Search Results - "WELSH, K."

Suprachiasmatic nucleus: cell autonomy and network properties by Welsh, David K, Takahashi, Joseph S, Kay, Steve A

“…The suprachiasmatic nucleus (SCN) is the primary circadian pacemaker in mammals. Individual SCN neurons in dispersed culture can generate independent circadian…”
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Genetic Disruption of Circadian Rhythms in the Suprachiasmatic Nucleus Causes Helplessness, Behavioral Despair, and Anxiety-like Behavior in Mice by Landgraf, Dominic, Long, Jaimie E, Proulx, Christophe D, Barandas, Rita, Malinow, Roberto, Welsh, David K

“…Abstract Background Major depressive disorder is associated with disturbed circadian rhythms. To investigate the causal relationship between mood disorders and…”
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Cellular Circadian Clocks in Mood Disorders by McCarthy, Michael J., Welsh, David K.

“…Bipolar disorder (BD) and major depressive disorder (MDD) are heritable neuropsychiatric disorders associated with disrupted circadian rhythms. The hypothesis…”
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Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR by Walton, Zandra E., Patel, Chirag H., Brooks, Rebekah C., Yu, Yongjun, Ibrahim-Hashim, Arig, Riddle, Malini, Porcu, Alessandra, Jiang, Tianying, Ecker, Brett L., Tameire, Feven, Koumenis, Constantinos, Weeraratna, Ashani T., Welsh, David K., Gillies, Robert, Alwine, James C., Zhang, Lin, Powell, Jonathan D., Dang, Chi V.

“…Recent reports indicate that hypoxia influences the circadian clock through the transcriptional activities of hypoxia-inducible factors (HIFs) at clock genes…”
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Circadian Clock and Stress Interactions in the Molecular Biology of Psychiatric Disorders by Landgraf, Dominic, McCarthy, Michael J., Welsh, David K.

“…Many psychiatric disorders are characterized by circadian rhythm abnormalities, including disturbed sleep/wake cycles, changes in locomotor activity, and…”
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Enhancing circadian clock function in cancer cells inhibits tumor growth by Kiessling, Silke, Beaulieu-Laroche, Lou, Blum, Ian D, Landgraf, Dominic, Welsh, David K, Storch, Kai-Florian, Labrecque, Nathalie, Cermakian, Nicolas

“…Circadian clocks control cell cycle factors, and circadian disruption promotes cancer. To address whether enhancing circadian rhythmicity in tumor cells…”
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Circadian modulation by time-restricted feeding rescues brain pathology and improves memory in mouse models of Alzheimer’s disease by Whittaker, Daniel S., Akhmetova, Laila, Carlin, Daniel, Romero, Haylie, Welsh, David K., Colwell, Christopher S., Desplats, Paula

“…Circadian disruptions impact nearly all people with Alzheimer’s disease (AD), emphasizing both their potential role in pathology and the critical need to…”
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Vulnerability to helpless behavior is regulated by the circadian clock component CRYPTOCHROME in the mouse nucleus accumbens by Porcu, Alessandra, Vaughan, Megan, Nilsson, Anna, Arimoto, Natsuko, Lamia, Katja, Welsh, David K.

“…The nucleus accumbens (NAc), a central component of the midbrain dopamine reward circuit, exhibits disturbed circadian rhythms in the postmortem brains of…”
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NPAS2 Compensates for Loss of CLOCK in Peripheral Circadian Oscillators by Landgraf, Dominic, Wang, Lexie L, Diemer, Tanja, Welsh, David K

“…Heterodimers of CLOCK and BMAL1 are the major transcriptional activators of the mammalian circadian clock. Because the paralog NPAS2 can substitute for CLOCK…”
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Identification of Small Molecule Activators of Cryptochrome by Hirota, Tsuyoshi, Lee, Jae Wook, St. John, Peter C., Sawa, Mariko, Iwaisako, Keiko, Noguchi, Takako, Pongsawakul, Pagkapol Y., Sonntag, Tim, Welsh, David K., Brenner, David A., Doyle, Francis J., Schultz, Peter G., Kay, Steve A.

“…Impairment of the circadian clock has been associated with numerous disorders, including metabolic disease. Although small molecules that modulate clock…”
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Evaluation of Long-term Survival After Hepatic Resection for Metastatic Colorectal Cancer : A Multifactorial Model of 929 Patients by REES, Myrddin, TEKKIS, Paris P, WELSH, Fenella K. S, O'ROURKE, Thomas, JOHN, Timothy G

“…To identify risk factors associated with cancer-specific survival and develop a predictive model for patients undergoing primary hepatic resection for…”
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Long-term in vivo recording of circadian rhythms in brains of freely moving mice by Mei, Long, 梅龙, Fan, Yanyan, 范艳艳, Lv, Xiaohua, 吕晓华, Welsh, David K., Zhan, Cheng, 占成, Zhang, Eric Erquan, 张二荃

“…Endogenous circadian clocks control 24-h physiological and behavioral rhythms in mammals. Here, we report a real-time in vivo fluorescence recording system…”
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Multisite pain and self-reported falls in older people: systematic review and meta-analysis by Welsh, Victoria K, Clarson, Lorna E, Mallen, Christian D, McBeth, John

“…Multisite pain and falls are common in older people, and isolated studies have identified multisite pain as a potential falls risk factor. This study aims to…”
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Cell type-specific functions of period genes revealed by novel adipocyte and hepatocyte circadian clock models by Ramanathan, Chidambaram, Xu, Haiyan, Khan, Sanjoy K, Shen, Yang, Gitis, Paula J, Welsh, David K, Hogenesch, John B, Liu, Andrew C

“…In animals, circadian rhythms in physiology and behavior result from coherent rhythmic interactions between clocks in the brain and those throughout the body…”
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Intercellular Coupling Confers Robustness against Mutations in the SCN Circadian Clock Network by Liu, Andrew C., Welsh, David K., Ko, Caroline H., Tran, Hien G., Zhang, Eric E., Priest, Aaron A., Buhr, Ethan D., Singer, Oded, Meeker, Kirsten, Verma, Inder M., Doyle, Francis J., Takahashi, Joseph S., Kay, Steve A.

“…Molecular mechanisms of the mammalian circadian clock have been studied primarily by genetic perturbation and behavioral analysis. Here, we used…”
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Cardiomyocyte Circadian Oscillations Are Cell-Autonomous, Amplified by β-Adrenergic Signaling, and Synchronized in Cardiac Ventricle Tissue by Beesley, Stephen, Noguchi, Takako, Welsh, David K

“…Circadian clocks impact vital cardiac parameters such as blood pressure and heart rate, and adverse cardiac events such as myocardial infarction and sudden…”
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Emergence of noise-induced oscillations in the central circadian pacemaker by Ko, Caroline H, Yamada, Yujiro R, Welsh, David K, Buhr, Ethan D, Liu, Andrew C, Zhang, Eric E, Ralph, Martin R, Kay, Steve A, Forger, Daniel B, Takahashi, Joseph S

“…Bmal1 is an essential transcriptional activator within the mammalian circadian clock. We report here that the suprachiasmatic nucleus (SCN) of Bmal1-null…”
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Persistent cell-autonomous circadian oscillations in fibroblasts revealed by six-week single-cell imaging of PER2::LUC bioluminescence by Leise, Tanya L, Wang, Connie W, Gitis, Paula J, Welsh, David K

“…Biological oscillators naturally exhibit stochastic fluctuations in period and amplitude due to the random nature of molecular reactions. Accurately measuring…”
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A survey of genomic studies supports association of circadian clock genes with bipolar disorder spectrum illnesses and lithium response by McCarthy, Michael J, Nievergelt, Caroline M, Kelsoe, John R, Welsh, David K

“…Circadian rhythm abnormalities in bipolar disorder (BD) have led to a search for genetic abnormalities in circadian "clock genes" associated with BD. However,…”
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Bioluminescence Imaging of Individual Fibroblasts Reveals Persistent, Independently Phased Circadian Rhythms of Clock Gene Expression by Welsh, David K., Yoo, Seung-Hee, Liu, Andrew C., Takahashi, Joseph S., Kay, Steve A.

“…Circadian (ca. 24 hr) oscillations in expression of mammalian “clock genes” are found not only in the suprachiasmatic nucleus (SCN), the central circadian…”
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