Search Results - "WENDUM, Dominique"

The IGF2/IR/IGF1R Pathway in Tumor Cells and Myofibroblasts Mediates Resistance to EGFR Inhibition in Cholangiocarcinoma by Vaquero, Javier, Lobe, Cindy, Tahraoui, Sylvana, Clapéron, Audrey, Mergey, Martine, Merabtene, Fatiha, Wendum, Dominique, Coulouarn, Cédric, Housset, Chantal, Desbois-Mouthon, Christèle, Praz, Françoise, Fouassier, Laura

“…Cholangiocarcinoma (CCA) is a desmoplastic tumor of the biliary tree in which epidermal growth factor receptor (EGFR) is overexpressed and contributes to…”
Get full text

Gemcitabine and oxaliplatin with or without cetuximab in advanced biliary-tract cancer (BINGO): a randomised, open-label, non-comparative phase 2 trial by Malka, David, Dr, Cervera, Pascale, MD, Foulon, Stéphanie, MSc, Trarbach, Tanja, MD, de la Fouchardière, Christelle, MD, Boucher, Eveline, MD, Fartoux, Laetitia, MD, Faivre, Sandrine, Prof, Blanc, Jean-Frédéric, Prof, Viret, Frédéric, MD, Assenat, Eric, MD, Seufferlein, Thomas, Prof, Herrmann, Thomas, Prof, Grenier, Julien, MD, Hammel, Pascal, Prof, Dollinger, Matthias, MD, André, Thierry, Prof, Hahn, Philipp, MD, Heinemann, Volker, Prof, Rousseau, Vanessa, PhD, Ducreux, Michel, Prof, Pignon, Jean-Pierre, MD, Wendum, Dominique, Prof, Rosmorduc, Olivier, Prof, Greten, Tim F, Prof

“…Summary Background Gemcitabine plus a platinum-based agent (eg, cisplatin or oxaliplatin) is the standard of care for advanced biliary cancers. We investigated…”
Get full text

EGF/EGFR axis contributes to the progression of cholangiocarcinoma through the induction of an epithelial-mesenchymal transition by Clapéron, Audrey, Mergey, Martine, Nguyen Ho-Bouldoires, Thanh Huong, Vignjevic, Danijela, Wendum, Dominique, Chrétien, Yves, Merabtene, Fatiha, Frazao, Alexandra, Paradis, Valérie, Housset, Chantal, Guedj, Nathalie, Fouassier, Laura

“…Background & Aims Epithelial-mesenchymal transition (EMT) is a cellular process involved in cancer progression. The first step of EMT consists in the…”
Get full text

Portal myofibroblasts promote vascular remodeling underlying cirrhosis formation through the release of microparticles by Lemoinne, Sara, Cadoret, Axelle, Rautou, Pierre‐Emmanuel, El Mourabit, Haquima, Ratziu, Vlad, Corpechot, Christophe, Rey, Colette, Bosselut, Nelly, Barbu, Véronique, Wendum, Dominique, Feldmann, Gérard, Boulanger, Chantal, Henegar, Corneliu, Housset, Chantal, Thabut, Dominique

“…Liver fibrosis expanding from portal tracts and vascular remodeling are determinant factors in the progression of liver diseases to cirrhosis. In the present…”
Get full text

Mitogenic Insulin Receptor-A Is Overexpressed in Human Hepatocellular Carcinoma due to EGFR-Mediated Dysregulation of RNA Splicing Factors by CHETTOUH, Hamza, FARTOUX, Laetitia, PRAZ, Françoise, HOUSSET, Chantal, ROSMORDUC, Olivier, DESBOIS-MOUTHON, Christèle, AOUDJEHANE, Lynda, WENDUM, Dominique, CLAPERON, Audrey, CHRÉTIEN, Yves, REY, Colette, SCATTON, Olivier, SOUBRANE, Olivier, CONTI, Filomena

“…Insulin receptor (IR) exists as two isoforms resulting from the alternative splicing of IR pre-mRNA. IR-B promotes the metabolic effects of insulin, whereas…”
Get full text

Bile Salts Control the Antimicrobial Peptide Cathelicidin Through Nuclear Receptors in the Human Biliary Epithelium by D'Aldebert, Emilie, Biyeyeme Bi Mve, Marie–Jeanne, Mergey, Martine, Wendum, Dominique, Firrincieli, Delphine, Coilly, Audrey, Fouassier, Laura, Corpechot, Christophe, Poupon, Raoul, Housset, Chantal, Chignard, Nicolas

“…Backgrounds & Aims Under normal conditions, the biliary tract is a microbial-free environment. The absence of microorganisms has been attributed to various…”
Get full text

Hepatic myofibroblasts promote the progression of human cholangiocarcinoma through activation of epidermal growth factor receptor by Clapéron, Audrey, Mergey, Martine, Aoudjehane, Lynda, Ho‐Bouldoires, Thanh Huong Nguyen, Wendum, Dominique, Prignon, Aurélie, Merabtene, Fatiha, Firrincieli, Delphine, Desbois‐Mouthon, Christèle, Scatton, Olivier, Conti, Filomena, Housset, Chantal, Fouassier, Laura

“…Intrahepatic cholangiocarcinoma (CCA) is characterized by an abundant desmoplastic environment. Poor prognosis of CCA has been associated with the presence of…”
Get full text

Implication of Metastasis Suppressor NM23-H1 in Maintaining Adherens Junctions and Limiting the Invasive Potential of Human Cancer Cells by BOISSAN, Mathieu, DE WEVER, Olivier, BRACKE, Marc, CHAVRIER, Philippe, GESPACH, Christian, LACOMBE, Marie-Lise, LIZARRAGA, Floria, WENDUM, Dominique, POINCLOUX, Renaud, CHIGNARD, Nicolas, DESBOIS-MOUTHON, Christèle, DUFOUR, Sylvie, NAWROCKI-RABY, Béatrice, BIREMBAUT, Philippe

“…Loss of NM23-H1 expression correlates with the degree of metastasis and with unfavorable clinical prognosis in several types of human carcinoma. However, the…”
Get full text

Diffusion‐weighted magnetic resonance imaging for the assessment of fibrosis in chronic hepatitis C by Lewin, Maïté, Poujol‐Robert, Armelle, Boëlle, Pierre‐Yves, Wendum, Dominique, Lasnier, Elisabeth, Viallon, Magalie, Guéchot, Jérôme, Hoeffel, Christine, Arrivé, Lionel, Tubiana, Jean‐Michel, Poupon, Raoul

“…Liver biopsy is the gold standard for assessing fibrosis but has several limitations. We evaluated a noninvasive method, so‐called diffusion‐weighted magnetic…”
Get full text

Testing for ROS1, ALK, MET, and HER2 rearrangements and amplifications in a large series of biliary tract adenocarcinomas by Augustin, Jeremy, Gabignon, Caroline, Scriva, Aurélie, Menu, Laëtitia, Calmel, Claire, Scatton, Olivier, Paye, François, Fléjou, Jean-François, Praz, Françoise, Cervera, Pascale, Wendum, Dominique

“…Biliary tract carcinomas are divided into intrahepatic, perihilar, distal extrahepatic cholangiocarcinomas, and gallbladder adenocarcinomas. Therapies…”
Get full text

Serum adipokine levels predictive of liver injury in non-alcoholic fatty liver disease by Lemoine, Maud, Ratziu, Vlad, Kim, Minji, Maachi, Mustapha, Wendum, Dominique, Paye, François, Bastard, Jean Philippe, Poupon, Raoul, Housset, Chantal, Capeau, Jacqueline, Serfaty, Lawrence

“…Aims: The aim of this study was to determine whether serum levels of adipokines, including the ratio of serum adiponectin to leptin (A/L) levels could predict…”
Get full text

KIF20A mRNA and Its Product MKlp2 Are Increased During Hepatocyte Proliferation and Hepatocarcinogenesis by Gasnereau, Isabelle, Boissan, Mathieu, Margall-Ducos, Germain, Couchy, Gabrielle, Wendum, Dominique, Bourgain-Guglielmetti, Florence, Desdouets, Chantal, Lacombe, Marie-Lise, Zucman-Rossi, Jessica, Sobczak-Thépot, Joëlle

“…Mitotic kinesin-like protein 2 (MKlp2), a microtubule-associated motor, is required during mitosis exit for the final step of cytokinesis. It also contributes…”
Get full text

Prominent contribution of portal mesenchymal cells to liver fibrosis in ischemic and obstructive cholestatic injuries by Beaussier, Marc, Wendum, Dominique, Schiffer, Eduardo, Dumont, Sylvie, Rey, Colette, Lienhart, André, Housset, Chantal

“…Liver fibrosis is produced by myofibroblasts of different origins. In culture models, rat myofibroblasts derived from hepatic stellate cells (HSCs) and from…”
Get full text

Long term outcome and response to therapy of primary biliary cirrhosis—autoimmune hepatitis overlap syndrome by Chazouillères, Olivier, Wendum, Dominique, Serfaty, Lawrence, Rosmorduc, Olivier, Poupon, Raoul

“…Whether primary biliary cirrhosis (PBC)—autoimmune hepatitis (AIH) overlap syndrome requires immunosuppressive therapy in addition to ursodeoxycholic acid…”
Get full text

Chronic liver injury during obstructive sleep apnea by TANNE, Florence, GAGNADOUX, Frédéric, CHAZOUILLERES, Olivier, FLEURY, Bernard, WENDUM, Dominique, LASNIER, Elisabeth, LEBEAU, Bernard, POUPON, Raoul, SERFATY, Lawrence

“…Patients with obstructive sleep apnea (OSA) are at risk for the development of fatty liver as a result of being overweight. Several data suggest that OSA per…”
Get full text

Metastasis suppressor NM23 limits oxidative stress in mammals by preventing activation of stress‐activated protein kinases/JNKs through its nucleoside diphosphate kinase activity by Peuchant, Evelyne, Bats, Marie‐Lise, Moranvillier, Isabelle, Lepoivre, Michel, Guitton, Jérôme, Wendum, Dominique, Lacombe, Marie‐Lise, Moreau‐Gaudry, François, Boissan, Mathieu, Dabernat, Sandrine

“…NME1 (nonmetastatic expressed 1) gene, which encodes nucleoside diphosphate kinase (NDPK) A [also known as nonmetastatic clone 23 (NM23)‐H1 in humans and…”
Get full text

Diagnosing Nodular Regenerative Hyperplasia of the Liver Is Thwarted by Low Interobserver Agreement by Jharap, Bindia, van Asseldonk, Dirk P, de Boer, Nanne K H, Bedossa, Pierre, Diebold, Joachim, Jonker, A Mieke, Leteurtre, Emmanuelle, Verheij, Joanne, Wendum, Dominique, Wrba, Fritz, Zondervan, Pieter E, Colombel, Jean-Frédéric, Reinisch, Walter, Mulder, Chris J J, Bloemena, Elisabeth, van Bodegraven, Adriaan A

“…Nodular regenerative hyperplasia (NRH) of the liver is associated with several diseases and drugs. Clinical symptoms of NRH may vary from absence of symptoms…”
Get full text

Protective potential of the gallbladder in primary sclerosing cholangitis by Cazzagon, Nora, Gonzalez-Sanchez, Ester, El-Mourabit, Haquima, Wendum, Dominique, Rainteau, Dominique, Humbert, Lydie, Corpechot, Christophe, Chazouillères, Olivier, Arrivé, Lionel, Housset, Chantal, Lemoinne, Sara

“…Gallbladder enlargement is common in patients with primary sclerosing cholangitis (PSC). The gallbladder may confer hepatoprotection against bile acid…”
Get full text

Liver biopsy for diagnosis of presumed benign hepatocellular lesions lacking magnetic resonance imaging diagnostic features of focal nodular hyperplasia by Sannier, Aurélie, Cazejust, Julien, Lequoy, Marie, Cervera, Pascale, Scatton, Olivier, Rosmorduc, Olivier, Wendum, Dominique

“…Background & Aims The contribution of liver biopsy for the diagnosis of presumed benign hepatocellular lesions lacking the diagnostic features of focal nodular…”
Get full text

Diet‐Induced Dysbiosis and Genetic Background Synergize With Cystic Fibrosis Transmembrane Conductance Regulator Deficiency to Promote Cholangiopathy in Mice by Debray, Dominique, El Mourabit, Haquima, Merabtene, Fatiha, Brot, Loïc, Ulveling, Damien, Chrétien, Yves, Rainteau, Dominique, Moszer, Ivan, Wendum, Dominique, Sokol, Harry, Housset, Chantal

“…The most typical expression of cystic fibrosis (CF)–related liver disease is a cholangiopathy that can progress to cirrhosis. We aimed to determine the…”
Get full text