖHR, T., D. SCHULTE WERMELING, I. WEINER AND J. FELDON. Rat strain differences in open-field behavior and the locomotor stimulating and rewarding effects of…”
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Analgesic effects of intranasal butorphanol tartrate administered via a unit-dose device in the dental impaction pain model: A randomized, double-blind, placebo-controlled, parallel-group study by Wermeling, Daniel P., Grant, George M., Lee, Allen, Alexander, Nicole, Rudy, Anita C.

“…Butorphanol tartrate (BT) nasal spray is currently marketed as a multidose spray pump product. However, access to excessive amounts of drug in a single bottle…”
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Ziconotide, an Intrathecally Administered N-Type Calcium Channel Antagonist for the Treatment of Chronic Pain by Wermeling, Daniel P.

“…Ziconotide is a novel peptide that blocks the entry of calcium into neuronal N‐type voltage‐sensitive calcium channels, preventing the conduction of nerve…”
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Clinical research: regulatory issues by Wermeling, DP

“…The regulatory issues faced by institutions performing clinical research are described. Many institutions do not have on staff an expert who understands the…”
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Pharmacokinetics of flunisolide administered via metered dose inhaler with and without a spacer device and following oral administration by Dickens, G R, Wermeling, D P, Matheny, C J, John, W, Abramowitz, W, Sista, S M, Foster, T, Choudhury, S

“…After inhalation of a glucocorticoid from a meter dose inhaler (MDI), a certain portion of the delivered dose is deposited in the lungs, and the remainder is…”
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Pharmacokinetics, Pharmacodynamics, and Safety of Metrifonate in Patients with Alzheimer's Disease by Pettigrew, L. Creed, Bieber, Florian, Lettieri, John, Wermeling, Daniel P., Schmitt, Frederick A., Tikhtman, Alex J., Ashford, J. Wesson, Smith, Charles D., Wekstein, David R., Markesbery, William R., Orazem, John, Ruzicka, Bianca B., Mas, Janice, Gulanski, Barbara

“…Metrifonate is converted nonenzymatically to 2,2, dimethyl dichlorovinyl phosphate (DDVP), an inhibitor of acetylcholinesterase (AChE). This 21‐day,…”
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Frontal lobe phosphorus metabolism and neuropsychological function in aging and in Alzheimer's disease by Smith, C D, Pettigrew, L C, Avison, M J, Kirsch, J E, Tinkhtman, A J, Schmitt, F A, Wermeling, D P, Wekstein, D R, Markesberry, W R

“…31P Magnetic resonance spectroscopy of the frontal lobe was performed in 17 patients with Alzheimer's disease (AD), 8 elderly controls (EC), and 17 young…”
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Ziconotide Infusion for Severe Chronic Pain: Case Series of Patients with Neuropathic Pain by Wermeling, Daniel P., Berger, Joseph R.

“…Ziconotide intrathecal infusion was recently approved by the United States Food and Drug Administration for the treatment of intractable severe chronic pain…”
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Seizures in Patients Receiving Concomitant Antimuscarinics and Acetylcholinesterase Inhibitor by Piecoro, Lance T., Wermeling, Daniel P., Schmitt, Frederick A., Ashford, J. Wesson

“…Seizures occurred in two patients with probable Alzheimer's disease who were receiving long‐term treatment with metrifonate, an irreversible…”
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Dirithromycin increases ethinyl estradiol clearance without allowing ovulation by Wermeling, Daniel P., Chandler, Mary H.H., Sides, Gregory D., Collins, Delwood, Muse, Ken N.

“…To use a novel, sensitive study design to detect a potential oral contraceptive (OC) and dirithromycin drug interaction by assessing the pharmacokinetics of…”
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Current issues surrounding women and minorities in drug trials by Wermeling, D P, Selwitz, A S

“…Our principal objective is to make readers aware of conflicting demands placed on investigators and the pharmaceutical industry regarding inclusion of women…”
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Financial impact of clinical research on a health system by Wermeling, D P, Piecoro, L T, Foster, T S

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Pharmacokinetics and Bioavailability of Single-Dose Intranasal Hydromorphone Hydrochloride in Healthy Volunteers by Coda, Barbara A., Rudy, Anita C., Archer, Sanford M., Wermeling, Daniel P.

“…We evaluated pharmacokinetics and absolute bioavailability of single doses of hydromorphone hydrochloride after administration of 1.0 and 2.0 mg of intranasal…”
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Value of investigational drugs by Wermeling, D P

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Gender-related considerations in clinical pharmacology and drug therapeutics by Xie, C X, Piecoro, L T, Wermeling, D P

“…The pharmacokinetics and pharmacodynamics in women are different from that in men because of women's unique anatomy and physiology. Recently, gender-related…”
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A dose-response study of orally administered torsemide in patients with ascites due to cirrhosis by Applefeld, J J, Kasmer, R J, Hak, L J, Dukes, G E, Wermeling, D P, McClain, C J

“…This study evaluated the dose-response relationship of torsemide, the first pyridine-sulphonylurea loop diuretic, in patients with ascites due to cirrhosis…”
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Effects of long-term oral carvedilol on the steady-state pharmacokinetics of oral digoxin in patients with mild to moderate hypertension by Wermeling, D P, Field, C J, Smith, D A, Chandler, M H, Clifton, G D, Boyle, D A

“…The effect of multiple oral doses of carvedilol on steady-state plasma digoxin pharmacokinetics was evaluated in 12 patients with mild to moderate…”
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A Multiple-Dose Phase I Study of Intranasal Hydromorphone Hydrochloride in Healthy Volunteers by Rudy, Anita C., Coda, Barbara A., Archer, Sanford M., Wermeling, Daniel P.

“…We evaluated the pharmacokinetics, tolerability, and safety of 1 and 2 mg of intranasal hydromorphone hydrochloride in an open-label, single- and multiple-dose…”
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