Search Results - "WEISSBERG, P. L."

Vascular smooth muscle cell phenotypic plasticity and the regulation of vascular calcification by IYEMERE, V. P., PROUDFOOT, D., WEISSBERG, P. L., SHANAHAN, C. M.

“… Vascular smooth muscle cells (VSMCs) exhibit an extraordinary capacity to undergo phenotypic change during development, in vitro and in association with…”
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Imaging atherosclerotic plaque inflammation with [18F]-fluorodeoxyglucose positron emission tomography by RUDD, J. H. F, WARBURTON, E. A, PICKARD, J. D, WEISSBERG, P. L, FRYER, T. D, JONES, H. A, CLARK, J. C, ANTOUN, N, JOHNSTRÖM, P, DAVENPORT, A. P, KIRKPATRICK, P. J, ARCH, B. N

“…Atherosclerotic plaque rupture is usually a consequence of inflammatory cell activity within the plaque. Current imaging techniques provide anatomic data but…”
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Evaluation of translocator protein quantification as a tool for characterising macrophage burden in human carotid atherosclerosis by Bird, J.L.E, Izquierdo-Garcia, D, Davies, J.R, Rudd, J.H.F, Probst, K.C, Figg, N, Clark, J.C, Weissberg, P.L, Davenport, A.P, Warburton, E.A

“…Abstract Macrophage presence within atherosclerotic plaque is a feature of instability and a risk factor for plaque rupture and clinical events. Activated…”
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Acetylated low-density lipoprotein stimulates human vascular smooth muscle cell calcification by promoting osteoblastic differentiation and inhibiting phagocytosis by PROUDFOOT, D, DAVIES, J. D, SKEPPER, J. N, WEISSBERG, P. L, SHANAHAN, C. M

“…Vascular smooth muscle cells (VSMCs) in atherosclerotic lesions display an osteogenic phenotype, and calcification commonly occurs in association with lipid…”
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Medial localization of mineralization-regulating proteins in association with Mönckeberg's sclerosis : Evidence for smooth muscle cell-mediated vascular calcification by SHANAHAN, C. M, CARY, N. R. B, SALISBURY, J. R, PROUDFOOT, D, WEISSBERG, P. L, EDMONDS, M. E

“…Calcification of the media of peripheral arteries is referred to as Mönckeberg's sclerosis (MS) and occurs commonly in aged and diabetic individuals. Its…”
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Vascular and valvar calcification: recent advances by Farzaneh-Far, A, Proudfoot, D, Shanahan, C, Weissberg, P L

“…There is evidence that alterations in calcification regulatory proteins and change to an osteogenic phenotype occur in an analogous fashion to vascular…”
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Defect in Insulin-Like Growth Factor-1 Survival Mechanism in Atherosclerotic Plaque-Derived Vascular Smooth Muscle Cells Is Mediated by Reduced Surface Binding and Signaling by Patel, V A, Zhang, Q.-J, Siddle, K, Soos, M A, Goddard, M, Weissberg, P L, Bennett, M R

“…ABSTRACT—Apoptosis of vascular smooth muscle cells (VSMCs) is increased in atherosclerosis compared with normal vessels, where it may contribute to plaque…”
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Isolation of Gene Markers of Differentiated and Proliferating Vascular Smooth Muscle Cells by Shanahan, Catherine M, Weissberg, Peter L, Metcalfe, James C

“…To isolate specific markers of both differentiated and proliferating vascular smooth muscle cells (VSMCs), we used the technique of differential cDNA screening…”
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Smooth Muscle Cell Heterogeneity: Patterns of Gene Expression in Vascular Smooth Muscle Cells In Vitro and In Vivo by Shanahan, Catherine M, Weissberg, Peter L

“…Early morphological and biochemical studies indicated that vascular smooth muscle cells (VSMCs) exhibited two distinct phenotypes and that a change from the…”
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Calcification of Human Vascular Cells In Vitro Is Correlated With High Levels of Matrix Gla Protein and Low Levels of Osteopontin Expression by Proudfoot, Diane, Skepper, Jeremy N, Shanahan, Catherine M, Weissberg, Peter L

“…The cellular and molecular events leading to calcification in atherosclerotic lesions are unknown. We and others have shown that bone-associated proteins,…”
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High expression of genes for calcification-regulating proteins in human atherosclerotic plaques by Shanahan, C M, Cary, N R, Metcalfe, J C, Weissberg, P L

“…Calcification is common in atheromatous plaques and may contribute to plaque rupture and subsequent thrombosis. However, little is known about the mechanisms…”
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Atherogenesis: current understanding of the causes of atheroma by Weissberg, Peter L

“…[...]recently, atherosclerosis was thought of as a degenerative, slowly progressive disease, predominantly affecting the elderly, and causing symptoms through…”
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Identifying aortic plaque inflammation as a potential cause of stroke by Moustafa, R R, Izquierdo, D, Weissberg, P L, Baron, J-C, Warburton, E A

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Post‐translational modifications regulate matrix Gla protein function: importance for inhibition of vascular smooth muscle cell calcification by SCHURGERS, L. J., SPRONK, H. M. H., SKEPPER, J. N., HACKENG, T. M., SHANAHAN, C. M., VERMEER, C., WEISSBERG, P. L., PROUDFOOT, D.

“…Background: Matrix Gla protein (MGP) is a small vitamin K‐dependent protein containing five γ‐carboxyglutamic acid (Gla) residues that are believed to be…”
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Cooperative Interactions Between RB and p53 Regulate Cell Proliferation, Cell Senescence, and Apoptosis in Human Vascular Smooth Muscle Cells From Atherosclerotic Plaques by Bennett, Martin R, Macdonald, Kirsty, Chan, Shiu-Wan, Boyle, Joseph J, Weissberg, Peter L

“…Compared with vascular smooth muscle cells (VSMCs) from normal vessels, VSMCs from human atherosclerotic plaques proliferate more slowly, undergo earlier…”
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High resolution magnetic resonance imaging of atherosclerosis and the response to balloon angioplasty by Coulden, R A, Moss, H, Graves, M J, Lomas, D J, Appleton, D S, Weissberg, P L

“…OBJECTIVE To explore the use of high resolution magnetic resonance imaging (MRI) of the popliteal artery in defining atheroscelerotic lesions and to monitor…”
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High adenoviral loads stimulate NFκB-dependent gene expression in human vascular smooth muscle cells by CLESHAM, G. J, ADAM, P. J, PROUDFOOT, D, FLYNN, P. D, EFSTATHIOU, S, WEISSBERG, P. L

“…Replication-deficient adenoviral vectors have been widely used for gene transfer with the aim of delivering genes of interest to investigate their function and…”
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Thrombin Generation by Apoptotic Vascular Smooth Muscle Cells by Flynn, Paul D., Byrne, Christopher D., Baglin, Trevor P., Weissberg, Peter L., Bennett, Martin R.

“…Thrombin activation requires assembly of a prothrombinase complex of activated coagulation factors on an anionic phospholipid surface, classically provided by…”
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Proliferation of Human Smooth Muscle Cells Promoted by Lipoprotein(a) by Grainger, David J., Kirschenlohr, Heide L., Metcalfe, James C., Weissberg, Peter L., Wade, David P., Lawn, Richard M.

“…Elevated blood concentrations of lipoprotein(a) [Lp(a)] and its constituent, apolipoprotein(a) [apo(a)], constitute a major risk factor for atherosclerosis,…”
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Increased Sensitivity of Human Vascular Smooth Muscle Cells From Atherosclerotic Plaques to p53-Mediated Apoptosis by Bennett, Martin R, Littlewood, Trevor D, Schwartz, Stephen M, Weissberg, Peter L

“…The recent demonstration that apoptosis of vascular smooth muscle cells (VSMCs) occurs in human atherosclerotic plaques suggests that VSMC apoptosis may…”
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