Search Results - "WEN-TIEN CHEN"

Detection and characterization of invasive circulating tumor cells derived from men with metastatic castration‐resistant prostate cancer by Friedlander, Terence W., Ngo, Vy T., Dong, Huan, Premasekharan, Gayatri, Weinberg, Vivian, Doty, Shaun, Zhao, Qiang, Gilbert, Elizabeth G., Ryan, Charles J., Chen, Wen‐Tien, Paris, Pamela L.

“…The Vitatex cell‐adhesion matrix (CAM) platform allows for isolation of invasive circulating tumor cells (iCTCs). Here we sought to determine the utility of…”
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Inflammatory interferon activates HIF-1α-mediated epithelial-to-mesenchymal transition via PI3K/AKT/mTOR pathway by Yeh, Yen-Hsiu, Hsiao, Ho-Fu, Yeh, Yen-Cheng, Chen, Tien-Wen, Li, Tsai-Kun

“…Tumor microenvironments (TMEs) activate various axes/pathways, predominantly inflammatory and hypoxic responses, impact tumorigenesis, metastasis and…”
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Isolation of circulating epithelial and tumor progenitor cells with an invasive phenotype from breast cancer patients by Lu, Janice, Fan, Tina, Zhao, Qiang, Zeng, Wei, Zaslavsky, Eva, Chen, John J., Frohman, Michael A., Golightly, Marc G., Madajewicz, Stefan, Chen, Wen‐Tien

“…Recent research advances show that tumor cell intravasation (entry into the circulation) and metastasis occur very early in breast cancer progression. Clinical…”
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Clinical Implications of Fibroblast Activation Protein in Patients with Colon Cancer by HENRY, Leonard R, LEE, Hyung-Ok, LEE, John S, KLEIN-SZANTO, Andres, WATTS, Perry, ROSS, Eric A, CHEN, Wen-Tien, CHENG, Jonathan D

“…Purpose: Human fibroblast activation protein (FAP)/seprase is a 97-kDa surface glycoprotein expressed on tumor associated fibroblasts in the majority of…”
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Activation of multiple proteolysis systems contributes to acute cadmium cytotoxicity by Yeh, Yen-Hsiu, Tsai, Chia-Chih, Chen, Tien-Wen, Lee, Chieh-Hua, Chang, Wei-Jer, Hsieh, Mei-Yi, Li, Tsai-Kun

“…Cadmium exhibits both toxic and carcinogenic effects, and its cytotoxicity is linked to various cellular pathways, such as oxidative stress,…”
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Critical appraisal of the use of matrix metalloproteinase inhibitors in cancer treatment by Zucker, S, Cao, J, Chen, W T

“…Experimental studies performed prior to 1990 led to the widely held belief that matrix metalloproteinases (MMPs) produced by cancer cells are of critical…”
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The propensity of invasive circulating tumor cells (iCTCs) in metastatic progression and therapeutic responsiveness by Dong, Huan, Tulley, Shaun, Zhao, Qiang, Cho, Leong, Chen, Donghai, Pearl, Michael L., Chen, Wen‐Tien

“…Circulating tumor cells (CTCs) are important clinical indicators of metastatic progression and treatment efficacy. However, because of their low number and…”
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The protease complex consisting of dipeptidyl peptidase iv and seprase plays a role in the migration and invasion of human endothelial cells in collagenous matrices by GHERSI, Giulio, QIANG ZHAO, SALAMONE, Monica, YEH, Yunyun, ZUCKER, Stanley, CHEN, Wen-Tien

“…Dipeptidyl peptidase IV (DPP4/CD26) and seprase/fibroblast activation protein alpha are homologous type II transmembrane, homodimeric glycoproteins that…”
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The efficacy of shock wave therapy in patients with knee osteoarthritis and popliteal cyamella by Chen, Tien-Wen, Lin, Cheng-Wei, Lee, Chia-Ling, Chen, Chia-Hsin, Chen, Yi-Jen, Lin, Tz-Yan, Huang, Mao-Hsiung

“…Abstract This randomized, controlled study was performed to compare the effects of extracorporeal shockwave therapy (ESWT) and ultrasound on the rehabilitation…”
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Assessing Clinical Outcomes in Colorectal Cancer with Assays for Invasive Circulating Tumor Cells by Zhang, Yue, Zarrabi, Kevin, Hou, Wei, Madajewicz, Stefan, Choi, Minsig, Zucker, Stanley, Chen, Wen-Tien

“…Colorectal carcinoma (CRC) is the second leading cause of cancer-related mortality. The goals of this study are to evaluate the association between levels of…”
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Association Between the Severity of Femoral Condylar Cartilage Erosion Related to Knee Osteoarthritis by Ultrasonographic Evaluation and the Clinical Symptoms and Functions by Chen, Yi-Jen, MD, MS, Chen, Chia-Hsin, MD, PhD, Wang, Chao-Ling, MD, Huang, Mao-Hsiung, MD, PhD, Chen, Tien-Wen, MD, Lee, Chia-Ling, MD, MS

“…Abstract Objective To determine the association between the severity of femoral condylar cartilage erosion resulting from knee osteoarthritis (OA) by an…”
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Seprase complexes in cellular invasiveness by Chen, Wen-Tien, Kelly, Thomas

“…A group of type II integral serine proteases, including dipeptidyl peptidase IV (DPP4/CD26), seprase/fibroblast activation protein alpha (FAPalpha) and related…”
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Fuzzy logic-based mobile computing system for hand rehabilitation after neurological injury by Chiu, Yu-Hsien, Chen, Tien-Wen, Chen, Yenming J, Su, Ching-I, Hwang, Kao-Shing, Ho, Wen-Hsien

“…Effective neurological rehabilitation requires long term assessment and treatment. The rapid progress of virtual reality-based assistive technologies and…”
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Regulation of Fibroblast Migration on Collagenous Matrix by a Cell Surface Peptidase Complex by Ghersi, Giulio, Dong, Huan, Goldstein, Leslie A, Yeh, Yunyun, Hakkinen, Lari, Larjava, Hannu S, Chen, Wen-Tien

“…The invasion of migratory cells through connective tissues involves metallo- and serine types of cell surface proteases. We show that formation of a novel…”
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Induction of Smad1 by MT1‐MMP contributes to tumor growth by Freudenberg, Jaclyn A., Chen, Wen‐Tien

“…MT1‐MMP is a key integral membrane protease, which regulates tumor growth by cleaving extracellular matrix components, activating growth factors and receptors,…”
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Specialized Surface Protrusions of Invasive Cells, Invadopodia and Lamellipodia, Have Differential MT1-MMP, MMP-2, and TIMP-2 Localization by CHEN, WEN-TIEN, WANG, JAW-YUAN

“…Surface protrusions, invadopodia, and analogous lamellipodia at the leading edge of an invasive cell, which make contact with the underlying extracellular…”
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Transmembrane/Cytoplasmic Domain-Mediated Membrane Type 1-Matrix Metalloprotease Docking to Invadopodia is Required for Cell Invasion by Nakahara, Hirokazu, Howard, Linda, Thompson, Erik W., Sato, Hiroshi, Seiki, Motoharu, Yeh, Yunyun, Chen, Wen-Tien

“…The invasion of human malignant melanoma cells into the extracellular matrix (ECM) involves the accumulation of proteases at sites of ECM degradation where…”
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The efficacy of ultrasound-guided extracorporeal shockwave therapy in patients with cervical spondylosis and nuchal ligament calcification by Lin, Tz-Yan, Chen, Jing-Ting, Chen, Yu-Yu, Chen, Tien-Wen, Lee, Chia-Ling, Chen, Chia-Hsin, Huang, Mao-Hsiung

“…Abstract We investigated the effects of extracorporeal shockwave therapy (ESWT) on the rehabilitation of cervical spondylosis with nuchal ligament (NL)…”
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Effects of Different Stretching Techniques on the Outcomes of Isokinetic Exercise in Patients with Knee Osteoarthritis by Weng, Ming-Cheng, Lee, Chia-Ling, Chen, Chia-Hsin, Hsu, Jui-Jen, Lee, Wei-Der, Huang, Mao-Hsiung, Chen, Tien-Wen

“…We recruited 132 subjects with bilateral knee osteoarthritis (Altman Grade II) to compare the effects of different stretching techniques on the outcomes of…”
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Transcriptional Regulation of Seprase in Invasive Melanoma Cells by Transforming Growth Factor-β Signaling by Tulley, Shaun, Chen, Wen-Tien

“…The tumor invasive phenotype driven by seprase expression/activity has been widely examined in an array of malignant tumor cell types; however, very little is…”
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