Search Results - "WEISS, HEIDI L."

mTORC1 and mTORC2 Regulate EMT, Motility, and Metastasis of Colorectal Cancer via RhoA and Rac1 Signaling Pathways by GULHATI, Pat, BOWEN, Kanika A, EVERS, B. Mark, JIANYU LIU, STEVENS, Payton D, RYCHAHOU, Piotr G, MIN CHEN, LEE, Eun Y, WEISS, Heidi L, O'CONNOR, Kathleen L, TIANYAN GAO

“…Activation of phosphoinositide 3-kinase (PI3K)/Akt signaling is associated with growth and progression of colorectal cancer (CRC). We have previously shown…”
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Downregulation of SREBP inhibits tumor growth and initiation by altering cellular metabolism in colon cancer by Wen, Yang-An, Xiong, Xiaopeng, Zaytseva, Yekaterina Y., Napier, Dana L., Vallee, Emma, Li, Austin T., Wang, Chi, Weiss, Heidi L., Evers, B. Mark, Gao, Tianyan

“…Sterol regulatory element-binding proteins (SREBPs) belong to a family of transcription factors that regulate the expression of genes required for the…”
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Biodistribution and bioimaging studies of hybrid paclitaxel nanocrystals: Lessons learned of the EPR effect and image-guided drug delivery by Hollis, Christin P., Weiss, Heidi L., Leggas, Markos, Evers, B. Mark, Gemeinhart, Richard A., Li, Tonglei

“…Paclitaxel (PTX) nanocrystals (200nm) were produced by crystallization from a solution. Antitumor efficacy and toxicity were examined through a survival study…”
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Inhibition of iNOS as a novel effective targeted therapy against triple-negative breast cancer by Granados-Principal, Sergio, Liu, Yi, Guevara, Maria L, Blanco, Elvin, Choi, Dong Soon, Qian, Wei, Patel, Tejal, Rodriguez, Angel A, Cusimano, Joseph, Weiss, Heidi L, Zhao, Hong, Landis, Melissa D, Dave, Bhuvanesh, Gross, Steven S, Chang, Jenny C

“…Triple-negative breast cancer (TNBC) is an aggressive form of breast cancer with no effective targeted therapy. Inducible nitric oxide synthase (iNOS) is…”
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The mitochondrial retrograde signaling regulates Wnt signaling to promote tumorigenesis in colon cancer by Wen, Yang-An, Xiong, Xiaopeng, Scott, Timothy, Li, Austin T., Wang, Chi, Weiss, Heidi L., Tan, Li, Bradford, Emily, Fan, Teresa W. M., Chandel, Navdeep S., Barrett, Terrence A., Gao, Tianyan

“…Cancer cells are known to upregulate aerobic glycolysis to promote growth, proliferation, and survival. However, the role of mitochondrial respiration in…”
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Inhibition of Fatty Acid Synthase Upregulates Expression of CD36 to Sustain Proliferation of Colorectal Cancer Cells by Drury, James, Rychahou, Piotr G, He, Daheng, Jafari, Naser, Wang, Chi, Lee, Eun Y, Weiss, Heidi L, Evers, Bernard Mark, Zaytseva, Yekaterina Y

“…Fatty acid synthase, a key enzyme of lipogenesis, is an attractive therapeutic target in cancer. The novel fatty acid synthase inhibitor, TVB-3664, shows…”
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S100A4 alters metabolism and promotes invasion of lung cancer cells by up-regulating mitochondrial complex I protein NDUFS2 by Liu, Lili, Qi, Lei, Knifley, Teresa, Piecoro, Dava W., Rychahou, Piotr, Liu, Jinpeng, Mitov, Mihail I., Martin, Jeremiah, Wang, Chi, Wu, Jianrong, Weiss, Heidi L., Butterfield, D. Allan, Evers, B. Mark, O'Connor, Kathleen L., Chen, Min

“…It is generally accepted that alterations in metabolism are critical for the metastatic process; however, the mechanisms by which these metabolic changes are…”
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De Novo Fatty Acid Synthesis-Driven Sphingolipid Metabolism Promotes Metastatic Potential of Colorectal Cancer by Jafari, Naser, Drury, James, Morris, Andrew J, Onono, Fredrick O, Stevens, Payton D, Gao, Tianyan, Liu, Jinpeng, Wang, Chi, Lee, Eun Y, Weiss, Heidi L, Evers, B Mark, Zaytseva, Yekaterina Y

“…Metastasis is the most common cause of death in colorectal cancer patients. Fatty acid synthase (FASN) and sphingosine kinase-1 and -2 (SPHK1 and 2) are…”
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Role of AMPK and Akt in triple negative breast cancer lung colonization by Johnson, Jeremy, Chow, Zeta, Lee, Eun, Weiss, Heidi L., Evers, B. Mark, Rychahou, Piotr

“…Triple negative breast cancer (TNBC) is an aggressive disease with a 5-y relative survival rate of 11% after distant metastasis. To survive the metastatic…”
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Increased expression of fatty acid synthase provides a survival advantage to colorectal cancer cells via upregulation of cellular respiration by Zaytseva, Yekaterina Y, Harris, Jennifer W, Mitov, Mihail I, Kim, Ji Tae, Butterfield, D Allan, Lee, Eun Y, Weiss, Heidi L, Gao, Tianyan, Evers, B Mark

“…Fatty acid synthase (FASN), a lipogenic enzyme, is upregulated in colorectal cancer (CRC). Increased de novo lipid synthesis is thought to be a metabolic…”
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Inhibition of Fatty Acid Synthase Attenuates CD44-Associated Signaling and Reduces Metastasis in Colorectal Cancer by ZAYTSEVA, Yekaterina Y, RYCHAHOU, Piotr G, EVERS, B. Mark, GULHATI, Pat, ELLIOTT, Victoria A, MUSTAIN, William C, O'CONNOR, Kathleen, MORRIS, Andrew J, SUNKARA, Manjula, WEISS, Heidi L, LEE, Eun Y

“…Fatty acid synthase (FASN) and ATP-citrate lyase, key enzymes of de novo lipogenesis, are significantly upregulated and activated in many cancers and portend…”
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Preclinical evaluation of novel fatty acid synthase inhibitors in primary colorectal cancer cells and a patient-derived xenograft model of colorectal cancer by Zaytseva, Yekaterina Y, Rychahou, Piotr G, Le, Anh-Thu, Scott, Timothy L, Flight, Robert M, Kim, Ji Tae, Harris, Jennifer, Liu, Jinpeng, Wang, Chi, Morris, Andrew J, Sivakumaran, Theru A, Fan, Teresa, Moseley, Hunter, Gao, Tianyan, Lee, Eun Y, Weiss, Heidi L, Heuer, Timothy S, Kemble, George, Evers, Mark

“…Fatty Acid Synthase (FASN), a key enzyme of lipogenesis, is upregulated in many cancers including colorectal cancer (CRC); increased FASN expression is…”
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Diverse expression patterns and tumorigenic role of neurotensin signaling components in colorectal cancer cells by Kim, Ji Tae, Weiss, Heidi L, Evers, B. Mark

“…Colorectal cancer (CRC), which is one of the most common malignancies worldwide, results from an accumulation of genetic and epigenetic modifications including…”
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Clinical Outcomes of Molecular Tumor Boards: A Systematic Review by Larson, Kara L, Huang, Bin, Weiss, Heidi L, Hull, Pam, Westgate, Philip M, Miller, Rachel W, Arnold, Susanne M, Kolesar, Jill M

“…We conducted this systematic review to evaluate the clinical outcomes associated with molecular tumor board (MTB) review in patients with cancer. A systematic…”
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Induction of AMPK activation by N,N'-diarylurea FND-4b decreases growth and increases apoptosis in triple negative and estrogen-receptor positive breast cancers by Johnson, Jeremy, Rychahou, Piotr, Sviripa, Vitaliy M, Weiss, Heidi L, Liu, Chunming, Watt, David S, Evers, B Mark

“…Triple negative breast cancer (TNBC) is the most lethal and aggressive subtype of breast cancer. AMP-activated protein kinase (AMPK) is a major energy…”
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Novel Expression Patterns of PI3K/Akt/mTOR Signaling Pathway Components in Colorectal Cancer by Johnson, Sara M., MD, Gulhati, Pat, BS, Rampy, Bill A., DO, PhD, Han, Yimei, MS, Rychahou, Piotr G., MD, Doan, Hung Q., BA, Weiss, Heidi L., PhD, Evers, B. Mark, MD, FACS

“…Background The phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR) pathway plays a critical role in the growth and progression of…”
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Nrbf2 Protein Suppresses Autophagy by Modulating Atg14L Protein-containing Beclin 1-Vps34 Complex Architecture and Reducing Intracellular Phosphatidylinositol-3 Phosphate Levels by Zhong, Yu, Morris, Deanna H., Jin, Lin, Patel, Mittul S., Karunakaran, Senthil K., Fu, You-Jun, Matuszak, Emily A., Weiss, Heidi L., Chait, Brian T., Wang, Qing Jun

“…Autophagy is a tightly regulated lysosomal degradation pathway for maintaining cellular homeostasis and responding to stresses. Beclin 1 and its interacting…”
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Profiles of Radioresistance Mechanisms in Prostate Cancer by Chaiswing, Luksana, Weiss, Heidi L, Jayswal, Rani D, Clair, Daret K St, Kyprianou, Natasha

“…Radiation therapy (RT) is commonly used for the treatment of localized prostate cancer (PCa). However, cancer cells often develop resistance to radiation…”
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Elevated integrin α6β4 expression is associated with venous invasion and decreased overall survival in non-small cell lung cancer by Stewart, Rachel L., DO, PhD, West, Dava, MD, Wang, Chi, PhD, Weiss, Heidi L., PhD, Gal, Tamas, PhD, Durbin, Eric, DrPH, MS, O'Connor, William, MD, Chen, Min, MD, PhD, O'Connor, Kathleen L., PhD

“…Summary Lung cancer carries a poor prognosis and is the most common cause of cancer-related death worldwide. The integrin α6β4, a laminin receptor, promotes…”
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Cancer cell-associated fatty acid synthase activates endothelial cells and promotes angiogenesis in colorectal cancer by Zaytseva, Yekaterina Y, Elliott, Victoria A, Rychahou, Piotr, Mustain, W Conan, Kim, Ji Tae, Valentino, Joseph, Gao, Tianyan, O'Connor, Kathleen L, Neltner, Janna M, Lee, Eun Y, Weiss, Heidi L, Evers, B Mark

“…Upregulation of fatty acid synthase (FASN), a key enzyme of de novo lipogenesis, is associated with metastasis in colorectal cancer (CRC). However, the…”
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