Use of CT Angiography in Comparison with Other Imaging Techniques for the Determination of Embolus and Remnant Size in Experimental Aneurysms Embolized with Hydrogel Filaments

Beam-hardening artifacts in CTA can be greatly reduced by using metal-free coils for aneurysm embolization. We compared the embolic masses and remnants of experimental rabbit aneurysms coiled with hydrogel filaments by using DSA, CTA and histology. Embolization of 12 rabbit bifurcation aneurysms was...

Full description

Saved in:

Bibliographic Details
Published in:	American journal of neuroradiology : AJNR Vol. 32; no. 5; pp. 923 - 928
Main Authors:	KILLER, M, MCCOY, M. R, VESTAL, M. C, WEITGASSER, L, CRUISE, G. M
Format:	Journal Article
Language:	English
Published:	Oak Brook, IL American Society of Neuroradiology 01-05-2011
Subjects:	Animals Biological and medical sciences Cerebral Angiography - methods Embolization, Therapeutic - instrumentation Equipment Design Equipment Failure Analysis Female Fundamental and applied biological sciences. Psychology Hydrogels Interventional Intracranial Aneurysm - complications Intracranial Aneurysm - diagnostic imaging Intracranial Aneurysm - surgery Intracranial Embolism - diagnostic imaging Intracranial Embolism - etiology Intracranial Embolism - prevention & control Investigative techniques, diagnostic techniques (general aspects) Male Materials Testing Medical sciences Nervous system Perception Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Rabbits Radiodiagnosis. Nmr imagery. Nmr spectrometry Reproducibility of Results Sensitivity and Specificity Stents Treatment Outcome Vision Vascular disease Nervous system diseases Filament Radiodiagnosis Aneurysm Cardiovascular disease Technique Angiocomputed tomography Comparative study
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Beam-hardening artifacts in CTA can be greatly reduced by using metal-free coils for aneurysm embolization. We compared the embolic masses and remnants of experimental rabbit aneurysms coiled with hydrogel filaments by using DSA, CTA and histology. Embolization of 12 rabbit bifurcation aneurysms was performed with detachable hydrogel filaments. Six aneurysms were embolized as completely as possible, and 6 aneurysms were embolized incompletely to intentionally leave remnants. Three aneurysms in each group underwent follow-up at 4 and 13 weeks. DSA, MRA, and CTA were performed immediately before sacrifice. The harvested aneurysms were evaluated histologically. For each imaging technique, the areas of the embolic mass and remnant were determined by using image analysis. Results were compared by using paired t tests. CTAs were suitable for quantification of the embolus and remnant areas because only small streaking artifacts were evident. The areas of the embolus were larger on CTA compared with DSA and histologic sections. The areas of the remnant were larger on CTA and MRA compared with DSA and histologic sections. Like DSA and MRA, CTA was suitable for determining whether aneurysm retreatment was necessary, provided that loops of hydrogel filaments were not present in the parent artery. We demonstrated that CTA is a technique with potential for surveillance of aneurysms treated with hydrogel filaments. Additional work is required to determine the accuracy of the technique compared with currently accepted imaging modalities of DSA and MRA.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Article-2 ObjectType-Feature-1
ISSN:	0195-6108 1936-959X
DOI:	10.3174/ajnr.A2554