Search Results - "WEISS, Stephen J"

Protease-dependent versus -independent cancer cell invasion programs: three-dimensional amoeboid movement revisited by Sabeh, Farideh, Shimizu-Hirota, Ryoko, Weiss, Stephen J

“…Tissue invasion during metastasis requires cancer cells to negotiate a stromal environment dominated by cross-linked networks of type I collagen. Although…”
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Methionine oxidation and reduction in proteins by Kim, Geumsoo, Weiss, Stephen J., Levine, Rodney L.

“…Cysteine and methionine are the two sulfur containing amino acids in proteins. While the roles of protein-bound cysteinyl residues as endogenous antioxidants…”
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Physical limits of cell migration: control by ECM space and nuclear deformation and tuning by proteolysis and traction force by Wolf, Katarina, Te Lindert, Mariska, Krause, Marina, Alexander, Stephanie, Te Riet, Joost, Willis, Amanda L, Hoffman, Robert M, Figdor, Carl G, Weiss, Stephen J, Friedl, Peter

“…Cell migration through 3D tissue depends on a physicochemical balance between cell deformability and physical tissue constraints. Migration rates are further…”
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Breaching the basement membrane: who, when and how? by Rowe, R. Grant, Weiss, Stephen J

“…The basement membrane (BM), a specialized network of extracellular matrix macromolecules, surrounds epithelial, endothelial, muscle, fat and nerve cells…”
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Navigating ECM barriers at the invasive front: the cancer cell-stroma interface by Rowe, R Grant, Weiss, Stephen J

“…A seminal event in cancer progression is the ability of the neoplastic cell to mobilize the necessary machinery to breach surrounding extracellular matrix…”
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Divergent regulation of basement membrane trafficking by human macrophages and cancer cells by Bahr, Julian C., Li, Xiao-Yan, Feinberg, Tamar Y., Jiang, Long, Weiss, Stephen J.

“…Macrophages and cancer cells populations are posited to navigate basement membrane barriers by either mobilizing proteolytic enzymes or deploying mechanical…”
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Canonical Wnt signaling regulates Slug activity and links epithelial–mesenchymal transition with epigenetic Breast Cancer 1, Early Onset (BRCA1) repression by Wu, Zhao-Qiu, Li, Xiao-Yan, Hu, Casey Yuexian, Ford, Michael, Kleer, Celina G, Weiss, Stephen J

“…Slug (Snail2) plays critical roles in regulating the epithelial–mesenchymal transition (EMT) programs operative during development and disease. However, the…”
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Neutrophil-Derived Matrix Metalloproteinase 9 Triggers Acute Aortic Dissection by KURIHARA, Tomohiro, SHIMIZU-HIROTA, Ryoko, SHIMODA, Masayuki, ADACHI, Takeshi, SHIMIZU, Hideyuki, WEISS, Stephen J, ITOH, Hiroshi, HORI, Shingo, AIKAWA, Naoki, OKADA, Yasunori

“…Acute aortic dissection (AAD) is a life-threatening vascular disease without effective pharmaceutical therapy. Matrix metalloproteinases (MMPs) are implicated…”
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Induction of a MT1-MMP and MT2-MMP-dependent basement membrane transmigration program in cancer cells by Snail1 by Ota, Ichiro, Li, Xiao-Yan, Hu, Yuexian, Weiss, Stephen J

“…The ability of carcinoma cells arising at primary sites to cross their underlying basement membrane (BM), a specialized form of extracellular matrix that…”
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MT1-MMP-Dependent Control of Skeletal Stem Cell Commitment via a β1-Integrin/YAP/TAZ Signaling Axis by Tang, Yi, Rowe, R. Grant, Botvinick, Elliot L., Kurup, Abhishek, Putnam, Andrew J., Seiki, Motoharu, Weaver, Valerie M., Keller, Evan T., Goldstein, Steven, Dai, Jinlu, Begun, Dana, Saunders, Thomas, Weiss, Stephen J.

“…In vitro, topographical and biophysical cues arising from the extracellular matrix (ECM) direct skeletal stem cell (SSC) commitment and differentiation…”
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A p53/miRNA-34 axis regulates Snail1-dependent cancer cell epithelial-mesenchymal transition by Kim, Nam Hee, Kim, Hyun Sil, Li, Xiao-Yan, Lee, Inhan, Choi, Hyung-Seok, Kang, Shi Eun, Cha, So Young, Ryu, Joo Kyung, Yoon, Dojun, Fearon, Eric R, Rowe, R Grant, Lee, Sanghyuk, Maher, Christopher A, Weiss, Stephen J, Yook, Jong In

“…Snail1 is a zinc finger transcriptional repressor whose pathological expression has been linked to cancer cell epithelial-mesenchymal transition (EMT) programs…”
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Immobilization after injury alters extracellular matrix and stem cell fate by Huber, Amanda K, Patel, Nicole, Pagani, Chase A, Marini, Simone, Padmanabhan, Karthik R, Matera, Daniel L, Said, Mohamed, Hwang, Charles, Hsu, Ginny Ching-Yun, Poli, Andrea A, Strong, Amy L, Visser, Noelle D, Greenstein, Joseph A, Nelson, Reagan, Li, Shuli, Longaker, Michael T, Tang, Yi, Weiss, Stephen J, Baker, Brendon M, James, Aaron W, Levi, Benjamin

“…Cells sense the extracellular environment and mechanical stimuli and translate these signals into intracellular responses through mechanotransduction, which…”
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The checkpoint inhibitor PD-1H/VISTA controls osteoclast-mediated multiple myeloma bone disease by Fu, Jing, Li, Shirong, Ma, Huihui, Yang, Jun, Pagnotti, Gabriel M., Brown, Lewis M., Weiss, Stephen J., Mapara, Markus Y., Lentzsch, Suzanne

“…Multiple myeloma bone disease is characterized by the development of osteolytic bone lesions. Recent work identified matrix metalloproteinase 13 as a…”
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p53 and microRNA-34 are suppressors of canonical Wnt signaling by Kim, Nam Hee, Kim, Hyun Sil, Kim, Nam-Gyun, Lee, Inhan, Choi, Hyung-Seok, Li, Xiao-Yan, Kang, Shi Eun, Cha, So Young, Ryu, Joo Kyung, Na, Jung Min, Park, Changbum, Kim, Kunhong, Lee, Sanghyuk, Gumbiner, Barry M, Yook, Jong In, Weiss, Stephen J

“…Although loss of p53 function and activation of canonical Wnt signaling cascades are frequently coupled in cancer, the links between these two pathways remain…”
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Adipose Snail1 Regulates Lipolysis and Lipid Partitioning by Suppressing Adipose Triacylglycerol Lipase Expression by Sun, Chengxin, Jiang, Lin, Liu, Yan, Shen, Hong, Weiss, Stephen J., Zhou, Yifa, Rui, Liangyou

“…Lipolysis provides metabolic fuel; however, aberrant adipose lipolysis results in ectopic lipid accumulation and lipotoxicity. While adipose triacylglycerol…”
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Canonical Wnt suppressor, Axin2, promotes colon carcinoma oncogenic activity by Wu, Zhao-Qiu, Brabletz, Thomas, Fearon, Eric, Willis, Amanda L, Hu, Casey Yuexian, Li, Xiao-Yan, Weiss, Stephen J

“…Aberrant activation of canonical Wingless-type MMTV integration site family (Wnt) signaling is pathognomonic of colorectal cancers (CRC) harboring functional…”
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A cancer cell metalloprotease triad regulates the basement membrane transmigration program by Hotary, Kevin, Li, Xiao-Yan, Allen, Edward, Stevens, Susan L, Weiss, Stephen J

“…Carcinoma cells initiate the metastatic cascade by inserting invasive pseudopodia through breaches in the basement membrane (BM), a specialized barrier of…”
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A ZEB1/p53 signaling axis in stromal fibroblasts promotes mammary epithelial tumours by Fu, Rong, Han, Chen-Feng, Ni, Ting, Di, Lei, Liu, Li-Juan, Lv, Wen-Cong, Bi, Yan-Ran, Jiang, Nan, He, Yin, Li, Hong-Mei, Wang, Shui, Xie, Hui, Chen, Bao-An, Wang, Xiao-Sheng, Weiss, Stephen J., Lu, Tao, Guo, Qing-Long, Wu, Zhao-Qiu

“…Accumulating evidence indicates that the zinc-finger transcription factor ZEB1 is predominantly expressed in the stroma of several tumours. However, the role…”
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Membrane-type I matrix metalloproteinase-dependent regulation of rheumatoid arthritis synoviocyte function by Sabeh, Farideh, Fox, David, Weiss, Stephen J

“…In rheumatoid arthritis, the coordinated expansion of the synoviocyte mass is coupled with a pathologic angiogenic response that leads to the destructive…”
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Hepatocyte-Derived Snail1 Propagates Liver Fibrosis Progression by Rowe, R. Grant, Lin, Yongshun, Shimizu-Hirota, Ryoko, Hanada, Shinichiro, Neilson, Eric G., Greenson, Joel K., Weiss, Stephen J.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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