Search Results - "WEISMAN, GARY A."

ATP7A delivers copper to the lysyl oxidase family of enzymes and promotes tumorigenesis and metastasis by Shanbhag, Vinit, Jasmer-McDonald, Kimberly, Zhu, Sha, Martin, Adam L., Gudekar, Nikita, Khan, Aslam, Ladomersky, Erik, Singh, Kamlendra, Weisman, Gary A., Petris, Michael J.

“…Lysyl oxidase (LOX) and LOX-like (LOXL) proteins are copperdependent metalloenzymes with well-documented roles in tumor metastasis and fibrotic diseases. The…”
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Purinergic receptors as potential therapeutic targets in Alzheimer's disease by Woods, Lucas T., Ajit, Deepa, Camden, Jean M., Erb, Laurie, Weisman, Gary A.

“…Alzheimer's disease (AD) is a neurodegenerative disorder characterized by a progressive loss of memory and cognitive ability and is a serious cause of…”
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Radiation-Induced Salivary Gland Dysfunction: Mechanisms, Therapeutics and Future Directions by Jasmer, Kimberly J, Gilman, Kristy E, Muñoz Forti, Kevin, Weisman, Gary A, Limesand, Kirsten H

“…Salivary glands sustain collateral damage following radiotherapy (RT) to treat cancers of the head and neck, leading to complications, including mucositis,…”
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Beneficial effects of dietary EGCG and voluntary exercise on behavior in an Alzheimer's disease mouse model by Walker, Jennifer M, Klakotskaia, Diana, Ajit, Deepa, Weisman, Gary A, Wood, W Gibson, Sun, Grace Y, Serfozo, Peter, Simonyi, Agnes, Schachtman, Todd R

“…Alzheimer's disease (AD) is a progressive, age-dependent neurodegenerative disorder affecting specific brain regions that control memory and cognitive…”
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International Union of Pharmacology LVIII: Update on the P2Y G Protein-Coupled Nucleotide Receptors: From Molecular Mechanisms and Pathophysiology to Therapy by Abbracchio, Maria P, Burnstock, Geoffrey, Boeynaems, Jean-Marie, Barnard, Eric A, Boyer, José L, Kennedy, Charles, Knight, Gillian E, Fumagalli, Marta, Gachet, Christian, Jacobson, Kenneth A, Weisman, Gary A

“…There have been many advances in our knowledge about different aspects of P2Y receptor signaling since the last review published by our International Union of…”
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Synthesis, structure-activity relationships and biological evaluation of benzimidazole derived sulfonylurea analogues as a new class of antagonists of P2Y1 receptor by Bano, Sehrish, Hussain, Zahid, Langer, Peter, Weisman, Gary A, Iqbal, Jamshed

“…The P2Y receptors are responsible for the regulation of various physiological processes including neurotransmission and inflammatory responses. These receptors…”
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Pro-inflammatory cytokines and lipopolysaccharide induce changes in cell morphology, and upregulation of ERK1/2, iNOS and sPLA₂-IIA expression in astrocytes and microglia by Sheng, Wenwen, Zong, Yijia, Mohammad, Arwa, Ajit, Deepa, Cui, Jiankun, Han, Dongdong, Hamilton, Jennifer L, Simonyi, Agnes, Sun, Albert Y, Gu, Zezong, Hong, Jau-Shyong, Weisman, Gary A, Sun, Grace Y

“…Activation of glial cells, including astrocytes and microglia, has been implicated in the inflammatory responses underlying brain injury and neurodegenerative…”
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Increased Expression of TGF-β Signaling Components in a Mouse Model of Fibrosis Induced by Submandibular Gland Duct Ligation by Woods, Lucas T, Camden, Jean M, El-Sayed, Farid G, Khalafalla, Mahmoud G, Petris, Michael J, Erb, Laurie, Weisman, Gary A

“…Transforming growth factor-β (TGF-β) is a multi-functional cytokine with a well-described role in the regulation of tissue fibrosis and regeneration in the…”
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Advances in the Understanding of Mammalian Copper Transporters by Wang, Yanfang, Hodgkinson, Victoria, Zhu, Sha, Weisman, Gary A., Petris, Michael J.

“…Copper (Cu) is an essential micronutrient. Its ability to exist in 2 oxidation states (Cu1+ and Cu2+) allows it to function as an enzymatic cofactor in…”
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Highly Potent and Selective Ectonucleotide Pyrophosphatase/Phosphodiesterase I Inhibitors Based on an Adenosine 5′-(α or γ)-Thio-(α,β- or β,γ)-methylenetriphosphate Scaffold by Nadel, Yael, Lecka, Joanna, Gilad, Yocheved, Ben-David, Gal, Förster, Daniel, Reiser, Georg, Kenigsberg, Sarah, Camden, Jean, Weisman, Gary A, Senderowitz, Hanoch, Sévigny, Jean, Fischer, Bilha

“…Aberrant nucleotide pyrophosphatase/phosphodiesterase-1 (NPP1) activity is associated with chondrocalcinosis, osteoarthritis, and type 2 diabetes. The…”
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P2Y receptors in the mammalian nervous system: pharmacology, ligands and therapeutic potential by Weisman, Gary A, Woods, Lucas T, Erb, Laurie, Seye, Cheikh I

“…P2Y receptors for extracellular nucleotides are coupled to activation of a variety of G proteins and stimulate diverse intracellular signaling pathways that…”
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Altered microglial copper homeostasis in a mouse model of Alzheimer’s disease by Zheng, Zhiqiang, White, Carine, Lee, Jaekwon, Peterson, Troy S., Bush, Ashley I., Sun, Grace Y., Weisman, Gary A., Petris, Michael J.

“…J. Neurochem. (2010) 114, 1630–1638. Alzheimer’s disease (AD) is characterized by progressive neurodegeneration associated with the aggregation and deposition…”
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P2X7 receptor activation induces inflammatory responses in salivary gland epithelium by Woods, Lucas T, Camden, Jean M, Batek, Josef M, Petris, Michael J, Erb, Laurie, Weisman, Gary A

“…Inflammation of the salivary gland is a well-documented aspect of salivary gland dysfunction that occurs in Sjogren's syndrome (SS), an autoimmune disease, and…”
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X-linked spinal muscular atrophy in mice caused by autonomous loss of ATP7A in the motor neuron by Hodgkinson, Victoria L, Dale, Jeffery M, Garcia, Michael L, Weisman, Gary A, Lee, Jaekwon, Gitlin, Jonathan D, Petris, Michael J

“…ATP7A is a copper‐transporting P‐type ATPase that is essential for cellular copper homeostasis. Loss‐of‐function mutations in the ATP7A gene result in Menkes…”
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P2 Receptors as Therapeutic Targets in the Salivary Gland: From Physiology to Dysfunction by Khalafalla, Mahmoud G, Woods, Lucas T, Jasmer, Kimberly J, Forti, Kevin Muñoz, Camden, Jean M, Jensen, Janicke L, Limesand, Kirsten H, Galtung, Hilde K, Weisman, Gary A

“…Although often overlooked in our daily lives, saliva performs a host of necessary physiological functions, including lubricating and protecting the oral…”
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Prolonged exposure of cortical neurons to oligomeric amyloid-β impairs NMDA receptor function via NADPH oxidase-mediated ROS production: protective effect of green tea (-)-epigallocatechin-3-gallate by He, Yan, Cui, Jiankun, Lee, James C-M, Ding, Shinghua, Chalimoniuk, Malgorzata, Simonyi, Agnes, Sun, Albert Y, Gu, Zezong, Weisman, Gary A, Wood, W Gibson, Sun, Grace Y

“…Excessive production of Aβ (amyloid β-peptide) has been shown to play an important role in the pathogenesis of AD (Alzheimer's disease). Although not yet well…”
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Characterization of the UDP-glucose receptor (re-named here the P2Y 14 receptor) adds diversity to the P2Y receptor family by Abbracchio, Maria P, Boeynaems, Jean-Marie, Barnard, Eric A, Boyer, José L, Kennedy, Charles, Miras-Portugal, Maria Teresa, King, Brian F, Gachet, Christian, Jacobson, Kenneth A, Weisman, Gary A, Burnstock, Geoffrey

“…The cloning of a human G-protein-coupled receptor (GPCR) that specifically responds to UDP-glucose and related sugar-nucleotides has been reported recently…”
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Evolution, correlation, structural impact and dynamics of emerging SARS-CoV-2 variants by Spratt, Austin N., Kannan, Saathvik R., Woods, Lucas T., Weisman, Gary A., Quinn, Thomas P., Lorson, Christian L., Sönnerborg, Anders, Byrareddy, Siddappa N., Singh, Kamal

“…[Display omitted] Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) infections remain unmanageable in some parts of the world. As with other RNA…”
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Conditional knockout of the Menkes disease copper transporter demonstrates its critical role in embryogenesis by Wang, Yanfang, Zhu, Sha, Weisman, Gary A, Gitlin, Jonathan D, Petris, Michael J

“…The transition metal, copper (Cu), is an enzymatic cofactor required for a wide range of biochemical processes. Its essentiality is demonstrated by Menkes…”
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Neuroprotective mechanisms of curcumin against cerebral ischemia-induced neuronal apoptosis and behavioral deficits by Wang, Qun, Sun, Albert Y., Simonyi, Agnes, Jensen, Michael D., Shelat, Phullara B., Rottinghaus, George E., MacDonald, Ruth S., Miller, Dennis K., Lubahn, Dennis E., Weisman, Gary A., Sun, Grace Y.

“…Increased oxidative stress has been regarded as an important underlying cause for neuronal damage induced by cerebral ischemia/reperfusion (I/R) injury. In…”
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