Search Results - "WEISS, Frank U"

A structured weight loss program increases gut microbiota phylogenetic diversity and reduces levels of Collinsella in obese type 2 diabetics: A pilot study by Frost, Fabian, Storck, Lena J, Kacprowski, Tim, Gärtner, Simone, Rühlemann, Malte, Bang, Corinna, Franke, Andre, Völker, Uwe, Aghdassi, Ali A, Steveling, Antje, Mayerle, Julia, Weiss, Frank U, Homuth, Georg, Lerch, Markus M

“…The global obesity epidemic constitutes a major cause of morbidity and mortality challenging public health care systems worldwide. Thus, a better understanding…”
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Identification and validation of a multivariable prediction model based on blood plasma and serum metabolomics for the distinction of chronic pancreatitis subjects from non-pancreas disease control subjects by Adam, M Gordian, Beyer, Georg, Christiansen, Nicole, Kamlage, Beate, Pilarsky, Christian, Distler, Marius, Fahlbusch, Tim, Chromik, Ansgar, Klein, Fritz, Bahra, Marcus, Uhl, Waldemar, Grützmann, Robert, Mahajan, Ujjwal M, Weiss, Frank U, Mayerle, Julia, Lerch, Markus M

“…Chronic pancreatitis (CP) is a fibroinflammatory syndrome leading to organ dysfunction, chronic pain, an increased risk for pancreatic cancer and considerable…”
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In mouse chronic pancreatitis CD25+FOXP3+ regulatory T cells control pancreatic fibrosis by suppression of the type 2 immune response by Glaubitz, Juliane, Wilden, Anika, Golchert, Janine, Homuth, Georg, Völker, Uwe, Bröker, Barbara M., Thiele, Thomas, Lerch, Markus M., Mayerle, Julia, Aghdassi, Ali A., Weiss, Frank U., Sendler, Matthias

“…Chronic pancreatitis (CP) is characterized by chronic inflammation and the progressive fibrotic replacement of exocrine and endocrine pancreatic tissue. We…”
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Pancreatic cancer risk in hereditary pancreatitis by Weiss, Frank U

“…Inflammation is part of the body's immune response in order to remove harmful stimuli-like pathogens, irritants or damaged cells-and start the healing process…”
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Carrying asymptomatic gallstones is not associated with changes in intestinal microbiota composition and diversity but cholecystectomy with significant dysbiosis by Frost, Fabian, Kacprowski, Tim, Rühlemann, Malte, Weiss, Stefan, Bang, Corinna, Franke, Andre, Pietzner, Maik, Aghdassi, Ali A., Sendler, Matthias, Völker, Uwe, Völzke, Henry, Mayerle, Julia, Weiss, Frank U., Homuth, Georg, Lerch, Markus M.

“…Gallstone disease affects up to twenty percent of the population in western countries and is a significant contributor to morbidity and health care…”
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Circulating U2 small nuclear RNA fragments as a novel diagnostic biomarker for pancreatic and colorectal adenocarcinoma by Baraniskin, Alexander, Nöpel‐Dünnebacke, Stefanie, Ahrens, Maike, Jensen, Steffen Grann, Zöllner, Hannah, Maghnouj, Abdelouahid, Wos, Alexandra, Mayerle, Julia, Munding, Johanna, Kost, Dennis, Reinacher‐Schick, Anke, Liffers, Sven, Schroers, Roland, Chromik, Ansgar M., Meyer, Helmut E., Uhl, Waldemar, Klein‐Scory, Susanne, Weiss, Frank U., Stephan, Christian, Schwarte‐Waldhoff, Irmgard, Lerch, Markus M., Tannapfel, Andrea, Schmiegel, Wolff, Andersen, Claus Lindbjerg, Hahn, Stephan A.

“…Improved non‐invasive strategies for early cancer detection are urgently needed to reduce morbidity and mortality. Non‐coding RNAs, such as microRNAs and small…”
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NMR Metabolomics Reveal Urine Markers of Microbiome Diversity and Identify Benzoate Metabolism as a Mediator between High Microbial Alpha Diversity and Metabolic Health by Hertel, Johannes, Fässler, Daniel, Heinken, Almut, Weiß, Frank U, Rühlemann, Malte, Bang, Corinna, Franke, Andre, Budde, Kathrin, Henning, Ann-Kristin, Petersmann, Astrid, Völker, Uwe, Völzke, Henry, Thiele, Ines, Grabe, Hans-Jörgen, Lerch, Markus M, Nauck, Matthias, Friedrich, Nele, Frost, Fabian

“…Microbial metabolites measured using NMR may serve as markers for physiological or pathological host-microbe interactions and possibly mediate the beneficial…”
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Fecal glycoprotein 2 is a marker of gut microbiota dysbiosis and systemic inflammation by Frost, Fabian, Weiss, Stefan, Hertel, Johannes, Rühlemann, Malte, Bang, Corinna, Franke, Andre, Nauck, Matthias, Dörr, Marcus, Völzke, Henry, Roggenbuck, Dirk, Schierack, Peter, Völker, Uwe, Homuth, Georg, Aghdassi, Ali A, Sendler, Matthias, Lerch, Markus M, Weiss, Frank U

“…Antimicrobial autoantigenic glycoprotein 2 (GP2) is an important component of the innate immune system which originates from the exocrine pancreas as well as…”
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Animal models for investigating chronic pancreatitis by Aghdassi, Alexander A, Mayerle, Julia, Christochowitz, Sandra, Weiss, Frank U, Sendler, Matthias, Lerch, Markus M

“…Chronic pancreatitis is defined as a continuous or recurrent inflammatory disease of the pancreas characterized by progressive and irreversible morphological…”
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Copy number variants and VNTR length polymorphisms of the carboxyl-ester lipase ( CEL ) gene as risk factors in pancreatic cancer by Dalva, Monica, El Jellas, Khadija, Steine, Solrun J, Johansson, Bente B, Ringdal, Monika, Torsvik, Janniche, Immervoll, Heike, Hoem, Dag, Laemmerhirt, Felix, Simon, Peter, Lerch, Markus M, Johansson, Stefan, Njølstad, Pål R, Weiss, Frank U, Fjeld, Karianne, Molven, Anders

“…Abstract Background/Objectives We have recently described copy number variants (CNVs) of the human carboxyl-ester lipase ( CEL) gene, including a recombined…”
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Determination of the Pathological Features of NPC1 Variants in a Cellular Complementation Test by Feng, Xiao, Cozma, Claudia, Pantoom, Supansa, Hund, Christina, Iwanov, Katharina, Petters, Janine, Völkner, Christin, Bauer, Claudia, Vogel, Florian, Bauer, Peter, Weiss, Frank U, Lerch, Markus M, Knospe, Anne-Marie, Hermann, Andreas, Frech, Moritz J, Luo, Jiankai, Rolfs, Arndt, Lukas, Jan

“…Niemann-Pick Type C (NP-C) is a rare disorder of lipid metabolism caused by mutations within the and genes. NP-C is a neurovisceral disease leading to a…”
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The composition of the stent microbiome is associated with morbidity and adverse events during endoscopic drainage therapy of pancreatic necroses and pseudocysts by Frost, Fabian, Khaimov, Valeria, Senz, Volkmar, Weiss, Stefan, Klußmann-Fricke, Bastian, Rühlemann, Malte, Bang, Corinna, Franke, Andre, Pickartz, Tilman, Budde, Christoph, Aghdassi, Ali A, Siewert, Stefan, Weiss, Frank U, Grabow, Niels, Lerch, Markus M, Sendler, Matthias

“…Development of pancreatic necroses or pseudocysts are typical complications of pancreatitis and may require endoscopic drainage therapy using metal or plastic…”
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Drug Efflux Transporter Multidrug Resistance-Associated Protein 5 Affects Sensitivity of Pancreatic Cancer Cell Lines to the Nucleoside Anticancer Drug 5-Fluorouracil by NAMBARU, Praveen K, HÜBNER, Tobias, ROSSKOPF, Dieter, KOWALCZYK, Dariusz W, KROEMER, Heyo K, WEISS, Frank U, MAYERLE, Julia, LERCH, Markus M, RITTER, Christoph A, KÖCK, Kathleen, MEWS, Steffen, GRUBE, Markus, PAYEN, Léa, GUITTON, Jérôme, SENDLER, Matthias, JEDLITSCHKY, Gabriele, RIMMBACH, Christian

“…Pancreatic adenocarcinoma is one of the malignancies that is highly resistant to therapy and among the leading causes of cancer-related death. Several factors…”
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Large-scale association analyses identify host factors influencing human gut microbiome composition by Kurilshikov, Alexander, Medina-Gomez, Carolina, Bacigalupe, Rodrigo, Radjabzadeh, Djawad, Wang, Jun, Demirkan, Ayse, Le Roy, Caroline I., Raygoza Garay, Juan Antonio, Finnicum, Casey T., Liu, Xingrong, Zhernakova, Daria V., Bonder, Marc Jan, Hansen, Tue H., Frost, Fabian, Rühlemann, Malte C., Turpin, Williams, Moon, Jee-Young, Kim, Han-Na, Lüll, Kreete, Barkan, Elad, Shah, Shiraz A., Fornage, Myriam, Szopinska-Tokov, Joanna, Wallen, Zachary D., Borisevich, Dmitrii, Agreus, Lars, Andreasson, Anna, Bang, Corinna, Bedrani, Larbi, Bell, Jordana T., Bisgaard, Hans, Boehnke, Michael, Boomsma, Dorret I., Burk, Robert D., Claringbould, Annique, Croitoru, Kenneth, Davies, Gareth E., van Duijn, Cornelia M., Duijts, Liesbeth, Falony, Gwen, Fu, Jingyuan, van der Graaf, Adriaan, Hansen, Torben, Homuth, Georg, Hughes, David A., Ijzerman, Richard G., Jackson, Matthew A., Jaddoe, Vincent W. V., Joossens, Marie, Jørgensen, Torben, Keszthelyi, Daniel, Knight, Rob, Laakso, Markku, Laudes, Matthias, Launer, Lenore J., Lieb, Wolfgang, Lusis, Aldons J., Masclee, Ad A. M., Moll, Henriette A., Mujagic, Zlatan, Qibin, Qi, Rothschild, Daphna, Shin, Hocheol, Sørensen, Søren J., Steves, Claire J., Thorsen, Jonathan, Timpson, Nicholas J., Vieira-Silva, Sara, Völker, Uwe, Völzke, Henry, Võsa, Urmo, Wade, Kaitlin H., Walter, Susanna, Watanabe, Kyoko, Weiss, Stefan, Weiss, Frank U., Weissbrod, Omer, Westra, Harm-Jan, Willemsen, Gonneke, Payami, Haydeh, Jonkers, Daisy M. A. E., Arias Vasquez, Alejandro, de Geus, Eco J. C., Stokholm, Jakob, Segal, Eran, Kim, Hyung-Lae, Kaplan, Robert C., Spector, Tim D., Uitterlinden, Andre G., Rivadeneira, Fernando, Franke, Andre, Lerch, Markus M., Franke, Lude, Sanna, Serena, D’Amato, Mauro, Pedersen, Oluf, Paterson, Andrew D., Kraaij, Robert, Raes, Jeroen, Zhernakova, Alexandra

“…To study the effect of host genetics on gut microbiome composition, the MiBioGen consortium curated and analyzed genome-wide genotypes and 16S fecal microbiome…”
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Association analysis of genetic variants in the myosin IXB gene in acute pancreatitis by Nijmeijer, Rian M, van Santvoort, Hjalmar C, Zhernakova, Alexandra, Teller, Steffen, Scheiber, Jonas A, de Kovel, Carolien G, Besselink, Marc G H, Visser, Jeroen T J, Lutgendorff, Femke, Bollen, Thomas L, Boermeester, Marja A, Rijkers, Ger T, Weiss, Frank U, Mayerle, Julia, Lerch, Markus M, Gooszen, Hein G, Akkermans, Louis M A, Wijmenga, Cisca

“…Impairment of the mucosal barrier plays an important role in the pathophysiology of acute pancreatitis. The myosin IXB (MYO9B) gene and the two tight-junction…”
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Impaired Exocrine Pancreatic Function Associates With Changes in Intestinal Microbiota Composition and Diversity by Frost, Fabian, Kacprowski, Tim, Rühlemann, Malte, Bülow, Robin, Kühn, Jens-Peter, Franke, Andre, Heinsen, Femke-Anouska, Pietzner, Maik, Nauck, Matthias, Völker, Uwe, Völzke, Henry, Aghdassi, Ali A., Sendler, Matthias, Mayerle, Julia, Weiss, Frank U., Homuth, Georg, Lerch, Markus M.

“…Changes in intestinal microbiome composition are associated with inflammatory, metabolic, and malignant disorders. We studied how exocrine pancreatic function…”
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Exocrine Pancreatic Function Modulates Plasma Metabolites Through Changes in Gut Microbiota Composition by Pietzner, Maik, Budde, Kathrin, Rühlemann, Malte, Völzke, Henry, Homuth, Georg, Weiss, Frank U, Lerch, Markus M, Frost, Fabian

“…Abstract Purpose Exocrine pancreatic function is critically involved in regulating the gut microbiota composition. At the same time, its impairment acutely…”
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Tumour necrosis factor α secretion induces protease activation and acinar cell necrosis in acute experimental pancreatitis in mice by Sendler, Matthias, Dummer, Annegret, Weiss, Frank U, Krüger, Burkhard, Wartmann, Thomas, Scharffetter-Kochanek, Karin, van Rooijen, Nico, Malla, Sudarshan Ravi, Aghdassi, Ali, Halangk, Walter, Lerch, Markus M, Mayerle, Julia

“…Acute pancreatitis has long been considered a disorder of pancreatic self-digestion, in which intracellular activation of digestive proteases induces tissue…”
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Helicobacter pylori infection associates with fecal microbiota composition and diversity by Frost, Fabian, Kacprowski, Tim, Rühlemann, Malte, Bang, Corinna, Franke, Andre, Zimmermann, Kathrin, Nauck, Matthias, Völker, Uwe, Völzke, Henry, Biffar, Reiner, Schulz, Christian, Mayerle, Julia, Weiss, Frank U., Homuth, Georg, Lerch, Markus M.

“…Helicobacter (H.) pylori is the most important cause for peptic ulcer disease and a risk factor for gastric carcinoma. How colonization with H. pylori affects…”
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Chronic pancreatitis: an update on genetic risk factors by Weiss, Frank U, Skube, Mariya E, Lerch, Markus M

“…PURPOSE OF REVIEWGenetic mutations in genes within and outside of the trypsin-dependent pathologic pathway have been found to be associated with chronic…”
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