Search Results - "WEISSMAN, Irving"

Pre-Clinical Development of a Humanized Anti-CD47 Antibody with Anti-Cancer Therapeutic Potential by Liu, Jie, Wang, Lijuan, Zhao, Feifei, Tseng, Serena, Narayanan, Cyndhavi, Shura, Lei, Willingham, Stephen, Howard, Maureen, Prohaska, Susan, Volkmer, Jens, Chao, Mark, Weissman, Irving L, Majeti, Ravindra

“…CD47 is a widely expressed cell surface protein that functions as a regulator of phagocytosis mediated by cells of the innate immune system, such as…”
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Macrophages are critical effectors of antibody therapies for cancer by Weiskopf, Kipp, Weissman, Irving L

“…Macrophages are innate immune cells that derive from circulating monocytes, reside in all tissues, and participate in many states of pathology. Macrophages…”
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The Role of Efferocytosis in Atherosclerosis by Kojima, Yoko, Weissman, Irving L, Leeper, Nicholas J

“…The necrotic core has long been a hallmark of the vulnerable atherosclerotic plaque. Although apoptotic cells are cleared quickly in almost all other tissue…”
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Phagocytosis checkpoints as new targets for cancer immunotherapy by Feng, Mingye, Jiang, Wen, Kim, Betty Y. S., Zhang, Cheng Cheng, Fu, Yang-Xin, Weissman, Irving L.

“…Cancer immunotherapies targeting adaptive immune checkpoints have substantially improved patient outcomes across multiple metastatic and treatment-refractory…”
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Stem cells are units of natural selection for tissue formation, for germline development, and in cancer development by Weissman, Irving L

“…It is obvious that natural selection operates at the level of individuals and collections of individuals. Nearly two decades ago we showed that in…”
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Quiescent Hematopoietic Stem Cells Accumulate DNA Damage during Aging that Is Repaired upon Entry into Cell Cycle by Beerman, Isabel, Seita, Jun, Inlay, Matthew A., Weissman, Irving L., Rossi, Derrick J.

“…Hematopoietic stem cells (HSCs) maintain homeostasis and regenerate the blood system throughout life. It has been postulated that HSCs may be uniquely capable…”
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The CD47–SIRPα pathway in cancer immune evasion and potential therapeutic implications by Chao, Mark P, Weissman, Irving L, Majeti, Ravindra

“…Highlights ► Phagocytic cells, macrophages, regulate tumor growth through phagocytic clearance. ► CD47 binds SIRPα on phagocytes which delivers an inhibitory…”
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Hematopoietic stem cell: self-renewal versus differentiation by Seita, Jun, Weissman, Irving L.

“…The mammalian blood system, containing more than 10 distinct mature cell types, stands on one specific cell type, hematopoietic stem cell (HSC). Within the…”
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Tumorigenicity as a clinical hurdle for pluripotent stem cell therapies by Lee, Andrew S, Tang, Chad, Rao, Mahendra S, Weissman, Irving L, Wu, Joseph C

“…There is much interest in the applications of pluripotent stem cells for regenerative medicine. In this Perspective, the authors discuss the factors that might…”
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A molecular cell atlas of the human lung from single-cell RNA sequencing by Travaglini, Kyle J., Nabhan, Ahmad N., Penland, Lolita, Sinha, Rahul, Gillich, Astrid, Sit, Rene V., Chang, Stephen, Conley, Stephanie D., Mori, Yasuo, Seita, Jun, Berry, Gerald J., Shrager, Joseph B., Metzger, Ross J., Kuo, Christin S., Neff, Norma, Weissman, Irving L., Quake, Stephen R., Krasnow, Mark A.

“…Although single-cell RNA sequencing studies have begun to provide compendia of cell expression profiles 1 – 9 , it has been difficult to systematically…”
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Improving immune–vascular crosstalk for cancer immunotherapy by Huang, Yuhui, Kim, Betty Y. S., Chan, Charles K., Hahn, Stephen M., Weissman, Irving L., Jiang, Wen

“…Normalization of the tumour vasculature can improve immune effector cell infiltration, leading to immunotherapy potentiation. In this Opinion article, Huang et…”
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CD24 signalling through macrophage Siglec-10 is a target for cancer immunotherapy by Barkal, Amira A., Brewer, Rachel E., Markovic, Maxim, Kowarsky, Mark, Barkal, Sammy A., Zaro, Balyn W., Krishnan, Venkatesh, Hatakeyama, Jason, Dorigo, Oliver, Barkal, Layla J., Weissman, Irving L.

“…Ovarian cancer and triple-negative breast cancer are among the most lethal diseases affecting women, with few targeted therapies and high rates of metastasis…”
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Mapping the Pairwise Choices Leading from Pluripotency to Human Bone, Heart, and Other Mesoderm Cell Types by Loh, Kyle M., Chen, Angela, Koh, Pang Wei, Deng, Tianda Z., Sinha, Rahul, Tsai, Jonathan M., Barkal, Amira A., Shen, Kimberle Y., Jain, Rajan, Morganti, Rachel M., Shyh-Chang, Ng, Fernhoff, Nathaniel B., George, Benson M., Wernig, Gerlinde, Salomon, Rachel E.A., Chen, Zhenghao, Vogel, Hannes, Epstein, Jonathan A., Kundaje, Anshul, Talbot, William S., Beachy, Philip A., Ang, Lay Teng, Weissman, Irving L.

“…Stem-cell differentiation to desired lineages requires navigating alternating developmental paths that often lead to unwanted cell types. Hence, comprehensive…”
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Clonal-level lineage commitment pathways of hematopoietic stem cells in vivo by Lu, Rong, Czechowicz, Agnieszka, Seita, Jun, Jiang, Du, Weissman, Irving L.

“…While the aggregate differentiation of the hematopoietic stem cell (HSC) population has been extensively studied, little is known about the lineage commitment…”
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Molecular Pathways: Activating T Cells after Cancer Cell Phagocytosis from Blockade of CD47 "Don't Eat Me" Signals by McCracken, Melissa N, Cha, Adriel C, Weissman, Irving L

“…Recent advances with immunotherapy agents for the treatment of cancer have provided remarkable, and in some cases, curative results. Our laboratory has…”
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CD47 Blockade by Hu5F9-G4 and Rituximab in Non-Hodgkin’s Lymphoma by Advani, Ranjana, Flinn, Ian, Popplewell, Leslie, Forero, Andres, Bartlett, Nancy L, Ghosh, Nilanjan, Kline, Justin, Roschewski, Mark, LaCasce, Ann, Collins, Graham P, Tran, Thu, Lynn, Judith, Chen, James Y, Volkmer, Jens-Peter, Agoram, Balaji, Huang, Jie, Majeti, Ravindra, Weissman, Irving L, Takimoto, Chris H, Chao, Mark P, Smith, Sonali M

“…An antibody to CD47 used in combination with rituximab induced responses in half of a small group of patients with refractory B-cell lymphoma. Inhibiting the…”
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Breaking Down the Barriers to Precision Cancer Nanomedicine by von Roemeling, Christina, Jiang, Wen, Chan, Charles K, Weissman, Irving L, Kim, Betty Y.S

“…Nanomedicine offers unique advantages in treating human cancers. However, physiological and pathological barriers within normal and disease tissues, which are…”
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Preleukemic mutations in human acute myeloid leukemia affect epigenetic regulators and persist in remission by Corces-Zimmerman, M. Ryan, Hong, Wan-Jen, Weissman, Irving L., Medeiros, Bruno C., Majeti, Ravindra

“…Cancer is widely characterized by the sequential acquisition of genetic lesions in a single lineage of cells. Our previous studies have shown that, in acute…”
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Hoxb5 marks long-term haematopoietic stem cells and reveals a homogenous perivascular niche by Chen, James Y., Miyanishi, Masanori, Wang, Sean K., Yamazaki, Satoshi, Sinha, Rahul, Kao, Kevin S., Seita, Jun, Sahoo, Debashis, Nakauchi, Hiromitsu, Weissman, Irving L.

“…Until recently, complex multi-parameters were required for the isolation and identification of haematopoietic stem cells, complicating study of their biology…”
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Existing cardiomyocytes generate cardiomyocytes at a low rate after birth in mice by Ali, Shah R., Hippenmeyer, Simon, Saadat, Lily V., Luo, Liqun, Weissman, Irving L., Ardehali, Reza

“…The mammalian heart has long been considered a postmitotic organ, implying that the total number of cardiomyocytes is set at birth. Analysis of cell division…”
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